GREMLIN Database
Q97ZA4 - Formate hydrogenlyase subunit 4 (HycD)
UniProt: Q97ZA4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 320 (294)
Sequences: 5421 (2596)
Seq/√Len: 151.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_T169_V5.0681.00
190_S248_L4.0561.00
37_K288_T3.8691.00
194_F282_I3.7701.00
30_Q51_P3.7431.00
246_S272_M3.4921.00
40_I288_T3.4171.00
249_L272_M3.0601.00
133_V223_Y2.9001.00
246_S276_W2.7011.00
52_Y55_I2.5451.00
173_Y182_F2.5251.00
253_I279_L2.5211.00
162_T182_F2.5211.00
183_Q253_I2.4991.00
198_L286_I2.4781.00
63_T229_L2.4491.00
193_F248_L2.4391.00
84_Y240_K2.3051.00
201_T283_S2.3011.00
183_Q190_S2.3011.00
169_V172_D2.2781.00
84_Y239_I2.1261.00
219_D222_L2.0791.00
111_A152_I2.0691.00
245_G279_L2.0681.00
80_V120_I2.0551.00
242_Y280_I2.0421.00
125_S137_V1.9961.00
72_L123_I1.9891.00
22_V239_I1.9881.00
172_D175_S1.9801.00
258_L271_V1.9381.00
87_I243_L1.9341.00
59_L231_A1.9291.00
267_I271_V1.9271.00
195_M306_F1.8821.00
211_L217_I1.8651.00
278_L282_I1.8621.00
197_W244_L1.8521.00
194_F198_L1.8411.00
80_V236_G1.8171.00
86_L109_G1.7971.00
180_H184_L1.7881.00
36_G281_L1.7781.00
211_L216_M1.7631.00
189_V252_F1.7461.00
181_Y275_K1.7261.00
29_Y280_I1.7191.00
57_K61_K1.7111.00
26_S239_I1.7011.00
258_L266_L1.6921.00
32_I281_L1.6851.00
109_G113_L1.6771.00
28_L51_P1.6641.00
166_N169_V1.6291.00
157_G189_V1.6221.00
39_I44_K1.6011.00
90_V109_G1.5501.00
208_S298_V1.5221.00
222_L230_L1.5161.00
140_I209_P1.4921.00
186_H317_V1.4911.00
143_F298_V1.4421.00
230_L234_K1.4131.00
162_T173_Y1.3851.00
197_W248_L1.3851.00
16_I20_I1.3821.00
208_S293_L1.3781.00
150_T196_L1.3721.00
20_I23_I1.3701.00
36_G284_V1.3691.00
151_L196_L1.3621.00
40_I285_I1.3481.00
248_L279_L1.3431.00
162_T170_T1.3391.00
26_S235_W1.3311.00
189_V313_L1.3261.00
153_T314_T1.3251.00
110_G114_F1.3231.00
89_F109_G1.3151.00
158_V170_T1.3121.00
36_G40_I1.2971.00
102_T166_N1.2931.00
267_I270_A1.2861.00
199_F206_V1.2851.00
73_F77_P1.2741.00
25_L242_Y1.2611.00
218_D223_Y1.2491.00
35_R39_I1.2411.00
301_Y306_F1.2401.00
285_I289_T1.2401.00
193_F244_L1.2401.00
50_Q54_D1.2331.00
168_Y172_D1.2271.00
150_T310_L1.2191.00
187_I191_I1.2181.00
130_S133_V1.2141.00
161_I186_H1.2141.00
86_L113_L1.2091.00
79_I83_I1.2051.00
155_F251_V1.2051.00
136_G209_P1.2051.00
31_G48_V1.2011.00
103_P109_G1.1911.00
88_S243_L1.1911.00
249_L253_I1.1681.00
241_Q280_I1.1671.00
76_A124_A1.1601.00
24_L52_Y1.1601.00
74_V229_L1.1591.00
122_I141_L1.1461.00
169_V173_Y1.1311.00
295_L299_Q1.1241.00
56_I60_R1.1170.99
76_A123_I1.1140.99
174_V182_F1.1080.99
157_G314_T1.1060.99
33_Y287_N1.1050.99
124_A127_E1.0950.99
59_L228_K1.0940.99
272_M276_W1.0920.99
208_S297_K1.0910.99
157_G310_L1.0720.99
33_Y203_K1.0670.99
258_L267_I1.0630.99
153_T311_L1.0590.99
52_Y56_I1.0570.99
201_T244_L1.0550.99
25_L277_L1.0470.99
266_L270_A1.0450.99
241_Q283_S1.0390.99
174_V254_F1.0380.99
66_S69_S1.0240.99
150_T302_L1.0220.99
118_A144_T1.0210.99
249_L276_W1.0170.99
210_G213_E1.0160.99
192_S309_S1.0120.99
228_K231_A1.0100.99
281_L285_I1.0100.99
187_I190_S1.0060.99
81_F232_I0.9960.99
107_F159_A0.9950.99
211_L214_M0.9950.99
253_I275_K0.9920.99
83_I113_L0.9900.99
