GREMLIN Database
Q97ZB2 - High-affinity nickel-transport protein (HoxN)
UniProt: Q97ZB2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 373 (318)
Sequences: 624 (397)
Seq/√Len: 22.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
331_G334_W4.1261.00
216_I225_V4.1091.00
132_L227_F4.0081.00
128_T223_Y3.9651.00
128_T227_F3.5441.00
168_Y316_T3.4761.00
53_F277_T3.4391.00
188_G191_D3.2931.00
131_I268_S3.2711.00
199_L202_R3.2491.00
89_L274_V3.1991.00
93_V274_V3.1981.00
117_F219_Q3.1311.00
178_F305_L3.1121.00
320_L334_W3.0001.00
163_S318_E3.0001.00
182_Y301_L2.8930.99
170_L225_V2.7820.99
331_G335_D2.7220.99
164_G319_L2.7010.99
329_L334_W2.5120.98
218_N221_Q2.5000.98
178_F301_L2.3110.97
107_K303_I2.2460.96
160_T322_L2.2380.96
134_S240_A2.2310.96
345_W348_I2.2070.96
217_T221_Q2.2060.96
61_Q65_T2.1400.95
129_V227_F2.0840.94
163_S229_F2.0520.94
365_M369_I2.0300.94
320_L331_G2.0160.93
63_P262_L1.9690.92
198_I202_R1.9330.92
84_S263_Y1.9070.91
224_I241_I1.8700.90
310_I352_V1.8350.89
60_P64_L1.8190.89
93_V353_I1.7980.88
123_S287_G1.7880.88
135_L139_M1.7550.87
185_Y297_I1.7450.87
195_L199_L1.7440.87
64_L67_N1.7420.87
66_L262_L1.7240.86
321_G341_N1.7150.86
169_L361_I1.7100.86
87_F205_M1.6490.84
309_L313_G1.6380.83
127_S159_E1.6220.83
123_S268_S1.6180.82
290_F296_K1.5910.81
107_K111_E1.5840.81
131_I261_L1.5830.81
103_N107_K1.5810.81
123_S159_E1.5680.80
105_T279_G1.5650.80
223_Y244_I1.5630.80
293_P296_K1.5620.80
74_I256_P1.5490.79
195_L202_R1.5170.78
64_L69_D1.5100.78
85_Y350_Y1.4980.77
128_T156_N1.4960.77
289_A296_K1.4720.76
204_F207_K1.4720.76
65_T354_L1.4470.75
107_K296_K1.4190.73
93_V120_T1.4110.73
79_T171_G1.4110.73
347_T350_Y1.4000.72
92_A274_V1.3890.71
196_E199_L1.3870.71
163_S238_E1.3870.71
134_S244_I1.3810.71
296_K300_N1.3800.71
313_G362_G1.3770.71
132_L136_A1.3690.70
58_T216_I1.3630.70
124_F223_Y1.3630.70
123_S134_S1.3490.69
100_A163_S1.3330.68
223_Y255_I1.3220.67
216_I221_Q1.3180.67
49_T53_F1.3140.67
172_L312_F1.3060.67
85_Y207_K1.3020.66
154_T157_L1.2870.65
100_A229_F1.2850.65
168_Y352_V1.2850.65
133_L144_V1.2830.65
166_F170_L1.2810.65
105_T298_W1.2800.65
239_V279_G1.2710.64
337_I358_I1.2660.64
161_L165_G1.2650.64
239_V290_F1.2480.63
103_N170_L1.2430.63
295_R360_W1.2400.62
129_V262_L1.2280.62
134_S245_S1.2260.61
187_E193_Q1.2150.61
320_L333_F1.2140.61
65_T69_D1.2070.60
356_F363_S1.2040.60
55_F61_Q1.1950.59
158_I162_I1.1930.59
109_L283_R1.1920.59
238_E318_E1.1890.59
73_L204_F1.1880.59
49_T52_L1.1860.59
171_G312_F1.1810.59
190_Y239_V1.1760.58
84_S241_I1.1750.58
325_A328_N1.1690.58
