GREMLIN Database
Q97ZB1 - Sulfurtransferase
UniProt: Q97ZB1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 278 (256)
Sequences: 4506 (3212)
Seq/√Len: 200.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_L105_A3.4721.00
8_V12_W3.3211.00
146_L149_E3.0811.00
16_N19_D2.8221.00
208_K212_E2.7401.00
14_N119_Y2.7051.00
30_Q34_Y2.6731.00
68_G132_S2.6521.00
113_K117_E2.5821.00
165_K169_D2.5631.00
13_L107_L2.5151.00
36_G115_L2.4351.00
166_E172_T2.3621.00
23_V76_D2.3231.00
111_I121_I2.3171.00
106_I241_Y2.2951.00
9_S108_N2.2931.00
12_W16_N2.2911.00
63_L67_L2.2551.00
209_S212_E2.2451.00
36_G123_S2.2111.00
59_S62_K2.1301.00
166_E171_L2.1171.00
165_K194_N2.0991.00
101_H134_Y2.0731.00
10_V113_K1.9351.00
9_S12_W1.8831.00
147_V268_V1.8761.00
240_W254_L1.8711.00
210_R214_E1.8571.00
257_G261_E1.8061.00
90_F237_S1.8031.00
208_K216_I1.8031.00
122_E126_I1.7991.00
147_V265_M1.7951.00
73_N132_S1.7601.00
64_S68_G1.7491.00
10_V117_E1.7451.00
25_I72_I1.7381.00
24_E38_I1.6961.00
13_L24_E1.6911.00
214_E218_S1.6831.00
68_G133_E1.6731.00
64_S136_A1.6721.00
10_V119_Y1.6611.00
33_Y37_H1.6551.00
45_N48_D1.6321.00
236_A254_L1.6121.00
145_I150_L1.6091.00
74_N135_K1.5961.00
145_I253_R1.5851.00
157_F227_V1.5561.00
57_F95_I1.5551.00
153_K227_V1.5541.00
44_I70_A1.5511.00
113_K206_T1.5151.00
202_N206_T1.5091.00
265_M268_V1.5081.00
167_E235_R1.4951.00
73_N76_D1.4851.00
25_I42_V1.4681.00
195_I216_I1.4501.00
147_V151_L1.4491.00
145_I149_E1.4401.00
244_K250_K1.4401.00
77_L103_N1.4381.00
162_S239_A1.4291.00
144_R256_D1.4231.00
145_I227_V1.4041.00
147_V261_E1.3961.00
63_L99_Y1.3861.00
7_L207_M1.3861.00
189_I192_A1.3851.00
221_S224_D1.3821.00
67_L96_L1.3791.00
65_K69_N1.3621.00
23_V129_N1.3431.00
11_E15_N1.3421.00
140_D143_S1.3351.00
158_V224_D1.3281.00
80_L92_V1.3241.00
57_F98_A1.3041.00
200_L217_F1.3031.00
27_Y80_L1.3021.00
153_K157_F1.2991.00
24_E27_Y1.2911.00
240_W252_V1.2731.00
151_L268_V1.2631.00
28_N32_N1.2541.00
102_S140_D1.2491.00
60_P64_S1.2481.00
228_V243_L1.2211.00
34_Y125_G1.2181.00
72_I78_I1.2041.00
97_K244_K1.1981.00
200_L213_L1.1941.00
64_S135_K1.1871.00
73_N133_E1.1761.00
185_M263_G1.1691.00
150_L227_V1.1681.00
225_K253_R1.1671.00
185_M270_V1.1601.00
228_V252_V1.1401.00
226_I243_L1.1361.00
150_L153_K1.1271.00
212_E215_R1.1171.00
210_R247_L1.1131.00
214_E222_K1.1101.00
8_V16_N1.1041.00
150_L154_L1.0851.00
243_L252_V1.0791.00
47_R55_R1.0681.00
189_I229_Y1.0511.00
202_N208_K1.0421.00
115_L121_I1.0331.00
90_F241_Y1.0321.00
31_I35_E1.0281.00
243_L249_F1.0241.00
33_Y126_I1.0241.00
111_I115_L1.0221.00
36_G121_I1.0181.00
242_A247_L1.0151.00
63_L95_I1.0001.00
159_L229_Y0.9981.00
184_Q263_G0.9981.00
31_I34_Y0.9981.00
98_A139_P0.9961.00
259_W263_G0.9951.00
222_K249_F0.9911.00
