GREMLIN Database
Q97ZB9 - Uncharacterized protein
UniProt: Q97ZB9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 411 (372)
Sequences: 18867 (14377)
Seq/√Len: 745.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_K202_E4.1321.00
54_R172_K3.9431.00
65_D401_H3.8481.00
147_I203_A3.5321.00
179_T182_L3.3211.00
100_K112_S3.3041.00
169_R206_A3.2721.00
68_R401_H3.0961.00
99_N119_D3.0401.00
123_Y126_K2.9721.00
110_K204_D2.9271.00
110_K202_E2.8741.00
49_V60_V2.8161.00
129_K207_T2.7751.00
222_E225_K2.7331.00
173_V190_V2.6671.00
57_I201_V2.5001.00
315_S318_K2.4861.00
112_S202_E2.4151.00
115_V120_A2.3371.00
52_E97_K2.3331.00
170_R204_D2.2621.00
61_V71_L2.2501.00
118_L122_N2.1921.00
63_F67_H2.1881.00
106_E127_R2.1731.00
125_R210_Y2.1281.00
176_S404_L2.1051.00
116_K119_D2.0671.00
101_T115_V2.0421.00
283_L287_A2.0301.00
109_L120_A2.0251.00
171_V190_V1.9661.00
55_Y58_E1.9611.00
50_I97_K1.9521.00
103_E110_K1.9291.00
224_G321_S1.9191.00
54_R201_V1.9041.00
57_I199_I1.8991.00
108_Y204_D1.8861.00
172_K181_E1.8831.00
173_V198_G1.8751.00
55_Y59_F1.8711.00
54_R58_E1.8701.00
352_S355_Q1.8571.00
124_L207_T1.8461.00
74_R77_G1.8211.00
333_I337_V1.8131.00
52_E56_D1.8111.00
93_L199_I1.8011.00
98_L112_S1.7891.00
111_I143_L1.7861.00
58_E62_K1.7751.00
108_Y169_R1.7741.00
61_V404_L1.7601.00
73_A199_I1.7571.00
356_N359_I1.7521.00
322_Q365_T1.7501.00
95_I199_I1.7411.00
358_N362_S1.7351.00
59_F62_K1.7281.00
53_D56_D1.7181.00
393_K397_I1.6871.00
123_Y127_R1.6731.00
104_Y123_Y1.6631.00
147_I168_I1.6601.00
275_G279_E1.6571.00
384_E387_R1.6451.00
172_K201_V1.6431.00
101_T123_Y1.6371.00
333_I336_D1.6171.00
265_N269_A1.6021.00
322_Q325_N1.5931.00
396_R402_N1.5931.00
174_V201_V1.5861.00
389_E393_K1.5751.00
148_A193_A1.5731.00
389_E392_K1.5661.00
325_N329_S1.5571.00
105_D108_Y1.5571.00
148_A200_I1.5431.00
58_E179_T1.5391.00
119_D122_N1.5311.00
147_I205_I1.5281.00
62_K65_D1.5251.00
64_C91_I1.5221.00
146_Y162_H1.5121.00
359_I362_S1.4971.00
190_V198_G1.4921.00
357_F361_D1.4871.00
109_L205_I1.4811.00
49_V91_I1.4731.00
361_D364_M1.4731.00
225_K228_K1.4731.00
57_I174_V1.4601.00
112_S115_V1.4531.00
392_K396_R1.4471.00
385_E389_E1.4311.00
95_I98_L1.4281.00
63_F69_I1.4021.00
224_G228_K1.3951.00
355_Q359_I1.3931.00
312_S315_S1.3851.00
351_I355_Q1.3731.00
100_K115_V1.3701.00
354_R358_N1.3651.00
232_D236_E1.3571.00
61_V65_D1.3541.00
318_K322_Q1.3471.00
111_I205_I1.3381.00
274_F277_E1.3331.00
395_K402_N1.3271.00
61_V174_V1.3181.00
390_L393_K1.3141.00
279_E283_L1.3011.00
170_R181_E1.2901.00
141_S146_Y1.2901.00
176_S398_V1.2841.00
277_E281_K1.2781.00
54_R179_T1.2721.00
111_I120_A1.2551.00
99_N112_S1.2481.00
122_N126_K1.2451.00
168_I171_V1.2421.00
57_I93_L1.2411.00
64_C71_L1.2361.00
358_N361_D1.2351.00
50_I94_D1.2311.00
388_L392_K1.2311.00
62_K66_I1.2301.00
322_Q366_K1.2111.00
228_K232_D1.2091.00
51_A60_V1.2051.00
61_V199_I1.2021.00
387_R390_L1.2001.00
300_N304_Y1.1971.00
58_E174_V1.1941.00
325_N328_G1.1911.00
