GREMLIN Database
RNZ - Ribonuclease Z
UniProt: Q97Z88 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 291 (286)
Sequences: 2364 (1655)
Seq/√Len: 97.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_Y116_I4.3671.00
168_K173_K3.9181.00
197_A215_V3.4531.00
95_K99_Y3.4151.00
120_N145_K3.2821.00
96_D103_E3.1041.00
127_S143_M3.0901.00
216_D251_K2.6881.00
214_G249_S2.6111.00
226_D239_T2.6061.00
30_V55_K2.5751.00
132_C203_M2.5241.00
85_T112_K2.4111.00
252_L280_I2.3951.00
87_Y114_E2.3571.00
141_L195_K2.3291.00
195_K215_V2.2651.00
174_T184_P2.2481.00
144_E194_S2.2321.00
239_T274_R2.2231.00
158_E187_Y2.2171.00
224_F233_Y2.1581.00
34_L142_I2.0991.00
39_G42_Y2.0871.00
97_F101_S2.0731.00
125_T143_M2.0571.00
74_I86_L2.0531.00
242_A275_I2.0051.00
143_M195_K1.9941.00
243_K247_E1.9801.00
254_A282_P1.9681.00
182_L187_Y1.9531.00
210_D213_K1.9301.00
24_L33_L1.9281.00
22_A33_L1.9241.00
167_R171_E1.9041.00
269_L273_R1.8691.00
93_K117_D1.8581.00
43_T46_N1.8521.00
4_I219_I1.8431.00
174_T183_K1.8421.00
89_L116_I1.8361.00
283_D286_S1.8231.00
3_Q26_R1.8091.00
58_G126_I1.7971.00
71_L101_S1.7871.00
280_I286_S1.7841.00
254_A288_I1.7751.00
85_T114_E1.7711.00
183_K186_D1.7701.00
220_H236_S1.7471.00
23_F256_T1.7171.00
10_G15_S1.7071.00
154_K157_K1.7041.00
47_Y285_L1.7021.00
203_M240_D1.6991.00
24_L31_N1.6991.00
282_P286_S1.6711.00
177_Y180_K1.6601.00
120_N125_T1.6471.00
56_I89_L1.6231.00
3_Q287_Y1.6071.00
151_D154_K1.6051.00
78_G110_S1.5911.00
197_A212_V1.5711.00
176_E181_L1.5571.00
4_I25_V1.5511.00
213_K249_S1.5451.00
209_V247_E1.5281.00
24_L49_L1.5251.00
222_S255_L1.5161.00
270_K273_R1.5091.00
239_T275_I1.5021.00
3_Q289_T1.4981.00
269_L281_L1.4921.00
22_A40_T1.4811.00
6_F9_T1.4681.00
209_V244_I1.4571.00
54_I73_V1.4121.00
212_V248_A1.4111.00
207_S210_D1.4051.00
19_K42_Y1.3670.99
64_G68_F1.3640.99
129_F211_S1.3350.99
139_G199_T1.3200.99
131_T139_G1.3130.99
25_V142_I1.3070.99
57_I70_L1.3060.99
43_T285_L1.2970.99
172_G184_P1.2940.99
5_F287_Y1.2930.99
184_P188_L1.2920.99
273_R279_S1.2840.99
255_L272_A1.2690.99
32_I124_I1.2570.99
226_D271_M1.2320.99
227_E271_M1.2280.99
150_I155_L1.2240.99
209_V248_A1.2230.99
265_V281_L1.2210.99
95_K115_F1.2160.99
56_I87_Y1.2130.99
238_V242_A1.2040.98
169_L187_Y1.2020.98
21_P256_T1.1900.98
152_E156_E1.1870.98
60_S140_Y1.1840.98
266_S269_L1.1820.98
75_A107_F1.1760.98
280_I288_I1.1720.98
243_K246_L1.1710.98
245_A253_L1.1690.98
88_I98_L1.1630.98
212_V215_V1.1580.98
134_T234_G1.1570.98
34_L58_G1.1550.98
238_V271_M1.1540.98
131_T199_T1.1530.98
225_L268_H1.1400.98
57_I73_V1.1190.97
6_F282_P1.1150.97
237_N241_A1.1150.97
141_L215_V1.1130.97
206_Q247_E1.1130.97
267_E270_K1.1110.97
132_C234_G1.1070.97
160_I166_I1.1050.97
266_S270_K1.1020.97
218_L250_V1.0900.97
176_E179_G1.0890.97
184_P187_Y1.0610.97
228_P232_T1.0610.97
90_G94_L1.0560.96
151_D189_V1.0470.96
95_K117_D1.0470.96
131_T137_S1.0370.96
32_I142_I1.0370.96
141_L197_A1.0360.96
239_T243_K1.0290.96
61_H66_H1.0220.96
252_L278_K1.0160.96
9_T18_R1.0090.95
239_T271_M1.0070.95
19_K40_T0.9960.95
125_T145_K0.9930.95
