GREMLIN Database
Y1041 - UPF0200 protein SSO1041
UniProt: Q97Z90 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 188 (171)
Sequences: 6332 (3851)
Seq/√Len: 294.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_R65_E3.8321.00
119_P149_L3.4061.00
57_M61_K2.8461.00
30_E178_E2.8381.00
42_V72_V2.6251.00
116_H163_I2.5561.00
59_F68_G2.4921.00
26_K174_K2.4401.00
168_S176_R2.4401.00
44_K48_I2.4131.00
158_A163_I2.1641.00
146_R150_K2.1481.00
73_A93_V2.1001.00
168_S172_E2.0531.00
114_A163_I2.0111.00
45_R78_E1.9641.00
46_Y60_A1.8701.00
103_K106_L1.8661.00
126_M141_L1.8611.00
134_D137_E1.8541.00
121_I124_K1.8191.00
55_R58_D1.8021.00
30_E174_K1.7791.00
115_V166_N1.7781.00
162_Y180_V1.7741.00
118_P167_D1.7711.00
58_D62_R1.7621.00
111_Y162_Y1.7601.00
79_E83_S1.7441.00
169_N172_E1.7331.00
73_A101_E1.7241.00
138_I142_I1.7151.00
49_E54_E1.6851.00
123_Y142_I1.6851.00
79_E82_T1.6711.00
26_K171_E1.6571.00
31_R178_E1.6401.00
51_K55_R1.5781.00
51_K54_E1.5661.00
121_I167_D1.5241.00
55_R74_R1.5031.00
143_R146_R1.5021.00
19_S117_S1.4661.00
151_L155_E1.4361.00
65_E143_R1.4351.00
77_V105_L1.4121.00
174_K178_E1.4041.00
114_A154_G1.3671.00
24_F177_C1.3391.00
155_E159_M1.3341.00
77_V81_G1.3271.00
13_I25_A1.3231.00
128_E131_R1.3101.00
137_E140_E1.3071.00
103_K160_A1.2991.00
77_V104_R1.2931.00
45_R50_A1.2751.00
26_K29_K1.2551.00
127_I138_I1.2501.00
81_G105_L1.2211.00
156_V160_A1.2061.00
59_F65_E1.1891.00
175_R179_E1.1881.00
172_E176_R1.1821.00
18_G126_M1.1701.00
74_R77_V1.1561.00
115_V177_C1.1501.00
168_S173_F1.1431.00
117_S166_N1.1431.00
119_P142_I1.1371.00
97_A100_E1.1371.00
45_R75_L1.1241.00
50_A53_G1.1131.00
175_R178_E1.1121.00
45_R48_I1.1111.00
155_E158_A1.1041.00
145_D149_L1.0851.00
14_T154_G1.0851.00
96_L100_E1.0681.00
34_K79_E1.0661.00
143_R147_E1.0601.00
49_E57_M1.0551.00
68_G71_V1.0501.00
34_K84_N1.0481.00
16_M148_E1.0451.00
165_T168_S1.0261.00
119_P146_R1.0191.00
56_L59_F1.0141.00
120_K124_K1.0131.00
39_S43_R1.0091.00
10_V88_V1.0091.00
176_R179_E1.0071.00
10_V110_V1.0021.00
36_I79_E0.9971.00
13_I27_L0.9921.00
127_I130_L0.9841.00
69_D95_S0.9651.00
56_L60_A0.9621.00
123_Y138_I0.9551.00
12_L109_S0.9551.00
119_P145_D0.9541.00
22_S91_D0.9371.00
55_R70_G0.9351.00
78_E82_T0.9321.00
58_D61_K0.9261.00
172_E175_R0.9261.00
14_T112_I0.9071.00
54_E57_M0.9041.00
99_V156_V0.9021.00
16_M122_R0.8761.00
41_V75_L0.8711.00
24_F174_K0.8711.00
113_V177_C0.8671.00
70_G74_R0.8521.00
127_I137_E0.8461.00
28_L35_V0.8411.00
140_E143_R0.8401.00
73_A76_C0.8381.00
44_K79_E0.8371.00
69_D98_E0.8341.00
103_K108_D0.8331.00
132_S135_S0.8241.00
33_A88_V0.8221.00
72_V76_C0.8161.00
165_T176_R0.8141.00
69_D97_A0.8121.00
55_R59_F0.8111.00
54_E58_D0.8081.00
116_H154_G0.8081.00
52_P74_R0.8061.00
165_T173_F0.8011.00
20_G23_E0.7990.99
153_I157_I0.7870.99
130_L133_D0.7810.99
103_K157_I0.7800.99
