GREMLIN Database
Q97ZA5 - Uncharacterized protein
UniProt: Q97ZA5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 213 (192)
Sequences: 394 (288)
Seq/√Len: 20.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_S137_V3.7901.00
49_G58_I3.7261.00
46_F61_G3.2691.00
10_L40_L3.2021.00
39_T69_T2.7930.99
180_I183_S2.7640.99
187_D192_V2.5730.98
22_Q101_N2.4980.98
97_E148_S2.3430.96
42_A65_I2.3070.96
62_I82_K2.2000.95
149_R152_T2.1990.95
193_I197_I2.1450.94
159_F186_L1.9890.91
46_F55_I1.9350.90
14_I195_S1.8740.89
38_S186_L1.8460.88
21_I145_L1.8460.88
19_F101_N1.7850.86
34_Q160_I1.7750.86
10_L43_I1.7600.85
65_I70_V1.7290.84
8_E92_K1.7180.84
44_L49_G1.6790.82
59_I71_L1.6740.82
89_E184_V1.6680.82
173_L179_L1.6660.82
183_S187_D1.6520.81
149_R155_Q1.6380.81
111_V197_I1.6360.81
46_F82_K1.6260.80
143_L146_I1.6170.80
139_L165_S1.6110.80
28_K153_I1.6100.80
62_I66_L1.5390.76
45_A173_L1.5310.76
159_F198_L1.5150.75
43_I53_F1.5110.75
176_I186_L1.4910.74
36_I39_T1.4720.73
138_L159_F1.4690.73
167_I170_G1.4560.72
109_S148_S1.4540.72
156_F173_L1.4170.70
9_L189_L1.4120.70
13_F40_L1.4020.69
17_S39_T1.3850.68
34_Q186_L1.3740.68
142_G161_E1.3690.67
195_S203_A1.3560.67
21_I161_E1.3500.66
89_E156_F1.3220.65
15_L71_L1.3200.65
96_S193_I1.3150.64
27_F31_I1.3060.64
46_F62_I1.2900.63
71_L75_F1.2810.62
41_I193_I1.2790.62
178_F189_L1.2780.62
72_I152_T1.2720.62
100_L144_F1.2530.60
153_I180_I1.2510.60
19_F107_I1.2470.60
76_L204_E1.2370.59
39_T58_I1.2190.58
22_Q141_Q1.2150.58
111_V134_F1.2130.58
26_Y151_S1.2030.57
151_S202_K1.1810.56
142_G165_S1.1790.56
30_A67_L1.1760.55
90_S97_E1.1760.55
155_Q181_E1.1680.55
87_A93_G1.1630.55
163_E171_I1.1610.54
134_F182_V1.1500.54
31_I96_S1.1480.54
28_K32_Y1.1450.53
25_A145_L1.1440.53
109_S142_G1.1380.53
38_S185_F1.1310.52
26_Y68_R1.1260.52
77_F81_V1.1250.52
151_S160_I1.1110.51
68_R135_A1.1100.51
66_L71_L1.0970.50
146_I158_G1.0960.50
68_R202_K1.0920.50
38_S89_E1.0890.50
161_E167_I1.0870.50
154_F160_I1.0850.49
85_P168_L1.0770.49
95_A102_L1.0670.48
25_A135_A1.0640.48
45_A199_T1.0580.48
159_F191_L1.0440.47
180_I184_V1.0310.46
135_A169_F1.0230.45
81_V140_F1.0200.45
25_A108_A1.0170.45
6_I23_G1.0110.45
68_R190_G1.0080.44
50_I58_I1.0050.44
64_V162_E1.0040.44
184_V192_V1.0030.44
38_S183_S0.9920.43
178_F186_L0.9900.43
74_I100_L0.9850.43
167_I183_S0.9740.42
191_L201_E0.9650.42
93_G96_S0.9640.42
67_L159_F0.9450.40
87_A155_Q0.9430.40
99_I179_L0.9420.40
26_Y198_L0.9390.40
17_S197_I0.9310.39
170_G177_P0.9250.39
75_F154_F0.9230.39
46_F79_G0.9230.39
17_S106_I0.9220.39
7_L17_S0.9200.39
6_I99_I0.9200.39
87_A97_E0.9190.39
132_L147_I0.9160.38
92_K100_L0.9090.38
101_N105_S0.9090.38
45_A171_I0.9070.38
41_I180_I0.9040.38
69_T98_L0.8970.37
14_I138_L0.8950.37
186_L195_S0.8940.37
152_T197_I0.8900.37
43_I70_V0.8890.37
47_H111_V0.8790.36
59_I99_I0.8770.36
55_I62_I0.8680.36
81_V115_F0.8670.35
56_D190_G0.8650.35
109_S116_V0.8650.35
6_I173_L0.8630.35
74_I184_V0.8620.35
165_S196_S0.8610.35
108_A137_V0.8610.35
11_S166_T0.8580.35
184_V202_K0.8550.35
160_I186_L0.8550.35
9_L52_L0.8510.34
6_I103_A0.8460.34
60_L159_F0.8430.34
35_A70_V0.8390.34
44_L98_L0.8370.34
