Q97ZB2 - SULSO - GREMLIN Contacts

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Q97ZB2 - High-affinity nickel-transport protein (HoxN)

UniProt:	Q97ZB2	Sequences: MLQNSRKIYMMDRQSIYAMRSILNTLTQTISYKNLVTLSLFYVLNVLLTALLFLFLYTLPQKPLTLNTDSGELIGTFITLGVLSYTFGLRHAVDADHLAAIDNVTRKMLQEGKNPVFVGTFFSFGHSTVVILLSLAVMMASRLVTNSLPSLENTGNLIETLISGGFLYLLGLLNTIVFYELYSFYKEGKYDKQKLEEILQKRGFMNKYFNKLFKIITNQWQMYIVGFLFGLGFDTATEVAILSISAILSSTYIHIPIYIILLYPILFSLGMSLVDTTDGLFMRFAYGWAFLSPLRKIWYNLTITLISILIAFGIGTIELLGLLQAEFNLTGLFWDQIAALNNVYWETIGYYVILTFAITWIGSGMIYRIKKIE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	373 (318)
Sequences:	624 (397)
Seq/√Len:	22.2

SULSO - Q97ZB2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
331_G	334_W	4.126	1.00
216_I	225_V	4.109	1.00
132_L	227_F	4.008	1.00
128_T	223_Y	3.965	1.00
128_T	227_F	3.544	1.00
168_Y	316_T	3.476	1.00
53_F	277_T	3.439	1.00
188_G	191_D	3.293	1.00
131_I	268_S	3.271	1.00
199_L	202_R	3.249	1.00
89_L	274_V	3.199	1.00
93_V	274_V	3.198	1.00
117_F	219_Q	3.131	1.00
178_F	305_L	3.112	1.00
320_L	334_W	3.000	1.00
163_S	318_E	3.000	1.00
182_Y	301_L	2.893	0.99
170_L	225_V	2.782	0.99
331_G	335_D	2.722	0.99
164_G	319_L	2.701	0.99
329_L	334_W	2.512	0.98
218_N	221_Q	2.500	0.98
178_F	301_L	2.311	0.97
107_K	303_I	2.246	0.96
160_T	322_L	2.238	0.96
134_S	240_A	2.231	0.96
345_W	348_I	2.207	0.96
217_T	221_Q	2.206	0.96
61_Q	65_T	2.140	0.95
129_V	227_F	2.084	0.94
163_S	229_F	2.052	0.94
365_M	369_I	2.030	0.94
320_L	331_G	2.016	0.93
63_P	262_L	1.969	0.92
198_I	202_R	1.933	0.92
84_S	263_Y	1.907	0.91
224_I	241_I	1.870	0.90
310_I	352_V	1.835	0.89
60_P	64_L	1.819	0.89
93_V	353_I	1.798	0.88
123_S	287_G	1.788	0.88
135_L	139_M	1.755	0.87
185_Y	297_I	1.745	0.87
195_L	199_L	1.744	0.87
64_L	67_N	1.742	0.87
66_L	262_L	1.724	0.86
321_G	341_N	1.715	0.86
169_L	361_I	1.710	0.86
87_F	205_M	1.649	0.84
309_L	313_G	1.638	0.83
127_S	159_E	1.622	0.83
123_S	268_S	1.618	0.82
290_F	296_K	1.591	0.81
107_K	111_E	1.584	0.81
131_I	261_L	1.583	0.81
103_N	107_K	1.581	0.81
123_S	159_E	1.568	0.80
105_T	279_G	1.565	0.80
223_Y	244_I	1.563	0.80
293_P	296_K	1.562	0.80
74_I	256_P	1.549	0.79
195_L	202_R	1.517	0.78
64_L	69_D	1.510	0.78
85_Y	350_Y	1.498	0.77
128_T	156_N	1.496	0.77
289_A	296_K	1.472	0.76
204_F	207_K	1.472	0.76
65_T	354_L	1.447	0.75
107_K	296_K	1.419	0.73
93_V	120_T	1.411	0.73
79_T	171_G	1.411	0.73
347_T	350_Y	1.400	0.72
92_A	274_V	1.389	0.71
196_E	199_L	1.387	0.71
163_S	238_E	1.387	0.71
