GREMLIN Database
CCA - CCA-adding enzyme
UniProt: Q97Z92 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 412 (378)
Sequences: 229 (184)
Seq/√Len: 9.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_K143_D5.9161.00
3_E242_Y5.7441.00
171_A213_I4.3470.99
35_D59_F3.5460.97
165_Q228_S3.4320.96
14_E18_K3.3470.95
44_K130_T3.3210.95
171_A223_V3.2700.95
133_V177_I3.2030.94
154_G252_F2.9150.90
321_L371_A2.8910.90
154_G253_P2.8760.90
151_F182_F2.8260.89
332_N349_N2.7280.87
231_N234_T2.6890.86
370_D373_T2.6890.86
132_Y201_T2.6870.86
3_E147_L2.3510.77
77_I96_V2.3430.77
152_M157_V2.3430.77
183_R242_Y2.3300.77
17_K45_G2.3160.76
155_I238_A2.3090.76
3_E183_R2.2430.74
28_R56_V2.2160.73
186_L239_A2.2040.73
212_I287_R2.1720.71
271_N274_E2.1260.70
189_A235_F2.0550.67
179_Y232_I2.0390.66
44_K133_V2.0280.66
300_G322_E2.0170.65
160_A363_I2.0100.65
39_E282_W1.9950.65
26_I100_I1.9870.64
6_V9_I1.9850.64
16_D73_A1.9830.64
90_Y170_Y1.9200.61
47_W194_H1.8930.60
176_I185_V1.8740.59
227_V235_F1.8720.59
93_H125_R1.8610.59
230_K357_D1.8550.59
13_T49_R1.8430.58
227_V232_I1.8420.58
160_A283_G1.8410.58
368_E377_K1.8260.57
39_E283_G1.8050.56
61_P281_V1.7990.56
185_V275_K1.7990.56
303_V371_A1.7930.56
116_G128_F1.7910.56
51_D153_K1.7650.55
123_V126_T1.7620.55
138_D141_G1.7610.55
148_L185_V1.7340.53
330_Y364_K1.6880.51
61_P87_T1.6830.51
303_V321_L1.6520.50
16_D50_Q1.6490.50
77_I98_V1.6410.49
123_V320_Q1.6250.48
277_S284_Q1.6030.47
77_I110_A1.5890.47
66_K92_E1.5860.47
332_N362_S1.5770.46
269_R274_E1.5720.46
107_I113_V1.5640.46
165_Q286_K1.5640.46
94_P125_R1.5600.46
199_E203_P1.5490.45
44_K162_L1.5460.45
186_L243_L1.5320.44
36_F56_V1.5320.44
145_V148_L1.5270.44
27_I98_V1.5180.44
113_V128_F1.5180.44
27_I217_V1.5180.44
211_L232_I1.5120.43
292_I375_A1.5080.43
232_I318_A1.5020.43
161_E181_N1.4930.43
54_I81_I1.4780.42
113_V119_A1.4720.42
7_L11_K1.4710.42
78_I96_V1.4650.41
171_A274_E1.4640.41
71_R75_N1.4540.41
81_I98_V1.4430.40
163_K174_L1.4420.40
227_V287_R1.4200.39
189_A192_W1.4160.39
105_V113_V1.4150.39
242_Y250_F1.4130.39
44_K164_V1.4130.39
353_W362_S1.4110.39
44_K353_W1.4100.39
48_L97_I1.4050.39
262_K320_Q1.3990.39
76_D186_L1.3930.38
184_K187_E1.3930.38
176_I328_Q1.3860.38
146_R160_A1.3720.37
73_A144_E1.3570.37
116_G207_F1.3390.36
196_I232_I1.3360.36
214_P290_N1.3290.36
110_A283_G1.3050.35
126_T192_W1.3030.35
264_D320_Q1.2960.34
