GREMLIN Database
Q97Z87 - Uncharacterized protein
UniProt: Q97Z87 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 314 (268)
Sequences: 2990 (2138)
Seq/√Len: 130.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
181_L193_G5.0861.00
208_L217_L4.5141.00
7_A41_F3.5501.00
208_L213_Y3.2031.00
64_I123_V3.1391.00
69_K73_E2.9391.00
95_L99_N2.7911.00
23_A162_N2.6841.00
148_Q200_M2.6321.00
9_L17_S2.6141.00
171_L194_S2.5861.00
67_D70_K2.5451.00
231_T269_G2.4881.00
160_L180_I2.4021.00
94_K117_I2.3661.00
6_Y38_V2.3411.00
201_L217_L2.2971.00
31_E42_E2.2551.00
162_N187_L2.1841.00
98_I115_I2.1681.00
201_L219_F2.1201.00
221_S224_N2.1161.00
49_A130_K2.0791.00
152_M274_A2.0601.00
194_S220_S2.0241.00
145_P210_Y2.0051.00
18_L22_R1.9951.00
41_F48_I1.9911.00
4_T42_E1.9781.00
261_A271_L1.9481.00
181_L191_C1.8911.00
52_S55_I1.8881.00
21_L26_N1.8811.00
16_L54_R1.8531.00
61_L64_I1.8421.00
171_L225_L1.8051.00
164_S232_S1.7931.00
7_A58_S1.7811.00
65_S74_M1.7611.00
208_L215_C1.7411.00
115_I126_L1.7211.00
117_I124_I1.7111.00
161_V164_S1.6961.00
136_K140_E1.6781.00
66_D70_K1.6741.00
59_G127_G1.6611.00
170_V234_A1.6601.00
72_N100_Y1.6571.00
75_L94_K1.6431.00
174_F235_T1.6311.00
119_L124_I1.6301.00
260_S264_T1.6251.00
48_I52_S1.5991.00
204_T217_L1.5801.00
170_V181_L1.5581.00
257_F261_A1.5541.00
245_N249_E1.5491.00
198_K219_F1.5451.00
5_S45_K1.5391.00
209_N214_Y1.5181.00
97_A101_E1.4801.00
45_K49_A1.4751.00
96_N99_N1.4531.00
223_T256_E1.4361.00
48_I58_S1.4361.00
54_R162_N1.4281.00
61_L125_I1.4201.00
194_S225_L1.4121.00
89_G93_D1.3891.00
193_G204_T1.3621.00
83_K114_K1.3431.00
166_P170_V1.3381.00
97_A100_Y1.3381.00
146_F206_I1.3371.00
88_M91_Q1.3181.00
84_E91_Q1.3091.00
117_I126_L1.3081.00
190_E216_S1.2961.00
164_S272_V1.2891.00
254_Y275_T1.2831.00
75_L126_L1.2771.00
19_A22_R1.2691.00
96_N100_Y1.2671.00
5_S43_G1.2541.00
4_T61_L1.2481.00
89_G92_K1.2481.00
235_T257_F1.2311.00
84_E89_G1.2301.00
222_A260_S1.2291.00
146_F203_K1.2291.00
10_K155_E1.2241.00
173_P235_T1.2191.00
57_R129_I1.2181.00
81_W84_E1.2141.00
99_N102_I1.2040.99
13_N159_L1.1980.99
94_K126_L1.1870.99
15_F19_A1.1820.99
60_E130_K1.1810.99
95_L100_Y1.1770.99
265_L269_G1.1610.99
18_L34_Y1.1540.99
170_V180_I1.1480.99
53_A57_R1.1470.99
181_L217_L1.1400.99
169_E232_S1.1360.99
148_Q203_K1.1310.99
160_L234_A1.1300.99
85_D88_M1.1100.99
17_S55_I1.0960.99
260_S263_E1.0960.99
161_V180_I1.0950.99
61_L127_G1.0950.99
81_W108_V1.0930.99
79_C105_G1.0910.99
160_L274_A1.0890.99
79_C112_C1.0820.99
202_Q205_K1.0800.99
170_V184_A1.0790.99
200_M203_K1.0770.99
259_S263_E1.0730.99
107_K111_E1.0690.99
206_I209_N1.0670.99
7_A21_L1.0650.99
195_D201_L1.0580.99
50_N53_A1.0560.99
82_I91_Q1.0310.98
175_V204_T1.0210.98
49_A58_S1.0200.98
19_A23_A1.0090.98
7_A48_I0.9990.98
49_A131_G0.9980.98
40_I61_L0.9950.98
4_T40_I0.9910.98
82_I90_S0.9900.98