134_S	244_I	1.381	0.71
296_K	300_N	1.380	0.71
313_G	362_G	1.377	0.71
132_L	136_A	1.369	0.70
58_T	216_I	1.363	0.70
124_F	223_Y	1.363	0.70
123_S	134_S	1.349	0.69
100_A	163_S	1.333	0.68
223_Y	255_I	1.322	0.67
216_I	221_Q	1.318	0.67
49_T	53_F	1.314	0.67
172_L	312_F	1.306	0.67
85_Y	207_K	1.302	0.66
154_T	157_L	1.287	0.65
100_A	229_F	1.285	0.65
168_Y	352_V	1.285	0.65
133_L	144_V	1.283	0.65
166_F	170_L	1.281	0.65
105_T	298_W	1.280	0.65
239_V	279_G	1.271	0.64
337_I	358_I	1.266	0.64
161_L	165_G	1.265	0.64
239_V	290_F	1.248	0.63
103_N	170_L	1.243	0.63
295_R	360_W	1.240	0.62
129_V	262_L	1.228	0.62
134_S	245_S	1.226	0.61
187_E	193_Q	1.215	0.61
320_L	333_F	1.214	0.61
65_T	69_D	1.207	0.60
356_F	363_S	1.204	0.60
55_F	61_Q	1.195	0.59
158_I	162_I	1.193	0.59
109_L	283_R	1.192	0.59
238_E	318_E	1.189	0.59
73_L	204_F	1.188	0.59
49_T	52_L	1.186	0.59
171_G	312_F	1.181	0.59
190_Y	239_V	1.176	0.58
84_S	241_I	1.175	0.58
325_A	328_N	1.169	0.58
118_V	222_M	1.165	0.57
121_F	246_A	1.162	0.57
223_Y	240_A	1.159	0.57
121_F	241_I	1.156	0.57
131_I	218_N	1.151	0.57
123_S	272_S	1.148	0.56
100_A	238_E	1.141	0.56
68_T	245_S	1.138	0.56
63_P	216_I	1.135	0.55
277_T	280_L	1.133	0.55
314_I	352_V	1.119	0.54
355_T	371_K	1.116	0.54
103_N	307_S	1.112	0.54
315_G	337_I	1.090	0.52
288_W	360_W	1.089	0.52
109_L	114_N	1.085	0.52
54_L	58_T	1.082	0.52
209_F	243_S	1.079	0.52
222_M	225_V	1.078	0.52
131_I	260_I	1.077	0.52
212_L	225_V	1.061	0.50
244_I	346_E	1.056	0.50
293_P	300_N	1.054	0.50
170_L	272_S	1.052	0.50
56_L	60_P	1.051	0.50
51_L	55_F	1.051	0.50
113_K	301_L	1.047	0.49
124_F	128_T	1.041	0.49
134_S	243_S	1.034	0.49
148_L	279_G	1.026	0.48
240_A	279_G	1.023	0.48
99_A	214_K	1.021	0.48
171_G	346_E	1.019	0.48
105_T	283_R	1.017	0.47
240_A	316_T	1.011	0.47
337_I	341_N	1.009	0.47
134_S	236_A	1.008	0.47
93_V	283_R	1.007	0.47
225_V	276_T	1.006	0.47
276_T	368_R	0.995	0.46
155_G	215_I	0.994	0.46
70_S	132_L	0.993	0.46
123_S	223_Y	0.988	0.45
123_S	127_S	0.979	0.45
100_A	222_M	0.978	0.45
56_L	303_I	0.978	0.45
120_T	272_S	0.971	0.44
227_F	351_Y	0.971	0.44
191_D	196_E	0.961	0.44
103_N	303_I	0.960	0.44
216_I	363_S	0.960	0.44
317_I	345_W	0.951	0.43
130_V	223_Y	0.944	0.42
155_G	177_V	0.944	0.42
53_F	57_Y	0.942	0.42
263_Y	319_L	0.940	0.42
137_V	308_I	0.939	0.42
350_Y	354_L	0.933	0.42
86_T	179_Y	0.933	0.42
105_T	114_N	0.927	0.41
51_L	54_L	0.927	0.41
221_Q	305_L	0.926	0.41
64_L	71_G	0.926	0.41
243_S	256_P	0.925	0.41
251_T	254_H	0.923	0.41