27_I54_I1.2900.34
183_R187_E1.2810.34
199_E214_P1.2790.34
181_N185_V1.2780.34
98_V282_W1.2750.34
377_K380_V1.2710.33
42_F162_L1.2680.33
121_T284_Q1.2660.33
194_H338_Y1.2600.33
227_V348_K1.2540.33
62_K128_F1.2520.33
199_E223_V1.2520.33
31_L198_I1.2510.33
146_R168_S1.2500.33
137_L207_F1.2290.32
18_K135_S1.2280.32
22_K256_K1.2220.31
123_V283_G1.2160.31
137_L145_V1.2130.31
99_N131_K1.2000.31
187_E198_I1.1980.31
171_A224_T1.1930.30
88_L332_N1.1900.30
131_K135_S1.1830.30
282_W310_G1.1800.30
336_Q362_S1.1680.29
22_K85_D1.1670.29
48_L144_E1.1660.29
98_V110_A1.1630.29
77_I284_Q1.1620.29
305_D319_V1.1580.29
277_S286_K1.1560.29
130_T353_W1.1540.29
190_S342_I1.1480.29
42_F130_T1.1470.29
44_K119_A1.1440.29
139_E142_K1.1390.28
192_W366_R1.1310.28
100_I256_K1.1300.28
148_L153_K1.1290.28
278_E282_W1.1220.28
35_D112_R1.1190.28
91_A125_R1.1150.27
289_V306_V1.1050.27
11_K49_R1.1030.27
91_A110_A1.0990.27
48_L172_T1.0930.27
48_L146_R1.0920.27
153_K250_F1.0910.27
296_L371_A1.0870.26
100_I103_V1.0860.26
78_I88_L1.0820.26
16_D320_Q1.0770.26
6_V10_I1.0650.26
88_L262_K1.0640.26
278_E283_G1.0640.26
161_E226_A1.0620.26
26_I101_N1.0560.25
4_E118_K1.0550.25
103_V347_Q1.0490.25
182_F251_F1.0430.25
50_Q285_I1.0410.25
45_G142_K1.0360.25
91_A94_P1.0310.25
93_H123_V1.0290.25
315_I374_I1.0270.24
237_I360_L1.0250.24
43_R110_A1.0230.24
155_I210_P1.0150.24
242_Y297_K1.0150.24
337_Y353_W1.0120.24
240_K361_Y1.0110.24
105_V310_G1.0100.24
8_K245_N1.0010.24
60_Y123_V0.9980.24
115_S187_E0.9970.23
368_E374_I0.9930.23
257_V285_I0.9930.23
175_L296_L0.9920.23
98_V283_G0.9920.23
164_V374_I0.9920.23
225_A298_Q0.9870.23
176_I343_E0.9860.23
8_K101_N0.9840.23
115_S244_K0.9800.23
283_G363_I0.9790.23
37_E357_D0.9790.23
230_K354_V0.9680.23
225_A311_D0.9650.22
161_E238_A0.9630.22
145_V348_K0.9610.22
349_N352_I0.9590.22
44_K127_P0.9570.22
244_K347_Q0.9550.22
230_K250_F0.9540.22
162_L282_W0.9390.22
163_K282_W0.9350.22
7_L143_D0.9340.22
106_D174_L0.9340.22
300_G359_R0.9320.21
103_V174_L0.9270.21
202_K357_D0.9230.21
92_E284_Q0.9180.21
211_L223_V0.9160.21
283_G320_Q0.9130.21
45_G188_E0.9120.21
247_S250_F0.9090.21
211_L287_R0.9090.21
5_E8_K0.9090.21
372_E376_K0.9080.21
214_P354_V0.9070.21
160_A262_K0.9070.21
335_P345_F0.8990.20
334_G345_F0.8990.20
49_R344_D0.8960.20
242_Y257_V0.8940.20
53_D124_D0.8930.20
88_L96_V0.8920.20
38_V42_F0.8880.20
