GREMLIN Database
Q97ZB4 - NADH dehydrogenase
UniProt: Q97ZB4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 331 (269)
Sequences: 51111 (35655)
Seq/√Len: 2173.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
128_T203_T4.4171.00
126_D147_K3.7891.00
149_T181_M3.4821.00
147_K179_N3.3351.00
232_D236_K2.9161.00
70_K242_D2.7661.00
27_R61_N2.7401.00
71_K79_E2.7331.00
94_N213_K2.6371.00
170_E174_R2.6001.00
14_A86_I2.5821.00
126_D204_E2.5191.00
128_T151_V2.5091.00
99_K188_E2.4891.00
224_N230_L2.4151.00
190_K195_V2.3421.00
188_E195_V2.3231.00
66_D69_N2.3051.00
126_D149_T2.2421.00
86_I275_I2.2051.00
67_F240_Y2.1711.00
73_I79_E2.1271.00
2_I18_N2.0681.00
84_K242_D2.0461.00
82_Y85_L2.0391.00
3_L80_L2.0191.00
153_R185_E1.9601.00
126_D146_K1.9431.00
92_H213_K1.9281.00
92_H216_Q1.9191.00
10_A246_A1.9181.00
149_T179_N1.9161.00
25_V80_L1.8921.00
92_H215_P1.8761.00
184_V198_Y1.8341.00
89_L249_C1.8221.00
126_D202_K1.7981.00
187_I195_V1.7981.00
3_L72_V1.7931.00
60_G76_N1.7491.00
86_I246_A1.7421.00
151_V201_I1.7281.00
155_N183_G1.7141.00
3_L82_Y1.7031.00
185_E197_S1.6961.00
71_K81_T1.6781.00
64_K73_I1.6621.00
181_M184_V1.6531.00
125_K204_E1.6021.00
244_Y274_N1.5721.00
236_K241_N1.5711.00
84_K244_Y1.5601.00
84_K275_I1.5541.00
224_N239_E1.5521.00
128_T194_V1.5351.00
187_I197_S1.5231.00
64_K220_N1.5161.00
229_L245_G1.5001.00
181_M200_E1.4901.00
271_V275_I1.4881.00
231_V250_V1.4871.00
189_I206_T1.4731.00
61_N75_D1.4611.00
268_G272_M1.4481.00
67_F243_V1.4451.00
272_M276_L1.4431.00
3_L25_V1.4281.00
4_I15_Y1.4091.00
5_L62_V1.3861.00
110_T113_D1.3851.00
127_I143_I1.3631.00
74_L80_L1.3531.00
172_L175_E1.3401.00
72_V76_N1.3391.00
21_N276_L1.3231.00
97_R101_A1.3071.00
152_Q182_L1.2961.00
23_L26_D1.2931.00
28_K61_N1.2861.00
66_D71_K1.2841.00
240_Y243_V1.2841.00
196_T201_I1.2761.00
102_K191_K1.2671.00
17_Q273_K1.2531.00
10_A264_A1.2501.00
196_T199_G1.2421.00
231_V245_G1.2411.00
63_Q73_I1.2371.00
88_S246_A1.2341.00
270_V274_N1.2301.00
132_G152_Q1.2281.00
149_T203_T1.2261.00
229_L249_C1.2161.00
127_I146_K1.2101.00
63_Q75_D1.1981.00
167_K170_E1.1901.00
137_V150_L1.1881.00
172_L176_L1.1831.00
74_L78_K1.1781.00
167_K171_D1.1771.00
170_E182_L1.1701.00
163_T167_K1.1671.00
112_E115_I1.1611.00
171_D174_R1.1571.00
217_I220_N1.1531.00
235_L250_V1.1411.00
124_V146_K1.1361.00
231_V235_L1.1341.00
60_G75_D1.1311.00
4_I11_G1.1301.00
7_G26_D1.1301.00
17_Q20_E1.1301.00
171_D175_E1.1291.00
156_R166_S1.1221.00
21_N273_K1.1211.00
66_D73_I1.1211.00
127_I205_L1.1131.00
113_D116_E1.1031.00
184_V196_T1.1011.00
5_L87_V1.1001.00
39_D42_C1.0891.00
5_L89_L1.0831.00
17_Q21_N1.0781.00
130_I206_T1.0721.00
246_A271_V1.0711.00
234_N274_N1.0571.00
42_C46_K1.0421.00
235_L271_V1.0341.00
29_D59_L1.0281.00
235_L270_V1.0251.00
236_K242_D1.0211.00
216_Q219_G1.0211.00
46_K49_D1.0191.00
237_S245_G1.0141.00
14_A246_A1.0071.00
17_Q269_R1.0041.00
