GREMLIN Database
Q97ZA7 - Formate hydrogenlyase subunit 5 (HycE)
UniProt: Q97ZA7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 391 (343)
Sequences: 4173 (2312)
Seq/√Len: 124.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
210_T298_V5.3131.00
292_E295_K4.0361.00
86_I89_S3.9941.00
276_E281_G3.9851.00
321_E338_K3.4871.00
137_A300_L3.4431.00
274_T288_M3.2401.00
207_I298_V3.2391.00
274_T281_G3.0121.00
103_I349_L2.9841.00
114_S326_V2.8971.00
122_S322_G2.8561.00
340_N345_D2.8461.00
214_K291_I2.8231.00
129_Y266_D2.7291.00
236_I241_S2.6991.00
137_A297_L2.6441.00
67_T75_G2.5581.00
141_L174_V2.4751.00
88_I96_A2.4151.00
204_L302_D2.3981.00
118_A337_V2.3921.00
363_S379_F2.3411.00
136_I263_P2.3321.00
288_M292_E2.3131.00
227_I231_Q2.3121.00
116_L191_N2.2081.00
88_I347_V2.1231.00
113_I139_I2.1221.00
321_E336_Y2.0841.00
241_S359_L2.0701.00
338_K345_D2.0681.00
134_K196_V2.0521.00
104_N382_W2.0421.00
96_A344_I2.0401.00
121_D322_G2.0331.00
217_F291_I2.0251.00
126_E132_Q1.9951.00
69_N74_L1.9831.00
66_I76_I1.9681.00
128_D131_T1.9661.00
75_G365_I1.9641.00
266_D303_E1.9581.00
270_R292_E1.9531.00
66_I372_F1.8991.00
319_G340_N1.8781.00
144_I290_I1.8711.00
337_V347_V1.8441.00
263_P267_L1.8031.00
133_L305_K1.7861.00
130_P199_D1.7621.00
323_L334_A1.7521.00
129_Y133_L1.7431.00
73_I372_F1.6781.00
362_K365_I1.6731.00
267_L300_L1.6681.00
241_S245_A1.6641.00
147_H289_E1.6481.00
46_S67_T1.6481.00
221_L283_F1.5971.00
227_I280_F1.5591.00
252_A257_K1.5471.00
262_L267_L1.5351.00
246_A251_L1.5321.00
136_I300_L1.5241.00
279_S375_N1.5221.00
120_E135_R1.5161.00
129_Y132_Q1.5141.00
133_L303_E1.5131.00
110_S139_I1.5101.00
322_G337_V1.5081.00
127_Q132_Q1.4951.00
253_Y258_D1.4851.00
367_T375_N1.4711.00
136_I267_L1.4601.00
382_W385_E1.4571.00
132_Q262_L1.4551.00
107_F110_S1.4371.00
263_P266_D1.4371.00
133_L263_P1.4341.00
261_A265_E1.4321.00
173_K208_D1.4221.00
238_D251_L1.4201.00
217_F287_G1.4191.00
335_Y349_L1.4151.00
204_L298_V1.4141.00
118_A322_G1.4071.00
204_L301_H1.3861.00
205_R208_D1.3851.00
64_F76_I1.3771.00
110_S329_P1.3711.00
114_S335_Y1.3681.00
122_S339_L1.3661.00
272_V288_M1.3531.00
111_H335_Y1.3501.00
282_R378_S1.3451.00
230_L287_G1.3251.00
261_A264_Y1.3221.00
131_T196_V1.3081.00
252_A258_D1.3041.00
117_L324_A1.3021.00
184_H187_F1.2931.00
298_V302_D1.2811.00
241_S244_P1.2781.00
351_T385_E1.2761.00
173_K176_R1.2711.00
361_L365_I1.2691.00
267_L296_I1.2641.00
110_S142_E1.2601.00
277_A281_G1.2571.00
268_G299_E1.2350.99
133_L267_L1.2350.99
210_T302_D1.2230.99
300_L304_I1.2190.99
210_T214_K1.2110.99
88_I100_V1.2080.99
100_V112_T1.2070.99
89_S346_S1.2040.99
109_A138_E1.2030.99
260_K264_Y1.2000.99
210_T294_A1.1870.99
138_E190_V1.1840.99
296_I299_E1.1800.99
357_L360_F1.1750.99
51_Y372_F1.1660.99
133_L300_L1.1620.99