293_E319_V0.8840.20
74_L88_L0.8770.20
92_E154_G0.8720.20
185_V243_L0.8710.20
307_Q354_V0.8710.20
185_V235_F0.8690.20
56_V371_A0.8660.20
125_R218_D0.8660.20
195_P232_I0.8660.20
77_I111_L0.8640.19
164_V375_A0.8620.19
94_P123_V0.8580.19
301_F366_R0.8580.19
77_I283_G0.8580.19
74_L284_Q0.8570.19
43_R199_E0.8560.19
132_Y190_S0.8550.19
96_V212_I0.8530.19
133_V238_A0.8500.19
39_E123_V0.8490.19
111_L320_Q0.8490.19
290_N294_R0.8490.19
49_R112_R0.8470.19
187_E276_S0.8430.19
25_E340_G0.8430.19
162_L283_G0.8420.19
69_L73_A0.8410.19
150_R252_F0.8400.19
160_A231_N0.8370.19
73_A102_N0.8370.19
321_L375_A0.8330.19
119_A320_Q0.8330.19
49_R154_G0.8310.19
44_K161_E0.8230.18
39_E264_D0.8190.18
45_G201_T0.8170.18
93_H218_D0.8130.18
39_E320_Q0.8120.18
97_I106_D0.8080.18
227_V283_G0.8070.18
65_G68_Y0.8050.18
90_Y123_V0.8050.18
295_A374_I0.8040.18
89_A161_E0.8030.18
283_G329_Y0.8010.18
132_Y290_N0.8000.18
90_Y93_H0.7980.18
133_V136_H0.7980.18
16_D34_L0.7970.18
104_E192_W0.7940.18
198_I379_I0.7910.18
51_D161_E0.7890.17
277_S310_G0.7880.17
71_R76_D0.7880.17
256_K265_V0.7870.17
24_L28_R0.7860.17
196_I290_N0.7850.17
69_L106_D0.7850.17
68_Y96_V0.7820.17
25_E294_R0.7810.17
14_E187_E0.7780.17
87_T161_E0.7760.17
36_F290_N0.7760.17
77_I282_W0.7750.17
336_Q359_R0.7750.17
128_F358_G0.7710.17
9_I248_I0.7710.17
44_K349_N0.7700.17
163_K237_I0.7700.17
6_V185_V0.7680.17
354_V370_D0.7650.17
157_V210_P0.7640.17
113_V162_L0.7630.17
232_I312_T0.7630.17
33_K96_V0.7620.17
291_K346_I0.7580.17
214_P289_V0.7580.17
111_L317_I0.7580.17
150_R243_L0.7570.17
278_E284_Q0.7530.17
62_K127_P0.7480.16
366_R371_A0.7470.16
49_R303_V0.7450.16
90_Y125_R0.7430.16
3_E49_R0.7430.16
115_S128_F0.7420.16
77_I121_T0.7380.16
144_E225_A0.7370.16
28_R36_F0.7370.16
232_I235_F0.7360.16
6_V154_G0.7360.16
88_L362_S0.7350.16
205_K287_R0.7340.16
51_D288_S0.7340.16
98_V132_Y0.7330.16
75_N176_I0.7330.16
39_E110_A0.7320.16
39_E92_E0.7320.16
155_I319_V0.7310.16
341_T361_Y0.7290.16
171_A211_L0.7290.16
24_L128_F0.7270.16
331_L356_E0.7260.16
60_Y74_L0.7260.16
136_H157_V0.7250.16
76_D176_I0.7230.16
94_P218_D0.7230.16
66_K73_A0.7200.16
149_K158_Y0.7190.16
38_V353_W0.7180.16
229_L232_I0.7170.16
88_L126_T0.7150.16
74_L283_G0.7150.16
264_D271_N0.7150.16
5_E318_A0.7120.16
227_V304_I0.7120.16
330_Y359_R0.7110.16
18_K22_K0.7080.15
198_I357_D0.7070.15
25_E63_D0.7070.15
352_I362_S0.7060.15