75_F160_I0.8330.33
78_R100_L0.8250.33
68_R177_P0.8240.33
59_I67_L0.8040.32
69_T82_K0.8000.32
137_V177_P0.7960.31
36_I136_F0.7930.31
71_L74_I0.7930.31
174_L183_S0.7920.31
27_F184_V0.7900.31
25_A41_I0.7890.31
73_T165_S0.7870.31
36_I99_I0.7810.30
89_E180_I0.7800.30
68_R163_E0.7760.30
37_Q187_D0.7750.30
105_S108_A0.7730.30
28_K77_F0.7730.30
60_L71_L0.7670.30
55_I66_L0.7620.29
26_Y165_S0.7600.29
21_I191_L0.7590.29
39_T43_I0.7580.29
163_E185_F0.7550.29
112_V191_L0.7550.29
100_L157_I0.7530.29
60_L199_T0.7510.29
57_Y203_A0.7490.29
189_L198_L0.7480.29
66_L136_F0.7470.29
62_I112_V0.7440.28
42_A184_V0.7420.28
56_D179_L0.7420.28
90_S93_G0.7420.28
46_F50_I0.7350.28
174_L180_I0.7340.28
91_S98_L0.7280.28
30_A154_F0.7210.27
29_P184_V0.7120.27
132_L190_G0.7080.27
101_N199_T0.6960.26
46_F150_K0.6950.26
31_I35_A0.6910.26
38_S45_A0.6900.26
35_A193_I0.6840.25
12_T171_I0.6810.25
48_L61_G0.6780.25
150_K154_F0.6760.25
155_Q190_G0.6740.25
137_V144_F0.6710.25
42_A46_F0.6700.25
43_I104_F0.6650.24
15_L70_V0.6630.24
39_T115_F0.6620.24
38_S69_T0.6600.24
144_F179_L0.6570.24
76_L114_Y0.6560.24
108_A198_L0.6550.24
68_R72_I0.6510.24
71_L100_L0.6470.23
34_Q157_I0.6370.23
139_L166_T0.6370.23
87_A149_R0.6350.23
58_I132_L0.6330.23
34_Q38_S0.6320.23
18_A159_F0.6280.23
109_S205_H0.6270.23
90_S96_S0.6260.23
170_G196_S0.6260.23
96_S136_F0.6250.22
27_F76_L0.6240.22
6_I39_T0.6220.22
143_L160_I0.6190.22
69_T115_F0.6160.22
30_A157_I0.6120.22
28_K66_L0.6100.22
79_G193_I0.6090.22
34_Q75_F0.6040.22
89_E106_I0.6020.21
146_I196_S0.6000.21
143_L190_G0.5990.21
138_L142_G0.5990.21
16_I81_V0.5970.21
37_Q164_N0.5950.21
129_T133_L0.5920.21
18_A42_A0.5920.21
55_I59_I0.5920.21
167_I182_V0.5920.21
98_L148_S0.5910.21
36_I71_L0.5900.21
130_L133_L0.5900.21
27_F82_K0.5890.21
145_L170_G0.5870.21
93_G106_I0.5820.21
21_I198_L0.5780.20
14_I45_A0.5770.20
32_Y194_I0.5760.20
63_T104_F0.5720.20
102_L204_E0.5700.20
14_I41_I0.5690.20
49_G205_H0.5670.20
75_F85_P0.5640.20
12_T185_F0.5630.20
46_F66_L0.5620.20
141_Q166_T0.5610.20
64_V172_L0.5600.20
78_R153_I0.5580.20
54_S92_K0.5560.19
170_G198_L0.5540.19
62_I71_L0.5540.19
144_F185_F0.5530.19
114_Y128_N0.5510.19
160_I166_T0.5440.19
17_S148_S0.5430.19
68_R83_E0.5370.19
136_F140_F0.5340.19
16_I196_S0.5300.18
56_D205_H0.5280.18
7_L175_P0.5250.18
146_I152_T0.5240.18
151_S200_L0.5220.18
8_E16_I0.5220.18
20_Y201_E0.5150.18
71_L86_G0.5150.18
10_L72_I0.5150.18
167_I187_D0.5110.18
10_L69_T0.5100.18
50_I63_T0.5090.18
6_I54_S0.5080.18
80_L83_E0.5080.18
16_I27_F0.5070.17
137_V198_L0.5060.17
78_R82_K0.5060.17
20_Y135_A0.5020.17
66_L103_A0.5010.17
45_A170_G0.5000.17
166_T170_G0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4he8K 1 0.3944 90.4 0.908 Contact Map
3rkoK 1 0.4131 79.4 0.921 Contact Map
3rkoM 1 0.9531 17.2 0.949 Contact Map
2qi9A 2 0.5915 10.3 0.954 Contact Map
4g1uA 2 0.5869 9.2 0.955 Contact Map
2nq2A 2 0.5915 5.8 0.959 Contact Map
3hzqA 3 0.3944 5.1 0.96 Contact Map
4humA 1 0.4413 4.6 0.961 Contact Map
3mktA 1 0.4366 4.6 0.961 Contact Map
3rkoN 1 0.9577 4.1 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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