GREMLIN Database
Q97ZB5 - Amino acid specific permease
UniProt: Q97ZB5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 468 (420)
Sequences: 24870 (16574)
Seq/√Len: 808.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_T347_G4.2331.00
329_V341_N4.2031.00
391_V395_K3.1501.00
332_K341_N2.9651.00
58_Y248_G2.9371.00
234_S238_K2.8101.00
17_G230_K2.7361.00
397_R401_I2.7321.00
229_A235_T2.5991.00
82_V322_D2.5371.00
182_L257_A2.5121.00
320_A331_S2.5091.00
99_G319_M2.4861.00
329_V332_K2.4521.00
231_V234_S2.4521.00
12_R15_V2.4311.00
143_I351_G2.3981.00
334_N340_G2.3951.00
22_A242_L2.3921.00
383_L412_I2.3741.00
70_E393_K2.3131.00
180_I184_A2.2841.00
18_T242_L2.2621.00
288_A292_M2.2311.00
227_E321_R2.1261.00
279_V282_S2.1141.00
344_I348_I2.0881.00
317_F321_R2.0761.00
86_K94_A2.0681.00
154_W340_G2.0451.00
228_E314_R2.0431.00
147_I351_G2.0391.00
21_V229_A2.0231.00
18_T235_T2.0161.00
150_T343_I2.0151.00
151_T155_L2.0151.00
399_A402_A1.9851.00
89_L391_V1.9631.00
158_K162_L1.9511.00
418_V421_F1.9491.00
18_T22_A1.9331.00
143_I354_S1.9181.00
238_K242_L1.9091.00
142_V354_S1.8911.00
169_L173_G1.8791.00
186_A189_S1.8661.00
323_G328_K1.8651.00
103_I346_T1.8591.00
67_V386_A1.8531.00
86_K91_S1.8521.00
330_F345_L1.8401.00
17_G20_L1.8301.00
59_L63_T1.8251.00
11_L333_V1.8241.00
415_Y418_V1.8211.00
113_G116_I1.8201.00
447_I451_V1.8101.00
266_N283_K1.7901.00
398_T401_I1.7821.00
192_P195_A1.7681.00
441_I445_H1.7531.00
409_I413_L1.7481.00
279_V283_K1.7401.00
42_L50_M1.7401.00
231_V235_T1.7241.00
411_S415_Y1.7161.00
185_G189_S1.7071.00
185_G190_I1.7061.00
89_L387_L1.7011.00
397_R403_K1.7001.00
147_I347_G1.6801.00
20_L165_L1.6751.00
153_M306_L1.6291.00
85_I98_V1.6251.00
334_N338_V1.6241.00
198_V201_N1.6211.00
241_L245_G1.6191.00
193_F196_V1.6081.00
22_A246_I1.6071.00
146_T350_T1.5961.00
391_V394_V1.5891.00
173_G177_I1.5841.00
439_W443_L1.5801.00
406_V410_I1.5761.00
16_L20_L1.5671.00
98_V384_F1.5511.00
53_T208_A1.5461.00
154_W344_I1.5431.00
411_S414_L1.5261.00
187_K190_I1.5241.00
25_G243_T1.5241.00
49_A205_V1.5241.00
336_Y340_G1.5191.00
12_R337_G1.5021.00
263_G266_N1.4981.00
282_S290_V1.4891.00
188_N191_L1.4691.00
112_A115_G1.4671.00
316_I342_A1.4561.00
341_N345_L1.4501.00
155_L336_Y1.4471.00
186_A190_I1.4181.00
399_A403_K1.4161.00
225_V310_T1.4151.00
245_G249_V1.4041.00
445_H448_T1.3981.00
174_F296_L1.3871.00
90_G93_L1.3841.00
386_A411_S1.3841.00
328_K331_S1.3821.00
127_S130_I1.3801.00
387_L391_V1.3771.00
192_P196_V1.3761.00
143_I147_I1.3701.00
150_T344_I1.3651.00
403_K407_I1.3641.00
57_S212_G1.3561.00
312_G346_T1.3531.00
65_L244_F1.3521.00
183_I257_A1.3431.00
231_V238_K1.3411.00
123_I141_I1.3381.00