14_E329_Y0.7020.15
257_V263_G0.7020.15
49_R375_A0.7020.15
217_V238_A0.7010.15
245_N376_K0.7010.15
264_D363_I0.6980.15
101_N186_L0.6950.15
103_V227_V0.6950.15
379_I384_K0.6930.15
298_Q362_S0.6910.15
9_I252_F0.6910.15
6_V49_R0.6900.15
206_I287_R0.6880.15
42_F160_A0.6840.15
134_T212_I0.6830.15
23_V319_V0.6830.15
306_V312_T0.6810.15
68_Y156_G0.6810.15
121_T162_L0.6810.15
27_I86_Y0.6810.15
66_K239_A0.6800.15
186_L306_V0.6790.15
147_L242_Y0.6780.15
39_E44_K0.6760.15
136_H177_I0.6760.15
45_G48_L0.6750.15
106_D119_A0.6730.15
132_Y288_S0.6730.15
39_E329_Y0.6730.15
136_H317_I0.6720.15
297_K329_Y0.6700.15
56_V176_I0.6700.15
50_Q225_A0.6690.15
144_E378_N0.6690.15
211_L226_A0.6650.15
54_I98_V0.6640.14
201_T287_R0.6600.14
85_D150_R0.6600.14
157_V234_T0.6580.14
34_L307_Q0.6570.14
15_E67_E0.6560.14
133_V337_Y0.6550.14
69_L320_Q0.6530.14
88_L274_E0.6530.14
223_V283_G0.6530.14
67_E244_K0.6520.14
199_E213_I0.6520.14
156_G162_L0.6510.14
5_E248_I0.6500.14
98_V113_V0.6500.14
97_I250_F0.6500.14
93_H121_T0.6490.14
349_N362_S0.6490.14
305_D317_I0.6470.14
349_N364_K0.6470.14
162_L341_T0.6470.14
43_R223_V0.6400.14
327_G349_N0.6390.14
53_D160_A0.6380.14
187_E292_I0.6380.14
13_T348_K0.6370.14
187_E318_A0.6360.14
205_K242_Y0.6360.14
56_V233_A0.6360.14
34_L367_K0.6350.14
128_F196_I0.6350.14
144_E153_K0.6350.14
244_K302_R0.6340.14
92_E278_E0.6330.14
349_N353_W0.6330.14
6_V143_D0.6300.14
302_R322_E0.6280.14
25_E245_N0.6270.14
148_L181_N0.6260.14
65_G89_A0.6240.14
42_F133_V0.6230.14
33_K68_Y0.6230.14
25_E179_Y0.6230.14
246_P251_F0.6230.14
201_T286_K0.6230.14
29_E184_K0.6220.14
48_L362_S0.6210.14
358_G375_A0.6190.14
217_V250_F0.6190.14
332_N351_N0.6190.14
230_K356_E0.6190.14
25_E72_N0.6190.14
77_I81_I0.6150.13
128_F241_Y0.6150.13
211_L235_F0.6140.13
209_E283_G0.6130.13
14_E131_K0.6130.13
247_S354_V0.6120.13
53_D349_N0.6090.13
112_R115_S0.6080.13
10_I107_I0.6070.13
91_A105_V0.6050.13
73_A320_Q0.6040.13
126_T304_I0.6030.13
104_E148_L0.6030.13
76_D333_I0.6020.13
89_A162_L0.6020.13
279_D305_D0.6010.13
217_V337_Y0.5990.13
90_Y100_I0.5990.13
155_I185_V0.5980.13
34_L88_L0.5980.13
93_H96_V0.5980.13
11_K144_E0.5980.13
94_P130_T0.5950.13
217_V247_S0.5940.13
195_P291_K0.5930.13
192_W224_T0.5930.13
194_H336_Q0.5890.13
213_I290_N0.5890.13
111_L217_V0.5880.13
98_V233_A0.5860.13
47_W366_R0.5850.13
156_G377_K0.5850.13
17_K290_N0.5840.13
3_E10_I0.5840.13
