Q97ZA7 - SULSO - GREMLIN Contacts

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Q97ZA7 - Formate hydrogenlyase subunit 5 (HycE)

UniProt:	Q97ZA7	Sequences: MKYYKWTQKGEGRKIGKIGDYCLYEKTITEEKCEENKPNITQTYGSFKFIYGPSAGGLLETIKFIITTNGEKILGIDAEVYKNREIVISGLTVDDALLRVERINAPFSASHTISFLLAVEDSLELEQDYPTQLKRIAEIELERIRNHLFVISRLTETTSLNVPTYHLLHLVEKVNRLIGKMCGHRYFFGVNAINGVNCDFGNLLRIIDITKEFKQIFDGLLESRIFIDRLQENGKIIDENSIGPAARAAGLAYDARKDFKALPYEDLGFRTVITQEADSFGRFLVRGMEIIESAKILVELHDEIKNSNNERGKNHKQGGGEGLARVESPSGDLAYYVKLNNGIIDSVSLLTPSQVNLNLFLKSVINTIFTDFQFNWESFGIWVSEIGVMLK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	391 (343)
Sequences:	4173 (2312)
Seq/√Len:	124.8

ECOLI - NUOCD HYCE HYFG MBHM MBHL
HALSA - Q9HRL9
SULSO - Q97ZA7 Q980H3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
210_T	298_V	5.313	1.00
292_E	295_K	4.036	1.00
86_I	89_S	3.994	1.00
276_E	281_G	3.985	1.00
321_E	338_K	3.487	1.00
137_A	300_L	3.443	1.00
274_T	288_M	3.240	1.00
207_I	298_V	3.239	1.00
274_T	281_G	3.012	1.00
103_I	349_L	2.984	1.00
114_S	326_V	2.897	1.00
122_S	322_G	2.856	1.00
340_N	345_D	2.846	1.00
214_K	291_I	2.823	1.00
129_Y	266_D	2.729	1.00
236_I	241_S	2.699	1.00
137_A	297_L	2.644	1.00
67_T	75_G	2.558	1.00
141_L	174_V	2.475	1.00
88_I	96_A	2.415	1.00
204_L	302_D	2.398	1.00
118_A	337_V	2.392	1.00
363_S	379_F	2.341	1.00
136_I	263_P	2.332	1.00
288_M	292_E	2.313	1.00
227_I	231_Q	2.312	1.00
116_L	191_N	2.208	1.00
88_I	347_V	2.123	1.00
113_I	139_I	2.122	1.00
321_E	336_Y	2.084	1.00
241_S	359_L	2.070	1.00
338_K	345_D	2.068	1.00
134_K	196_V	2.052	1.00
104_N	382_W	2.042	1.00
96_A	344_I	2.040	1.00
121_D	322_G	2.033	1.00
217_F	291_I	2.025	1.00
126_E	132_Q	1.995	1.00
69_N	74_L	1.983	1.00
66_I	76_I	1.968	1.00
128_D	131_T	1.966	1.00
75_G	365_I	1.964	1.00
266_D	303_E	1.958	1.00
270_R	292_E	1.953	1.00
66_I	372_F	1.899	1.00
319_G	340_N	1.878	1.00
144_I	290_I	1.871	1.00
337_V	347_V	1.844	1.00
263_P	267_L	1.803	1.00
133_L	305_K	1.786	1.00
130_P	199_D	1.762	1.00
323_L	334_A	1.752	1.00
129_Y	133_L	1.743	1.00
73_I	372_F	1.678	1.00
362_K	365_I	1.673	1.00
267_L	300_L	1.668	1.00
241_S	245_A	1.664	1.00
147_H	289_E	1.648	1.00
46_S	67_T	1.648	1.00
221_L	283_F	1.597	1.00
227_I	280_F	1.559	1.00
252_A	257_K	1.547	1.00
262_L	267_L	1.535	1.00
246_A	251_L	1.532	1.00
136_I	300_L	1.524	1.00
279_S	375_N	1.522	1.00
120_E	135_R	1.516	1.00
129_Y	132_Q	1.514	1.00
133_L	303_E	1.513	1.00
110_S	139_I	1.510	1.00
322_G	337_V	1.508	1.00
127_Q	132_Q	1.495	1.00
253_Y	258_D	1.485	1.00
367_T	375_N	1.471	1.00
136_I	267_L	1.460	1.00
382_W	385_E	1.457	1.00
132_Q	262_L	1.455	1.00
107_F	110_S	1.437	1.00
263_P	266_D	1.437	1.00
133_L	263_P	1.434	1.00
