GREMLIN Database
Q97ZA8 - Formate hydrogenlyase subunit 7 (HycG)
UniProt: Q97ZA8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 201 (173)
Sequences: 226 (161)
Seq/√Len: 12.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_Q34_G4.4921.00
162_C184_C4.2611.00
95_C162_C3.8810.99
98_C184_C3.6090.99
95_C184_C3.4750.98
98_C162_C3.3500.98
101_E104_L2.7790.94
104_L107_S2.6120.91
101_E107_S2.5670.91
40_T165_S2.5630.91
95_C98_C2.4470.88
53_C56_C2.4060.87
93_G136_T2.3650.87
53_C59_C2.3050.85
52_R181_I2.1880.82
111_D125_H2.0690.78
144_K148_E1.9960.75
56_C59_C1.9510.73
102_L130_V1.9370.73
140_K144_K1.7670.66
91_D94_T1.7600.65
38_C56_C1.7260.64
38_C59_C1.6440.60
187_N190_T1.6400.60
156_V177_A1.5510.55
51_E99_N1.5190.54
113_T118_F1.5040.53
38_C53_C1.5030.53
193_E197_K1.4980.53
124_R149_A1.4950.52
80_L115_F1.4860.52
137_E140_K1.4840.52
162_C186_P1.4620.51
147_Y156_V1.4490.50
179_V198_V1.4220.49
97_G162_C1.4140.48
173_V179_V1.3750.46
90_I135_M1.3520.45
112_M117_I1.3440.45
129_L175_L1.3400.45
98_C186_P1.3360.44
76_K79_P1.2810.42
69_P73_T1.2720.41
124_R182_P1.2670.41
57_R111_D1.2660.41
131_V177_A1.2570.40
74_I115_F1.2510.40
36_V41_N1.2380.39
90_I139_M1.2300.39
154_K187_N1.2180.39
121_N194_A1.2170.38
79_P200_G1.2130.38
105_I117_I1.2010.38
124_R136_T1.1980.38
174_P195_L1.1950.37
52_R114_R1.1900.37
97_G184_C1.1870.37
125_H138_K1.1820.37
88_Y122_T1.1750.36
88_Y132_M1.1720.36
112_M115_F1.1700.36
54_V59_C1.1660.36
39_P53_C1.1660.36
88_Y99_N1.1640.36
92_S99_N1.1340.35
152_E171_E1.1330.35
141_E145_K1.1310.34
126_A188_P1.1110.34
87_L91_D1.0790.32
56_C126_A1.0750.32
74_I157_I1.0750.32
147_Y154_K1.0720.32
130_V191_I1.0690.32
117_I195_L1.0670.32
49_I56_C1.0610.31
62_N179_V1.0400.30
108_P193_E1.0350.30
106_S118_F1.0180.29
120_T180_E1.0170.29
59_C84_S1.0170.29
86_Y89_P1.0100.29
115_F196_M1.0090.29
53_C126_A1.0040.29
35_T64_R1.0030.29
86_Y108_P1.0020.29
102_L191_I0.9990.29
96_G138_K0.9930.28
34_G37_N0.9930.28
98_C136_T0.9830.28
181_I194_A0.9760.28
151_P175_L0.9700.27
90_I126_A0.9680.27
75_N196_M0.9630.27
135_M175_L0.9630.27
86_Y113_T0.9610.27
39_P56_C0.9540.27
79_P117_I0.9420.26
136_T176_E0.9380.26
58_R108_P0.9380.26
124_R190_T0.9350.26
51_E164_I0.9220.26
39_P128_A0.9210.26
113_T120_T0.9140.25
157_I167_G0.9130.25
71_I195_L0.9070.25
71_I188_P0.9060.25
135_M146_A0.8930.24
41_N52_R0.8880.24
49_I59_C0.8860.24
64_R75_N0.8760.24
56_C188_P0.8750.24
84_S117_I0.8720.24
130_V139_M0.8690.24
107_S145_K0.8670.24
121_N142_V0.8660.23
54_V87_L0.8620.23
152_E194_A0.8540.23
34_G96_G0.8530.23
165_S168_I0.8510.23
33_E47_K0.8500.23
120_T142_V0.8500.23
103_K120_T0.8490.23
97_G186_P0.8440.23
64_R67_L0.8320.22
57_R60_Y0.8270.22
88_Y121_N0.8230.22
111_D138_K0.8220.22
84_S126_A0.8210.22
173_V190_T0.8170.22
93_G114_R0.8140.22
56_C84_S0.8050.21
171_E199_K0.7960.21
63_Y117_I0.7950.21
131_V172_G0.7910.21
57_R81_F0.7900.21
33_E63_Y0.7900.21
47_K62_N0.7890.21
