GREMLIN Database
Q97Z91 - Uncharacterized protein
UniProt: Q97Z91 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 194 (171)
Sequences: 2312 (1788)
Seq/√Len: 136.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_G87_W3.7071.00
160_V175_K3.5331.00
42_L105_L3.4671.00
158_N178_E3.3731.00
67_F156_V3.3371.00
165_T174_D3.1901.00
8_E162_F3.0521.00
5_I59_M3.0391.00
116_E119_K3.0231.00
29_I128_G2.9961.00
75_G89_G2.8391.00
163_K174_D2.7591.00
55_V108_L2.7001.00
6_G162_F2.4701.00
163_K176_L2.4191.00
166_L171_P2.3851.00
5_I44_L2.3481.00
3_L47_V2.3371.00
7_I156_V2.2011.00
59_M104_I2.1001.00
5_I104_I2.0511.00
10_P154_F1.9791.00
68_K153_T1.9571.00
68_K155_E1.9481.00
159_V179_V1.9371.00
71_L88_V1.9171.00
70_T153_T1.8901.00
167_T170_G1.8641.00
15_L88_V1.8591.00
42_L115_P1.7871.00
60_S177_F1.7701.00
44_L108_L1.7651.00
101_R105_L1.7451.00
162_F175_K1.7411.00
19_F37_I1.7351.00
62_L159_V1.7101.00
64_F181_S1.6571.00
56_K177_F1.6551.00
77_F87_W1.6361.00
175_K178_E1.6021.00
32_V171_P1.5791.00
48_R51_R1.5701.00
3_L161_L1.5141.00
36_N173_Y1.5121.00
64_F103_Y1.4811.00
88_V127_I1.4571.00
105_L115_P1.4441.00
13_P34_P1.4441.00
41_L159_V1.4171.00
167_T172_I1.3861.00
9_V162_F1.3711.00
160_V178_E1.3451.00
36_N171_P1.2831.00
104_I108_L1.2411.00
29_I130_V1.2241.00
72_K92_E1.2091.00
33_E36_N1.2071.00
71_L125_L1.2071.00
129_R166_L1.1700.99
32_V129_R1.1540.99
59_M159_V1.1450.99
52_V56_K1.1340.99
3_L44_L1.1310.99
31_L128_G1.1310.99
83_P130_V1.1060.99
51_R54_E1.0820.99
109_L115_P1.0730.99
44_L47_V1.0620.99
9_V154_F1.0570.99
77_F89_G1.0560.99
44_L113_I1.0180.98
42_L101_R1.0100.98
101_R123_P0.9990.98
8_E160_V0.9960.98
18_I22_V0.9930.98
107_E111_R0.9860.98
59_M161_L0.9780.98
56_K179_V0.9760.98
166_L173_Y0.9710.98
86_V128_G0.9520.98
39_I90_I0.9300.97
44_L104_I0.9270.97
161_L179_V0.9260.97
41_L100_I0.9240.97
78_P84_R0.9180.97
93_G96_Q0.9070.97
78_P83_P0.9020.97
36_N164_S0.9000.97
7_I41_L0.8870.96
108_L111_R0.8720.96
129_R164_S0.8690.96
47_V51_R0.8680.96
17_E21_I0.8620.96
42_L104_I0.8550.96
32_V37_I0.8490.95
7_I97_L0.8480.95
31_L86_V0.8360.95
2_R43_F0.8340.95
14_K17_E0.8280.95
58_S104_I0.8230.95
3_L45_G0.8220.94
7_I67_F0.8200.94
19_F22_V0.8200.94
16_L19_F0.8200.94
177_F180_S0.8180.94
71_L90_I0.8100.94
158_N181_S0.8000.94
84_R130_V0.7960.93
55_V59_M0.7860.93
47_V52_V0.7800.93
42_L108_L0.7740.93
14_K152_G0.7740.93
113_I116_E0.7700.92
5_I159_V0.7630.92
53_E56_K0.7570.92
157_N180_S0.7560.92
2_R129_R0.7540.92
99_Q103_Y0.7470.91
59_M179_V0.7410.91
54_E110_K0.7400.91
15_L19_F0.7400.91
125_L128_G0.7380.91
30_K131_K0.7280.90
5_I55_V0.7230.90
43_F129_R0.7210.90
98_R123_P0.7120.89
78_P85_V0.7090.89
5_I161_L0.7050.89
46_E166_L0.7040.89
11_Q34_P0.7010.88
2_R46_E0.6960.88
69_V97_L0.6930.88
30_K129_R0.6900.88
71_L154_F0.6900.88
58_S107_E0.6880.87
167_T171_P0.6870.87
