GREMLIN Database
Q97ZB8 - Uncharacterized protein
UniProt: Q97ZB8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 295 (292)
Sequences: 155 (104)
Seq/√Len: 6.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_L77_A4.6010.97
200_T290_L4.1300.95
25_R88_L3.9210.93
117_I126_V3.9020.93
73_L81_I3.7070.91
182_I193_I3.5070.88
2_I255_S3.3980.87
88_L91_L3.2330.84
181_V228_I2.9980.78
58_L91_L2.9300.77
166_T196_V2.8710.75
199_T210_V2.8470.74
149_I258_C2.7210.71
77_A81_I2.6680.69
248_I252_E2.6360.68
176_K179_D2.5900.67
53_N144_S2.5120.64
210_V280_L2.4890.64
158_V196_V2.4410.62
81_I251_L2.3170.58
163_F189_T2.2730.56
165_I230_I2.1890.53
42_F129_V2.1690.53
187_K239_P2.1540.52
9_V84_L2.1120.51
106_F280_L2.0990.50
156_R179_D2.0810.49
184_I239_P2.0660.49
176_K199_T2.0120.47
23_R32_Y2.0080.47
57_I213_I2.0050.47
32_Y43_I1.9810.46
26_L91_L1.9690.45
184_I188_I1.8800.42
37_A126_V1.8260.40
2_I6_L1.7940.39
200_T287_S1.7850.39
5_T88_L1.7830.39
248_I251_L1.7780.39
60_R138_E1.7650.38
105_L143_A1.7450.38
84_L110_L1.7030.36
13_L84_L1.6780.35
163_F185_Y1.6450.34
92_N96_K1.6280.34
163_F230_I1.6280.34
50_V99_E1.6170.33
3_L248_I1.6060.33
123_D242_E1.5930.33
176_K276_E1.5910.33
2_I84_L1.5890.33
77_A159_K1.5650.32
16_K185_Y1.5570.32
34_E39_E1.5560.32
153_K232_T1.5470.31
25_R91_L1.5340.31
184_I264_Y1.5340.31
160_F194_Y1.5330.31
246_L252_E1.5310.31
23_R30_V1.5200.30
6_L251_L1.5160.30
82_I251_L1.5020.30
101_N267_N1.4550.29
157_I165_I1.4440.28
32_Y35_I1.4040.27
70_N123_D1.4030.27
4_K8_E1.4030.27
42_F143_A1.4020.27
146_V225_S1.3950.27
279_E283_R1.3940.27
194_Y197_P1.3900.27
13_L22_I1.3720.26
44_K272_Y1.3590.26
6_L85_A1.3520.26
94_R99_E1.3460.25
143_A201_G1.3300.25
50_V101_N1.3150.25
57_I191_H1.3140.25
221_L255_S1.3080.24
120_K211_S1.2920.24
191_H235_K1.2920.24
90_L268_G1.2840.24
20_Q24_E1.2720.23
22_I83_S1.2660.23
195_M242_E1.2590.23
23_R27_E1.2490.23
3_L149_I1.2490.23
23_R92_N1.2460.23
163_F234_S1.2430.23
147_I209_N1.2390.23
241_Y250_M1.2380.23
123_D183_D1.2350.23
132_D221_L1.2300.22
58_L120_K1.2230.22
6_L123_D1.2140.22
26_L88_L1.2120.22
187_K264_Y1.2110.22
111_S128_L1.1990.22
11_D251_L1.1810.21
185_Y188_I1.1690.21
157_I220_W1.1650.21
277_L287_S1.1640.21
9_V73_L1.1630.21
47_Y106_F1.1620.21
8_E25_R1.1600.21
135_L245_V1.1500.21
64_I77_A1.1450.20
237_V281_E1.1440.20
58_L137_V1.1430.20
185_Y196_V1.1410.20
7_L248_I1.1390.20
126_V221_L1.1320.20
239_P288_S1.1300.20
235_K259_I1.1290.20
239_P286_K1.1290.20
246_L251_L1.1260.20
55_V144_S1.1240.20
200_T289_L1.1160.20
48_E156_R1.1150.20
6_L252_E1.0990.19
36_K213_I1.0990.19
84_L210_V1.0980.19
265_I277_L1.0970.19
86_V259_I1.0970.19
36_K237_V1.0860.19
134_A195_M1.0770.19
169_V217_I1.0730.19
81_I248_I1.0730.19
170_K272_Y1.0600.18
111_S241_Y1.0470.18
81_I246_L1.0460.18
242_E266_E1.0440.18
64_I241_Y1.0360.18
157_I288_S1.0360.18
70_N264_Y1.0290.18
163_F258_C1.0250.18
152_T213_I1.0240.18
118_P290_L1.0210.18
198_L210_V1.0190.18
268_G278_E1.0160.18
120_K269_G1.0100.17
55_V143_A1.0100.17
63_A111_S1.0080.17
54_K103_D1.0050.17
57_I86_V1.0000.17
51_G165_I0.9980.17
158_V255_S0.9940.17
126_V239_P0.9900.17