19_K55_K0.9991.00
111_L115_I0.9991.00
87_V249_C0.9971.00
263_I267_A0.9971.00
157_L182_L0.9951.00
225_K230_L0.9901.00
100_G188_E0.9891.00
18_N272_M0.9851.00
15_Y24_V0.9771.00
14_A268_G0.9701.00
181_M201_I0.9681.00
128_T201_I0.9641.00
184_V197_S0.9621.00
60_G74_L0.9581.00
190_K193_S0.9571.00
140_A150_L0.9511.00
114_A117_L0.9461.00
108_I112_E0.9411.00
130_I210_G0.9351.00
109_E113_D0.9291.00
62_V72_V0.9241.00
11_G15_Y0.9201.00
149_T201_I0.9191.00
71_K74_L0.9141.00
3_L23_L0.9131.00
203_T206_T0.9101.00
245_G249_C0.9091.00
91_H212_L0.9051.00
168_K171_D0.9041.00
156_R163_T0.9021.00
166_S170_E0.8781.00
103_E191_K0.8771.00
39_D43_G0.8761.00
70_K74_L0.8751.00
144_K147_K0.8751.00
47_L51_I0.8741.00
14_A271_V0.8741.00
18_N275_I0.8731.00
168_K172_L0.8721.00
66_D70_K0.8701.00
145_G148_I0.8701.00
184_V200_E0.8661.00
39_D44_M0.8641.00
230_L239_E0.8641.00
111_L114_A0.8601.00
75_D78_K0.8591.00
132_G157_L0.8531.00
114_A118_K0.8531.00
74_L77_S0.8471.00
69_N79_E0.8451.00
264_A268_G0.8421.00
136_G152_Q0.8381.00
64_K85_L0.8361.00
65_I85_L0.8331.00
110_T114_A0.8331.00
85_L243_V0.8321.00
106_H120_R0.8311.00
86_I271_V0.8261.00
250_V267_A0.8261.00
245_G250_V0.8261.00
151_V184_V0.8251.00
4_I14_A0.8151.00
151_V181_M0.8151.00
271_V274_N0.8131.00
129_I140_A0.8091.00
109_E117_L0.8051.00
16_N20_E0.8041.00
192_D202_K0.8021.00
236_K244_Y0.7951.00
23_L80_L0.7931.00
112_E116_E0.7891.00
35_P42_C0.7811.00
41_I44_M0.7771.00
42_C45_K0.7761.00
43_G46_K0.7751.00
170_E180_L0.7711.00
110_T115_I0.7711.00
151_V196_T0.7701.00
130_I208_F0.7691.00
236_K274_N0.7681.00
152_Q159_P0.7661.00
25_V82_Y0.7651.00
144_K176_L0.7641.00
130_I186_A0.7621.00
108_I111_L0.7611.00
2_I86_I0.7581.00
34_T38_I0.7531.00
25_V62_V0.7521.00
103_E106_H0.7451.00
67_F70_K0.7451.00
24_V58_I0.7431.00
109_E112_E0.7421.00
115_I118_K0.7411.00
244_Y271_V0.7391.00
244_Y275_I0.7381.00
23_L56_K0.7371.00
156_R170_E0.7361.00
108_I114_A0.7341.00
40_F43_G0.7321.00
101_A208_F0.7301.00
60_G63_Q0.7291.00
19_K54_Y0.7281.00
15_Y55_K0.7271.00
3_L26_D0.7261.00
95_L101_A0.7251.00
126_D203_T0.7181.00
152_Q155_N0.7161.00
89_L217_I0.7151.00
13_S268_G0.7121.00
72_V75_D0.7111.00
128_T206_T0.7111.00
44_M47_L0.7081.00
166_S169_A0.7051.00
225_K228_R0.7021.00
52_V55_K0.7001.00
23_L27_R0.6981.00
236_K240_Y0.6951.00
64_K70_K0.6941.00
62_V65_I0.6921.00
48_E51_I0.6921.00
14_A272_M0.6901.00
120_R146_K0.6901.00
43_G47_L0.6891.00
11_G88_S0.6841.00
125_K146_K0.6821.00
269_R273_K0.6821.00
58_I80_L0.6811.00
140_A148_I0.6801.00
165_S168_K0.6791.00
235_L274_N0.6781.00
226_N251_T0.6771.00
169_A173_L0.6731.00
95_L102_K0.6721.00
140_A178_V0.6691.00
223_A229_L0.6671.00
196_T200_E0.6661.00
216_Q220_N0.6651.00
195_V198_Y0.6651.00
87_V217_I0.6651.00
237_S240_Y0.6641.00
150_L180_L0.6641.00
100_G103_E0.6641.00
13_S265_V0.6611.00
96_P101_A0.6611.00
13_S17_Q0.6591.00
253_E259_M0.6571.00
139_L142_N0.6571.00
