GREMLIN Database
Q97ZA2 - Uncharacterized protein
UniProt: Q97ZA2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 232 (223)
Sequences: 7192 (5149)
Seq/√Len: 344.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_L102_E3.3261.00
95_E123_K3.0031.00
138_I169_N2.8301.00
201_F204_N2.7651.00
80_Y116_D2.4561.00
98_I106_I2.3341.00
129_A149_Y2.3101.00
200_S210_E2.2081.00
219_N223_K2.1901.00
122_V143_D2.1321.00
164_Q201_F2.1241.00
91_I116_D2.0171.00
110_A117_A1.9901.00
47_G72_F1.9051.00
95_E124_N1.8891.00
172_L206_L1.8751.00
99_K124_N1.8731.00
80_Y87_K1.8261.00
67_I73_V1.8191.00
208_I213_L1.8081.00
172_L216_I1.7981.00
39_L69_K1.7831.00
115_K119_N1.7711.00
172_L208_I1.7711.00
138_I142_K1.7661.00
13_Y17_K1.7411.00
215_R219_N1.7401.00
47_G107_N1.7341.00
167_L202_M1.7011.00
131_F144_I1.6971.00
14_L17_K1.6941.00
122_V147_A1.6751.00
199_I210_E1.6611.00
92_K96_E1.6271.00
7_A221_F1.6271.00
133_W154_N1.6271.00
38_S46_V1.6201.00
76_V97_Q1.5951.00
143_D146_S1.5801.00
161_K165_E1.5651.00
142_K146_S1.5641.00
76_V106_I1.5601.00
110_A114_W1.5511.00
177_T199_I1.5491.00
60_L96_E1.5431.00
96_E99_K1.5311.00
142_K169_N1.4951.00
141_L151_I1.4881.00
157_V202_M1.4811.00
130_I224_A1.4801.00
36_T40_K1.4751.00
150_F174_N1.4741.00
91_I119_N1.4661.00
137_P140_L1.4541.00
153_I167_L1.4491.00
94_F108_V1.4191.00
165_E168_K1.4191.00
27_S30_Y1.4131.00
150_F223_K1.4001.00
196_P200_S1.3941.00
200_S204_N1.3721.00
14_L18_Y1.3621.00
218_S222_F1.3581.00
118_F143_D1.3501.00
103_G128_S1.3471.00
161_K164_Q1.3351.00
95_E120_I1.3201.00
164_Q205_F1.3191.00
91_I95_E1.3081.00
4_Y199_I1.2981.00
119_N123_K1.2951.00
15_K18_Y1.2911.00
86_P89_L1.2771.00
36_T39_L1.2711.00
62_R65_S1.2621.00
171_D174_N1.2601.00
5_F218_S1.2571.00
151_I170_V1.2551.00
9_C181_G1.2431.00
197_N200_S1.2391.00
212_K215_R1.2371.00
185_Y194_D1.2371.00
94_F117_A1.2351.00
209_E212_K1.2331.00
53_W82_F1.2311.00
4_Y214_V1.2251.00
28_M31_Q1.2141.00
208_I212_K1.2101.00
80_Y91_I1.1831.00
199_I217_I1.1711.00
91_I120_I1.1711.00
176_L224_A1.1701.00
185_Y197_N1.1651.00
35_D39_L1.1611.00
218_S221_F1.1561.00
145_E174_N1.1521.00
202_M213_L1.1501.00
153_I175_V1.1471.00
30_Y34_M1.1421.00
87_K91_I1.1411.00
190_L194_D1.1371.00
25_A31_Q1.1351.00
139_N142_K1.1291.00
34_M46_V1.1281.00
201_F205_F1.1251.00
88_E92_K1.1101.00
34_M38_S1.1091.00
4_Y195_I1.1041.00
5_F221_F1.0921.00
217_I221_F1.0891.00
59_D62_R1.0831.00
165_E169_N1.0831.00