118_V222_M1.1650.57
121_F246_A1.1620.57
223_Y240_A1.1590.57
121_F241_I1.1560.57
131_I218_N1.1510.57
123_S272_S1.1480.56
100_A238_E1.1410.56
68_T245_S1.1380.56
63_P216_I1.1350.55
277_T280_L1.1330.55
314_I352_V1.1190.54
355_T371_K1.1160.54
103_N307_S1.1120.54
315_G337_I1.0900.52
288_W360_W1.0890.52
109_L114_N1.0850.52
54_L58_T1.0820.52
209_F243_S1.0790.52
222_M225_V1.0780.52
131_I260_I1.0770.52
212_L225_V1.0610.50
244_I346_E1.0560.50
293_P300_N1.0540.50
170_L272_S1.0520.50
56_L60_P1.0510.50
51_L55_F1.0510.50
113_K301_L1.0470.49
124_F128_T1.0410.49
134_S243_S1.0340.49
148_L279_G1.0260.48
240_A279_G1.0230.48
99_A214_K1.0210.48
171_G346_E1.0190.48
105_T283_R1.0170.47
240_A316_T1.0110.47
337_I341_N1.0090.47
134_S236_A1.0080.47
93_V283_R1.0070.47
225_V276_T1.0060.47
276_T368_R0.9950.46
155_G215_I0.9940.46
70_S132_L0.9930.46
123_S223_Y0.9880.45
123_S127_S0.9790.45
100_A222_M0.9780.45
56_L303_I0.9780.45
120_T272_S0.9710.44
227_F351_Y0.9710.44
191_D196_E0.9610.44
103_N303_I0.9600.44
216_I363_S0.9600.44
317_I345_W0.9510.43
130_V223_Y0.9440.42
155_G177_V0.9440.42
53_F57_Y0.9420.42
263_Y319_L0.9400.42
137_V308_I0.9390.42
350_Y354_L0.9330.42
86_T179_Y0.9330.42
105_T114_N0.9270.41
51_L54_L0.9270.41
221_Q305_L0.9260.41
64_L71_G0.9260.41
243_S256_P0.9250.41
251_T254_H0.9230.41
288_W296_K0.9210.41
248_L251_T0.9150.41
341_N346_E0.9140.40
128_T183_S0.9110.40
49_T54_L0.9100.40
289_A300_N0.9100.40
113_K116_V0.9090.40
270_G278_D0.9080.40
86_T244_I0.8910.39
306_I355_T0.8910.39
58_T204_F0.8840.39
186_K189_K0.8810.38
129_V355_T0.8740.38
60_P71_G0.8720.38
197_E201_K0.8710.38
67_N71_G0.8690.38
60_P63_P0.8610.37
89_L163_S0.8580.37
185_Y294_L0.8560.37
199_L206_N0.8510.36
135_L261_L0.8470.36
108_M352_V0.8450.36
288_W300_N0.8430.36
86_T298_W0.8420.36
289_A363_S0.8410.36
69_D72_E0.8310.35
63_P66_L0.8300.35
138_M363_S0.8250.35
138_M260_I0.8240.35
239_V249_S0.8240.35
112_G371_K0.8240.35
240_A348_I0.8180.34
108_M294_L0.8170.34
159_E223_Y0.8160.34
280_L305_L0.8140.34
292_S312_F0.8120.34
301_L338_A0.8090.34
151_L158_I0.8040.33
285_A288_W0.8020.33
136_A149_P0.8000.33
104_V222_M0.7980.33
120_T269_L0.7960.33
216_I222_M0.7940.33
83_L87_F0.7930.33
157_L326_E0.7910.33
87_F348_I0.7900.33
110_Q363_S0.7870.32
58_T306_I0.7870.32
231_L261_L0.7860.32
89_L229_F0.7830.32
318_E346_E0.7810.32
195_L290_F0.7790.32
232_G235_T0.7750.32
52_L60_P0.7720.32
189_K358_I0.7720.32
116_V321_G0.7710.32
313_G371_K0.7670.31
67_N81_G0.7670.31
158_I161_L0.7660.31
279_G306_I0.7650.31
324_Q361_I0.7610.31
142_R268_S0.7610.31
57_Y268_S0.7590.31
105_T121_F0.7580.31