40_F44_M0.6561.00
174_R179_N0.6551.00
144_K177_G0.6531.00
10_A88_S0.6521.00
246_A268_G0.6481.00
7_G31_F0.6471.00
141_G176_L0.6461.00
266_A269_R0.6461.00
109_E114_A0.6451.00
113_D117_L0.6431.00
122_N125_K0.6421.00
173_L180_L0.6421.00
39_D45_K0.6421.00
266_A270_V0.6411.00
25_V28_K0.6381.00
40_F46_K0.6301.00
107_K113_D0.6301.00
137_V173_L0.6301.00
45_K49_D0.6281.00
95_L107_K0.6271.00
72_V77_S0.6251.00
62_V74_L0.6231.00
35_P39_D0.6211.00
260_T264_A0.6181.00
98_L101_A0.6181.00
24_V27_R0.6141.00
73_I77_S0.6121.00
128_T149_T0.6111.00
169_A172_L0.6081.00
179_N182_L0.6081.00
13_S16_N0.6081.00
67_F242_D0.6071.00
129_I136_G0.6061.00
246_A275_I0.6061.00
94_N97_R0.6051.00
131_G136_G0.6031.00
218_V221_L0.6011.00
116_E119_R0.5981.00
144_K178_V0.5971.00
217_I221_L0.5971.00
38_I43_G0.5971.00
34_T37_I0.5961.00
71_K78_K0.5951.00
16_N53_K0.5941.00
115_I119_R0.5931.00
40_F45_K0.5931.00
195_V199_G0.5931.00
133_G211_G0.5921.00
99_K102_K0.5901.00
189_I194_V0.5881.00
117_L205_L0.5871.00
228_R259_M0.5871.00
23_L66_D0.5851.00
262_D266_A0.5841.00
157_L166_S0.5811.00
35_P40_F0.5771.00
94_N210_G0.5771.00
260_T263_I0.5771.00
154_R159_P0.5761.00
109_E115_I0.5751.00
139_L207_I0.5731.00
26_D29_D0.5681.00
221_L240_Y0.5661.00
3_L85_L0.5651.00
43_G48_E0.5651.00
41_I46_K0.5641.00
164_A167_K0.5631.00
96_P208_F0.5631.00
219_G222_H0.5631.00
87_V243_V0.5601.00
120_R205_L0.5601.00
135_T209_A0.5591.00
223_A240_Y0.5571.00
248_D264_A0.5551.00
47_L50_I0.5551.00
26_D31_F0.5541.00
23_L58_I0.5531.00
95_L208_F0.5521.00
131_G211_G0.5501.00
60_G78_K0.5491.00
102_K106_H0.5471.00
107_K110_T0.5471.00
112_E117_L0.5471.00
35_P38_I0.5421.00
38_I42_C0.5411.00
14_A18_N0.5411.00
93_Q96_P0.5401.00
116_E120_R0.5351.00
225_K231_V0.5341.00
82_Y242_D0.5341.00
230_L233_K0.5331.00
68_K81_T0.5331.00
202_K205_L0.5311.00
65_I217_I0.5311.00
10_A86_I0.5261.00
108_I113_D0.5261.00
156_R167_K0.5261.00
2_I84_K0.5261.00
34_T46_K0.5241.00
17_Q272_M0.5221.00
187_I190_K0.5211.00
9_F13_S0.5161.00
40_F47_L0.5161.00
25_V74_L0.5151.00
137_V157_L0.5141.00
135_T139_L0.5131.00
54_Y57_V0.5131.00
13_S269_R0.5131.00
260_T267_A0.5131.00
21_N272_M0.5121.00
226_N230_L0.5111.00
98_L189_I0.5101.00
127_I207_I0.5081.00
56_K59_L0.5061.00
18_N276_L0.5061.00
106_H109_E0.5031.00
183_G197_S0.5021.00
125_K205_L0.5021.00
139_L209_A0.5001.00
14_A275_I0.5001.00
68_K242_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g6hA 2 0.9909 100 0.302 Contact Map
4nwzA 2 0.9879 100 0.348 Contact Map
1ojtA 2 0.9637 100 0.367 Contact Map
3l8kA 3 0.9607 100 0.378 Contact Map
3kljA 1 0.9607 100 0.38 Contact Map
3h8lA 2 0.8852 100 0.381 Contact Map
1lvlA 2 0.9517 100 0.381 Contact Map
2a8xA 2 0.9607 100 0.382 Contact Map
3urhA 2 0.9728 100 0.383 Contact Map
2yquA 2 0.9637 100 0.383 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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