40_T43_I0.7880.21
112_M196_M0.7880.21
94_T103_K0.7850.21
66_N71_I0.7830.21
31_Q35_T0.7810.21
179_V195_L0.7790.20
94_T104_L0.7790.20
110_Y187_N0.7760.20
42_A53_C0.7710.20
29_E32_G0.7660.20
89_P94_T0.7660.20
95_C186_P0.7660.20
110_Y191_I0.7590.20
139_M167_G0.7550.20
143_L178_V0.7530.20
55_F115_F0.7510.20
81_F167_G0.7480.19
150_M198_V0.7420.19
141_E172_G0.7390.19
35_T58_R0.7370.19
100_M109_E0.7350.19
87_L157_I0.7230.19
139_M157_I0.7160.18
40_T200_G0.7110.18
182_P190_T0.7070.18
32_G45_D0.7050.18
53_C188_P0.7040.18
90_I99_N0.7030.18
75_N145_K0.6990.18
110_Y179_V0.6990.18
95_C161_A0.6970.18
66_N73_T0.6950.18
142_V194_A0.6940.18
159_L191_I0.6930.18
146_A188_P0.6900.18
108_P170_G0.6890.18
163_A181_I0.6840.18
122_T142_V0.6800.17
81_F134_V0.6770.17
75_N129_L0.6720.17
156_V175_L0.6720.17
73_T181_I0.6710.17
63_Y106_S0.6600.17
59_C188_P0.6560.17
132_M177_A0.6560.17
36_V44_K0.6560.17
125_H159_L0.6520.17
161_A164_I0.6520.17
126_A146_A0.6510.17
49_I53_C0.6480.16
63_Y79_P0.6480.16
87_L128_A0.6470.16
46_G65_P0.6450.16
89_P132_M0.6450.16
84_S95_C0.6440.16
44_K60_Y0.6440.16
106_S117_I0.6410.16
41_N140_K0.6300.16
84_S112_M0.6300.16
40_T51_E0.6280.16
88_Y92_S0.6260.16
42_A84_S0.6250.16
136_T184_C0.6230.16
140_K148_E0.6190.16
137_E180_E0.6190.16
83_R177_A0.6190.16
80_L126_A0.6180.16
76_K110_Y0.6130.16
148_E169_I0.6120.15
134_V139_M0.6100.15
99_N139_M0.6090.15
150_M174_P0.6010.15
152_E200_G0.6010.15
32_G44_K0.6000.15
91_D170_G0.5990.15
129_L156_V0.5980.15
53_C84_S0.5970.15
86_Y94_T0.5950.15
48_W56_C0.5940.15
99_N197_K0.5900.15
38_C49_I0.5890.15
52_R82_K0.5860.15
105_I188_P0.5840.15
146_A149_A0.5760.15
173_V177_A0.5740.15
186_P194_A0.5720.14
169_I201_K0.5640.14
77_T147_Y0.5640.14
54_V57_R0.5610.14
85_F128_A0.5600.14
39_P59_C0.5550.14
76_K200_G0.5540.14
94_T110_Y0.5540.14
37_N41_N0.5530.14
140_K172_G0.5520.14
53_C195_L0.5520.14
137_E198_V0.5510.14
100_M139_M0.5510.14
55_F125_H0.5480.14
90_I146_A0.5430.14
37_N47_K0.5430.14
158_L186_P0.5420.14
129_L151_P0.5410.14
46_G148_E0.5410.14
125_H155_V0.5380.14
49_I57_R0.5360.14
63_Y76_K0.5340.14
172_G178_V0.5250.13
35_T136_T0.5240.13
30_I141_E0.5230.13
97_G161_A0.5220.13
131_V158_L0.5210.13
52_R59_C0.5200.13
85_F132_M0.5180.13
58_R115_F0.5160.13
31_Q61_P0.5130.13
34_G95_C0.5100.13
117_I126_A0.5080.13
34_G162_C0.5060.13
84_S188_P0.5060.13
55_F59_C0.5050.13
40_T76_K0.5020.13
121_N125_H0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i9v6 1 0.5821 100 0.548 Contact Map
4ue3S 2 0.597 100 0.621 Contact Map
3ayxB 2 0.592 100 0.622 Contact Map
3myrA 3 0.597 100 0.626 Contact Map
4uqlA 1 0.597 100 0.629 Contact Map
1h2aS 1 0.6119 100 0.63 Contact Map
2wpnA 1 0.5871 100 0.631 Contact Map
4u9hS 1 0.602 100 0.632 Contact Map
1yq9A 2 0.597 100 0.635 Contact Map
4kn9S 1 0.597 100 0.639 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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