21_P198_Y0.9880.95
203_M234_G0.9880.95
98_L115_F0.9770.95
231_Y240_D0.9740.94
99_Y103_E0.9740.94
207_S211_S0.9650.94
6_F23_F0.9620.94
41_Q72_G0.9610.94
269_L279_S0.9560.94
88_I94_L0.9520.94
169_L172_G0.9510.94
51_I54_I0.9480.94
204_P240_D0.9480.94
217_I254_A0.9440.93
64_G223_T0.9420.93
146_D193_G0.9270.93
58_G89_L0.9220.93
4_I217_I0.9170.92
199_T208_V0.9130.92
31_N54_I0.9130.92
246_L275_I0.9060.92
204_P244_I0.8990.92
63_H66_H0.8940.91
79_L82_R0.8900.91
130_K136_E0.8830.91
153_E157_K0.8820.91
130_K138_Q0.8780.91
59_I94_L0.8740.91
230_A237_N0.8720.90
168_K172_G0.8720.90
214_G251_K0.8700.90
229_S233_Y0.8680.90
183_K187_Y0.8670.90
208_V244_I0.8660.90
258_I281_L0.8660.90
217_I252_L0.8650.90
174_T181_L0.8600.90
98_L102_F0.8600.90
240_D243_K0.8570.90
215_V250_V0.8460.89
17_K263_E0.8390.89
258_I265_V0.8380.89
61_H65_D0.8350.88
146_D192_R0.8320.88
66_H201_D0.8320.88
270_K274_R0.8280.88
16_K46_N0.8280.88
173_K184_P0.8220.88
10_G18_R0.8180.87
60_S200_G0.8120.87
273_R278_K0.8080.87
106_K136_E0.8060.87
165_V168_K0.8040.86
68_F75_A0.8030.86
70_L74_I0.7970.86
158_E186_D0.7950.86
222_S238_V0.7950.86
226_D238_V0.7930.86
129_F141_L0.7910.86
152_E166_I0.7870.85
154_K158_E0.7850.85
213_K247_E0.7830.85
164_R168_K0.7820.85
118_N140_Y0.7800.85
101_S105_S0.7760.84
25_V32_I0.7740.84
254_A280_I0.7710.84
195_K216_D0.7710.84
55_K84_E0.7710.84
169_L175_V0.7700.84
149_K189_V0.7660.84
154_K186_D0.7660.84
258_I282_P0.7650.84
238_V272_A0.7640.84
51_I73_V0.7630.83
30_V121_D0.7630.83
198_Y219_I0.7570.83
150_I170_K0.7530.83
172_G175_V0.7510.82
165_V175_V0.7500.82
209_V213_K0.7500.82
5_F47_Y0.7460.82
242_A276_F0.7440.82
214_G250_V0.7370.81
33_L54_I0.7370.81
155_L187_Y0.7360.81
67_V71_L0.7320.81
219_I256_T0.7310.81
9_T282_P0.7310.81
222_S268_H0.7310.81
265_V268_H0.7290.81
160_I169_L0.7270.80
283_D288_I0.7260.80
38_E41_Q0.7250.80
33_L44_L0.7250.80
241_A250_V0.7210.80
36_C40_T0.7210.80
200_G236_S0.7210.80
63_H201_D0.7170.79
208_V212_V0.7150.79
44_L49_L0.7120.79
68_F105_S0.7110.79
200_G220_H0.7100.79
44_L54_I0.7090.79
163_W167_R0.7080.79
82_R111_F0.7080.79
99_Y115_F0.7070.79
158_E182_L0.7050.78
19_K43_T0.7050.78
228_P231_Y0.7050.78
68_F107_F0.7010.78
61_H201_D0.6990.78
266_S283_D0.6980.78
97_F105_S0.6950.77
5_F49_L0.6890.77
90_G93_K0.6890.77
177_Y182_L0.6870.77
102_F107_F0.6870.77
92_R117_D0.6870.77
161_R165_V0.6850.76
62_M94_L0.6840.76
25_V34_L0.6830.76
60_S199_T0.6830.76
280_I283_D0.6820.76
10_G260_P0.6800.76
160_I165_V0.6790.76
82_R86_L0.6780.76
153_E156_E0.6770.75
226_D267_E0.6760.75
74_I111_F0.6760.75
129_F210_D0.6740.75
73_V76_S0.6740.75
12_G20_L0.6730.75
174_T185_E0.6710.75
206_Q209_V0.6660.74
133_H140_Y0.6640.74
182_L186_D0.6630.74
276_F279_S0.6620.74
4_I254_A0.6600.74
123_N145_K0.6590.74
11_A21_P0.6590.74
74_I107_F0.6590.74
137_S140_Y0.6580.73
118_N138_Q0.6560.73
137_S200_G0.6540.73
100_T104_Y0.6490.72
229_S232_T0.6480.72
252_L288_I0.6470.72
180_K186_D0.6450.72
67_V105_S0.6450.72
205_C211_S0.6430.72
225_L238_V0.6420.72
59_I70_L0.6420.72
33_L40_T0.6390.71
218_L244_I0.6370.71