160_T318_E0.7570.31
281_F357_A0.7560.31
222_M322_L0.7550.31
113_K357_A0.7540.31
92_A299_Y0.7520.30
157_L361_I0.7520.30
87_F268_S0.7510.30
108_M250_S0.7510.30
171_G279_G0.7490.30
59_L265_I0.7480.30
159_E346_E0.7450.30
175_T312_F0.7430.30
123_S149_P0.7420.30
131_I265_I0.7360.29
93_V367_Y0.7360.29
362_G366_I0.7360.29
165_G169_L0.7360.29
51_L265_I0.7350.29
109_L115_P0.7310.29
93_V272_S0.7290.29
214_K332_L0.7250.29
359_T363_S0.7240.29
137_V141_S0.7230.29
103_N296_K0.7200.29
199_L204_F0.7190.29
129_V152_E0.7190.29
338_A365_M0.7190.29
274_V305_L0.7190.29
77_F281_F0.7180.28
114_N214_K0.7140.28
169_L301_L0.7140.28
173_L208_Y0.7130.28
288_W293_P0.7130.28
145_T368_R0.7130.28
105_T346_E0.7120.28
153_N365_M0.7100.28
128_T308_I0.7080.28
65_T68_T0.7040.28
140_A242_L0.7000.27
188_G192_K0.6990.27
145_T216_I0.6970.27
110_Q171_G0.6970.27
205_M326_E0.6970.27
282_M286_Y0.6960.27
333_F368_R0.6940.27
90_R95_A0.6930.27
163_S334_W0.6900.27
294_L340_L0.6880.27
133_L168_Y0.6880.27
107_K300_N0.6880.27
164_G290_F0.6880.27
162_I223_Y0.6860.27
141_S161_L0.6830.27
260_I323_L0.6820.27
129_V351_Y0.6810.26
139_M255_I0.6800.26
212_L351_Y0.6800.26
227_F280_L0.6790.26
202_R207_K0.6780.26
198_I245_S0.6770.26
180_E219_Q0.6750.26
87_F101_I0.6730.26
87_F341_N0.6710.26
135_L157_L0.6700.26
142_R257_I0.6700.26
151_L155_G0.6690.26
111_E170_L0.6660.26
124_F159_E0.6650.26
225_V291_L0.6650.26
55_F120_T0.6630.26
117_F321_G0.6580.25
139_M187_E0.6560.25
171_G208_Y0.6530.25
272_S371_K0.6520.25
113_K371_K0.6510.25
135_L330_T0.6480.25
104_V321_G0.6470.25
55_F169_L0.6470.25
169_L216_I0.6440.25
184_F189_K0.6440.25
121_F258_Y0.6440.25
177_V334_W0.6420.24
82_V225_V0.6420.24
60_P105_T0.6390.24
93_V178_F0.6390.24
62_K208_Y0.6390.24
308_I352_V0.6380.24
177_V314_I0.6380.24
216_I248_L0.6370.24
351_Y354_L0.6360.24
104_V274_V0.6350.24
65_T239_V0.6350.24
59_L63_P0.6340.24
178_F297_I0.6320.24
203_G238_E0.6320.24
166_F241_I0.6320.24
288_W295_R0.6320.24
181_L297_I0.6300.24
285_A293_P0.6300.24
64_L68_T0.6290.24
85_Y121_F0.6270.24
173_L305_L0.6250.24
152_E159_E0.6220.23
274_V348_I0.6220.23
205_M211_K0.6210.23
238_E315_G0.6190.23
346_E350_Y0.6190.23
308_I312_F0.6190.23
168_Y319_L0.6190.23
237_T240_A0.6140.23
243_S258_Y0.6140.23
208_Y351_Y0.6130.23
255_I279_G0.6130.23
183_S312_F0.6110.23
80_L112_G0.6100.23
214_K225_V0.6090.23
116_V182_Y0.6080.23
187_E339_A0.6070.23
340_L348_I0.6060.23
117_F168_Y0.6050.23
112_G115_P0.6030.23
197_E306_I0.6020.22
332_L335_D0.6020.22
237_T360_W0.6010.22
173_L204_F0.6010.22
101_I168_Y0.6010.22
191_D202_R0.6010.22
100_A166_F0.5990.22
