GREMLIN Database
Q97ZC1 - Sugar ABC transporter
UniProt: Q97ZC1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (245)
Sequences: 68405 (45179)
Seq/√Len: 2886.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_N180_S4.1231.00
66_I70_E3.2721.00
168_R177_R3.1201.00
153_Q157_S3.0601.00
27_A52_L2.7721.00
64_P221_T2.7311.00
92_R164_E2.6761.00
63_D66_I2.6501.00
164_E182_L2.6351.00
167_A177_R2.5761.00
74_L137_A2.5521.00
155_T189_G2.5151.00
173_N176_N2.4571.00
78_I141_T2.4521.00
216_S224_Q2.4501.00
50_N53_L2.4351.00
53_L57_Q2.3921.00
76_G194_F2.3861.00
62_I66_I2.3811.00
174_L177_R2.3291.00
230_N233_A2.3161.00
152_L190_I2.3021.00
175_F179_F2.2901.00
50_N54_T2.2521.00
95_R98_A2.1451.00
176_N179_F2.0771.00
172_A176_N2.0651.00
84_I178_L2.0611.00
148_A193_A1.9931.00
91_S157_S1.9931.00
163_L185_L1.9291.00
156_F186_A1.9291.00
167_A172_A1.9161.00
102_I153_Q1.8641.00
84_I186_A1.8561.00
80_I194_F1.8331.00
25_L29_N1.8191.00
21_Y25_L1.8121.00
168_R174_L1.7891.00
164_E177_R1.7521.00
63_D67_K1.7491.00
72_A198_W1.7271.00
83_A148_A1.7011.00
84_I152_L1.6451.00
70_E74_L1.6441.00
54_T233_A1.6351.00
90_L149_T1.6251.00
75_V201_S1.6211.00
18_F22_I1.5851.00
86_A149_T1.5781.00
164_E168_R1.5741.00
24_V239_L1.5131.00
148_A197_S1.4931.00
94_P98_A1.4801.00
97_I100_S1.4801.00
205_F209_I1.4711.00
161_I164_E1.4651.00
54_T57_Q1.4551.00
71_T217_T1.4521.00
91_S153_Q1.4381.00
87_G152_L1.4181.00
192_A196_I1.4141.00
81_A85_P1.4131.00
183_L190_I1.4111.00
6_Y10_I1.4101.00
48_T51_N1.3841.00
60_A63_D1.3831.00
156_F182_L1.3731.00
152_L193_A1.3521.00
79_T197_S1.3471.00
49_L53_L1.3301.00
22_I26_L1.3191.00
167_A181_V1.2961.00
161_I165_H1.2941.00
254_K257_R1.2761.00
139_A211_L1.2761.00
92_R161_I1.2741.00
162_D165_H1.2291.00
205_F223_Y1.2251.00
216_S221_T1.2251.00
84_I190_I1.2211.00
207_Y211_L1.2161.00
88_Y156_F1.2161.00
74_L77_I1.2111.00
100_S103_I1.2031.00
52_L239_L1.1991.00
159_I185_L1.1901.00
77_I81_A1.1761.00
67_K70_E1.1701.00
173_N177_R1.1661.00
136_L208_A1.1481.00
80_I190_I1.1361.00
10_I14_I1.1291.00
23_L239_L1.1281.00
137_A141_T1.1261.00
187_A191_A1.1191.00
145_L149_T1.1191.00
204_E207_Y1.1071.00
250_F254_K1.1011.00
132_S135_G1.0981.00
100_S104_L1.0771.00
54_T58_G1.0701.00
129_L134_V1.0691.00
208_A217_T1.0671.00
152_L189_G1.0651.00
74_L78_I1.0581.00
75_V140_Q1.0561.00
68_S218_L1.0541.00
151_I193_A1.0541.00
56_L62_I1.0521.00
131_E135_G1.0461.00
85_P89_G1.0441.00
88_Y178_L1.0421.00
185_L188_P1.0401.00
91_S156_F1.0361.00
221_T237_F1.0351.00
217_T220_V1.0351.00
78_I137_A1.0341.00
75_V79_T1.0231.00
98_A157_S1.0201.00
164_E174_L1.0181.00
26_L235_I1.0041.00
88_Y174_L0.9971.00
61_F237_F0.9921.00