71_V74_R0.7690.99
170_Y174_K0.7630.99
13_I89_V0.7590.99
123_Y127_I0.7590.99
88_V109_S0.7590.99
25_A35_V0.7580.99
33_A87_L0.7560.99
32_G86_D0.7500.99
13_I113_V0.7490.99
164_I173_F0.7440.99
46_Y57_M0.7430.99
39_S94_R0.7410.99
127_I132_S0.7360.99
37_V40_D0.7360.99
41_V45_R0.7200.99
56_L75_L0.7120.99
42_V76_C0.7060.99
44_K82_T0.7040.99
13_I115_V0.7030.99
11_I111_Y0.7020.99
99_V157_I0.7020.99
176_R180_V0.7000.99
16_M19_S0.6970.99
56_L74_R0.6970.99
133_D136_K0.6930.99
99_V102_F0.6900.99
164_I180_V0.6890.99
27_L89_V0.6860.98
102_F106_L0.6850.98
127_I131_R0.6710.98
46_Y49_E0.6690.98
38_M76_C0.6690.98
142_I146_R0.6690.98
131_R134_D0.6690.98
12_L112_I0.6600.98
103_K156_V0.6580.98
78_E81_G0.6560.98
15_G19_S0.6520.98
20_G125_R0.6520.98
100_E156_V0.6520.98
42_V56_L0.6510.98
124_K128_E0.6440.98
111_Y181_T0.6430.98
48_I82_T0.6410.98
120_K142_I0.6400.98
34_K83_S0.6380.98
111_Y180_V0.6360.97
117_S122_R0.6320.97
31_R174_K0.6290.97
45_R56_L0.6260.97
28_L34_K0.6250.97
36_I41_V0.6240.97
42_V46_Y0.6240.97
28_L89_V0.6230.97
26_K30_E0.6210.97
136_K145_D0.6180.97
42_V60_A0.6150.97
167_D173_F0.6120.97
96_L156_V0.6100.97
46_Y53_G0.6070.97
24_F173_F0.6030.97
80_L84_N0.5990.96
120_K123_Y0.5980.96
171_E175_R0.5950.96
10_V109_S0.5940.96
52_P55_R0.5920.96
147_E150_K0.5910.96
41_V79_E0.5910.96
118_P121_I0.5900.96
59_F71_V0.5880.96
136_K140_E0.5860.96
52_P78_E0.5850.96
67_Y72_V0.5830.96
79_E84_N0.5800.96
18_G141_L0.5800.96
17_P140_E0.5790.96
79_E87_L0.5740.95
158_A161_D0.5730.95
13_I28_L0.5720.95
98_E102_F0.5700.95
66_I94_R0.5700.95
10_V107_G0.5690.95
27_L177_C0.5630.95
45_R53_G0.5610.95
152_G155_E0.5560.95
95_S98_E0.5560.95
24_F125_R0.5560.95
132_S137_E0.5550.95
95_S102_F0.5510.94
129_R136_K0.5510.94
10_V76_C0.5470.94
35_V40_D0.5440.94
146_R149_L0.5410.94
55_R71_V0.5400.94
16_M89_V0.5370.94
61_K134_D0.5370.94
96_L153_I0.5360.93
102_F109_S0.5340.93
23_E125_R0.5330.93
129_R144_R0.5320.93
65_E68_G0.5310.93
100_E103_K0.5310.93
11_I181_T0.5260.93
17_P122_R0.5260.93
139_S143_R0.5250.93
116_H165_T0.5240.93
69_D101_E0.5240.93
15_G18_G0.5230.93
100_E155_E0.5200.92
123_Y141_L0.5200.92
113_V162_Y0.5170.92
84_N87_L0.5140.92
105_L108_D0.5140.92
42_V67_Y0.5080.92
10_V102_F0.5070.91
34_K87_L0.5070.91
49_E53_G0.5050.91
25_A28_L0.5020.91
128_E132_S0.5020.91
96_L99_V0.5010.91
119_P123_Y0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gmtA 1 0.8351 99.9 0.428 Contact Map
4qbgB 1 0.9415 99.9 0.444 Contact Map
2c95A 1 0.984 99.9 0.45 Contact Map
1ukzA 1 0.9787 99.9 0.454 Contact Map
1zakA 2 0.9681 99.9 0.454 Contact Map
4jzkA 1 0.9202 99.9 0.455 Contact Map
3be4A 1 0.9309 99.9 0.457 Contact Map
4pzlA 2 0.9681 99.9 0.458 Contact Map
1akyA 1 0.9415 99.9 0.461 Contact Map
3tlxA 1 0.9681 99.9 0.462 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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