123_D239_P0.9900.17
6_L69_V0.9860.17
195_M198_L0.9830.17
64_I73_L0.9750.17
30_V228_I0.9730.17
118_P239_P0.9730.17
176_K220_W0.9720.17
82_I163_F0.9710.17
134_A137_V0.9670.17
31_K179_D0.9640.17
52_N103_D0.9620.16
193_I251_L0.9590.16
149_I198_L0.9500.16
61_L80_A0.9500.16
69_V123_D0.9470.16
21_K132_D0.9450.16
81_I252_E0.9440.16
63_A127_P0.9420.16
183_D264_Y0.9390.16
5_T196_V0.9340.16
63_A112_I0.9340.16
18_P64_I0.9320.16
188_I247_N0.9220.16
115_K207_D0.9200.16
46_L184_I0.9200.16
147_I163_F0.9190.16
163_F233_V0.9180.16
99_E278_E0.9170.16
6_L188_I0.9160.16
57_I149_I0.9130.16
15_S96_K0.9100.15
115_K127_P0.9080.15
209_N272_Y0.9050.15
64_I149_I0.9050.15
28_S34_E0.9040.15
3_L186_N0.9040.15
28_S224_D0.8980.15
221_L266_E0.8970.15
6_L26_L0.8960.15
198_L251_L0.8920.15
86_V133_E0.8900.15
13_L156_R0.8890.15
23_R141_P0.8840.15
176_K278_E0.8830.15
130_G134_A0.8790.15
144_S165_I0.8730.15
24_E33_E0.8650.15
103_D135_L0.8600.15
11_D73_L0.8590.15
55_V287_S0.8580.15
112_I127_P0.8540.14
156_R183_D0.8490.14
46_L105_L0.8430.14
26_L45_A0.8420.14
158_V211_S0.8390.14
10_I246_L0.8370.14
25_R73_L0.8360.14
30_V268_G0.8350.14
259_I271_V0.8340.14
80_A244_G0.8250.14
157_I211_S0.8220.14
5_T191_H0.8220.14
4_K221_L0.8110.14
279_E290_L0.8050.14
4_K51_G0.8040.14
21_K224_D0.8020.14
33_E137_V0.7990.14
24_E117_I0.7990.14
96_K146_V0.7970.13
266_E275_K0.7960.13
166_T187_K0.7950.13
188_I195_M0.7940.13
143_A258_C0.7940.13
91_L107_V0.7900.13
21_K157_I0.7890.13
244_G285_G0.7840.13
153_K247_N0.7830.13
42_F258_C0.7790.13
14_E245_V0.7790.13
171_D291_K0.7780.13
176_K198_L0.7770.13
2_I188_I0.7760.13
44_K143_A0.7750.13
94_R146_V0.7730.13
5_T25_R0.7730.13
18_P191_H0.7720.13
120_K176_K0.7630.13
14_E135_L0.7590.13
127_P152_T0.7570.13
30_V171_D0.7560.13
241_Y247_N0.7540.13
105_L140_E0.7520.13
23_R171_D0.7520.13
281_E286_K0.7500.13
10_I36_K0.7450.13
183_D252_E0.7430.13
158_V259_I0.7420.13
157_I209_N0.7410.13
133_E195_M0.7410.13
224_D288_S0.7400.13
195_M256_R0.7350.12
73_L251_L0.7340.12
6_L196_V0.7310.12
47_Y220_W0.7310.12
25_R81_I0.7290.12
69_V266_E0.7280.12
143_A221_L0.7280.12
278_E282_N0.7270.12
61_L244_G0.7240.12
9_V81_I0.7220.12
41_T216_L0.7130.12
195_M252_E0.7120.12
236_Q277_L0.7120.12
38_G63_A0.7110.12
188_I220_W0.7090.12
161_D250_M0.7080.12
70_N239_P0.7060.12
20_Q272_Y0.7050.12
20_Q113_K0.7050.12
141_P146_V0.7040.12
7_L252_E0.7020.12
16_K94_R0.7010.12
82_I105_L0.6990.12
35_I82_I0.6970.12
91_L249_E0.6960.12
110_L147_I0.6930.12
80_A152_T0.6930.12
32_Y48_E0.6920.12
166_T183_D0.6910.12
146_V281_E0.6900.12
2_I7_L0.6900.12
173_Y196_V0.6860.12
166_T248_I0.6860.12
144_S163_F0.6850.12
7_L25_R0.6830.12
171_D189_T0.6810.12
31_K158_V0.6800.12
71_K123_D0.6790.12
193_I246_L0.6770.12
63_A115_K0.6750.12
158_V235_K0.6740.12
207_D217_I0.6710.12
183_D186_N0.6700.11
33_E57_I0.6690.11
25_R173_Y0.6670.11
53_N196_V0.6630.11
73_L246_L0.6600.11
146_V169_V0.6570.11
186_N235_K0.6570.11
51_G101_N0.6550.11
69_V242_E0.6540.11
43_I83_S0.6530.11
84_L255_S0.6520.11
157_I198_L0.6520.11
157_I270_K0.6520.11
77_A217_I0.6500.11
84_L183_D0.6480.11
55_V134_A0.6480.11