407_I411_S1.3311.00
431_L434_A1.3311.00
110_G350_T1.3301.00
291_Y295_I1.3291.00
146_T347_G1.3251.00
328_K332_K1.3251.00
11_L317_F1.3221.00
20_L161_G1.3211.00
332_K340_G1.3211.00
404_H408_P1.3201.00
85_I384_F1.3191.00
420_Y424_Y1.3171.00
417_A421_F1.3161.00
282_S287_P1.3151.00
317_F333_V1.3151.00
75_I87_K1.3111.00
232_P237_P1.3101.00
313_S343_I1.2941.00
418_V422_G1.2871.00
100_Y445_H1.2781.00
89_L93_L1.2761.00
413_L417_A1.2741.00
59_L410_I1.2741.00
440_A444_I1.2741.00
179_S253_L1.2721.00
65_L240_L1.2681.00
149_I305_A1.2621.00
78_S227_E1.2551.00
64_T386_A1.2531.00
285_F289_I1.2521.00
430_P433_I1.2441.00
29_N247_L1.2441.00
450_Y454_S1.2411.00
172_I176_I1.2381.00
411_S418_V1.2371.00
397_R400_N1.2351.00
185_G260_I1.2291.00
63_T410_I1.2291.00
18_T238_K1.2271.00
235_T238_K1.2221.00
139_A143_I1.2201.00
128_P131_A1.2161.00
387_L412_I1.2131.00
83_A87_K1.2071.00
186_A191_L1.2071.00
103_I316_I1.2061.00
249_V253_L1.2031.00
88_G388_G1.2001.00
66_I241_L1.1971.00
16_L21_V1.1921.00
51_P256_Y1.1881.00
49_A198_V1.1851.00
400_N403_K1.1761.00
182_L261_V1.1761.00
405_V409_I1.1741.00
42_L46_V1.1681.00
416_I420_Y1.1641.00
404_H407_I1.1531.00
19_W23_S1.1511.00
430_P434_A1.1511.00
16_L161_G1.1491.00
26_I246_I1.1481.00
187_K191_L1.1381.00
92_S452_I1.1321.00
198_V202_W1.1271.00
316_I325_L1.1261.00
25_G222_P1.1211.00
448_T451_V1.1191.00
152_I163_L1.1181.00
445_H449_Y1.1171.00
443_L447_I1.1171.00
77_A83_A1.1161.00
21_V239_A1.1161.00
178_T182_L1.1151.00
321_R331_S1.1101.00
412_I416_I1.1091.00
273_L276_P1.1091.00
419_I422_G1.1061.00
67_V408_P1.1051.00
230_K235_T1.1021.00
68_I81_Y1.0961.00
408_P412_I1.0931.00
446_I450_Y1.0881.00
406_V409_I1.0871.00
163_L167_I1.0861.00
341_N344_I1.0811.00
70_E73_K1.0751.00
112_A116_I1.0591.00
394_V405_V1.0571.00
24_Y225_V1.0461.00
150_T154_W1.0391.00
72_S84_M1.0391.00
55_I252_I1.0391.00
162_L166_V1.0361.00
333_V337_G1.0271.00
438_A442_L1.0271.00
273_L279_V1.0251.00
397_R402_A1.0251.00
164_N306_L1.0141.00
348_I352_A1.0131.00
383_L416_I1.0091.00
411_S421_F1.0091.00
432_N435_V1.0071.00
261_V280_I1.0071.00
440_A443_L1.0031.00
144_I148_E1.0021.00
420_Y423_T1.0011.00
177_I181_V0.9941.00
398_T403_K0.9931.00
140_A144_I0.9861.00
217_G378_V0.9841.00
30_A33_A0.9821.00
390_I409_I0.9821.00
407_I414_L0.9821.00
125_L128_P0.9801.00
435_V438_A0.9751.00
451_V454_S0.9741.00
185_G188_N0.9701.00
414_L418_V0.9681.00
60_I414_L0.9671.00
389_L408_P0.9671.00
96_F100_Y0.9661.00
226_A236_L0.9641.00
176_I180_I0.9631.00
404_H411_S0.9611.00
119_I145_V0.9601.00
147_I151_T0.9591.00
408_P422_G0.9591.00
15_V230_K0.9581.00
197_P201_N0.9551.00
167_I303_S0.9551.00
263_G283_K0.9451.00
157_V310_T0.9441.00