261_A	265_E	1.432	1.00
173_K	208_D	1.422	1.00
238_D	251_L	1.420	1.00
217_F	287_G	1.419	1.00
335_Y	349_L	1.415	1.00
204_L	298_V	1.414	1.00
118_A	322_G	1.407	1.00
204_L	301_H	1.386	1.00
205_R	208_D	1.385	1.00
64_F	76_I	1.377	1.00
110_S	329_P	1.371	1.00
114_S	335_Y	1.368	1.00
122_S	339_L	1.366	1.00
272_V	288_M	1.353	1.00
111_H	335_Y	1.350	1.00
282_R	378_S	1.345	1.00
230_L	287_G	1.325	1.00
261_A	264_Y	1.322	1.00
131_T	196_V	1.308	1.00
252_A	258_D	1.304	1.00
117_L	324_A	1.302	1.00
184_H	187_F	1.293	1.00
298_V	302_D	1.281	1.00
241_S	244_P	1.278	1.00
351_T	385_E	1.276	1.00
173_K	176_R	1.271	1.00
361_L	365_I	1.269	1.00
267_L	296_I	1.264	1.00
110_S	142_E	1.260	1.00
277_A	281_G	1.257	1.00
268_G	299_E	1.235	0.99
133_L	267_L	1.235	0.99
210_T	302_D	1.223	0.99
300_L	304_I	1.219	0.99
210_T	214_K	1.211	0.99
88_I	100_V	1.208	0.99
100_V	112_T	1.207	0.99
89_S	346_S	1.204	0.99
109_A	138_E	1.203	0.99
260_K	264_Y	1.200	0.99
210_T	294_A	1.187	0.99
138_E	190_V	1.184	0.99
296_I	299_E	1.180	0.99
357_L	360_F	1.175	0.99
51_Y	372_F	1.166	0.99
133_L	300_L	1.162	0.99
143_R	293_S	1.158	0.99
127_Q	131_T	1.156	0.99
270_R	295_K	1.156	0.99
170_L	216_I	1.151	0.99
64_F	78_A	1.127	0.99
96_A	100_V	1.116	0.99
104_N	385_E	1.115	0.99
214_K	218_D	1.115	0.99
107_F	382_W	1.113	0.99
221_L	284_L	1.112	0.99
107_F	385_E	1.109	0.99
65_I	77_D	1.109	0.99
91_L	95_D	1.108	0.99
207_I	210_T	1.107	0.99
117_L	132_Q	1.106	0.99
104_N	330_S	1.100	0.99
177_L	203_L	1.099	0.99
351_T	354_Q	1.091	0.99
76_I	364_V	1.091	0.99
156_E	161_N	1.089	0.99
123_L	317_Q	1.077	0.99
248_A	285_V	1.077	0.99
338_K	346_S	1.076	0.99
206_I	210_T	1.064	0.98
137_A	301_H	1.060	0.98
173_K	215_Q	1.052	0.98
269_F	299_E	1.049	0.98
311_R	314_N	1.041	0.98
213_F	217_F	1.031	0.98
136_I	262_L	1.024	0.98
252_A	271_T	1.017	0.98
257_K	260_K	1.009	0.98
325_R	332_D	1.007	0.98
145_R	149_F	0.999	0.98
54_S	58_L	0.998	0.98
204_L	207_I	0.994	0.98
260_K	267_L	0.994	0.98
93_V	339_L	0.992	0.98
142_E	188_F	0.991	0.98
381_I	385_E	0.983	0.97
206_I	294_A	0.982	0.97
243_G	247_R	0.981	0.97
113_I	117_L	0.976	0.97
72_K	368_I	0.975	0.97
152_S	167_L	0.975	0.97
335_Y	347_V	0.975	0.97
114_S	324_A	0.974	0.97
250_G	256_R	0.971	0.97
215_Q	218_D	0.966	0.97
245_A	379_F	0.964	0.97
116_L	193_I	0.959	0.97
243_G	246_A	0.954	0.97
256_R	261_A	0.950	0.97
247_R	289_E	0.949	0.97
139_I	326_V	0.946	0.97
234_G	375_N	0.944	0.97
132_Q	136_I	0.944	0.97
376_W	381_I	0.935	0.97
103_I	335_Y	0.933	0.96
88_I	344_I	0.929	0.96
207_I	294_A	0.928	0.96
133_L	266_D	0.922	0.96
156_E	159_S	0.919	0.96
138_E	181_M	0.918	0.96
226_F	230_L	0.918	0.96
253_Y	256_R	0.917	0.96
269_F	272_V	0.916	0.96
206_I	298_V	0.910	0.96
