Q97ZB6 - SULSO - GREMLIN Contacts

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Q97ZB6 - Uncharacterized protein

UniProt:	Q97ZB6	Sequences: MRKQLSIGMKNLYKINFSISHQGCWTSKIKDSVVTLNVSKYNNKKVRVTIASPKLIVTDLKRSENVYEILKYRKVKGGYIIDFLEDLSTTISGYILSSSNILEYRNVVREGIEKWEVTTLAKSLVGKLSERFPIDSIVVKEIKFSDMFYNGLTEKEILVLKTAITMGYFNYPRQIKAKEIAEKLGISKQDFLYHLRKSIEKIIFSSVIE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	209 (189)
Sequences:	1799 (1450)
Seq/√Len:	105.5

HALSA - O54637 Q9HSM9 Q9HR58 Q9HSR5 Q9HQD9 Q9HPS7 DMSR Q9HQU9
SULSO - Q97ZB6 Q7LXI8 Q97YL7 Q97YT8 Q97WR0 Q97UD7 Q97Y14 Q97UC0 Q97X87 Q97ZX5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
169_F	199_I	4.286	1.00
175_I	180_I	3.933	1.00
162_T	166_M	3.746	1.00
159_V	184_L	3.310	1.00
162_T	180_I	3.205	1.00
190_D	194_H	3.134	1.00
187_S	190_D	3.021	1.00
166_M	183_K	2.967	1.00
164_I	204_F	2.943	1.00
176_K	179_E	2.937	1.00
166_M	180_I	2.891	1.00
95_I	101_I	2.789	1.00
175_I	179_E	2.693	1.00
101_I	119_T	2.638	1.00
155_K	194_H	2.603	1.00
170_N	174_Q	2.514	1.00
155_K	158_L	2.296	1.00
30_K	111_G	2.281	1.00
48_V	83_F	2.262	1.00
177_A	191_F	2.189	1.00
171_Y	192_L	2.176	1.00
157_I	161_K	2.022	1.00
155_K	159_V	1.930	1.00
188_K	192_L	1.917	1.00
18_S	112_I	1.891	1.00
57_V	81_I	1.890	1.00
177_A	192_L	1.854	1.00
194_H	197_K	1.769	1.00
17_F	117_V	1.752	1.00
39_S	42_N	1.706	1.00
186_I	191_F	1.685	1.00
104_Y	118_T	1.606	1.00
173_R	196_R	1.591	1.00
180_I	191_F	1.573	1.00
160_L	203_I	1.570	1.00
194_H	201_K	1.547	1.00
72_Y	108_V	1.502	1.00
159_V	194_H	1.498	1.00
53_P	56_I	1.487	1.00
193_Y	197_K	1.481	1.00
71_K	81_I	1.474	1.00
70_L	175_I	1.469	1.00
18_S	138_V	1.434	1.00
159_V	186_I	1.394	1.00
50_I	56_I	1.371	1.00
177_A	194_H	1.353	1.00
18_S	140_K	1.348	0.99
131_R	135_D	1.313	0.99
51_A	78_G	1.309	0.99
168_Y	173_R	1.302	0.99
15_I	124_L	1.290	0.99
66_V	69_I	1.287	0.99
167_G	174_Q	1.267	0.99
171_Y	193_Y	1.250	0.99
101_I	105_R	1.243	0.99
30_K	112_I	1.241	0.99
179_E	182_E	1.236	0.99
175_I	183_K	1.236	0.99
160_L	169_F	1.233	0.99
29_I	63_S	1.232	0.99
159_V	180_I	1.221	0.99
187_S	196_R	1.183	0.99
72_Y	80_I	1.177	0.99
128_L	137_I	1.142	0.98
90_T	93_G	1.138	0.98
159_V	198_S	1.121	0.98
182_E	185_G	1.120	0.98
71_K	79_Y	1.119	0.98
169_F	195_L	1.101	0.98
55_L	58_T	1.098	0.98
38_V	42_N	1.097	0.98
129_S	133_P	1.081	0.98
171_Y	189_Q	1.078	0.98
190_D	193_Y	1.077	0.97
158_L	161_K	1.072	0.97
180_I	184_L	1.069	0.97
152_L	198_S	1.064	0.97
109_R	112_I	1.058	0.97
54_K	57_V	1.054	0.97
126_G	129_S	1.048	0.97
161_K	165_T	1.029	0.97
34_V	38_V	1.021	0.97
