GREMLIN Database
Q97ZB6 - Uncharacterized protein
UniProt: Q97ZB6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 209 (189)
Sequences: 1799 (1450)
Seq/√Len: 105.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
169_F199_I4.2861.00
175_I180_I3.9331.00
162_T166_M3.7461.00
159_V184_L3.3101.00
162_T180_I3.2051.00
190_D194_H3.1341.00
187_S190_D3.0211.00
166_M183_K2.9671.00
164_I204_F2.9431.00
176_K179_E2.9371.00
166_M180_I2.8911.00
95_I101_I2.7891.00
175_I179_E2.6931.00
101_I119_T2.6381.00
155_K194_H2.6031.00
170_N174_Q2.5141.00
155_K158_L2.2961.00
30_K111_G2.2811.00
48_V83_F2.2621.00
177_A191_F2.1891.00
171_Y192_L2.1761.00
157_I161_K2.0221.00
155_K159_V1.9301.00
188_K192_L1.9171.00
18_S112_I1.8911.00
57_V81_I1.8901.00
177_A192_L1.8541.00
194_H197_K1.7691.00
17_F117_V1.7521.00
39_S42_N1.7061.00
186_I191_F1.6851.00
104_Y118_T1.6061.00
173_R196_R1.5911.00
180_I191_F1.5731.00
160_L203_I1.5701.00
194_H201_K1.5471.00
72_Y108_V1.5021.00
159_V194_H1.4981.00
53_P56_I1.4871.00
193_Y197_K1.4811.00
71_K81_I1.4741.00
70_L175_I1.4691.00
18_S138_V1.4341.00
159_V186_I1.3941.00
50_I56_I1.3711.00
177_A194_H1.3531.00
18_S140_K1.3480.99
131_R135_D1.3130.99
51_A78_G1.3090.99
168_Y173_R1.3020.99
15_I124_L1.2900.99
66_V69_I1.2870.99
167_G174_Q1.2670.99
171_Y193_Y1.2500.99
101_I105_R1.2430.99
30_K112_I1.2410.99
179_E182_E1.2360.99
175_I183_K1.2360.99
160_L169_F1.2330.99
29_I63_S1.2320.99
159_V180_I1.2210.99
187_S196_R1.1830.99
72_Y80_I1.1770.99
128_L137_I1.1420.98
90_T93_G1.1380.98
159_V198_S1.1210.98
182_E185_G1.1200.98
71_K79_Y1.1190.98
169_F195_L1.1010.98
55_L58_T1.0980.98
38_V42_N1.0970.98
129_S133_P1.0810.98
171_Y189_Q1.0780.98
190_D193_Y1.0770.97
158_L161_K1.0720.97
180_I184_L1.0690.97
152_L198_S1.0640.97
109_R112_I1.0580.97
54_K57_V1.0540.97
126_G129_S1.0480.97
161_K165_T1.0290.97
34_V38_V1.0210.97
15_I18_S1.0130.96
105_R169_F0.9950.96
114_K140_K0.9920.96
177_A188_K0.9920.96
53_P57_V0.9910.96
171_Y200_E0.9900.96
189_Q193_Y0.9810.96
93_G97_S0.9600.95
171_Y196_R0.9590.95
49_T78_G0.9550.95
118_T169_F0.9500.95
159_V191_F0.9480.95
35_T38_V0.9360.94
195_L199_I0.9350.94
53_P79_Y0.9340.94
68_E71_K0.9320.94
17_F111_G0.9290.94
188_K197_K0.9280.94
101_I104_Y0.9250.94
91_I94_Y0.9220.94
40_K44_K0.9130.94
166_M175_I0.9130.94
139_V142_I0.9120.94
181_A191_F0.9080.93
190_D195_L0.9060.93
155_K193_Y0.9000.93
49_T116_E0.8990.93
89_T169_F0.8980.93
162_T183_K0.8930.93
57_V69_I0.8890.93
103_E117_V0.8830.92
168_Y177_A0.8800.92
138_V170_N0.8650.92
107_V114_K0.8640.92
123_S126_G0.8620.92
24_C27_S0.8540.91
78_G81_I0.8420.91
178_K188_K0.8400.90
172_P196_R0.8400.90
36_L56_I0.8330.90
65_N153_T0.8310.90
25_W28_K0.8270.90
14_K143_K0.8250.90
171_Y194_H0.8240.90
63_S66_V0.8220.89
127_K188_K0.8180.89
49_T80_I0.8110.89
151_G204_F0.8080.89
178_K196_R0.7980.88
170_N200_E0.7960.88
162_T184_L0.7960.88
46_V49_T0.7940.88
108_V113_E0.7880.87
78_G154_E0.7870.87
36_L79_Y0.7790.87
190_D198_S0.7790.87
33_V38_V0.7780.87
66_V71_K0.7770.87
17_F128_L0.7690.86
164_I169_F0.7670.86
32_S36_L0.7650.86
84_L188_K0.7640.86
138_V200_E0.7590.85
41_Y44_K0.7560.85
21_H27_S0.7560.85
44_K95_I0.7530.85
67_Y86_D0.7520.85