242_I	246_A	0.907	0.96
330_S	382_W	0.892	0.95
328_S	333_L	0.892	0.95
136_I	296_I	0.889	0.95
210_T	295_K	0.886	0.95
104_N	107_F	0.886	0.95
141_L	297_L	0.880	0.95
51_Y	373_Q	0.877	0.95
330_S	380_G	0.875	0.95
256_R	260_K	0.871	0.95
94_D	193_I	0.871	0.95
284_L	288_M	0.868	0.95
101_E	189_G	0.866	0.95
211_K	214_K	0.866	0.95
317_Q	320_G	0.864	0.95
210_T	291_I	0.858	0.94
279_S	374_F	0.858	0.94
101_E	112_T	0.858	0.94
232_E	235_K	0.852	0.94
307_S	311_R	0.851	0.94
113_I	262_L	0.850	0.94
144_I	294_A	0.847	0.94
377_E	381_I	0.845	0.94
246_A	249_A	0.844	0.94
206_I	209_I	0.840	0.94
146_N	330_S	0.839	0.94
166_H	169_H	0.839	0.94
73_I	367_T	0.837	0.94
107_F	380_G	0.836	0.94
260_K	265_E	0.835	0.94
209_I	213_F	0.834	0.93
247_R	327_E	0.834	0.93
353_S	356_N	0.832	0.93
288_M	291_I	0.828	0.93
150_V	380_G	0.828	0.93
144_I	148_L	0.827	0.93
209_I	212_E	0.826	0.93
268_G	272_V	0.825	0.93
117_L	121_D	0.825	0.93
260_K	268_G	0.824	0.93
46_S	69_N	0.822	0.93
252_A	256_R	0.820	0.93
250_G	254_D	0.819	0.93
300_L	303_E	0.818	0.93
111_H	114_S	0.815	0.93
75_G	361_L	0.815	0.93
359_L	363_S	0.814	0.93
142_E	146_N	0.813	0.93
155_T	158_T	0.811	0.93
58_L	62_I	0.810	0.92
155_T	163_P	0.810	0.92
289_E	327_E	0.810	0.92
134_K	200_F	0.805	0.92
106_P	380_G	0.805	0.92
84_R	87_V	0.804	0.92
244_P	248_A	0.801	0.92
213_F	290_I	0.800	0.92
240_N	246_A	0.799	0.92
235_K	238_D	0.798	0.92
241_S	246_A	0.798	0.92
222_E	227_I	0.797	0.92
316_K	320_G	0.793	0.92
129_Y	263_P	0.786	0.91
217_F	221_L	0.785	0.91
330_S	381_I	0.784	0.91
218_D	222_E	0.783	0.91
278_D	281_G	0.777	0.91
81_Y	86_I	0.777	0.91
108_S	186_Y	0.777	0.91
140_E	293_S	0.776	0.91
272_V	275_Q	0.775	0.91
107_F	111_H	0.771	0.91
280_F	284_L	0.771	0.91
208_D	212_E	0.770	0.90
46_S	74_L	0.768	0.90
209_I	290_I	0.768	0.90
140_E	297_L	0.768	0.90
257_K	271_T	0.767	0.90
212_E	215_Q	0.764	0.90
104_N	380_G	0.762	0.90
307_S	310_E	0.761	0.90
264_Y	267_L	0.761	0.90
251_L	256_R	0.761	0.90
230_L	279_S	0.760	0.90
262_L	265_E	0.760	0.90
333_L	352_P	0.759	0.90
208_D	211_K	0.757	0.90
281_G	284_L	0.755	0.90
260_K	266_D	0.755	0.90
268_G	271_T	0.751	0.89
294_A	298_V	0.749	0.89
274_T	285_V	0.747	0.89
145_R	174_V	0.746	0.89
154_L	377_E	0.746	0.89
364_V	375_N	0.745	0.89
305_K	308_N	0.745	0.89
254_D	264_Y	0.744	0.89
97_L	116_L	0.741	0.89
292_E	296_I	0.740	0.89
145_R	178_I	0.739	0.89
249_A	285_V	0.739	0.89
121_D	324_A	0.735	0.88
109_A	182_C	0.734	0.88
251_L	254_D	0.729	0.88
214_K	298_V	0.725	0.88
151_I	226_F	0.725	0.88
192_A	197_N	0.724	0.88
130_P	307_S	0.722	0.87
51_Y	66_I	0.721	0.87
140_E	143_R	0.720	0.87
146_N	380_G	0.720	0.87
353_S	385_E	0.719	0.87
295_K	299_E	0.717	0.87
283_F	287_G	0.716	0.87