288_W	296_K	0.921	0.41
248_L	251_T	0.915	0.41
341_N	346_E	0.914	0.40
128_T	183_S	0.911	0.40
49_T	54_L	0.910	0.40
289_A	300_N	0.910	0.40
113_K	116_V	0.909	0.40
270_G	278_D	0.908	0.40
86_T	244_I	0.891	0.39
306_I	355_T	0.891	0.39
58_T	204_F	0.884	0.39
186_K	189_K	0.881	0.38
129_V	355_T	0.874	0.38
60_P	71_G	0.872	0.38
197_E	201_K	0.871	0.38
67_N	71_G	0.869	0.38
60_P	63_P	0.861	0.37
89_L	163_S	0.858	0.37
185_Y	294_L	0.856	0.37
199_L	206_N	0.851	0.36
135_L	261_L	0.847	0.36
108_M	352_V	0.845	0.36
288_W	300_N	0.843	0.36
86_T	298_W	0.842	0.36
289_A	363_S	0.841	0.36
69_D	72_E	0.831	0.35
63_P	66_L	0.830	0.35
138_M	363_S	0.825	0.35
138_M	260_I	0.824	0.35
239_V	249_S	0.824	0.35
112_G	371_K	0.824	0.35
240_A	348_I	0.818	0.34
108_M	294_L	0.817	0.34
159_E	223_Y	0.816	0.34
280_L	305_L	0.814	0.34
292_S	312_F	0.812	0.34
301_L	338_A	0.809	0.34
151_L	158_I	0.804	0.33
285_A	288_W	0.802	0.33
136_A	149_P	0.800	0.33
104_V	222_M	0.798	0.33
120_T	269_L	0.796	0.33
216_I	222_M	0.794	0.33
83_L	87_F	0.793	0.33
157_L	326_E	0.791	0.33
87_F	348_I	0.790	0.33
110_Q	363_S	0.787	0.32
58_T	306_I	0.787	0.32
231_L	261_L	0.786	0.32
89_L	229_F	0.783	0.32
318_E	346_E	0.781	0.32
195_L	290_F	0.779	0.32
232_G	235_T	0.775	0.32
52_L	60_P	0.772	0.32
189_K	358_I	0.772	0.32
116_V	321_G	0.771	0.32
313_G	371_K	0.767	0.31
67_N	81_G	0.767	0.31
158_I	161_L	0.766	0.31
279_G	306_I	0.765	0.31
324_Q	361_I	0.761	0.31
142_R	268_S	0.761	0.31
57_Y	268_S	0.759	0.31
105_T	121_F	0.758	0.31
160_T	318_E	0.757	0.31
281_F	357_A	0.756	0.31
222_M	322_L	0.755	0.31
113_K	357_A	0.754	0.31
92_A	299_Y	0.752	0.30
157_L	361_I	0.752	0.30
87_F	268_S	0.751	0.30
108_M	250_S	0.751	0.30
171_G	279_G	0.749	0.30
59_L	265_I	0.748	0.30
159_E	346_E	0.745	0.30
175_T	312_F	0.743	0.30
123_S	149_P	0.742	0.30
131_I	265_I	0.736	0.29
93_V	367_Y	0.736	0.29
362_G	366_I	0.736	0.29
165_G	169_L	0.736	0.29
51_L	265_I	0.735	0.29
109_L	115_P	0.731	0.29
93_V	272_S	0.729	0.29
214_K	332_L	0.725	0.29
359_T	363_S	0.724	0.29
137_V	141_S	0.723	0.29
103_N	296_K	0.720	0.29
199_L	204_F	0.719	0.29
129_V	152_E	0.719	0.29
338_A	365_M	0.719	0.29
274_V	305_L	0.719	0.29
77_F	281_F	0.718	0.28
114_N	214_K	0.714	0.28
169_L	301_L	0.714	0.28
173_L	208_Y	0.713	0.28
288_W	293_P	0.713	0.28
145_T	368_R	0.713	0.28
105_T	346_E	0.712	0.28
153_N	365_M	0.710	0.28
128_T	308_I	0.708	0.28
65_T	68_T	0.704	0.28
140_A	242_L	0.700	0.27
188_G	192_K	0.699	0.27
145_T	216_I	0.697	0.27
110_Q	171_G	0.697	0.27