321_S325_N1.1871.00
329_S359_I1.1821.00
324_K328_G1.1781.00
284_D287_A1.1701.00
359_I364_M1.1651.00
132_Q165_N1.1541.00
248_Q252_S1.1491.00
56_D59_F1.1481.00
109_L207_T1.1421.00
330_N359_I1.1361.00
104_Y129_K1.1361.00
65_D403_I1.1321.00
104_Y109_L1.1281.00
393_K396_R1.1221.00
121_L135_P1.1181.00
165_N208_V1.1161.00
360_I364_M1.1151.00
266_V269_A1.1111.00
372_E375_S1.1081.00
378_V381_R1.1061.00
60_V91_I1.1041.00
51_A56_D1.1041.00
299_T303_E1.0921.00
172_K179_T1.0911.00
74_R92_V1.0881.00
147_I162_H1.0811.00
109_L124_L1.0811.00
353_D357_F1.0611.00
190_V200_I1.0591.00
175_G398_V1.0591.00
375_S378_V1.0581.00
280_M283_L1.0571.00
168_I191_A1.0541.00
326_A329_S1.0481.00
71_L93_L1.0471.00
277_E280_M1.0451.00
144_G203_A1.0421.00
298_L301_F1.0351.00
60_V93_L1.0331.00
356_N361_D1.0301.00
75_G142_T1.0301.00
350_F353_D1.0281.00
50_I96_Q1.0171.00
189_A390_L1.0171.00
281_K284_D1.0161.00
264_W271_T1.0131.00
352_S356_N1.0051.00
221_D225_K1.0011.00
374_H378_V1.0011.00
357_F360_I0.9981.00
266_V271_T0.9871.00
283_L286_L0.9851.00
70_P90_S0.9781.00
372_E378_V0.9721.00
182_L188_L0.9721.00
268_L271_T0.9691.00
232_D235_N0.9681.00
68_R403_I0.9671.00
244_T247_D0.9631.00
47_G91_I0.9581.00
229_F232_D0.9521.00
119_D123_Y0.9511.00
327_L330_N0.9481.00
231_K235_N0.9451.00
95_I113_P0.9401.00
143_L205_I0.9341.00
350_F354_R0.9341.00
317_L321_S0.9331.00
373_I376_L0.9281.00
362_S365_T0.9261.00
79_S83_Q0.9141.00
374_H381_R0.9141.00
368_G371_F0.9111.00
372_E380_D0.9071.00
69_I91_I0.9041.00
57_I98_L0.9031.00
301_F304_Y0.9011.00
71_L403_I0.9011.00
54_R174_V0.8981.00
322_Q326_A0.8971.00
353_D356_N0.8961.00
354_R361_D0.8951.00
171_V188_L0.8911.00
318_K321_S0.8881.00
280_M284_D0.8871.00
265_N271_T0.8861.00
74_R94_D0.8841.00
46_L89_P0.8821.00
300_N303_E0.8811.00
374_H380_D0.8801.00
54_R112_S0.8781.00
353_D364_M0.8771.00
252_S255_A0.8721.00
296_S299_T0.8701.00
334_H337_V0.8651.00
319_V366_K0.8631.00
168_I203_A0.8621.00
70_P405_N0.8551.00
227_V231_K0.8551.00
246_E249_E0.8541.00
237_R240_I0.8531.00
322_Q363_I0.8531.00
160_G164_H0.8521.00
279_E286_L0.8521.00
186_N189_A0.8511.00
355_Q358_N0.8511.00
117_V146_Y0.8491.00
57_I95_I0.8481.00
228_K231_K0.8431.00
360_I363_I0.8421.00
307_E310_L0.8391.00
175_G180_F0.8381.00
118_L140_I0.8371.00
118_L139_Y0.8361.00
357_F364_M0.8341.00
171_V203_A0.8271.00
87_I90_S0.8271.00
356_N360_I0.8261.00
200_I203_A0.8251.00
264_W269_A0.8241.00
59_F63_F0.8241.00
129_K209_D0.8231.00
319_V323_V0.8221.00
24_I28_S0.8201.00
367_E370_P0.8201.00
299_T302_S0.8191.00
372_E376_L0.8181.00
117_V135_P0.8171.00
372_E377_V0.8151.00
51_A95_I0.8151.00
99_N115_V0.8131.00
115_V119_D0.8111.00
354_R357_F0.8091.00
315_S366_K0.8091.00
374_H377_V0.8051.00
356_N364_M0.8001.00
326_A330_N0.7921.00
75_G113_P0.7911.00
161_Y164_H0.7901.00
278_V281_K0.7811.00
132_Q208_V0.7811.00
371_F374_H0.7771.00
372_E381_R0.7771.00
76_A142_T0.7761.00
117_V120_A0.7741.00
377_V380_D0.7711.00
240_I244_T0.7711.00
193_A197_T0.7691.00