55_V93_Y1.0781.00
115_K140_L1.0701.00
114_W140_L1.0681.00
177_T202_M1.0661.00
65_S69_K1.0641.00
20_G45_L1.0611.00
14_L43_N1.0581.00
150_F224_A1.0561.00
99_K102_E1.0561.00
136_G140_L1.0541.00
185_Y188_K1.0511.00
53_W85_A1.0441.00
138_I166_V1.0391.00
65_S68_I1.0381.00
13_Y18_Y1.0361.00
32_S36_T1.0301.00
13_Y21_Y1.0271.00
89_L92_K1.0251.00
64_L68_I1.0251.00
103_G127_K1.0191.00
83_A87_K1.0171.00
115_K143_D1.0101.00
32_S62_R1.0061.00
191_E194_D1.0021.00
177_T195_I0.9891.00
12_S30_Y0.9811.00
54_R57_E0.9771.00
88_E91_I0.9731.00
216_I219_N0.9721.00
199_I214_V0.9681.00
153_I170_V0.9661.00
167_L206_L0.9651.00
33_A36_T0.9481.00
152_S176_L0.9471.00
81_R112_D0.9411.00
214_V218_S0.9371.00
23_I34_M0.9361.00
61_T64_L0.9321.00
11_Y192_P0.9291.00
61_T65_S0.9231.00
118_F144_I0.9221.00
64_L100_A0.9191.00
157_V167_L0.9161.00
55_V89_L0.9101.00
62_R66_L0.9081.00
177_T217_I0.9041.00
212_K216_I0.9041.00
9_C21_Y0.9031.00
18_Y21_Y0.8981.00
35_D46_V0.8941.00
20_G222_F0.8921.00
184_E187_G0.8891.00
199_I213_L0.8881.00
87_K116_D0.8821.00
213_L217_I0.8671.00
7_A176_L0.8621.00
206_L213_L0.8591.00
14_L19_E0.8581.00
172_L213_L0.8561.00
60_L64_L0.8541.00
26_V30_Y0.8491.00
138_I165_E0.8471.00
196_P210_E0.8371.00
129_A224_A0.8361.00
167_L205_F0.8351.00
145_E171_D0.8321.00
210_E214_V0.8301.00
17_K21_Y0.8301.00
156_S159_F0.8291.00
25_A28_M0.8271.00
28_M59_D0.8221.00
145_E151_I0.8221.00
108_V131_F0.8161.00
4_Y218_S0.8081.00
108_V117_A0.8061.00
35_D69_K0.8051.00
130_I225_Y0.7961.00
7_A130_I0.7871.00
5_F20_G0.7871.00
114_W144_I0.7831.00
211_Y215_R0.7831.00
38_S44_V0.7831.00
53_W84_K0.7781.00
199_I203_S0.7721.00
35_D48_V0.7711.00
114_W136_G0.7711.00
73_V76_V0.7701.00
168_K205_F0.7691.00
31_Q34_M0.7681.00
171_D206_L0.7661.00
118_F140_L0.7651.00
116_D119_N0.7631.00
103_G126_V0.7611.00
30_Y33_A0.7541.00
175_V206_L0.7531.00
128_S226_G0.7521.00
17_K20_G0.7481.00
89_L93_Y0.7481.00
17_K189_L0.7370.99
29_D32_S0.7330.99
110_A136_G0.7310.99
24_A47_G0.7300.99
195_I198_A0.7290.99
130_I152_S0.7260.99
95_E99_K0.7240.99
32_S66_L0.7180.99
202_M206_L0.7150.99
120_I123_K0.7150.99
168_K207_G0.7130.99
150_F176_L0.7130.99
4_Y196_P0.7080.99
83_A86_P0.7080.99
14_L21_Y0.7010.99
219_N222_F0.6950.99
98_I124_N0.6920.99
159_F184_E0.6850.99
163_H166_V0.6830.99
141_L166_V0.6830.99
120_I124_N0.6810.99
208_I216_I0.6790.99
110_A144_I0.6780.99
27_S31_Q0.6720.99
84_K87_K0.6710.99
35_D38_S0.6670.99