30_Q48_D0.9911.00
225_K251_L0.9881.00
34_Y124_D0.9881.00
150_L157_F0.9811.00
42_V129_N0.9761.00
62_K65_K0.9690.99
68_G131_K0.9690.99
8_V105_A0.9640.99
87_R235_R0.9590.99
232_T260_V0.9530.99
39_P114_W0.9510.99
30_Q43_L0.9480.99
49_F66_V0.9460.99
93_Y240_W0.9380.99
153_K159_L0.9360.99
65_K131_K0.9350.99
23_V72_I0.9350.99
80_L96_L0.9270.99
207_M238_V0.9270.99
16_N22_V0.9220.99
150_L159_L0.9210.99
36_G111_I0.9180.99
6_M244_K0.9120.99
49_F69_N0.9110.99
62_K66_V0.9090.99
72_I76_D0.9090.99
63_L96_L0.9060.99
28_N31_I0.9050.99
74_N134_Y0.9040.99
199_I216_I0.9000.99
207_M246_V0.8970.99
200_L239_A0.8970.99
241_Y246_V0.8970.99
74_N137_R0.8940.99
42_V126_I0.8940.99
67_L72_I0.8820.99
200_L216_I0.8800.99
208_K213_L0.8770.99
98_A143_S0.8750.99
22_V79_V0.8740.99
80_L93_Y0.8710.99
93_Y244_K0.8680.99
74_N133_E0.8670.99
249_F252_V0.8670.99
7_L108_N0.8660.99
164_S172_T0.8660.99
66_V69_N0.8590.99
8_V13_L0.8520.99
255_Y261_E0.8510.99
145_I153_K0.8500.99
25_I44_I0.8470.99
97_K240_W0.8430.99
13_L22_V0.8400.99
168_Y188_H0.8380.99
16_N77_L0.8370.98
200_L238_V0.8310.98
145_I157_F0.8300.98
23_V26_G0.8290.98
149_E153_K0.8290.98
158_V193_K0.8260.98
167_E174_A0.8250.98
185_M268_V0.8220.98
158_V221_S0.8200.98
122_E125_G0.8190.98
64_S132_S0.8190.98
38_I114_W0.8180.98
195_I200_L0.8170.98
167_E232_T0.8160.98
21_K24_E0.8140.98
153_K225_K0.8080.98
82_S89_A0.8080.98
165_K199_I0.8010.98
112_Y116_K0.7970.98
14_N120_P0.7950.98
55_R232_T0.7940.98
195_I217_F0.7860.98
22_V77_L0.7830.98
25_I92_V0.7830.98
46_W234_A0.7800.98
167_E231_R0.7730.97
215_R218_S0.7730.97
42_V70_A0.7650.97
230_C258_S0.7640.97
28_N43_L0.7620.97
20_V24_E0.7560.97
67_L134_Y0.7510.97
213_L217_F0.7510.97
217_F243_L0.7510.97
207_M242_A0.7500.97
74_N101_H0.7500.97
154_L191_G0.7500.97
25_I70_A0.7490.97
7_L241_Y0.7450.97
228_V240_W0.7450.97
58_A91_Y0.7450.97
86_N207_M0.7420.97
192_A229_Y0.7390.97
164_S198_T0.7380.97
69_N131_K0.7370.97
11_E119_Y0.7370.97
30_Q45_N0.7370.97
166_E169_D0.7330.97
93_Y97_K0.7310.96
189_I271_E0.7300.96
21_K77_L0.7270.96
164_S167_E0.7270.96
23_V42_V0.7260.96
20_V26_G0.7260.96
211_D214_E0.7250.96
21_K76_D0.7200.96
21_K75_D0.7160.96
226_I249_F0.7140.96
149_E152_S0.7120.96
37_H81_Y0.7120.96
22_V76_D0.7100.96
44_I92_V0.7090.96
72_I96_L0.7090.96
261_E264_N0.7070.96
217_F239_A0.7060.96
188_H192_A0.7030.96
23_V27_Y0.7020.96
158_V226_I0.6950.95
147_V154_L0.6940.95
213_L216_I0.6930.95
170_G187_G0.6930.95
263_G270_V0.6910.95
196_P199_I0.6910.95
86_N238_V0.6900.95
55_R234_A0.6900.95
55_R167_E0.6870.95
259_W270_V0.6860.95
168_Y192_A0.6850.95
172_T175_P0.6840.95
84_M112_Y0.6840.95
32_N35_E0.6830.95
259_W269_P0.6760.95
85_N201_L0.6750.95
74_N102_S0.6720.94
143_S253_R0.6690.94
57_F144_R0.6680.94
107_L114_W0.6680.94