60_L122_K0.7510.85
184_L191_F0.7500.85
144_F157_I0.7490.85
60_L198_S0.7460.84
155_K199_I0.7430.84
171_Y178_K0.7340.83
158_L162_T0.7320.83
82_D186_I0.7220.82
126_G174_Q0.7200.82
92_S95_I0.7180.82
142_I168_Y0.7150.82
197_K200_E0.7140.82
16_N114_K0.7140.82
200_E204_F0.7120.82
177_A190_D0.7090.81
92_S191_F0.7080.81
148_F197_K0.7060.81
144_F147_M0.7020.81
62_R77_G0.7020.81
106_N115_W0.7010.81
38_V48_V0.7000.80
169_F177_A0.6990.80
119_T169_F0.6990.80
125_V128_L0.6920.80
21_H24_C0.6830.79
46_V52_S0.6830.79
54_K67_Y0.6820.79
79_Y82_D0.6780.78
37_N204_F0.6770.78
54_K61_K0.6760.78
132_F186_I0.6760.78
20_S201_K0.6730.78
15_I117_V0.6720.78
164_I203_I0.6700.78
86_D139_V0.6690.77
111_G133_P0.6680.77
127_K193_Y0.6680.77
44_K62_R0.6650.77
167_G170_N0.6620.77
82_D137_I0.6600.76
57_V60_L0.6590.76
105_R199_I0.6550.76
124_L142_I0.6550.76
27_S30_K0.6550.76
77_G134_I0.6530.76
46_V85_E0.6510.75
184_L192_L0.6500.75
28_K65_N0.6470.75
160_L199_I0.6440.75
176_K204_F0.6430.75
56_I64_E0.6430.75
27_S66_V0.6360.74
125_V190_D0.6300.73
167_G192_L0.6240.72
21_H115_W0.6230.72
24_C113_E0.6150.71
32_S37_N0.6140.71
25_W29_I0.6140.71
155_K173_R0.6120.71
65_N199_I0.6100.71
92_S103_E0.6090.71
25_W115_W0.6080.70
58_T62_R0.6070.70
95_I115_W0.6070.70
85_E149_Y0.6060.70
117_V127_K0.6050.70
92_S160_L0.6030.70
21_H113_E0.6020.70
135_D143_K0.6010.70
175_I191_F0.6000.69
136_S146_D0.5990.69
103_E116_E0.5980.69
38_V80_I0.5960.69
16_N25_W0.5960.69
85_E97_S0.5950.69
54_K58_T0.5950.69
153_T201_K0.5920.68
55_L182_E0.5920.68
33_V36_L0.5920.68
119_T196_R0.5880.68
14_K106_N0.5880.68
162_T175_I0.5880.68
119_T127_K0.5850.67
158_L183_K0.5790.67
34_V37_N0.5740.66
104_Y189_Q0.5690.65
171_Y190_D0.5670.65
119_T138_V0.5650.65
94_Y135_D0.5640.65
186_I194_H0.5640.65
198_S203_I0.5620.64
169_F198_S0.5610.64
74_K93_G0.5570.64
91_I186_I0.5540.63
17_F115_W0.5540.63
34_V52_S0.5540.63
112_I146_D0.5540.63
68_E123_S0.5540.63
95_I160_L0.5530.63
104_Y128_L0.5510.63
88_S169_F0.5500.63
177_A198_S0.5500.63
15_I121_A0.5480.62
23_G186_I0.5460.62
114_K181_A0.5460.62
180_I185_G0.5450.62
128_L190_D0.5440.62
22_Q27_S0.5410.62
144_F165_T0.5390.61
78_G147_M0.5380.61
104_Y139_V0.5340.61
95_I154_E0.5340.61
126_G138_V0.5340.61
21_H25_W0.5330.60
137_I192_L0.5320.60
32_S35_T0.5310.60
24_C30_K0.5290.60
116_E124_L0.5280.60
85_E113_E0.5240.59
186_I189_Q0.5240.59
32_S125_V0.5230.59
160_L198_S0.5230.59
62_R97_S0.5220.59
121_A142_I0.5210.59
45_K103_E0.5150.58
140_K145_S0.5110.57
168_Y202_I0.5080.57
85_E92_S0.5080.57
92_S96_L0.5080.57
68_E84_L0.5060.56
63_S198_S0.5060.56
39_S44_K0.5030.56
83_F171_Y0.5010.56
131_R137_I0.5010.56
132_F181_A0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wszA 2 0.2632 97.6 0.838 Contact Map
1ku3A 1 0.2919 97.6 0.838 Contact Map
1s7oA 3 0.3254 97.5 0.841 Contact Map
1xsvA 2 0.3206 97.4 0.843 Contact Map
3c57A 2 0.244 97.4 0.843 Contact Map
2o8xA 7 0.2919 97.3 0.845 Contact Map
1je8A 2 0.2679 97.2 0.847 Contact Map
1x3uA 1 0.3158 97.2 0.848 Contact Map
2rnjA 1 0.2632 97.2 0.848 Contact Map
1fseA 2 0.2727 97.1 0.849 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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