285_A290_F0.5990.22
123_S145_T0.5980.22
350_Y368_R0.5970.22
50_A216_I0.5910.22
110_Q177_V0.5900.22
61_Q187_E0.5900.22
83_L155_G0.5890.22
64_L70_S0.5890.22
149_P155_G0.5880.22
59_L66_L0.5860.22
128_T169_L0.5850.22
118_V305_L0.5850.22
76_T79_T0.5840.22
105_T116_V0.5840.22
57_Y322_L0.5830.22
307_S311_A0.5790.21
358_I362_G0.5790.21
136_A257_I0.5780.21
55_F58_T0.5730.21
120_T124_F0.5730.21
87_F294_L0.5720.21
109_L287_G0.5710.21
316_T320_L0.5680.21
120_T170_L0.5680.21
294_L298_W0.5680.21
83_L274_V0.5670.21
208_Y269_L0.5660.21
239_V321_G0.5640.21
229_F318_E0.5630.21
53_F237_T0.5620.21
162_I225_V0.5620.21
333_F338_A0.5620.21
151_L337_I0.5610.21
84_S316_T0.5610.21
217_T261_L0.5600.21
128_T177_V0.5590.20
172_L191_D0.5590.20
217_T363_S0.5590.20
81_G266_L0.5570.20
169_L358_I0.5560.20
53_F56_L0.5560.20
169_L277_T0.5530.20
242_L279_G0.5520.20
179_Y183_S0.5510.20
302_T360_W0.5500.20
160_T170_L0.5500.20
204_F358_I0.5470.20
118_V129_V0.5460.20
60_P67_N0.5450.20
334_W363_S0.5440.20
134_S142_R0.5440.20
123_S132_L0.5430.20
93_V104_V0.5420.20
109_L303_I0.5420.20
80_L152_E0.5410.20
335_D361_I0.5410.20
196_E306_I0.5400.20
124_F130_V0.5400.20
116_V283_R0.5390.20
121_F369_I0.5370.20
87_F269_L0.5350.19
196_E202_R0.5350.19
62_K66_L0.5340.19
329_L368_R0.5330.19
61_Q208_Y0.5320.19
83_L89_L0.5310.19
298_W346_E0.5310.19
177_V206_N0.5300.19
66_L316_T0.5300.19
152_E321_G0.5280.19
49_T85_Y0.5260.19
210_N302_T0.5230.19
133_L236_A0.5230.19
113_K218_N0.5220.19
180_E357_A0.5210.19
65_T172_L0.5210.19
173_L338_A0.5200.19
211_K214_K0.5180.19
149_P243_S0.5160.19
180_E218_N0.5150.19
211_K340_L0.5150.19
277_T312_F0.5140.19
120_T367_Y0.5140.19
187_E210_N0.5130.19
168_Y172_L0.5120.18
120_T274_V0.5120.18
212_L215_I0.5100.18
61_Q361_I0.5090.18
166_F360_W0.5090.18
113_K291_L0.5080.18
104_V170_L0.5080.18
152_E155_G0.5070.18
296_K303_I0.5070.18
234_D237_T0.5060.18
194_K361_I0.5050.18
51_L190_Y0.5050.18
220_W272_S0.5030.18
181_L213_F0.5030.18
140_A219_Q0.5030.18
216_I250_S0.5030.18
108_M264_P0.5010.18
85_Y294_L0.5010.18
258_Y320_L0.5000.18
85_Y272_S0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m20A 2 0.1609 22.8 0.979 Contact Map
2l2tA 2 0.118 15.5 0.98 Contact Map
3hb3B 1 0.1689 13.4 0.981 Contact Map
2kluA 1 0.1662 9.9 0.982 Contact Map
2kogA 1 0.1609 7.6 0.983 Contact Map
3mk7C 2 0.2011 6 0.984 Contact Map
2lzrA 1 0.1287 5.7 0.984 Contact Map
1fftB 1 0.126 5.7 0.984 Contact Map
2ks1B 1 0.1153 4.9 0.984 Contact Map
4ogqG 1 0.0992 3.7 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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