7_L255_S0.6460.11
166_T291_K0.6460.11
2_I242_E0.6450.11
161_D253_H0.6430.11
31_K43_I0.6430.11
147_I265_I0.6430.11
23_R96_K0.6420.11
45_A173_Y0.6420.11
64_I286_K0.6410.11
117_I156_R0.6400.11
77_A251_L0.6380.11
55_V58_L0.6350.11
141_P179_D0.6350.11
22_I104_V0.6330.11
2_I259_I0.6330.11
225_S254_A0.6310.11
146_V274_E0.6300.11
119_H243_T0.6280.11
16_K45_A0.6250.11
85_A286_K0.6230.11
196_V213_I0.6210.11
45_A249_E0.6190.11
9_V85_A0.6180.11
107_V221_L0.6150.11
143_A198_L0.6130.11
30_V95_D0.6120.11
176_K274_E0.6120.11
23_R26_L0.6110.11
61_L119_H0.6050.11
183_D187_K0.6040.11
55_V280_L0.6040.11
186_N193_I0.6030.11
13_L33_E0.6020.11
126_V253_H0.5970.10
221_L234_S0.5940.10
82_I258_C0.5900.10
114_A285_G0.5890.10
182_I238_I0.5880.10
166_T199_T0.5860.10
58_L144_S0.5860.10
81_I239_P0.5840.10
58_L107_V0.5800.10
73_L88_L0.5790.10
4_K106_F0.5780.10
209_N287_S0.5780.10
82_I173_Y0.5760.10
115_K152_T0.5730.10
163_F254_A0.5730.10
64_I110_L0.5710.10
231_A240_G0.5700.10
139_V230_I0.5700.10
2_I58_L0.5680.10
8_E34_E0.5680.10
53_N165_I0.5680.10
234_S280_L0.5660.10
247_N250_M0.5650.10
156_R176_K0.5650.10
5_T43_I0.5630.10
139_V198_L0.5620.10
50_V188_I0.5610.10
11_D210_V0.5600.10
46_L239_P0.5600.10
159_K207_D0.5590.10
149_I251_L0.5580.10
64_I161_D0.5540.10
54_K135_L0.5540.10
42_F134_A0.5540.10
8_E165_I0.5530.10
7_L247_N0.5510.10
106_F160_F0.5480.10
129_V245_V0.5480.10
188_I266_E0.5480.10
131_L255_S0.5480.10
58_L146_V0.5460.10
23_R50_V0.5440.10
163_F211_S0.5430.10
73_L268_G0.5420.10
176_K281_E0.5420.10
32_Y92_N0.5390.10
275_K278_E0.5390.10
123_D266_E0.5390.10
157_I177_L0.5370.10
129_V287_S0.5370.10
83_S252_E0.5370.10
20_Q270_K0.5350.10
211_S292_A0.5350.10
144_S234_S0.5340.10
58_L134_A0.5330.10
287_S290_L0.5330.10
112_I115_K0.5280.10
70_N184_I0.5280.10
184_I278_E0.5260.10
193_I207_D0.5260.10
16_K210_V0.5250.10
131_L210_V0.5230.10
133_E198_L0.5220.10
88_L96_K0.5200.09
177_L199_T0.5200.09
173_Y200_T0.5200.09
210_V281_E0.5180.09
42_F57_I0.5150.09
82_I148_S0.5140.09
134_A291_K0.5140.09
61_L285_G0.5130.09
279_E282_N0.5130.09
11_D96_K0.5110.09
210_V237_V0.5110.09
161_D242_E0.5100.09
12_I117_I0.5100.09
111_S127_P0.5090.09
176_K286_K0.5080.09
53_N283_R0.5080.09
113_K238_I0.5060.09
22_I101_N0.5060.09
6_L91_L0.5050.09
58_L143_A0.5050.09
85_A209_N0.5050.09
81_I191_H0.5050.09
187_K251_L0.5040.09
252_E256_R0.5030.09
2_I81_I0.5030.09
55_V105_L0.5020.09
36_K270_K0.5020.09
86_V165_I0.5020.09
196_V235_K0.5020.09
51_G274_E0.5010.09
30_V107_V0.5010.09
214_S218_S0.5010.09
215_T218_S0.5010.09
230_I234_S0.5000.09
2_I55_V0.5000.09
80_A115_K0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pp8A 2 0.6983 51.9 0.976 Contact Map
2rb7A 2 0.8542 48.3 0.977 Contact Map
1a4iA 2 0.5356 37.9 0.978 Contact Map
2w6kA 1 0.2407 30.8 0.979 Contact Map
4h2kA 1 0.7492 27.1 0.98 Contact Map
4xcvA 2 0.7186 25.2 0.98 Contact Map
3by5A 2 0.2068 22.1 0.981 Contact Map
1y0yA 5 0.7458 20.2 0.981 Contact Map
3ramA 4 0.8678 18 0.981 Contact Map
1q7lA 2 0.5186 17.1 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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