224_Q227_T0.9911.00
122_V126_K0.9891.00
22_I25_L0.9881.00
172_A177_R0.9861.00
216_S220_V0.9811.00
177_R180_S0.9771.00
204_E208_A0.9711.00
69_L73_T0.9531.00
65_F218_L0.9461.00
140_Q201_S0.9351.00
41_S44_P0.9201.00
221_T224_Q0.9131.00
41_S45_V0.9081.00
87_G91_S0.9061.00
43_L46_S0.9031.00
75_V137_A0.8981.00
70_E73_T0.8911.00
209_I220_V0.8911.00
120_I211_L0.8881.00
77_I194_F0.8851.00
96_A99_Y0.8851.00
106_L150_F0.8841.00
73_T77_I0.8811.00
155_T186_A0.8781.00
212_I216_S0.8771.00
79_T83_A0.8771.00
113_A143_I0.8771.00
187_A190_I0.8721.00
5_V9_A0.8661.00
251_A255_Y0.8631.00
65_F69_L0.8571.00
27_A31_P0.8541.00
55_A240_I0.8541.00
179_F183_L0.8531.00
139_A207_Y0.8521.00
148_A152_L0.8491.00
121_A125_L0.8481.00
152_L186_A0.8471.00
120_I139_A0.8471.00
78_I81_A0.8471.00
87_G149_T0.8421.00
26_L29_N0.8421.00
186_A189_G0.8421.00
178_L183_L0.8361.00
70_E133_V0.8351.00
197_S201_S0.8341.00
224_Q228_R0.8341.00
83_A149_T0.8331.00
74_L141_T0.8231.00
177_R182_L0.8191.00
19_P23_L0.8181.00
90_L102_I0.8111.00
51_N232_L0.8051.00
13_G17_L0.8051.00
245_V249_T0.8031.00
71_T140_Q0.8021.00
87_G156_F0.8021.00
129_L132_S0.8001.00
26_L30_S0.7991.00
89_G95_R0.7991.00
117_G206_T0.7981.00
99_Y102_I0.7961.00
187_A255_Y0.7931.00
79_T144_T0.7901.00
18_F21_Y0.7851.00
66_I69_L0.7831.00
23_L235_I0.7771.00
163_L181_V0.7741.00
28_F47_L0.7721.00
226_V229_G0.7711.00
30_S45_V0.7701.00
117_G210_L0.7631.00
80_I152_L0.7631.00
64_P67_K0.7631.00
86_A145_L0.7601.00
178_L182_L0.7561.00
83_A152_L0.7501.00
172_A180_S0.7471.00
30_S46_S0.7471.00
19_P26_L0.7461.00
152_L156_F0.7431.00
174_L178_L0.7421.00
125_L130_F0.7411.00
106_L109_N0.7381.00
29_N44_P0.7361.00
225_D234_G0.7351.00
26_L31_P0.7341.00
225_D229_G0.7291.00
247_I251_A0.7271.00
116_I142_L0.7261.00
90_L101_I0.7261.00
90_L153_Q0.7251.00
54_T230_N0.7231.00
72_A76_G0.7221.00
79_T148_A0.7211.00
76_G198_W0.7201.00
190_I193_A0.7141.00
235_I239_L0.7131.00
7_L10_I0.7121.00
233_A237_F0.7101.00
28_F48_T0.7071.00
161_I168_R0.7071.00
222_I237_F0.7061.00
23_L238_S0.7001.00
166_Q170_D0.6961.00
62_I65_F0.6951.00
159_I186_A0.6941.00
221_T225_D0.6911.00
49_L52_L0.6901.00
219_P241_F0.6901.00
46_S49_L0.6881.00
113_A206_T0.6871.00
235_I238_S0.6871.00
64_P218_L0.6851.00
131_E214_Y0.6841.00
136_L140_Q0.6821.00
144_T200_F0.6731.00
29_N46_S0.6711.00
12_V16_F0.6691.00
76_G80_I0.6661.00
102_I150_F0.6651.00
55_A237_F0.6651.00
51_N54_T0.6641.00
58_G62_I0.6631.00
82_L141_T0.6611.00
182_L185_L0.6611.00
13_G16_F0.6601.00
56_L59_T0.6601.00
144_T197_S0.6591.00
79_T201_S0.6561.00
124_F130_F0.6561.00
89_G93_L0.6551.00
47_L50_N0.6541.00
130_F133_V0.6531.00
136_L212_I0.6501.00
220_V224_Q0.6491.00