15_I	18_S	1.013	0.96
105_R	169_F	0.995	0.96
114_K	140_K	0.992	0.96
177_A	188_K	0.992	0.96
53_P	57_V	0.991	0.96
171_Y	200_E	0.990	0.96
189_Q	193_Y	0.981	0.96
93_G	97_S	0.960	0.95
171_Y	196_R	0.959	0.95
49_T	78_G	0.955	0.95
118_T	169_F	0.950	0.95
159_V	191_F	0.948	0.95
35_T	38_V	0.936	0.94
195_L	199_I	0.935	0.94
53_P	79_Y	0.934	0.94
68_E	71_K	0.932	0.94
17_F	111_G	0.929	0.94
188_K	197_K	0.928	0.94
101_I	104_Y	0.925	0.94
91_I	94_Y	0.922	0.94
40_K	44_K	0.913	0.94
166_M	175_I	0.913	0.94
139_V	142_I	0.912	0.94
181_A	191_F	0.908	0.93
190_D	195_L	0.906	0.93
155_K	193_Y	0.900	0.93
49_T	116_E	0.899	0.93
89_T	169_F	0.898	0.93
162_T	183_K	0.893	0.93
57_V	69_I	0.889	0.93
103_E	117_V	0.883	0.92
168_Y	177_A	0.880	0.92
138_V	170_N	0.865	0.92
107_V	114_K	0.864	0.92
123_S	126_G	0.862	0.92
24_C	27_S	0.854	0.91
78_G	81_I	0.842	0.91
178_K	188_K	0.840	0.90
172_P	196_R	0.840	0.90
36_L	56_I	0.833	0.90
65_N	153_T	0.831	0.90
25_W	28_K	0.827	0.90
14_K	143_K	0.825	0.90
171_Y	194_H	0.824	0.90
63_S	66_V	0.822	0.89
127_K	188_K	0.818	0.89
49_T	80_I	0.811	0.89
151_G	204_F	0.808	0.89
178_K	196_R	0.798	0.88
170_N	200_E	0.796	0.88
162_T	184_L	0.796	0.88
46_V	49_T	0.794	0.88
108_V	113_E	0.788	0.87
78_G	154_E	0.787	0.87
36_L	79_Y	0.779	0.87
190_D	198_S	0.779	0.87
33_V	38_V	0.778	0.87
66_V	71_K	0.777	0.87
17_F	128_L	0.769	0.86
164_I	169_F	0.767	0.86
32_S	36_L	0.765	0.86
84_L	188_K	0.764	0.86
138_V	200_E	0.759	0.85
41_Y	44_K	0.756	0.85
21_H	27_S	0.756	0.85
44_K	95_I	0.753	0.85
67_Y	86_D	0.752	0.85
60_L	122_K	0.751	0.85
184_L	191_F	0.750	0.85
144_F	157_I	0.749	0.85
60_L	198_S	0.746	0.84
155_K	199_I	0.743	0.84
171_Y	178_K	0.734	0.83
158_L	162_T	0.732	0.83
82_D	186_I	0.722	0.82
126_G	174_Q	0.720	0.82
92_S	95_I	0.718	0.82
142_I	168_Y	0.715	0.82
197_K	200_E	0.714	0.82
16_N	114_K	0.714	0.82
200_E	204_F	0.712	0.82
177_A	190_D	0.709	0.81
92_S	191_F	0.708	0.81
148_F	197_K	0.706	0.81
144_F	147_M	0.702	0.81
62_R	77_G	0.702	0.81
106_N	115_W	0.701	0.81
38_V	48_V	0.700	0.80
169_F	177_A	0.699	0.80
119_T	169_F	0.699	0.80
125_V	128_L	0.692	0.80
21_H	24_C	0.683	0.79
46_V	52_S	0.683	0.79
54_K	67_Y	0.682	0.79
79_Y	82_D	0.678	0.78
37_N	204_F	0.677	0.78
54_K	61_K	0.676	0.78
132_F	186_I	0.676	0.78
20_S	201_K	0.673	0.78
15_I	117_V	0.672	0.78
164_I	203_I	0.670	0.78
86_D	139_V	0.669	0.77
111_G	133_P	0.668	0.77
127_K	193_Y	0.668	0.77
44_K	62_R	0.665	0.77
167_G	170_N	0.662	0.77
82_D	137_I	0.660	0.76
57_V	60_L	0.659	0.76
105_R	199_I	0.655	0.76
124_L	142_I	0.655	0.76
27_S	30_K	0.655	0.76
77_G	134_I	0.653	0.76
46_V	85_E	0.651	0.75