107_F	146_N	0.714	0.87
286_R	380_G	0.710	0.87
115_F	119_V	0.710	0.87
82_K	384_S	0.706	0.86
264_Y	269_F	0.704	0.86
260_K	269_F	0.703	0.86
118_A	324_A	0.699	0.86
110_S	328_S	0.698	0.86
248_A	254_D	0.697	0.86
261_A	267_L	0.696	0.85
264_Y	271_T	0.694	0.85
364_V	376_W	0.690	0.85
363_S	375_N	0.687	0.85
177_L	213_F	0.686	0.85
161_N	165_Y	0.685	0.85
129_Y	303_E	0.685	0.85
344_I	347_V	0.685	0.85
260_K	263_P	0.682	0.84
61_T	382_W	0.680	0.84
117_L	262_L	0.676	0.84
98_L	189_G	0.674	0.84
145_R	175_N	0.673	0.83
96_A	115_F	0.673	0.83
255_A	259_F	0.672	0.83
106_P	382_W	0.671	0.83
101_E	184_H	0.668	0.83
92_T	95_D	0.667	0.83
213_F	216_I	0.666	0.83
106_P	142_E	0.666	0.83
115_F	347_V	0.665	0.83
325_R	334_A	0.660	0.82
132_Q	263_P	0.659	0.82
138_E	182_C	0.658	0.82
339_L	344_I	0.655	0.82
138_E	196_V	0.655	0.82
257_K	264_Y	0.654	0.82
131_T	310_E	0.654	0.82
151_I	287_G	0.654	0.82
146_N	149_F	0.654	0.82
155_T	160_L	0.653	0.82
49_F	68_T	0.653	0.82
135_R	194_N	0.652	0.82
107_F	329_P	0.652	0.82
376_W	383_V	0.649	0.81
356_N	381_I	0.649	0.81
249_A	252_A	0.648	0.81
380_G	385_E	0.644	0.81
170_L	208_D	0.643	0.81
243_G	256_R	0.643	0.81
65_I	79_E	0.641	0.80
275_Q	281_G	0.641	0.80
108_S	142_E	0.640	0.80
171_V	175_N	0.639	0.80
93_V	317_Q	0.639	0.80
106_P	385_E	0.637	0.80
160_L	163_P	0.637	0.80
348_S	351_T	0.637	0.80
109_A	142_E	0.633	0.80
328_S	352_P	0.632	0.80
256_R	264_Y	0.631	0.79
305_K	309_N	0.629	0.79
119_V	337_V	0.628	0.79
340_N	343_I	0.626	0.79
287_G	291_I	0.626	0.79
183_G	327_E	0.626	0.79
229_R	233_N	0.622	0.78
110_S	326_V	0.621	0.78
274_T	284_L	0.619	0.78
259_F	325_R	0.619	0.78
167_L	216_I	0.619	0.78
112_T	191_N	0.616	0.78
385_E	388_V	0.616	0.78
265_E	268_G	0.615	0.78
255_A	260_K	0.615	0.78
315_H	320_G	0.614	0.78
131_T	134_K	0.613	0.77
107_F	381_I	0.613	0.77
244_P	286_R	0.612	0.77
190_V	196_V	0.612	0.77
257_K	270_R	0.611	0.77
244_P	247_R	0.611	0.77
169_H	215_Q	0.610	0.77
182_C	187_F	0.610	0.77
169_H	173_K	0.608	0.77
122_S	320_G	0.608	0.77
380_G	383_V	0.607	0.77
217_F	222_E	0.606	0.77
61_T	104_N	0.606	0.77
328_S	353_S	0.604	0.76
146_N	329_P	0.604	0.76
231_Q	280_F	0.603	0.76
279_S	378_S	0.600	0.76
316_K	319_G	0.598	0.76
111_H	351_T	0.594	0.75
203_L	218_D	0.593	0.75
310_E	313_K	0.593	0.75
93_V	341_N	0.592	0.75
106_P	145_R	0.591	0.75
130_P	134_K	0.591	0.75
241_S	248_A	0.590	0.75
244_P	285_V	0.590	0.75
109_A	178_I	0.589	0.75
139_I	261_A	0.587	0.74
131_T	135_R	0.586	0.74
181_M	200_F	0.585	0.74
377_E	385_E	0.585	0.74
175_N	185_R	0.584	0.74
130_P	309_N	0.584	0.74
59_L	377_E	0.583	0.74
108_S	188_F	0.581	0.74
51_Y	58_L	0.580	0.73
360_F	376_W	0.580	0.73
73_I	364_V	0.579	0.73
61_T	386_I	0.579	0.73