297_R301_F0.7681.00
169_R204_D0.7681.00
170_R182_L0.7681.00
260_I269_A0.7671.00
143_L203_A0.7661.00
302_S306_Y0.7651.00
264_W268_L0.7631.00
224_G317_L0.7611.00
75_G95_I0.7611.00
244_T248_Q0.7611.00
109_L123_Y0.7601.00
259_A265_N0.7601.00
273_S277_E0.7591.00
259_A262_G0.7561.00
96_Q142_T0.7541.00
128_G210_Y0.7521.00
262_G265_N0.7521.00
272_K278_V0.7511.00
353_D359_I0.7501.00
352_S361_D0.7491.00
108_Y206_A0.7491.00
359_I363_I0.7491.00
377_V382_V0.7481.00
247_D250_A0.7471.00
336_D340_L0.7461.00
281_K285_E0.7431.00
326_A359_I0.7431.00
144_G148_A0.7421.00
25_D29_K0.7411.00
351_I354_R0.7391.00
113_P203_A0.7381.00
318_K366_K0.7361.00
249_E252_S0.7341.00
179_T201_V0.7331.00
294_T297_R0.7301.00
73_A95_I0.7291.00
350_F357_F0.7281.00
352_S357_F0.7281.00
184_G398_V0.7281.00
175_G179_T0.7261.00
276_E279_E0.7251.00
23_V26_H0.7231.00
120_A143_L0.7231.00
288_F291_I0.7221.00
278_V282_F0.7211.00
350_F361_D0.7201.00
294_T301_F0.7181.00
54_R98_L0.7181.00
373_I380_D0.7161.00
65_D177_T0.7151.00
352_S359_I0.7131.00
25_D44_R0.7131.00
230_L234_E0.7131.00
353_D361_D0.7121.00
117_V141_S0.7121.00
247_D255_A0.7091.00
395_K405_N0.7091.00
373_I381_R0.7061.00
98_L201_V0.7031.00
172_K182_L0.7011.00
176_S403_I0.7001.00
54_R57_I0.6981.00
388_L391_M0.6941.00
174_V179_T0.6941.00
294_T305_F0.6921.00
294_T298_L0.6911.00
281_K286_L0.6901.00
262_G271_T0.6891.00
262_G269_A0.6871.00
261_P271_T0.6821.00
373_I378_V0.6821.00
300_N305_F0.6811.00
282_F286_L0.6801.00
394_Y398_V0.6791.00
296_S301_F0.6791.00
278_V285_E0.6761.00
185_E196_T0.6751.00
51_A97_K0.6741.00
260_I264_W0.6731.00
310_L369_I0.6711.00
320_V324_K0.6681.00
265_N268_L0.6661.00
251_L255_A0.6651.00
58_E61_V0.6631.00
301_F306_Y0.6631.00
48_V92_V0.6611.00
147_I200_I0.6591.00
188_L191_A0.6591.00
356_N363_I0.6581.00
387_R391_M0.6571.00
373_I379_N0.6571.00
326_A363_I0.6541.00
274_F278_V0.6541.00
319_V322_Q0.6541.00
321_S324_K0.6511.00
250_A253_L0.6501.00
170_R202_E0.6501.00
61_V176_S0.6491.00
298_L305_F0.6491.00
96_Q116_K0.6481.00
175_G181_E0.6461.00
375_S380_D0.6451.00
26_H29_K0.6451.00
237_R242_R0.6441.00
331_V337_V0.6431.00
274_F280_M0.6431.00
296_S302_S0.6431.00
24_I44_R0.6411.00
374_H379_N0.6401.00
370_P375_S0.6391.00
24_I27_Y0.6381.00
171_V200_I0.6351.00
130_E210_Y0.6331.00
226_L230_L0.6311.00
184_G187_T0.6301.00
372_E379_N0.6301.00
249_E253_L0.6301.00
276_E280_M0.6301.00
310_L313_L0.6301.00
297_R302_S0.6291.00
220_F229_F0.6271.00
379_N382_V0.6271.00
376_L379_N0.6271.00
23_V27_Y0.6271.00
231_K234_E0.6261.00
301_F305_F0.6261.00
104_Y207_T0.6231.00
267_I271_T0.6221.00
354_R364_M0.6221.00
367_E371_F0.6201.00
29_K42_G0.6191.00
253_L256_K0.6181.00
337_V340_L0.6181.00
241_R244_T0.6181.00
322_Q327_L0.6181.00
378_V382_V0.6171.00
30_S33_L0.6171.00
244_T249_E0.6161.00
131_L134_Y0.6161.00
56_D60_V0.6151.00
51_A98_L0.6151.00
138_F141_S0.6151.00
389_E396_R0.6141.00
298_L302_S0.6101.00
293_V298_L0.6091.00
101_T112_S0.6091.00
369_I372_E0.6091.00
265_N270_S0.6071.00