184_L	192_L	0.650	0.75
28_K	65_N	0.647	0.75
160_L	199_I	0.644	0.75
176_K	204_F	0.643	0.75
56_I	64_E	0.643	0.75
27_S	66_V	0.636	0.74
125_V	190_D	0.630	0.73
167_G	192_L	0.624	0.72
21_H	115_W	0.623	0.72
24_C	113_E	0.615	0.71
32_S	37_N	0.614	0.71
25_W	29_I	0.614	0.71
155_K	173_R	0.612	0.71
65_N	199_I	0.610	0.71
92_S	103_E	0.609	0.71
25_W	115_W	0.608	0.70
58_T	62_R	0.607	0.70
95_I	115_W	0.607	0.70
85_E	149_Y	0.606	0.70
117_V	127_K	0.605	0.70
92_S	160_L	0.603	0.70
21_H	113_E	0.602	0.70
135_D	143_K	0.601	0.70
175_I	191_F	0.600	0.69
136_S	146_D	0.599	0.69
103_E	116_E	0.598	0.69
38_V	80_I	0.596	0.69
16_N	25_W	0.596	0.69
85_E	97_S	0.595	0.69
54_K	58_T	0.595	0.69
153_T	201_K	0.592	0.68
55_L	182_E	0.592	0.68
33_V	36_L	0.592	0.68
119_T	196_R	0.588	0.68
14_K	106_N	0.588	0.68
162_T	175_I	0.588	0.68
119_T	127_K	0.585	0.67
158_L	183_K	0.579	0.67
34_V	37_N	0.574	0.66
104_Y	189_Q	0.569	0.65
171_Y	190_D	0.567	0.65
119_T	138_V	0.565	0.65
94_Y	135_D	0.564	0.65
186_I	194_H	0.564	0.65
198_S	203_I	0.562	0.64
169_F	198_S	0.561	0.64
74_K	93_G	0.557	0.64
91_I	186_I	0.554	0.63
17_F	115_W	0.554	0.63
34_V	52_S	0.554	0.63
112_I	146_D	0.554	0.63
68_E	123_S	0.554	0.63
95_I	160_L	0.553	0.63
104_Y	128_L	0.551	0.63
88_S	169_F	0.550	0.63
177_A	198_S	0.550	0.63
15_I	121_A	0.548	0.62
23_G	186_I	0.546	0.62
114_K	181_A	0.546	0.62
180_I	185_G	0.545	0.62
128_L	190_D	0.544	0.62
22_Q	27_S	0.541	0.62
144_F	165_T	0.539	0.61
78_G	147_M	0.538	0.61
104_Y	139_V	0.534	0.61
95_I	154_E	0.534	0.61
126_G	138_V	0.534	0.61
21_H	25_W	0.533	0.60
137_I	192_L	0.532	0.60
32_S	35_T	0.531	0.60
24_C	30_K	0.529	0.60
116_E	124_L	0.528	0.60
85_E	113_E	0.524	0.59
186_I	189_Q	0.524	0.59
32_S	125_V	0.523	0.59
160_L	198_S	0.523	0.59
62_R	97_S	0.522	0.59
121_A	142_I	0.521	0.59
45_K	103_E	0.515	0.58
140_K	145_S	0.511	0.57
168_Y	202_I	0.508	0.57
85_E	92_S	0.508	0.57
92_S	96_L	0.508	0.57
68_E	84_L	0.506	0.56
63_S	198_S	0.506	0.56
39_S	44_K	0.503	0.56
83_F	171_Y	0.501	0.56
131_R	137_I	0.501	0.56
132_F	181_A	0.500	0.56

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4wszA	2	0.2632	97.6	0.838	Contact Map
1ku3A	1	0.2919	97.6	0.838	Contact Map
1s7oA	3	0.3254	97.5	0.841	Contact Map
1xsvA	2	0.3206	97.4	0.843	Contact Map
3c57A	2	0.244	97.4	0.843	Contact Map
2o8xA	7	0.2919	97.3	0.845	Contact Map
1je8A	2	0.2679	97.2	0.847	Contact Map
1x3uA	1	0.3158	97.2	0.848	Contact Map
2rnjA	1	0.2632	97.2	0.848	Contact Map
1fseA	2	0.2727	97.1	0.849	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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