205_M	326_E	0.697	0.27
282_M	286_Y	0.696	0.27
333_F	368_R	0.694	0.27
90_R	95_A	0.693	0.27
163_S	334_W	0.690	0.27
294_L	340_L	0.688	0.27
133_L	168_Y	0.688	0.27
107_K	300_N	0.688	0.27
164_G	290_F	0.688	0.27
162_I	223_Y	0.686	0.27
141_S	161_L	0.683	0.27
260_I	323_L	0.682	0.27
129_V	351_Y	0.681	0.26
139_M	255_I	0.680	0.26
212_L	351_Y	0.680	0.26
227_F	280_L	0.679	0.26
202_R	207_K	0.678	0.26
198_I	245_S	0.677	0.26
180_E	219_Q	0.675	0.26
87_F	101_I	0.673	0.26
87_F	341_N	0.671	0.26
135_L	157_L	0.670	0.26
142_R	257_I	0.670	0.26
151_L	155_G	0.669	0.26
111_E	170_L	0.666	0.26
124_F	159_E	0.665	0.26
225_V	291_L	0.665	0.26
55_F	120_T	0.663	0.26
117_F	321_G	0.658	0.25
139_M	187_E	0.656	0.25
171_G	208_Y	0.653	0.25
272_S	371_K	0.652	0.25
113_K	371_K	0.651	0.25
135_L	330_T	0.648	0.25
104_V	321_G	0.647	0.25
55_F	169_L	0.647	0.25
169_L	216_I	0.644	0.25
184_F	189_K	0.644	0.25
121_F	258_Y	0.644	0.25
177_V	334_W	0.642	0.24
82_V	225_V	0.642	0.24
60_P	105_T	0.639	0.24
93_V	178_F	0.639	0.24
62_K	208_Y	0.639	0.24
308_I	352_V	0.638	0.24
177_V	314_I	0.638	0.24
216_I	248_L	0.637	0.24
351_Y	354_L	0.636	0.24
104_V	274_V	0.635	0.24
65_T	239_V	0.635	0.24
59_L	63_P	0.634	0.24
178_F	297_I	0.632	0.24
203_G	238_E	0.632	0.24
166_F	241_I	0.632	0.24
288_W	295_R	0.632	0.24
181_L	297_I	0.630	0.24
285_A	293_P	0.630	0.24
64_L	68_T	0.629	0.24
85_Y	121_F	0.627	0.24
173_L	305_L	0.625	0.24
152_E	159_E	0.622	0.23
274_V	348_I	0.622	0.23
205_M	211_K	0.621	0.23
238_E	315_G	0.619	0.23
346_E	350_Y	0.619	0.23
308_I	312_F	0.619	0.23
168_Y	319_L	0.619	0.23
237_T	240_A	0.614	0.23
243_S	258_Y	0.614	0.23
208_Y	351_Y	0.613	0.23
255_I	279_G	0.613	0.23
183_S	312_F	0.611	0.23
80_L	112_G	0.610	0.23
214_K	225_V	0.609	0.23
116_V	182_Y	0.608	0.23
187_E	339_A	0.607	0.23
340_L	348_I	0.606	0.23
117_F	168_Y	0.605	0.23
112_G	115_P	0.603	0.23
197_E	306_I	0.602	0.22
332_L	335_D	0.602	0.22
237_T	360_W	0.601	0.22
173_L	204_F	0.601	0.22
101_I	168_Y	0.601	0.22
191_D	202_R	0.601	0.22
100_A	166_F	0.599	0.22
285_A	290_F	0.599	0.22
123_S	145_T	0.598	0.22
350_Y	368_R	0.597	0.22
50_A	216_I	0.591	0.22
110_Q	177_V	0.590	0.22
61_Q	187_E	0.590	0.22
83_L	155_G	0.589	0.22
64_L	70_S	0.589	0.22
149_P	155_G	0.588	0.22
59_L	66_L	0.586	0.22
128_T	169_L	0.585	0.22
118_V	305_L	0.585	0.22
76_T	79_T	0.584	0.22
105_T	116_V	0.584	0.22
57_Y	322_L	0.583	0.22
307_S	311_A	0.579	0.21
358_I	362_G	0.579	0.21
136_A	257_I	0.578	0.21
55_F	58_T	0.573	0.21
120_T	124_F	0.573	0.21