48_K	67_T	0.579	0.73
64_F	376_W	0.575	0.73
254_D	260_K	0.574	0.73
219_G	223_S	0.574	0.73
357_L	383_V	0.572	0.72
154_L	378_S	0.571	0.72
151_I	290_I	0.571	0.72
249_A	277_A	0.570	0.72
154_L	230_L	0.570	0.72
62_I	78_A	0.569	0.72
67_T	77_D	0.569	0.72
257_K	269_F	0.566	0.72
356_N	380_G	0.565	0.72
148_L	290_I	0.565	0.72
203_L	297_L	0.565	0.72
112_T	187_F	0.564	0.71
57_G	377_E	0.563	0.71
61_T	380_G	0.562	0.71
131_T	194_N	0.562	0.71
309_N	312_G	0.561	0.71
91_L	96_A	0.561	0.71
221_L	280_F	0.560	0.71
234_G	237_I	0.560	0.71
146_N	381_I	0.559	0.71
258_D	271_T	0.558	0.71
172_E	176_R	0.557	0.70
82_K	87_V	0.556	0.70
252_A	255_A	0.555	0.70
242_I	247_R	0.553	0.70
50_I	63_K	0.552	0.70
133_L	304_I	0.549	0.69
124_E	127_Q	0.548	0.69
137_A	141_L	0.546	0.69
268_G	295_K	0.545	0.69
120_E	194_N	0.545	0.69
130_P	305_K	0.544	0.69
275_Q	288_M	0.543	0.69
202_N	306_N	0.543	0.69
267_L	272_V	0.542	0.68
377_E	380_G	0.542	0.68
54_S	62_I	0.541	0.68
149_F	171_V	0.540	0.68
226_F	229_R	0.540	0.68
138_E	188_F	0.539	0.68
247_R	254_D	0.539	0.68
353_S	381_I	0.539	0.68
259_F	267_L	0.538	0.68
76_I	211_K	0.537	0.68
261_A	268_G	0.536	0.68
106_P	330_S	0.535	0.67
119_V	193_I	0.533	0.67
217_F	223_S	0.532	0.67
170_L	212_E	0.532	0.67
106_P	149_F	0.532	0.67
100_V	335_Y	0.531	0.67
69_N	72_K	0.529	0.67
139_I	327_E	0.527	0.66
353_S	382_W	0.526	0.66
253_Y	259_F	0.526	0.66
269_F	273_I	0.525	0.66
53_P	83_N	0.522	0.66
147_H	244_P	0.520	0.65
109_A	188_F	0.519	0.65
149_F	153_R	0.517	0.65
149_F	168_L	0.516	0.65
126_E	129_Y	0.513	0.64
51_Y	73_I	0.513	0.64
373_Q	377_E	0.513	0.64
141_L	177_L	0.511	0.64
111_H	385_E	0.511	0.64
105_A	385_E	0.510	0.64
131_T	195_G	0.510	0.64
87_V	91_L	0.510	0.64
303_E	306_N	0.510	0.64
91_L	99_R	0.509	0.64
266_D	270_R	0.509	0.64
229_R	234_G	0.508	0.63
171_V	185_R	0.507	0.63
107_F	330_S	0.507	0.63
156_E	164_T	0.507	0.63
231_Q	234_G	0.507	0.63
376_W	380_G	0.506	0.63
217_F	298_V	0.505	0.63
58_L	61_T	0.505	0.63
61_T	383_V	0.505	0.63
293_S	296_I	0.505	0.63
217_F	220_L	0.504	0.63
214_K	217_F	0.503	0.63
151_I	167_L	0.502	0.63
110_S	333_L	0.502	0.63
243_G	253_Y	0.501	0.62
158_T	161_N	0.500	0.62

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3i9v4	1	0.8542	100	0.18	Contact Map
4kn9L	2	0.867	100	0.224	Contact Map
4uqlQ	1	0.8849	100	0.247	Contact Map
4u9hL	1	0.8772	100	0.249	Contact Map
3ze9B	1	0.8696	100	0.251	Contact Map
4omfA	1	0.8696	100	0.261	Contact Map
1e3dB	1	0.8875	100	0.262	Contact Map
1yq9H	1	0.867	100	0.265	Contact Map
4ue3L	2	0.9054	100	0.284	Contact Map
3myrB	2	0.8721	100	0.292	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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