246_S250_N0.9900.99
175_S257_F0.9720.99
66_S73_F0.9670.98
28_L48_V0.9590.98
102_T168_Y0.9580.98
279_L282_I0.9570.98
31_G51_P0.9540.98
204_L290_L0.9520.98
35_R61_K0.9510.98
124_A225_Y0.9500.98
164_T170_T0.9400.98
30_Q238_Y0.9380.98
76_A120_I0.9370.98
294_R299_Q0.9350.98
191_I195_M0.9350.98
150_T307_L0.9350.98
32_I36_G0.9350.98
175_S179_S0.9290.98
180_H185_D0.9280.98
65_I74_V0.9270.98
80_V233_L0.9270.98
81_F85_L0.9190.98
41_E46_P0.9170.98
269_I273_F0.9170.98
110_G167_P0.9130.98
138_S209_P0.9120.98
55_I59_L0.9110.98
90_V106_D0.9110.98
38_A44_K0.9060.98
124_A233_L0.9040.98
90_V110_G0.9030.98
119_F295_L0.9000.98
157_G186_H0.8980.98
55_I235_W0.8980.98
20_I24_L0.8960.98
58_L231_A0.8940.97
181_Y184_L0.8940.97
179_S183_Q0.8920.97
32_I284_V0.8900.97
255_P275_K0.8900.97
154_V192_S0.8900.97
211_L292_K0.8880.97
13_V17_T0.8790.97
282_I286_I0.8790.97
37_K287_N0.8730.97
207_E292_K0.8730.97
35_R48_V0.8720.97
154_V196_L0.8600.97
55_I60_R0.8580.97
81_F236_G0.8580.97
174_V181_Y0.8570.97
50_Q57_K0.8520.97
194_F248_L0.8520.97
203_K207_E0.8520.97
186_H313_L0.8470.97
58_L234_K0.8470.97
194_F283_S0.8450.96
293_L297_K0.8450.96
74_V78_Y0.8420.96
106_D166_N0.8400.96
216_M220_G0.8390.96
76_A127_E0.8390.96
130_S283_S0.8380.96
285_I290_L0.8350.96
23_I85_L0.8320.96
190_S252_F0.8280.96
216_M292_K0.8200.96
150_T306_F0.8150.96
272_M275_K0.8110.96
209_P221_V0.8110.96
143_F147_S0.8080.95
31_G39_I0.8080.95
103_P233_L0.8070.95
193_F252_F0.8070.95
46_P50_Q0.8040.95
143_F202_G0.8040.95
208_S217_I0.7990.95
111_A155_F0.7980.95
54_D57_K0.7970.95
126_L129_G0.7960.95
181_Y255_P0.7910.95
69_S73_F0.7890.95
18_Q100_L0.7840.95
159_A165_N0.7840.95
309_S313_L0.7830.95
171_L256_W0.7820.95
313_L317_V0.7810.95
30_Q33_Y0.7690.94
31_G37_K0.7690.94
207_E210_G0.7620.94
95_Y172_D0.7580.94
181_Y254_F0.7570.94
222_L234_K0.7560.94
23_I27_P0.7560.94
12_V16_I0.7520.93
82_G316_T0.7460.93
171_L255_P0.7450.93
244_L248_L0.7440.93
184_L187_I0.7370.93
107_F170_T0.7350.93
73_F225_Y0.7330.92
49_L52_Y0.7310.92
182_F185_D0.7310.92
34_D43_R0.7230.92
72_L76_A0.7210.92
77_P225_Y0.7200.92
140_I211_L0.7200.92
84_Y243_L0.7160.92
154_V157_G0.7160.92
204_L214_M0.7150.92
25_L28_L0.7130.91
210_G216_M0.7130.91
198_L283_S0.7130.91
193_F197_W0.7120.91
28_L52_Y0.7120.91
231_A235_W0.7110.91
10_Q14_L0.7090.91
254_F275_K0.7070.91
27_P55_I0.7050.91
249_L275_K0.7040.91
227_G231_A0.7040.91
146_L299_Q0.7030.91
151_L302_L0.7010.91
199_F298_V0.7000.91
47_S53_Y0.6970.90
103_P110_G0.6940.90
61_K304_V0.6890.90
268_D271_V0.6890.90
200_E203_K0.6810.89
28_L31_G0.6810.89
192_S195_M0.6800.89
292_K296_F0.6790.89
80_V117_A0.6790.89
296_F299_Q0.6760.89
41_E45_G0.6760.89
34_D54_D0.6760.89
121_K140_I0.6760.89
86_L169_V0.6740.89
75_Y78_Y0.6740.89
300_D304_V0.6690.89
19_V23_I0.6680.89
91_I246_S0.6660.88
93_V100_L0.6650.88
214_M219_D0.6650.88
34_D210_G0.6640.88
83_I116_L0.6640.88
179_S270_A0.6610.88
167_P247_V0.6600.88
25_L280_I0.6560.88
27_P31_G0.6530.87
152_I155_F0.6520.87
157_G313_L0.6510.87
170_T251_V0.6500.87
83_I117_A0.6490.87
38_A43_R0.6480.87
65_I69_S0.6470.87
107_F167_P0.6440.87
217_I221_V0.6410.86
280_I284_V0.6410.86
37_K42_G0.6390.86