154_W338_V0.9371.00
77_A87_K0.9371.00
148_E302_N0.9371.00
119_I298_A0.9341.00
390_I408_P0.9341.00
444_I447_I0.9311.00
26_I247_L0.9311.00
137_L140_A0.9301.00
408_P411_S0.9211.00
415_Y422_G0.9141.00
401_I404_H0.9131.00
23_S165_L0.9131.00
383_L387_L0.9001.00
82_V318_G0.9001.00
414_L421_F0.8981.00
220_T224_G0.8901.00
286_N289_I0.8881.00
256_Y260_I0.8871.00
127_S131_A0.8761.00
179_S183_I0.8751.00
154_W334_N0.8751.00
309_A347_G0.8731.00
51_P259_T0.8721.00
178_T281_Y0.8711.00
396_M401_I0.8681.00
407_I418_V0.8661.00
179_S257_A0.8651.00
15_V158_K0.8641.00
149_I306_L0.8601.00
79_Y83_A0.8601.00
396_M399_A0.8601.00
418_V423_T0.8561.00
20_L162_L0.8511.00
172_I250_G0.8511.00
242_L246_I0.8431.00
100_Y325_L0.8431.00
340_G344_I0.8421.00
30_A35_A0.8421.00
436_Y439_W0.8411.00
411_S424_Y0.8411.00
58_Y216_F0.8371.00
48_G259_T0.8371.00
248_G252_I0.8351.00
120_A123_I0.8341.00
415_Y419_I0.8331.00
437_A440_A0.8291.00
421_F424_Y0.8291.00
79_Y82_V0.8231.00
71_W389_L0.8201.00
411_S422_G0.8201.00
330_F341_N0.8201.00
406_V411_S0.8191.00
325_L330_F0.8171.00
221_T311_S0.8141.00
86_K322_D0.8111.00
202_W206_L0.8101.00
193_F197_P0.8091.00
189_S192_P0.8081.00
141_I144_I0.8081.00
414_L423_T0.8061.00
421_F425_P0.8041.00
63_T67_V0.8041.00
429_F432_N0.8041.00
85_I93_L0.8031.00
409_I412_I0.8031.00
448_T452_I0.8011.00
440_A447_I0.8011.00
19_W165_L0.8001.00
62_A66_I0.7981.00
199_N202_W0.7961.00
63_T407_I0.7941.00
275_D279_V0.7921.00
43_A50_M0.7921.00
171_S300_M0.7911.00
146_T354_S0.7911.00
207_T211_F0.7831.00
179_S254_N0.7811.00
404_H415_Y0.7771.00
139_A354_S0.7771.00
162_L165_L0.7761.00
404_H414_L0.7731.00
55_I59_L0.7731.00
90_G453_K0.7721.00
445_H452_I0.7721.00
449_Y452_I0.7701.00
190_I260_I0.7651.00
373_F377_Y0.7641.00
151_T154_W0.7621.00
18_T239_A0.7601.00
120_A141_I0.7601.00
149_I309_A0.7591.00
389_L393_K0.7571.00
85_I388_G0.7561.00
52_L56_L0.7561.00
444_I448_T0.7561.00
155_L159_P0.7561.00
198_V205_V0.7561.00
347_G351_G0.7551.00
11_L314_R0.7541.00
22_A239_A0.7521.00
102_Y106_Y0.7511.00
414_L417_A0.7501.00
11_L228_E0.7501.00
422_G425_P0.7461.00
116_I119_I0.7451.00
388_G392_R0.7441.00
408_P423_T0.7431.00
436_Y440_A0.7431.00
201_N204_L0.7431.00
62_A241_L0.7421.00
276_P280_I0.7421.00
334_N337_G0.7421.00
348_I351_G0.7411.00
287_P291_Y0.7391.00
113_G117_L0.7381.00
448_T453_K0.7361.00
183_I253_L0.7341.00
446_I449_Y0.7341.00
288_A291_Y0.7291.00
109_A374_G0.7271.00
390_I394_V0.7261.00
93_L384_F0.7261.00
30_A171_S0.7221.00
441_I448_T0.7191.00
52_L205_V0.7171.00
417_A420_Y0.7161.00
82_V86_K0.7151.00
399_A404_H0.7151.00
217_G382_H0.7151.00
139_A142_V0.7141.00
396_M403_K0.7131.00
161_G165_L0.7121.00
52_L55_I0.7081.00