71_T136_L0.6491.00
53_L56_L0.6481.00
246_I250_F0.6471.00
68_S219_P0.6461.00
52_L236_A0.6441.00
55_A233_A0.6441.00
82_L145_L0.6431.00
208_A212_I0.6401.00
19_P27_A0.6401.00
223_Y227_T0.6381.00
166_Q169_V0.6351.00
189_G193_A0.6341.00
94_P99_Y0.6331.00
14_I18_F0.6321.00
95_R101_I0.6241.00
109_N146_P0.6221.00
114_I210_L0.6201.00
60_A221_T0.6201.00
29_N45_V0.6171.00
204_E217_T0.6141.00
218_L241_F0.6121.00
8_G12_V0.6101.00
97_I101_I0.6101.00
122_V125_L0.6101.00
71_T137_A0.6101.00
86_A105_L0.6081.00
60_A216_S0.6051.00
190_I194_F0.6051.00
105_L146_P0.6031.00
208_A220_V0.5981.00
200_F203_D0.5971.00
46_S50_N0.5901.00
120_I123_D0.5891.00
68_S202_W0.5891.00
79_T141_T0.5891.00
31_P44_P0.5861.00
109_N147_L0.5851.00
71_T75_V0.5841.00
206_T209_I0.5811.00
72_A202_W0.5811.00
231_L235_I0.5781.00
59_T63_D0.5781.00
48_T52_L0.5781.00
19_P24_V0.5761.00
179_F182_L0.5711.00
151_I189_G0.5701.00
231_L234_G0.5701.00
123_D130_F0.5681.00
75_V141_T0.5661.00
96_A100_S0.5661.00
87_G153_Q0.5651.00
140_Q143_I0.5651.00
130_F135_G0.5641.00
173_N179_F0.5601.00
177_R181_V0.5601.00
27_A239_L0.5581.00
191_A194_F0.5571.00
27_A236_A0.5541.00
127_L130_F0.5541.00
99_Y103_I0.5541.00
252_L255_Y0.5541.00
199_M203_D0.5521.00
72_A201_S0.5521.00
251_A254_K0.5501.00
44_P47_L0.5491.00
59_T62_I0.5481.00
24_V28_F0.5481.00
9_A13_G0.5481.00
103_I107_V0.5481.00
194_F197_S0.5451.00
201_S204_E0.5441.00
206_T210_L0.5431.00
241_F245_V0.5421.00
17_L21_Y0.5401.00
250_F253_Q0.5391.00
80_I84_I0.5381.00
140_Q204_E0.5371.00
143_I146_P0.5361.00
93_L174_L0.5331.00
101_I105_L0.5331.00
129_L133_V0.5331.00
193_A197_S0.5331.00
113_A117_G0.5321.00
88_Y182_L0.5311.00
58_G233_A0.5281.00
76_G201_S0.5281.00
94_P161_I0.5271.00
42_L45_V0.5271.00
71_T133_V0.5251.00
108_T146_P0.5251.00
127_L132_S0.5241.00
67_K217_T0.5231.00
86_A89_G0.5231.00
182_L186_A0.5201.00
244_P247_I0.5181.00
247_I250_F0.5131.00
140_Q208_A0.5111.00
225_D228_R0.5091.00
166_Q172_A0.5061.00
131_E134_V0.5051.00
159_I164_E0.5041.00
220_V223_Y0.5041.00
137_A140_Q0.5021.00
116_I143_I0.5011.00
19_P22_I0.5011.00
111_M115_V0.5011.00
165_H168_R0.5011.00
102_I157_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquN 1 0.9476 100 0.265 Contact Map
2onkC 2 0.8951 100 0.27 Contact Map
3rlfG 1 0.9813 100 0.278 Contact Map
3d31C 2 0.8839 100 0.303 Contact Map
4tquM 1 0.9139 100 0.31 Contact Map
3rlfF 1 0.9176 100 0.366 Contact Map
4ymuD 2 0.7978 99.9 0.456 Contact Map
3tuiA 2 0.7753 99.9 0.508 Contact Map
4mrsA 2 0.3521 4.1 0.955 Contact Map
2nwlA 3 0.6142 3.4 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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