143_R293_S1.1580.99
127_Q131_T1.1560.99
270_R295_K1.1560.99
170_L216_I1.1510.99
64_F78_A1.1270.99
96_A100_V1.1160.99
104_N385_E1.1150.99
214_K218_D1.1150.99
107_F382_W1.1130.99
221_L284_L1.1120.99
107_F385_E1.1090.99
65_I77_D1.1090.99
91_L95_D1.1080.99
207_I210_T1.1070.99
117_L132_Q1.1060.99
104_N330_S1.1000.99
177_L203_L1.0990.99
351_T354_Q1.0910.99
76_I364_V1.0910.99
156_E161_N1.0890.99
123_L317_Q1.0770.99
248_A285_V1.0770.99
338_K346_S1.0760.99
206_I210_T1.0640.98
137_A301_H1.0600.98
173_K215_Q1.0520.98
269_F299_E1.0490.98
311_R314_N1.0410.98
213_F217_F1.0310.98
136_I262_L1.0240.98
252_A271_T1.0170.98
257_K260_K1.0090.98
325_R332_D1.0070.98
145_R149_F0.9990.98
54_S58_L0.9980.98
204_L207_I0.9940.98
260_K267_L0.9940.98
93_V339_L0.9920.98
142_E188_F0.9910.98
381_I385_E0.9830.97
206_I294_A0.9820.97
243_G247_R0.9810.97
113_I117_L0.9760.97
72_K368_I0.9750.97
152_S167_L0.9750.97
335_Y347_V0.9750.97
114_S324_A0.9740.97
250_G256_R0.9710.97
215_Q218_D0.9660.97
245_A379_F0.9640.97
116_L193_I0.9590.97
243_G246_A0.9540.97
256_R261_A0.9500.97
247_R289_E0.9490.97
139_I326_V0.9460.97
234_G375_N0.9440.97
132_Q136_I0.9440.97
376_W381_I0.9350.97
103_I335_Y0.9330.96
88_I344_I0.9290.96
207_I294_A0.9280.96
133_L266_D0.9220.96
156_E159_S0.9190.96
138_E181_M0.9180.96
226_F230_L0.9180.96
253_Y256_R0.9170.96
269_F272_V0.9160.96
206_I298_V0.9100.96
242_I246_A0.9070.96
330_S382_W0.8920.95
328_S333_L0.8920.95
136_I296_I0.8890.95
210_T295_K0.8860.95
104_N107_F0.8860.95
141_L297_L0.8800.95
51_Y373_Q0.8770.95
330_S380_G0.8750.95
256_R260_K0.8710.95
94_D193_I0.8710.95
284_L288_M0.8680.95
101_E189_G0.8660.95
211_K214_K0.8660.95
317_Q320_G0.8640.95
210_T291_I0.8580.94
279_S374_F0.8580.94
101_E112_T0.8580.94
232_E235_K0.8520.94
307_S311_R0.8510.94
113_I262_L0.8500.94
144_I294_A0.8470.94
377_E381_I0.8450.94
246_A249_A0.8440.94
206_I209_I0.8400.94
146_N330_S0.8390.94
166_H169_H0.8390.94
73_I367_T0.8370.94
107_F380_G0.8360.94
260_K265_E0.8350.94
209_I213_F0.8340.93
247_R327_E0.8340.93
353_S356_N0.8320.93
288_M291_I0.8280.93
150_V380_G0.8280.93
144_I148_L0.8270.93
209_I212_E0.8260.93
268_G272_V0.8250.93
117_L121_D0.8250.93
260_K268_G0.8240.93
46_S69_N0.8220.93
252_A256_R0.8200.93
250_G254_D0.8190.93
300_L303_E0.8180.93
111_H114_S0.8150.93
75_G361_L0.8150.93
359_L363_S0.8140.93
142_E146_N0.8130.93
155_T158_T0.8110.93
58_L62_I0.8100.92
155_T163_P0.8100.92
289_E327_E0.8100.92
134_K200_F0.8050.92
106_P380_G0.8050.92
84_R87_V0.8040.92
244_P248_A0.8010.92
213_F290_I0.8000.92
240_N246_A0.7990.92
235_K238_D0.7980.92
241_S246_A0.7980.92
222_E227_I0.7970.92
316_K320_G0.7930.92
129_Y263_P0.7860.91
217_F221_L0.7850.91
330_S381_I0.7840.91
218_D222_E0.7830.91
278_D281_G0.7770.91
81_Y86_I0.7770.91
108_S186_Y0.7770.91
140_E293_S0.7760.91