15_V157_V0.7081.00
335_K340_G0.7071.00
89_L388_G0.7071.00
30_A34_V0.7071.00
435_V439_W0.7041.00
411_S425_P0.7041.00
320_A330_F0.7031.00
441_I444_I0.7021.00
43_A46_V0.7011.00
31_P251_L0.7001.00
31_P34_V0.6991.00
415_Y421_F0.6991.00
401_I407_I0.6981.00
402_A408_P0.6981.00
29_N243_T0.6981.00
74_E397_R0.6961.00
121_S124_Y0.6941.00
71_W84_M0.6941.00
270_Y276_P0.6941.00
153_M343_I0.6921.00
414_L422_G0.6921.00
154_W343_I0.6911.00
28_A307_A0.6911.00
143_I355_L0.6911.00
197_P200_N0.6911.00
149_I302_N0.6901.00
68_I385_A0.6901.00
202_W205_V0.6891.00
27_A168_G0.6891.00
330_F342_A0.6851.00
254_N258_Q0.6851.00
19_W162_L0.6841.00
120_A142_V0.6801.00
237_P240_L0.6791.00
88_G391_V0.6781.00
15_V19_W0.6761.00
154_W336_Y0.6761.00
396_M400_N0.6751.00
37_L371_I0.6751.00
105_Q378_V0.6741.00
231_V237_P0.6741.00
313_S342_A0.6721.00
236_L240_L0.6711.00
439_W442_L0.6701.00
376_F438_A0.6691.00
153_M310_T0.6691.00
404_H422_G0.6651.00
366_A369_F0.6651.00
92_S97_T0.6621.00
323_G327_P0.6611.00
50_M255_S0.6601.00
125_L129_S0.6571.00
72_S223_I0.6541.00
146_T351_G0.6541.00
195_A199_N0.6531.00
438_A443_L0.6531.00
339_P342_A0.6501.00
78_S317_F0.6471.00
412_I415_Y0.6471.00
22_A25_G0.6471.00
147_I150_T0.6471.00
441_I449_Y0.6461.00
159_P162_L0.6461.00
28_A31_P0.6461.00
408_P415_Y0.6461.00
61_Y219_A0.6451.00
254_N277_M0.6451.00
253_L257_A0.6441.00
119_I122_F0.6441.00
440_A445_H0.6441.00
73_K398_T0.6411.00
65_L219_A0.6371.00
242_L245_G0.6361.00
275_D278_I0.6341.00
415_Y423_T0.6331.00
88_G392_R0.6321.00
246_I250_G0.6321.00
28_A308_F0.6291.00
314_R317_F0.6281.00
51_P55_I0.6271.00
227_E317_F0.6241.00
72_S236_L0.6231.00
431_L435_V0.6231.00
404_H421_F0.6221.00
101_G381_G0.6221.00
90_G94_A0.6211.00
438_A441_I0.6191.00
82_V99_G0.6181.00
233_K398_T0.6181.00
206_L417_A0.6171.00
417_A422_G0.6161.00
125_L130_I0.6151.00
309_A313_S0.6151.00
204_L207_T0.6151.00
192_P197_P0.6141.00
377_Y381_G0.6091.00
443_L446_I0.6091.00
190_I259_T0.6091.00
408_P414_L0.6081.00
181_V285_F0.6071.00
438_A447_I0.6071.00
71_W88_G0.6061.00
233_K238_K0.6061.00
145_V305_A0.6061.00
126_I130_I0.6051.00
447_I450_Y0.6041.00
122_F297_V0.6031.00
54_V215_T0.6011.00
107_L346_T0.6001.00
386_A412_I0.6001.00
120_A124_Y0.5991.00
281_Y285_F0.5971.00
92_S446_I0.5971.00
156_G159_P0.5961.00
161_G306_L0.5941.00
418_V425_P0.5931.00
51_P252_I0.5931.00
185_G191_L0.5921.00
316_I345_L0.5921.00
329_V333_V0.5911.00
123_I298_A0.5901.00
106_Y308_F0.5861.00
312_G316_I0.5861.00
223_I240_L0.5851.00
383_L415_Y0.5841.00
36_T39_F0.5841.00
433_I436_Y0.5821.00
108_V373_F0.5821.00
228_E339_P0.5821.00
401_I406_V0.5811.00
224_G311_S0.5801.00
442_L446_I0.5791.00
217_G220_T0.5781.00
26_I168_G0.5781.00