213_L242_A0.6660.94
33_Y41_A0.6640.94
85_N112_Y0.6640.94
44_I66_V0.6610.94
14_N18_K0.6600.94
197_W201_L0.6550.94
244_K252_V0.6530.93
51_D54_S0.6520.93
80_L104_L0.6510.93
255_Y258_S0.6490.93
112_Y115_L0.6490.93
260_V263_G0.6480.93
142_S253_R0.6460.93
83_E112_Y0.6430.93
113_K116_K0.6380.93
78_I96_L0.6370.93
212_E216_I0.6310.92
60_P136_A0.6250.92
97_K102_S0.6230.92
13_L79_V0.6230.92
93_Y104_L0.6220.92
163_R192_A0.6210.92
237_S254_L0.6200.92
239_A242_A0.6190.92
86_N106_I0.6190.92
33_Y124_D0.6180.92
50_L95_I0.6150.91
151_L154_L0.6100.91
82_S91_Y0.6090.91
55_R174_A0.6080.91
164_S235_R0.6080.91
231_R235_R0.6070.91
66_V70_A0.6050.91
183_T263_G0.6030.90
6_M241_Y0.6010.90
202_N212_E0.5980.90
48_D69_N0.5970.90
68_G73_N0.5960.90
160_I226_I0.5930.90
21_K26_G0.5900.90
86_N201_L0.5900.90
113_K119_Y0.5880.89
78_I101_H0.5860.89
148_W151_L0.5850.89
237_S240_W0.5850.89
158_V220_L0.5850.89
244_K251_L0.5840.89
18_K21_K0.5830.89
10_V14_N0.5820.89
220_L249_F0.5810.89
176_P184_Q0.5780.89
86_N89_A0.5780.89
13_L114_W0.5770.88
37_H122_E0.5740.88
200_L242_A0.5730.88
33_Y42_V0.5690.88
38_I107_L0.5650.87
44_I49_F0.5640.87
80_L106_I0.5640.87
160_I195_I0.5630.87
176_P183_T0.5630.87
35_E123_S0.5630.87
11_E117_E0.5630.87
149_E253_R0.5610.87
67_L99_Y0.5600.87
149_E225_K0.5580.87
228_V239_A0.5540.86
32_N83_E0.5540.86
49_F52_D0.5530.86
74_N132_S0.5450.86
188_H229_Y0.5450.86
49_F70_A0.5440.85
29_P32_N0.5420.85
58_A95_I0.5400.85
148_W152_S0.5380.85
154_L159_L0.5380.85
214_E250_K0.5380.85
29_P43_L0.5370.85
75_D132_S0.5350.84
81_Y111_I0.5350.84
6_M246_V0.5350.84
77_L80_L0.5330.84
128_V131_K0.5320.84
93_Y241_Y0.5320.84
50_L55_R0.5310.84
6_M105_A0.5290.84
87_R90_F0.5270.84
160_I220_L0.5260.83
52_D62_K0.5260.83
201_L238_V0.5240.83
56_D256_D0.5230.83
126_I129_N0.5220.83
67_L70_A0.5210.83
151_L262_Y0.5210.83
65_K68_G0.5190.83
98_A144_R0.5190.83
114_W119_Y0.5190.83
160_I193_K0.5190.83
41_A81_Y0.5130.82
55_R231_R0.5130.82
163_R259_W0.5120.82
99_Y134_Y0.5110.82
99_Y136_A0.5110.82
202_N205_E0.5080.81
68_G134_Y0.5070.81
162_S194_N0.5060.81
155_K225_K0.5050.81
147_V255_Y0.5030.81
37_H41_A0.5030.81
161_D192_A0.5020.81
197_W235_R0.5020.81
217_F242_A0.5020.81
218_S221_S0.5000.80
10_V107_L0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3aayA 1 0.982 100 0.266 Contact Map
1uarA 1 0.9568 100 0.271 Contact Map
3hzuA 2 0.9964 100 0.273 Contact Map
1urhA 1 0.8813 100 0.274 Contact Map
1rhsA 1 0.964 100 0.284 Contact Map
1e0cA 1 0.9388 100 0.296 Contact Map
3utnX 1 0.9568 100 0.3 Contact Map
4jgtA 1 0.9317 100 0.306 Contact Map
2wlrA 1 0.9676 100 0.306 Contact Map
1okgA 1 0.9388 100 0.31 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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