27_P37_K0.6380.86
133_V219_D0.6380.86
307_L310_L0.6360.86
266_L269_I0.6360.86
143_F146_L0.6350.86
136_G140_I0.6340.86
114_F117_A0.6340.86
143_F217_I0.6330.86
96_P168_Y0.6320.86
151_L154_V0.6320.86
11_I14_L0.6310.86
81_F223_Y0.6300.85
128_S225_Y0.6280.85
102_T106_D0.6270.85
194_F279_L0.6270.85
214_M218_D0.6270.85
24_L27_P0.6250.85
15_T101_L0.6240.85
33_Y37_K0.6230.85
107_F155_F0.6230.85
234_K287_N0.6180.84
33_Y238_Y0.6150.84
147_S199_F0.6150.84
294_R297_K0.6140.84
276_W280_I0.6130.84
93_V246_S0.6110.84
66_S77_P0.6100.84
13_V190_S0.6080.83
173_Y179_S0.6080.83
278_L281_L0.6060.83
172_D257_F0.6060.83
80_V87_I0.6040.83
39_I284_V0.6020.83
80_V121_K0.5980.82
68_N227_G0.5980.82
70_L129_G0.5980.82
100_L235_W0.5970.82
172_D255_P0.5970.82
121_K202_G0.5960.82
156_F159_A0.5950.82
49_L53_Y0.5920.82
36_G285_I0.5890.81
91_I243_L0.5880.81
270_A274_G0.5880.81
221_V234_K0.5870.81
120_I123_I0.5860.81
248_L253_I0.5850.81
53_Y131_N0.5840.81
79_I82_G0.5760.80
158_V186_H0.5750.80
43_R50_Q0.5730.80
161_I185_D0.5700.79
293_L302_L0.5680.79
274_G277_L0.5670.79
119_F151_L0.5670.79
194_F285_I0.5660.79
22_V26_S0.5630.78
15_T18_Q0.5620.78
11_I17_T0.5620.78
100_L105_V0.5610.78
116_L305_A0.5600.78
55_I231_A0.5590.78
284_V287_N0.5590.78
102_T105_V0.5580.78
298_V307_L0.5570.78
41_E224_E0.5570.78
158_V251_V0.5560.78
183_Q187_I0.5560.78
91_I100_L0.5540.77
249_L268_D0.5520.77
150_T295_L0.5500.77
146_L287_N0.5500.77
219_D234_K0.5480.77
198_L244_L0.5480.77
310_L317_V0.5480.77
188_F313_L0.5480.77
114_F248_L0.5470.76
175_S182_F0.5460.76
302_L305_A0.5450.76
85_L239_I0.5440.76
15_T19_V0.5430.76
114_F240_K0.5430.76
128_S133_V0.5420.76
249_L279_L0.5420.76
31_G35_R0.5420.76
146_L307_L0.5400.76
56_I59_L0.5400.76
51_P284_V0.5390.75
43_R220_G0.5390.75
123_I127_E0.5380.75
154_V189_V0.5380.75
120_I152_I0.5370.75
144_T152_I0.5350.75
256_W275_K0.5350.75
157_G317_V0.5330.75
192_S306_F0.5300.74
13_V191_I0.5290.74
110_G243_L0.5280.74
210_G220_G0.5270.74
201_T240_K0.5270.74
10_Q13_V0.5270.74
238_Y287_N0.5270.74
10_Q278_L0.5260.74
83_I86_L0.5250.74
247_V251_V0.5250.74
140_I217_I0.5230.73
87_I240_K0.5230.73
310_L314_T0.5210.73
120_I137_V0.5200.73
171_L275_K0.5190.73
237_S241_Q0.5180.73
265_S268_D0.5170.72
179_S182_F0.5160.72
277_L281_L0.5160.72
158_V271_V0.5160.72
203_K238_Y0.5140.72
202_G240_K0.5140.72
156_F314_T0.5120.72
250_N256_W0.5120.72
14_L18_Q0.5120.72
54_D292_K0.5110.72
26_S37_K0.5110.72
188_F192_S0.5110.72
27_P51_P0.5100.71
111_A120_I0.5100.71
106_D113_L0.5090.71
198_L201_T0.5080.71
312_S316_T0.5070.71
39_I152_I0.5050.71
190_S253_I0.5020.70
10_Q169_V0.5020.70
14_L141_L0.5020.70
34_D41_E0.5010.70
33_Y284_V0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4he8H 1 0.8187 100 0.111 Contact Map
1q2fA 1 0.0969 8 0.969 Contact Map
2jpkA 1 0.0969 6.1 0.971 Contact Map
1qleD 1 0.1344 5.9 0.971 Contact Map
3rkoL 1 0.875 4.7 0.972 Contact Map
3dacP 1 0.0406 3.3 0.975 Contact Map
3rkoN 1 0.8406 3.2 0.975 Contact Map
1u7gA 3 0.1781 2.9 0.975 Contact Map
2ih3C 4 0.1344 2.3 0.976 Contact Map
3mp7A 1 0.1719 2.2 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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