122_V146_S0.6660.99
78_L113_A0.6630.99
175_V213_L0.6620.99
24_A107_N0.6600.99
25_A34_M0.6600.99
7_A107_N0.6590.99
76_V93_Y0.6570.99
144_I151_I0.6560.99
141_L145_E0.6540.99
161_K168_K0.6520.99
48_V66_L0.6500.99
107_N225_Y0.6460.99
28_M62_R0.6430.99
156_S163_H0.6380.99
4_Y177_T0.6370.99
72_F107_N0.6370.99
145_E169_N0.6350.98
4_Y210_E0.6310.98
170_V175_V0.6310.98
203_S210_E0.6250.98
14_L20_G0.6240.98
176_L221_F0.6200.98
114_W118_F0.6200.98
173_K223_K0.6170.98
23_I44_V0.6160.98
143_D147_A0.6060.98
130_I176_L0.6060.98
118_F122_V0.6040.98
150_F220_N0.6030.98
55_V85_A0.6030.98
56_H86_P0.6020.98
145_E170_V0.6020.98
60_L100_A0.5960.98
25_A30_Y0.5960.98
98_I120_I0.5960.98
164_Q168_K0.5950.98
81_R111_L0.5900.98
56_H89_L0.5880.98
216_I223_K0.5870.98
25_A36_T0.5870.98
27_S33_A0.5860.97
141_L170_V0.5830.97
162_K165_E0.5830.97
173_K216_I0.5820.97
103_G226_G0.5810.97
175_V217_I0.5810.97
5_F22_L0.5800.97
118_F147_A0.5760.97
134_Y140_L0.5760.97
12_S33_A0.5750.97
131_F152_S0.5740.97
31_Q35_D0.5740.97
206_L216_I0.5710.97
181_G190_L0.5690.97
134_Y144_I0.5690.97
27_S57_E0.5670.97
157_V213_L0.5630.97
93_Y97_Q0.5610.97
216_I220_N0.5600.97
56_H85_A0.5570.97
18_Y22_L0.5540.96
125_D149_Y0.5530.96
53_W83_A0.5440.96
110_A113_A0.5410.96
59_D93_Y0.5400.96
157_V163_H0.5380.96
194_D197_N0.5370.96
58_E62_R0.5350.96
108_V129_A0.5340.96
155_P158_S0.5330.96
163_H167_L0.5300.95
211_Y214_V0.5300.95
68_I102_E0.5290.95
124_N127_K0.5280.95
22_L221_F0.5260.95
63_I67_I0.5260.95
148_G151_I0.5250.95
96_E100_A0.5210.95
140_L144_I0.5210.95
153_I156_S0.5210.95
5_F222_F0.5210.95
58_E61_T0.5200.95
24_A34_M0.5200.95
114_W117_A0.5180.95
28_M32_S0.5160.95
49_G97_Q0.5160.95
97_Q101_G0.5160.95
157_V164_Q0.5120.95
23_I28_M0.5110.95
134_Y141_L0.5110.95
31_Q38_S0.5070.94
16_K19_E0.5060.94
7_A10_H0.5050.94
29_D57_E0.5050.94
78_L91_I0.5040.94
131_F149_Y0.5030.94
38_S41_S0.5010.94
158_S201_F0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e2vA 1 0.9741 100 0.237 Contact Map
3ipwA 1 0.9828 100 0.298 Contact Map
2xioA 1 0.9784 100 0.352 Contact Map
3gg7A 1 0.9655 100 0.36 Contact Map
1j6oA 1 0.9914 100 0.405 Contact Map
3rcmA 1 0.9914 100 0.429 Contact Map
2y1hA 2 1 100 0.433 Contact Map
1xwyA 1 0.9698 100 0.442 Contact Map
1zzmA 1 0.9828 100 0.446 Contact Map
2gzxA 1 0.9612 100 0.453 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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