240_I249_E0.6071.00
58_E180_F0.6051.00
197_T394_Y0.6051.00
101_T111_I0.6051.00
277_E286_L0.6051.00
186_N397_I0.6051.00
264_W267_I0.6041.00
46_L90_S0.6021.00
302_S305_F0.6011.00
375_S379_N0.6011.00
117_V143_L0.6011.00
278_V286_L0.6001.00
263_K266_V0.6001.00
259_A266_V0.5991.00
153_G156_S0.5991.00
308_V312_S0.5991.00
293_V296_S0.5981.00
252_S256_K0.5971.00
373_I377_V0.5971.00
292_Y298_L0.5971.00
293_V305_F0.5961.00
371_F376_L0.5951.00
266_V270_S0.5941.00
350_F356_N0.5921.00
45_V92_V0.5901.00
343_E347_Y0.5901.00
377_V381_R0.5881.00
296_S304_Y0.5881.00
370_P373_I0.5841.00
122_N125_R0.5841.00
121_L130_E0.5811.00
124_L127_R0.5801.00
299_T305_F0.5801.00
374_H382_V0.5801.00
150_G161_Y0.5791.00
246_E250_A0.5781.00
244_T250_A0.5781.00
254_V257_N0.5781.00
217_L220_F0.5771.00
376_L380_D0.5761.00
296_S306_Y0.5761.00
171_V191_A0.5751.00
260_I267_I0.5751.00
79_S84_V0.5751.00
54_R202_E0.5741.00
402_N405_N0.5731.00
242_R247_D0.5721.00
25_D33_L0.5711.00
292_Y297_R0.5711.00
27_Y30_S0.5711.00
104_Y127_R0.5701.00
260_I263_K0.5681.00
63_F91_I0.5681.00
51_A57_I0.5681.00
224_G318_K0.5681.00
259_A269_A0.5661.00
272_K277_E0.5651.00
342_G345_V0.5641.00
368_G373_I0.5641.00
273_S278_V0.5631.00
165_N206_A0.5621.00
27_Y50_I0.5621.00
103_E106_E0.5611.00
323_V327_L0.5591.00
156_S161_Y0.5591.00
244_T252_S0.5571.00
240_I243_I0.5491.00
293_V297_R0.5491.00
274_F285_E0.5481.00
246_E251_L0.5471.00
196_T395_K0.5461.00
300_N306_Y0.5451.00
365_T368_G0.5431.00
250_A254_V0.5351.00
236_E284_D0.5351.00
248_Q255_A0.5321.00
339_T342_G0.5321.00
72_L90_S0.5321.00
100_K103_E0.5321.00
186_N394_Y0.5301.00
260_I265_N0.5301.00
263_K269_A0.5301.00
297_R304_Y0.5301.00
297_R300_N0.5301.00
324_K327_L0.5301.00
259_A270_S0.5301.00
308_V313_L0.5291.00
296_S300_N0.5281.00
293_V299_T0.5271.00
136_S146_Y0.5251.00
245_I249_E0.5251.00
103_E108_Y0.5241.00
242_R246_E0.5241.00
366_K370_P0.5231.00
258_R261_P0.5221.00
242_R249_E0.5181.00
70_P403_I0.5161.00
259_A271_T0.5151.00
227_V230_L0.5131.00
258_R262_G0.5131.00
330_N355_Q0.5121.00
239_K242_R0.5111.00
181_E202_E0.5111.00
47_G69_I0.5101.00
120_A131_L0.5101.00
121_L210_Y0.5101.00
70_P406_P0.5081.00
368_G374_H0.5081.00
293_V300_N0.5071.00
249_E254_V0.5061.00
64_C403_I0.5051.00
357_F363_I0.5051.00
316_F319_V0.5031.00
264_W270_S0.5031.00
319_V324_K0.5031.00
246_E254_V0.5021.00
62_K179_T0.5021.00
318_K325_N0.5011.00
121_L124_L0.5011.00
295_M301_F0.5011.00
81_I84_V0.5001.00
116_K142_T0.5001.00
339_T343_E0.5001.00
76_A116_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pm9A 5 0.9757 100 0.342 Contact Map
2uuuA 2 0.9538 100 0.357 Contact Map
1f0xA 1 0.9538 100 0.371 Contact Map
4bbyA 2 0.9878 100 0.387 Contact Map
1wvfA 2 0.9708 100 0.406 Contact Map
2exrA 1 0.9221 100 0.408 Contact Map
1w1oA 1 0.9197 100 0.408 Contact Map
4mlaA 1 0.9392 100 0.417 Contact Map
4xloA 2 0.9611 100 0.42 Contact Map
4o95A 1 0.9173 100 0.422 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0116 seconds.