GREMLIN Database
Q97ZC0 - Sugar ABC transporter
UniProt: Q97ZC0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 324 (245)
Sequences: 37085 (24060)
Seq/√Len: 1537.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_E202_R3.9131.00
16_I19_N3.2291.00
7_D20_G3.2141.00
75_N152_S3.0001.00
4_E24_K2.9911.00
6_I58_K2.9881.00
32_V200_A2.9401.00
10_K47_I2.8591.00
31_F204_A2.7331.00
9_V56_K2.5331.00
197_L218_K2.4351.00
5_L8_I2.4231.00
216_D219_T2.4171.00
4_E60_I2.3681.00
215_S219_T2.3461.00
26_E29_E2.3141.00
11_K16_I2.2101.00
204_A211_F2.1591.00
202_R214_V2.0611.00
62_D152_S2.0571.00
9_V20_G2.0431.00
6_I60_I2.0321.00
105_K108_E2.0191.00
19_N210_K1.9691.00
45_L155_L1.9611.00
45_L189_V1.8961.00
125_I128_K1.8431.00
112_R150_N1.8281.00
9_V16_I1.8221.00
8_I54_L1.8151.00
10_K52_E1.7641.00
112_R115_K1.7551.00
10_K55_D1.7421.00
128_K132_Q1.7121.00
27_T152_S1.6701.00
114_E126_L1.6641.00
92_R127_D1.6501.00
176_K198_S1.6481.00
92_R96_A1.6091.00
5_L23_E1.5931.00
7_D22_T1.5811.00
116_A148_V1.5581.00
204_A214_V1.5521.00
12_Y43_T1.5481.00
32_V196_A1.5431.00
219_T223_Y1.5371.00
190_T196_A1.5341.00
90_S93_D1.5331.00
215_S220_L1.5321.00
92_R126_L1.5141.00
23_E204_A1.4871.00
25_I31_F1.4811.00
46_K51_I1.4801.00
119_L182_L1.4741.00
115_K119_L1.4731.00
11_K55_D1.4521.00
9_V19_N1.4311.00
47_I54_L1.3841.00
110_I114_E1.3771.00
202_R213_Q1.3721.00
88_N131_T1.3621.00
12_Y17_V1.3601.00
108_E111_E1.3521.00
117_A126_L1.3451.00
118_K123_S1.3011.00
217_P221_Y1.2991.00
96_A113_V1.2721.00
46_K52_E1.2681.00
89_M97_F1.2531.00
150_N184_G1.2461.00
89_M94_N1.2381.00
77_A146_A1.2341.00
207_H212_E1.2301.00
94_N145_R1.2151.00
107_E111_E1.2151.00
49_A78_M1.2101.00
5_L48_L1.2101.00
172_R198_S1.2051.00
50_G53_K1.1971.00
89_M93_D1.1961.00
21_I44_L1.1951.00
29_E201_D1.1801.00
96_A109_I1.1791.00
156_L186_F1.1741.00
91_V133_I1.1681.00
108_E112_R1.1601.00
111_E115_K1.1581.00
31_F202_R1.1491.00
257_P260_V1.1461.00
92_R113_V1.1431.00
120_L144_A1.1431.00
23_E44_L1.1411.00
6_I22_T1.1371.00
227_K231_Q1.1281.00
31_F214_V1.1271.00
256_R260_V1.1241.00
221_Y224_P1.1191.00
172_R195_E1.1131.00
100_K109_I1.0991.00
30_F186_F1.0981.00
95_I117_A1.0961.00
163_L171_A1.0921.00
33_I187_I1.0911.00
48_L187_I1.0871.00
255_F258_E1.0781.00
219_T222_E1.0771.00
92_R110_I1.0711.00
133_I141_V1.0671.00
256_R259_W1.0651.00
18_I47_I1.0651.00
218_K222_E1.0601.00
79_V156_L1.0571.00
217_P220_L1.0531.00
129_K132_Q1.0501.00
52_E55_D1.0481.00
130_V141_V1.0471.00
114_E118_K1.0381.00
114_E122_I1.0351.00
230_A234_G1.0221.00
26_E202_R1.0201.00
218_K221_Y1.0181.00
93_D96_A1.0131.00
188_Y200_A1.0111.00
229_V233_V1.0091.00
79_V146_A1.0091.00