272_V275_Q0.7750.91
107_F111_H0.7710.91
280_F284_L0.7710.91
208_D212_E0.7700.90
46_S74_L0.7680.90
209_I290_I0.7680.90
140_E297_L0.7680.90
257_K271_T0.7670.90
212_E215_Q0.7640.90
104_N380_G0.7620.90
307_S310_E0.7610.90
264_Y267_L0.7610.90
251_L256_R0.7610.90
230_L279_S0.7600.90
262_L265_E0.7600.90
333_L352_P0.7590.90
208_D211_K0.7570.90
281_G284_L0.7550.90
260_K266_D0.7550.90
268_G271_T0.7510.89
294_A298_V0.7490.89
274_T285_V0.7470.89
145_R174_V0.7460.89
154_L377_E0.7460.89
364_V375_N0.7450.89
305_K308_N0.7450.89
254_D264_Y0.7440.89
97_L116_L0.7410.89
292_E296_I0.7400.89
145_R178_I0.7390.89
249_A285_V0.7390.89
121_D324_A0.7350.88
109_A182_C0.7340.88
251_L254_D0.7290.88
214_K298_V0.7250.88
151_I226_F0.7250.88
192_A197_N0.7240.88
130_P307_S0.7220.87
51_Y66_I0.7210.87
140_E143_R0.7200.87
146_N380_G0.7200.87
353_S385_E0.7190.87
295_K299_E0.7170.87
283_F287_G0.7160.87
107_F146_N0.7140.87
286_R380_G0.7100.87
115_F119_V0.7100.87
82_K384_S0.7060.86
264_Y269_F0.7040.86
260_K269_F0.7030.86
118_A324_A0.6990.86
110_S328_S0.6980.86
248_A254_D0.6970.86
261_A267_L0.6960.85
264_Y271_T0.6940.85
364_V376_W0.6900.85
363_S375_N0.6870.85
177_L213_F0.6860.85
161_N165_Y0.6850.85
129_Y303_E0.6850.85
344_I347_V0.6850.85
260_K263_P0.6820.84
61_T382_W0.6800.84
117_L262_L0.6760.84
98_L189_G0.6740.84
145_R175_N0.6730.83
96_A115_F0.6730.83
255_A259_F0.6720.83
106_P382_W0.6710.83
101_E184_H0.6680.83
92_T95_D0.6670.83
213_F216_I0.6660.83
106_P142_E0.6660.83
115_F347_V0.6650.83
325_R334_A0.6600.82
132_Q263_P0.6590.82
138_E182_C0.6580.82
339_L344_I0.6550.82
138_E196_V0.6550.82
257_K264_Y0.6540.82
131_T310_E0.6540.82
151_I287_G0.6540.82
146_N149_F0.6540.82
155_T160_L0.6530.82
49_F68_T0.6530.82
135_R194_N0.6520.82
107_F329_P0.6520.82
376_W383_V0.6490.81
356_N381_I0.6490.81
249_A252_A0.6480.81
380_G385_E0.6440.81
170_L208_D0.6430.81
243_G256_R0.6430.81
65_I79_E0.6410.80
275_Q281_G0.6410.80
108_S142_E0.6400.80
171_V175_N0.6390.80
93_V317_Q0.6390.80
106_P385_E0.6370.80
160_L163_P0.6370.80
348_S351_T0.6370.80
109_A142_E0.6330.80
328_S352_P0.6320.80
256_R264_Y0.6310.79
305_K309_N0.6290.79
119_V337_V0.6280.79
340_N343_I0.6260.79
287_G291_I0.6260.79
183_G327_E0.6260.79
229_R233_N0.6220.78
110_S326_V0.6210.78
274_T284_L0.6190.78
259_F325_R0.6190.78
167_L216_I0.6190.78
112_T191_N0.6160.78
385_E388_V0.6160.78
265_E268_G0.6150.78
255_A260_K0.6150.78
315_H320_G0.6140.78
131_T134_K0.6130.77
107_F381_I0.6130.77
244_P286_R0.6120.77
190_V196_V0.6120.77
257_K270_R0.6110.77
244_P247_R0.6110.77
169_H215_Q0.6100.77
182_C187_F0.6100.77
169_H173_K0.6080.77
122_S320_G0.6080.77
380_G383_V0.6070.77
217_F222_E0.6060.77
61_T104_N0.6060.77
328_S353_S0.6040.76
146_N329_P0.6040.76
231_Q280_F0.6030.76
279_S378_S0.6000.76
316_K319_G0.5980.76