92_E162_L0.5820.13
164_V174_L0.5810.13
6_V123_V0.5800.13
3_E152_M0.5790.13
240_K297_K0.5790.13
189_A239_A0.5770.13
262_K363_I0.5750.13
90_Y94_P0.5750.13
100_I281_V0.5740.13
47_W240_K0.5730.13
132_Y318_A0.5730.13
32_N36_F0.5720.13
133_V146_R0.5690.13
107_I112_R0.5690.13
233_A277_S0.5690.13
22_K101_N0.5680.12
74_L263_G0.5660.12
56_V291_K0.5650.12
13_T244_K0.5650.12
161_E164_V0.5640.12
28_R96_V0.5630.12
176_I312_T0.5630.12
211_L291_K0.5630.12
38_V338_Y0.5620.12
336_Q342_I0.5620.12
36_F282_W0.5620.12
217_V225_A0.5600.12
112_R255_K0.5590.12
67_E157_V0.5540.12
213_I285_I0.5530.12
68_Y304_I0.5530.12
207_F284_Q0.5520.12
44_K80_R0.5510.12
71_R131_K0.5510.12
116_G360_L0.5480.12
160_A282_W0.5480.12
98_V288_S0.5470.12
113_V296_L0.5460.12
187_E317_I0.5460.12
9_I107_I0.5450.12
22_K255_K0.5440.12
106_D122_A0.5430.12
295_A299_Y0.5430.12
38_V200_L0.5430.12
363_I375_A0.5420.12
359_R367_K0.5420.12
8_K131_K0.5420.12
112_R184_K0.5410.12
91_A123_V0.5400.12
77_I137_L0.5400.12
148_L184_K0.5370.12
39_E284_Q0.5370.12
19_G257_V0.5360.12
42_F81_I0.5360.12
249_E311_D0.5360.12
24_L343_E0.5350.12
213_I223_V0.5340.12
47_W225_A0.5320.12
160_A227_V0.5290.12
30_R54_I0.5280.12
176_I225_A0.5260.12
3_E148_L0.5260.12
44_K163_K0.5240.12
108_V158_Y0.5240.12
108_V149_K0.5240.12
117_D220_K0.5240.12
320_Q327_G0.5240.12
72_N319_V0.5240.12
226_A291_K0.5220.12
176_I340_G0.5210.12
230_K234_T0.5210.12
126_T358_G0.5210.12
236_S317_I0.5190.12
6_V299_Y0.5190.12
93_H110_A0.5190.12
155_I239_A0.5160.12
70_E121_T0.5160.12
154_G286_K0.5160.12
198_I368_E0.5150.11
238_A318_A0.5140.11
106_D223_V0.5140.11
49_R117_D0.5130.11
139_E202_K0.5100.11
295_A298_Q0.5100.11
39_E353_W0.5080.11
212_I245_N0.5060.11
123_V223_V0.5040.11
264_D283_G0.5040.11
3_E133_V0.5040.11
24_L308_A0.5040.11
23_V81_I0.5030.11
193_K229_L0.5010.11
188_E194_H0.5000.11
75_N257_V0.5000.11
6_V35_D0.5000.11
30_R348_K0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r89A 2 0.9879 100 0.39 Contact Map
4s3nA 1 0.6432 100 0.711 Contact Map
4xq7A 1 0.6068 100 0.716 Contact Map
1px5A 1 0.6117 100 0.718 Contact Map
4at7B 1 0.6408 100 0.725 Contact Map
4at7A 1 0.6675 100 0.776 Contact Map
2hhpA 1 0.9029 100 0.791 Contact Map
1q79A 1 0.8447 100 0.793 Contact Map
4zrlA 1 0.5631 100 0.826 Contact Map
4xj5A 1 0.6165 100 0.827 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0117 seconds.