166_L170_G0.6870.87
61_G107_E0.6850.87
18_I21_I0.6840.87
93_G98_R0.6830.87
101_R120_D0.6800.87
2_R164_S0.6780.87
29_I131_K0.6740.86
48_R52_V0.6740.86
107_E110_K0.6720.86
58_S108_L0.6710.86
69_V90_I0.6700.86
42_L113_I0.6670.86
7_I159_V0.6670.86
141_N145_E0.6670.86
67_F100_I0.6670.86
85_V129_R0.6630.85
33_E170_G0.6600.85
39_I125_L0.6570.85
101_R121_F0.6550.85
62_L103_Y0.6540.85
16_L34_P0.6520.84
41_L101_R0.6510.84
129_R171_P0.6480.84
108_L114_R0.6410.83
5_I179_V0.6400.83
71_L151_I0.6380.83
131_K164_S0.6380.83
158_N180_S0.6370.83
60_S179_V0.6320.83
47_V55_V0.6300.82
29_I125_L0.6280.82
9_V125_L0.6270.82
56_K59_M0.6270.82
156_V159_V0.6260.82
14_K149_V0.6230.82
8_E175_K0.6200.81
44_L55_V0.6170.81
67_F97_L0.6150.81
129_R170_G0.6140.81
95_Q98_R0.6070.80
56_K60_S0.6070.80
131_K172_I0.6060.80
130_V139_L0.6030.80
98_R102_S0.6030.80
29_I36_N0.6020.79
32_V36_N0.6000.79
76_A139_L0.6000.79
57_D145_E0.5970.79
13_P16_L0.5960.79
15_L18_I0.5950.79
28_D134_N0.5900.78
7_I154_F0.5890.78
65_N96_Q0.5880.78
17_E145_E0.5880.78
27_A128_G0.5870.78
28_D164_S0.5860.78
103_Y107_E0.5840.77
30_K33_E0.5820.77
92_E95_Q0.5820.77
73_G152_G0.5800.77
101_R108_L0.5770.77
50_D65_N0.5760.76
64_F99_Q0.5730.76
15_L122_S0.5710.76
72_K150_D0.5700.76
131_K170_G0.5650.75
16_L20_E0.5640.75
19_F23_K0.5630.75
59_M62_L0.5600.74
41_L97_L0.5590.74
25_A139_L0.5590.74
5_I42_L0.5590.74
57_D180_S0.5540.74
130_V171_P0.5520.73
72_K151_I0.5500.73
104_I107_E0.5500.73
32_V126_T0.5460.73
50_D54_E0.5440.72
75_G134_N0.5420.72
61_G110_K0.5420.72
3_L176_L0.5410.72
69_V154_F0.5400.72
58_S111_R0.5390.72
47_V113_I0.5380.71
62_L107_E0.5370.71
12_S152_G0.5360.71
72_K95_Q0.5350.71
51_R113_I0.5350.71
6_G9_V0.5340.71
41_L104_I0.5320.71
46_E120_D0.5310.70
3_L52_V0.5300.70
121_F171_P0.5290.70
11_Q145_E0.5280.70
105_L108_L0.5260.70
95_Q99_Q0.5250.70
29_I135_S0.5250.70
32_V83_P0.5240.69
46_E84_R0.5240.69
168_P171_P0.5230.69
44_L179_V0.5220.69
90_I94_Q0.5210.69
72_K88_V0.5200.69
72_K148_N0.5170.68
90_I152_G0.5170.68
69_V94_Q0.5160.68
48_R54_E0.5140.68
58_S110_K0.5130.68
19_F164_S0.5130.68
165_T172_I0.5100.67
86_V125_L0.5100.67
127_I133_Y0.5090.67
49_E53_E0.5080.67
106_N109_L0.5060.67
129_R165_T0.5040.66
164_S172_I0.5040.66
32_V172_I0.5020.66
50_D109_L0.5010.66
29_I78_P0.5010.66
97_L156_V0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vgjA 1 0.9278 100 0.264 Contact Map
1iuhA 1 0.8969 100 0.294 Contact Map
4qakA 1 0.8763 100 0.297 Contact Map
3j4qA 1 0.9742 100 0.314 Contact Map
2vfkA 1 0.9278 100 0.348 Contact Map
4h7wA 1 0.8711 100 0.409 Contact Map
2d4gA 2 0.8402 100 0.419 Contact Map
1jh6A 5 0.8763 100 0.429 Contact Map
2fsqA 1 0.8557 97.7 0.833 Contact Map
2ivyA 2 0.3608 41.1 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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