111_H351_T0.5940.75
203_L218_D0.5930.75
310_E313_K0.5930.75
93_V341_N0.5920.75
106_P145_R0.5910.75
130_P134_K0.5910.75
241_S248_A0.5900.75
244_P285_V0.5900.75
109_A178_I0.5890.75
139_I261_A0.5870.74
131_T135_R0.5860.74
181_M200_F0.5850.74
377_E385_E0.5850.74
175_N185_R0.5840.74
130_P309_N0.5840.74
59_L377_E0.5830.74
108_S188_F0.5810.74
51_Y58_L0.5800.73
360_F376_W0.5800.73
73_I364_V0.5790.73
61_T386_I0.5790.73
48_K67_T0.5790.73
64_F376_W0.5750.73
254_D260_K0.5740.73
219_G223_S0.5740.73
357_L383_V0.5720.72
154_L378_S0.5710.72
151_I290_I0.5710.72
249_A277_A0.5700.72
154_L230_L0.5700.72
62_I78_A0.5690.72
67_T77_D0.5690.72
257_K269_F0.5660.72
356_N380_G0.5650.72
148_L290_I0.5650.72
203_L297_L0.5650.72
112_T187_F0.5640.71
57_G377_E0.5630.71
61_T380_G0.5620.71
131_T194_N0.5620.71
309_N312_G0.5610.71
91_L96_A0.5610.71
221_L280_F0.5600.71
234_G237_I0.5600.71
146_N381_I0.5590.71
258_D271_T0.5580.71
172_E176_R0.5570.70
82_K87_V0.5560.70
252_A255_A0.5550.70
242_I247_R0.5530.70
50_I63_K0.5520.70
133_L304_I0.5490.69
124_E127_Q0.5480.69
137_A141_L0.5460.69
268_G295_K0.5450.69
120_E194_N0.5450.69
130_P305_K0.5440.69
275_Q288_M0.5430.69
202_N306_N0.5430.69
267_L272_V0.5420.68
377_E380_G0.5420.68
54_S62_I0.5410.68
149_F171_V0.5400.68
226_F229_R0.5400.68
138_E188_F0.5390.68
247_R254_D0.5390.68
353_S381_I0.5390.68
259_F267_L0.5380.68
76_I211_K0.5370.68
261_A268_G0.5360.68
106_P330_S0.5350.67
119_V193_I0.5330.67
217_F223_S0.5320.67
170_L212_E0.5320.67
106_P149_F0.5320.67
100_V335_Y0.5310.67
69_N72_K0.5290.67
139_I327_E0.5270.66
353_S382_W0.5260.66
253_Y259_F0.5260.66
269_F273_I0.5250.66
53_P83_N0.5220.66
147_H244_P0.5200.65
109_A188_F0.5190.65
149_F153_R0.5170.65
149_F168_L0.5160.65
126_E129_Y0.5130.64
51_Y73_I0.5130.64
373_Q377_E0.5130.64
141_L177_L0.5110.64
111_H385_E0.5110.64
105_A385_E0.5100.64
131_T195_G0.5100.64
87_V91_L0.5100.64
303_E306_N0.5100.64
91_L99_R0.5090.64
266_D270_R0.5090.64
229_R234_G0.5080.63
171_V185_R0.5070.63
107_F330_S0.5070.63
156_E164_T0.5070.63
231_Q234_G0.5070.63
376_W380_G0.5060.63
217_F298_V0.5050.63
58_L61_T0.5050.63
61_T383_V0.5050.63
293_S296_I0.5050.63
217_F220_L0.5040.63
214_K217_F0.5030.63
151_I167_L0.5020.63
110_S333_L0.5020.63
243_G253_Y0.5010.62
158_T161_N0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i9v4 1 0.8542 100 0.18 Contact Map
4kn9L 2 0.867 100 0.224 Contact Map
4uqlQ 1 0.8849 100 0.247 Contact Map
4u9hL 1 0.8772 100 0.249 Contact Map
3ze9B 1 0.8696 100 0.251 Contact Map
4omfA 1 0.8696 100 0.261 Contact Map
1e3dB 1 0.8875 100 0.262 Contact Map
1yq9H 1 0.867 100 0.265 Contact Map
4ue3L 2 0.9054 100 0.284 Contact Map
3myrB 2 0.8721 100 0.292 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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