30_V124_I0.6340.71
127_S211_S0.6260.70
272_A276_F0.6260.70
176_E249_S0.6250.70
121_D145_K0.6220.69
159_K163_W0.6220.69
36_C59_I0.6200.69
32_I58_G0.6190.69
242_A245_A0.6190.69
106_K135_I0.6160.68
252_L289_T0.6160.68
258_I284_D0.6150.68
26_R31_N0.6130.68
66_H221_D0.6110.68
60_S198_Y0.6100.68
222_S258_I0.6100.68
205_C212_V0.6080.67
77_M111_F0.6070.67
169_L184_P0.6050.67
171_E192_R0.6050.67
172_G182_L0.6050.67
25_V196_V0.6040.67
90_G117_D0.6040.67
59_I88_I0.6040.67
156_E207_S0.6020.67
201_D257_H0.6010.67
256_T282_P0.6010.67
271_M274_R0.6000.66
273_R280_I0.5990.66
12_G260_P0.5980.66
11_A258_I0.5980.66
161_R166_I0.5970.66
174_T188_L0.5950.66
237_N245_A0.5950.66
168_K175_V0.5920.65
17_K22_A0.5910.65
62_M97_F0.5870.65
129_F139_G0.5860.65
242_A248_A0.5830.64
246_L277_P0.5820.64
247_E275_I0.5810.64
128_T138_Q0.5800.64
12_G223_T0.5790.64
26_R29_G0.5780.64
273_R277_P0.5780.64
206_Q210_D0.5770.63
253_L272_A0.5730.63
154_K187_Y0.5720.63
129_F208_V0.5700.63
18_R284_D0.5700.63
139_G208_V0.5640.62
238_V268_H0.5640.62
222_S282_P0.5640.62
35_D65_D0.5630.62
94_L101_S0.5620.61
213_K248_A0.5620.61
66_H257_H0.5600.61
96_D99_Y0.5580.61
204_P247_E0.5580.61
177_Y181_L0.5580.61
11_A20_L0.5570.61
119_Y124_I0.5560.61
264_D267_E0.5540.60
22_A36_C0.5530.60
181_L231_Y0.5520.60
209_V243_K0.5520.60
54_I57_I0.5520.60
91_P140_Y0.5510.60
167_R175_V0.5510.60
200_G223_T0.5500.60
10_G79_L0.5500.60
131_T208_V0.5490.60
204_P248_A0.5460.59
38_E72_G0.5440.59
6_F254_A0.5440.59
208_V211_S0.5440.59
4_I283_D0.5440.59
43_T47_Y0.5430.59
119_Y164_R0.5420.59
202_T241_A0.5420.59
86_L110_S0.5420.59
220_H244_I0.5410.59
143_M146_D0.5400.58
90_G101_S0.5380.58
94_L98_L0.5370.58
131_T200_G0.5370.58
61_H257_H0.5360.58
59_I62_M0.5360.58
9_T284_D0.5340.58
104_Y107_F0.5340.58
70_L88_I0.5330.57
169_L183_K0.5310.57
129_F140_Y0.5300.57
275_I279_S0.5290.57
243_K275_I0.5290.57
121_D124_I0.5250.56
170_K191_K0.5240.56
199_T220_H0.5240.56
259_S262_Y0.5230.56
141_L212_V0.5230.56
197_A211_S0.5230.56
71_L160_I0.5220.56
119_Y126_I0.5220.56
213_K270_K0.5220.56
156_E161_R0.5210.56
227_E267_E0.5200.56
202_T205_C0.5190.55
242_A272_A0.5170.55
123_N147_R0.5160.55
88_I93_K0.5160.55
10_G16_K0.5150.55
222_S272_A0.5100.54
274_R277_P0.5090.54
35_D61_H0.5080.54
158_E180_K0.5080.54
201_D235_H0.5060.54
32_I56_I0.5040.53
203_M231_Y0.5040.53
196_V215_V0.5040.53
44_L47_Y0.5040.53
194_S272_A0.5030.53
245_A276_F0.5030.53
164_R167_R0.5030.53
205_C208_V0.5020.53
212_V218_L0.5010.53
66_H235_H0.5010.53
220_H241_A0.5010.53
205_C210_D0.5010.53
64_G75_A0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zwfA 2 0.7835 100 0.32 Contact Map
2cbnA 2 0.9966 100 0.376 Contact Map
1y44A 2 0.9966 100 0.391 Contact Map
2e7yA 2 0.8729 100 0.537 Contact Map
1zkpA 2 0.8247 100 0.569 Contact Map
3jxpA 2 0.8557 100 0.581 Contact Map
3g1pA 2 0.7766 100 0.595 Contact Map
4ojvA 2 0.8351 100 0.603 Contact Map
3md7A 2 0.7835 100 0.615 Contact Map
3bk2A 2 0.8041 100 0.681 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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