109_I113_V1.0061.00
39_E206_L1.0041.00
6_I24_K0.9991.00
27_T62_D0.9961.00
96_A100_K0.9961.00
249_K252_E0.9941.00
150_N182_L0.9931.00
49_A155_L0.9901.00
247_K251_Q0.9831.00
118_K124_E0.9811.00
200_A203_I0.9801.00
116_A119_L0.9771.00
175_L186_F0.9771.00
101_M106_K0.9741.00
106_K109_I0.9711.00
18_I21_I0.9701.00
94_N130_V0.9641.00
231_Q235_E0.9621.00
77_A151_P0.9541.00
25_I185_T0.9521.00
253_I256_R0.9471.00
7_D56_K0.9471.00
205_I220_L0.9351.00
92_R114_E0.9341.00
254_G257_P0.9341.00
33_I44_L0.9301.00
121_G170_T0.9231.00
227_K230_A0.9231.00
8_I47_I0.9221.00
87_P131_T0.9161.00
90_S127_D0.9161.00
5_L59_I0.9141.00
252_E256_R0.9071.00
174_E177_R0.9061.00
25_I153_Y0.9021.00
248_E251_Q0.9021.00
90_S94_N0.8991.00
3_V153_Y0.8971.00
205_I224_P0.8941.00
27_T183_K0.8901.00
115_K118_K0.8831.00
62_D75_N0.8811.00
168_R192_D0.8781.00
153_Y185_T0.8741.00
47_I59_I0.8691.00
106_K110_I0.8591.00
95_I148_V0.8591.00
116_A144_A0.8551.00
212_E226_T0.8491.00
90_S129_K0.8491.00
44_L206_L0.8471.00
114_E124_E0.8471.00
42_S46_K0.8451.00
188_Y199_L0.8401.00
51_I80_F0.8351.00
104_M108_E0.8351.00
5_L44_L0.8351.00
248_E252_E0.8341.00
54_L59_I0.8331.00
211_F214_V0.8331.00
91_V141_V0.8281.00
47_I52_E0.8271.00
10_K43_T0.8251.00
203_I217_P0.8201.00
247_K250_A0.8121.00
255_F260_V0.8121.00
253_I257_P0.8111.00
176_K199_L0.8111.00
97_F101_M0.8101.00
221_Y225_K0.8081.00
246_M249_K0.8081.00
105_K109_I0.7981.00
254_G258_E0.7951.00
155_L187_I0.7941.00
28_G185_T0.7931.00
238_M241_L0.7921.00
98_P101_M0.7921.00
11_K19_N0.7911.00
255_F259_W0.7881.00
253_I259_W0.7831.00
86_Y89_M0.7821.00
107_E110_I0.7801.00
101_M105_K0.7791.00
20_G56_K0.7761.00
104_M109_I0.7751.00
173_G176_K0.7751.00
158_E191_H0.7741.00
240_F243_G0.7711.00
98_P145_R0.7691.00
112_R116_A0.7671.00
249_K253_I0.7661.00
85_L94_N0.7651.00
36_P39_E0.7651.00
154_F184_G0.7611.00
154_F186_F0.7601.00
99_L148_V0.7571.00
33_I204_A0.7571.00
11_K15_N0.7511.00
236_F240_F0.7511.00
116_A120_L0.7391.00
31_F187_I0.7381.00
236_F239_N0.7381.00
252_E255_F0.7371.00
220_L224_P0.7341.00
11_K17_V0.7331.00
30_F199_L0.7321.00
160_L195_E0.7281.00
30_F200_A0.7271.00
12_Y52_E0.7241.00
26_E185_T0.7231.00
250_A254_G0.7211.00
34_L205_I0.7171.00
253_I258_E0.7161.00
79_V143_L0.7141.00
169_T173_G0.7111.00
99_L102_R0.7111.00
81_Q135_G0.7101.00
254_G260_V0.7101.00
91_V94_N0.7041.00
119_L177_R0.7031.00
251_Q255_F0.7011.00
194_K198_S0.6961.00
18_I44_L0.6961.00
75_N149_R0.6941.00
110_I126_L0.6921.00
231_Q234_G0.6911.00
223_Y227_K0.6901.00
230_A233_V0.6891.00
10_K18_I0.6871.00
168_R195_E0.6871.00
11_K14_K0.6831.00
252_E260_V0.6831.00
252_E259_W0.6821.00
99_L103_G0.6801.00