87_F	294_L	0.572	0.21
109_L	287_G	0.571	0.21
316_T	320_L	0.568	0.21
120_T	170_L	0.568	0.21
294_L	298_W	0.568	0.21
83_L	274_V	0.567	0.21
208_Y	269_L	0.566	0.21
239_V	321_G	0.564	0.21
229_F	318_E	0.563	0.21
53_F	237_T	0.562	0.21
162_I	225_V	0.562	0.21
333_F	338_A	0.562	0.21
151_L	337_I	0.561	0.21
84_S	316_T	0.561	0.21
217_T	261_L	0.560	0.21
128_T	177_V	0.559	0.20
172_L	191_D	0.559	0.20
217_T	363_S	0.559	0.20
81_G	266_L	0.557	0.20
169_L	358_I	0.556	0.20
53_F	56_L	0.556	0.20
169_L	277_T	0.553	0.20
242_L	279_G	0.552	0.20
179_Y	183_S	0.551	0.20
302_T	360_W	0.550	0.20
160_T	170_L	0.550	0.20
204_F	358_I	0.547	0.20
118_V	129_V	0.546	0.20
60_P	67_N	0.545	0.20
334_W	363_S	0.544	0.20
134_S	142_R	0.544	0.20
123_S	132_L	0.543	0.20
93_V	104_V	0.542	0.20
109_L	303_I	0.542	0.20
80_L	152_E	0.541	0.20
335_D	361_I	0.541	0.20
196_E	306_I	0.540	0.20
124_F	130_V	0.540	0.20
116_V	283_R	0.539	0.20
121_F	369_I	0.537	0.20
87_F	269_L	0.535	0.19
196_E	202_R	0.535	0.19
62_K	66_L	0.534	0.19
329_L	368_R	0.533	0.19
61_Q	208_Y	0.532	0.19
83_L	89_L	0.531	0.19
298_W	346_E	0.531	0.19
177_V	206_N	0.530	0.19
66_L	316_T	0.530	0.19
152_E	321_G	0.528	0.19
49_T	85_Y	0.526	0.19
210_N	302_T	0.523	0.19
133_L	236_A	0.523	0.19
113_K	218_N	0.522	0.19
180_E	357_A	0.521	0.19
65_T	172_L	0.521	0.19
173_L	338_A	0.520	0.19
211_K	214_K	0.518	0.19
149_P	243_S	0.516	0.19
180_E	218_N	0.515	0.19
211_K	340_L	0.515	0.19
277_T	312_F	0.514	0.19
120_T	367_Y	0.514	0.19
187_E	210_N	0.513	0.19
168_Y	172_L	0.512	0.18
120_T	274_V	0.512	0.18
212_L	215_I	0.510	0.18
61_Q	361_I	0.509	0.18
166_F	360_W	0.509	0.18
113_K	291_L	0.508	0.18
104_V	170_L	0.508	0.18
152_E	155_G	0.507	0.18
296_K	303_I	0.507	0.18
234_D	237_T	0.506	0.18
194_K	361_I	0.505	0.18
51_L	190_Y	0.505	0.18
220_W	272_S	0.503	0.18
181_L	213_F	0.503	0.18
140_A	219_Q	0.503	0.18
216_I	250_S	0.503	0.18
108_M	264_P	0.501	0.18
85_Y	294_L	0.501	0.18
258_Y	320_L	0.500	0.18
85_Y	272_S	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2m20A	2	0.1609	22.8	0.979	Contact Map
2l2tA	2	0.118	15.5	0.98	Contact Map
3hb3B	1	0.1689	13.4	0.981	Contact Map
2kluA	1	0.1662	9.9	0.982	Contact Map
2kogA	1	0.1609	7.6	0.983	Contact Map
3mk7C	2	0.2011	6	0.984	Contact Map
2lzrA	1	0.1287	5.7	0.984	Contact Map
1fftB	1	0.126	5.7	0.984	Contact Map
2ks1B	1	0.1153	4.9	0.984	Contact Map
4ogqG	1	0.0992	3.7	0.985	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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