70_E74_E0.5771.00
98_V381_G0.5771.00
295_I299_F0.5761.00
124_Y138_W0.5761.00
125_L131_A0.5751.00
257_A260_I0.5751.00
65_L69_Y0.5741.00
181_V286_N0.5741.00
107_L349_V0.5731.00
368_I371_I0.5721.00
435_V441_I0.5721.00
193_F198_V0.5711.00
40_V368_I0.5701.00
157_V225_V0.5691.00
69_Y73_K0.5691.00
329_V345_L0.5681.00
56_L209_M0.5671.00
81_Y220_T0.5671.00
232_P235_T0.5671.00
432_N436_Y0.5661.00
352_A355_L0.5641.00
35_A39_F0.5621.00
266_N271_A0.5601.00
26_I29_N0.5571.00
64_T415_Y0.5571.00
229_A236_L0.5561.00
195_A198_V0.5551.00
123_I127_S0.5551.00
414_L425_P0.5551.00
442_L445_H0.5541.00
407_I421_F0.5521.00
57_S216_F0.5521.00
170_I174_F0.5521.00
357_S366_A0.5501.00
25_G239_A0.5491.00
30_A250_G0.5491.00
93_L97_T0.5491.00
145_V149_I0.5491.00
170_I296_L0.5481.00
165_L169_L0.5471.00
80_G223_I0.5461.00
82_V94_A0.5431.00
400_N404_H0.5431.00
410_I414_L0.5431.00
160_G310_T0.5431.00
408_P418_V0.5421.00
120_A138_W0.5411.00
150_T309_A0.5371.00
413_L416_I0.5371.00
405_V408_P0.5361.00
57_S213_V0.5361.00
437_A441_I0.5341.00
119_I301_F0.5341.00
333_V336_Y0.5331.00
340_G343_I0.5331.00
345_L349_V0.5311.00
442_L449_Y0.5301.00
159_P163_L0.5291.00
228_E333_V0.5291.00
245_G248_G0.5271.00
262_Y279_V0.5261.00
438_A449_Y0.5261.00
16_L157_V0.5261.00
147_I344_I0.5241.00
45_L208_A0.5221.00
164_N171_S0.5221.00
33_A39_F0.5221.00
430_P435_V0.5221.00
144_I147_I0.5221.00
367_S371_I0.5211.00
74_E398_T0.5211.00
437_A445_H0.5201.00
34_V38_Y0.5201.00
234_S237_P0.5191.00
81_Y224_G0.5191.00
112_A117_L0.5191.00
194_T197_P0.5191.00
229_A239_A0.5191.00
403_K406_V0.5171.00
246_I253_L0.5171.00
103_I107_L0.5161.00
85_I94_A0.5151.00
34_V37_L0.5151.00
314_R333_V0.5151.00
45_L207_T0.5151.00
62_A245_G0.5141.00
417_A423_T0.5121.00
38_Y255_S0.5121.00
434_A438_A0.5101.00
145_V302_N0.5091.00
31_P171_S0.5081.00
262_Y280_I0.5081.00
412_I423_T0.5081.00
378_V381_G0.5081.00
64_T220_T0.5081.00
21_V235_T0.5071.00
17_G158_K0.5061.00
300_M303_S0.5061.00
438_A445_H0.5061.00
105_Q377_Y0.5061.00
31_P35_A0.5051.00
170_I299_F0.5031.00
407_I410_I0.5021.00
54_V255_S0.5021.00
174_F292_M0.5011.00
21_V225_V0.5011.00
261_V284_Y0.5001.00
316_I320_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8996 100 0.314 Contact Map
3giaA 1 0.9209 100 0.355 Contact Map
4djkA 2 0.891 100 0.372 Contact Map
3dh4A 3 0.9124 99 0.856 Contact Map
2xq2A 2 0.9124 98.9 0.861 Contact Map
2jlnA 1 0.8953 98.7 0.869 Contact Map
2a65A 2 0.906 97.4 0.905 Contact Map
4xp4A 1 0.9316 97.4 0.905 Contact Map
4us3A 1 0.8526 97.2 0.908 Contact Map
4wgvA 2 0.7799 97.2 0.909 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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