96_A110_I0.6771.00
253_I260_V0.6771.00
88_N129_K0.6761.00
250_A253_I0.6761.00
249_K257_P0.6671.00
235_E238_M0.6661.00
88_N93_D0.6631.00
252_E257_P0.6621.00
156_L175_L0.6601.00
47_I55_D0.6591.00
134_S137_Q0.6571.00
102_R106_K0.6561.00
245_L248_E0.6541.00
30_F188_Y0.6541.00
245_L249_K0.6541.00
233_V236_F0.6531.00
173_G177_R0.6521.00
30_F176_K0.6511.00
232_F235_E0.6491.00
7_D10_K0.6431.00
92_R95_I0.6431.00
123_S126_L0.6401.00
79_V139_Q0.6381.00
233_V237_P0.6381.00
21_I211_F0.6371.00
228_W232_F0.6371.00
85_L138_Q0.6361.00
246_M250_A0.6361.00
234_G237_P0.6341.00
48_L155_L0.6341.00
251_Q254_G0.6301.00
97_F100_K0.6291.00
207_H210_K0.6251.00
217_P228_W0.6241.00
11_K56_K0.6241.00
116_A147_I0.6181.00
76_V153_Y0.6181.00
228_W231_Q0.6181.00
242_P245_L0.6171.00
20_G210_K0.6161.00
173_G198_S0.6161.00
85_L130_V0.6151.00
232_F236_F0.6141.00
62_D74_R0.6141.00
96_A99_L0.6121.00
28_G183_K0.6121.00
254_G259_W0.6101.00
152_S184_G0.6081.00
210_K214_V0.6051.00
111_E114_E0.5961.00
243_G247_K0.5941.00
110_I113_V0.5941.00
252_E258_E0.5911.00
242_P246_M0.5911.00
206_L211_F0.5871.00
100_K106_K0.5851.00
217_P224_P0.5841.00
61_A74_R0.5831.00
223_Y226_T0.5811.00
197_L216_D0.5801.00
133_I137_Q0.5781.00
222_E225_K0.5761.00
175_L199_L0.5751.00
243_G246_M0.5731.00
153_Y187_I0.5701.00
216_D220_L0.5651.00
25_I187_I0.5641.00
226_T229_V0.5631.00
229_V232_F0.5601.00
19_N209_G0.5551.00
13_G16_I0.5551.00
8_I59_I0.5531.00
224_P229_V0.5521.00
241_L244_E0.5501.00
43_T52_E0.5481.00
239_N243_G0.5481.00
30_F201_D0.5471.00
195_E199_L0.5461.00
87_P138_Q0.5431.00
80_F83_Y0.5431.00
98_P102_R0.5401.00
45_L49_A0.5381.00
9_V18_I0.5371.00
126_L129_K0.5361.00
60_I63_G0.5361.00
165_A169_T0.5351.00
110_I127_D0.5351.00
102_R149_R0.5351.00
109_I112_R0.5341.00
117_A122_I0.5321.00
192_D195_E0.5311.00
151_P182_L0.5301.00
128_K133_I0.5261.00
3_V61_A0.5251.00
231_Q240_F0.5221.00
234_G238_M0.5211.00
249_K256_R0.5141.00
160_L171_A0.5121.00
16_I20_G0.5121.00
156_L188_Y0.5101.00
239_N242_P0.5091.00
3_V48_L0.5091.00
63_G73_K0.5091.00
182_L186_F0.5091.00
130_V138_Q0.5081.00
196_A200_A0.5071.00
135_G140_R0.5051.00
50_G61_A0.5031.00
248_E253_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2it1A 1 0.8889 100 0.229 Contact Map
3tuiC 2 0.9907 100 0.229 Contact Map
1g291 4 0.8704 100 0.229 Contact Map
1v43A 2 0.9414 100 0.229 Contact Map
2yyzA 1 0.9907 100 0.23 Contact Map
3rlfA 2 0.9969 100 0.234 Contact Map
1oxxK 1 0.9877 100 0.234 Contact Map
4u00A 1 0.7315 100 0.237 Contact Map
4mkiB 2 0.8364 100 0.238 Contact Map
4yerA 2 0.8642 100 0.238 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0128 seconds.