222_A257_F0.9880.98
55_I58_S0.9870.98
78_G82_I0.9860.98
53_A58_S0.9860.98
196_L221_S0.9830.98
186_W213_Y0.9740.98
86_V89_G0.9720.98
45_K130_K0.9700.98
269_G275_T0.9700.98
60_E128_K0.9680.98
94_K99_N0.9620.97
70_K74_M0.9620.97
256_E259_S0.9590.97
246_K251_T0.9510.97
80_F93_D0.9470.97
131_G135_S0.9380.97
129_I135_S0.9360.97
269_G273_F0.9280.97
97_A102_I0.9220.97
52_S56_K0.9210.97
52_S58_S0.9200.97
19_A165_R0.9190.97
17_S162_N0.9130.96
161_V170_V0.9100.96
15_F34_Y0.9000.96
35_F38_V0.8950.96
135_S138_L0.8870.96
151_T177_T0.8860.96
95_L101_E0.8860.96
16_L163_L0.8830.96
161_V232_S0.8790.96
116_D127_G0.8770.96
94_K98_I0.8770.96
77_G90_S0.8750.96
269_G277_S0.8710.95
86_V91_Q0.8610.95
206_I210_Y0.8580.95
84_E90_S0.8580.95
250_L254_Y0.8570.95
84_E88_M0.8550.95
161_V184_A0.8550.95
171_L192_I0.8520.95
150_G242_S0.8510.95
19_A162_N0.8500.95
94_K97_A0.8490.95
138_L141_H0.8460.95
17_S54_R0.8450.95
84_E92_K0.8400.94
145_P206_I0.8370.94
160_L276_D0.8360.94
72_N97_A0.8350.94
77_G82_I0.8300.94
65_S124_I0.8300.94
261_A265_L0.8270.94
84_E93_D0.8250.94
161_V234_A0.8250.94
230_I268_G0.8240.94
68_P72_N0.8240.94
27_D31_E0.8210.94
185_R191_C0.8200.94
100_Y104_R0.8150.93
96_N101_E0.8120.93
195_D200_M0.8120.93
96_N102_I0.8090.93
6_Y127_G0.8040.93
88_M92_K0.8000.93
90_S93_D0.7930.93
16_L19_A0.7920.93
22_R27_D0.7910.92
272_V275_T0.7910.92
147_S203_K0.7890.92
64_I125_I0.7880.92
172_D176_G0.7880.92
220_S226_P0.7880.92
80_F85_D0.7870.92
233_I261_A0.7850.92
45_K60_E0.7830.92
225_L260_S0.7810.92
82_I93_D0.7800.92
195_D220_S0.7770.92
81_W111_E0.7730.92
46_G49_A0.7730.92
235_T273_F0.7710.91
137_S141_H0.7680.91
192_I216_S0.7660.91
47_D50_N0.7630.91
5_S41_F0.7630.91
226_P263_E0.7580.91
78_G84_E0.7560.91
22_R32_I0.7470.90
77_G87_I0.7460.90
76_R103_K0.7380.90
79_C84_E0.7350.89
16_L162_N0.7330.89
45_K50_N0.7310.89
213_Y217_L0.7280.89
16_L159_L0.7270.89
20_E24_L0.7260.89
67_D72_N0.7250.89
85_D93_D0.7230.89
69_K72_N0.7190.88
5_S26_N0.7160.88
79_C91_Q0.7150.88
227_F264_T0.7130.88
270_F274_A0.7120.88
107_K110_K0.7060.87
99_N106_V0.7040.87
194_S218_L0.7030.87
51_R58_S0.7010.87
82_I85_D0.6940.87
257_F273_F0.6920.86
53_A56_K0.6920.86
79_C82_I0.6910.86
216_S220_S0.6910.86
4_T64_I0.6910.86
193_G215_C0.6890.86
82_I88_M0.6870.86
103_K106_V0.6820.86
7_A39_A0.6820.86
226_P264_T0.6800.85
80_F99_N0.6790.85
181_L215_C0.6790.85
33_N40_I0.6780.85
194_S222_A0.6750.85
185_R213_Y0.6730.85
150_G236_D0.6730.85
95_L102_I0.6710.85
205_K214_Y0.6690.85
81_W93_D0.6670.84
141_H186_W0.6670.84
79_C107_K0.6650.84
143_K182_I0.6620.84
78_G81_W0.6610.84
49_A52_S0.6600.84
201_L204_T0.6590.84
146_F199_A0.6580.84
169_E230_I0.6580.84
151_T154_P0.6570.83
52_S60_E0.6570.83
240_G244_K0.6560.83
244_K249_E0.6550.83
56_K153_N0.6550.83
233_I271_L0.6540.83
182_I211_F0.6520.83
45_K244_K0.6480.83
147_S200_M0.6460.82
249_E252_Q0.6430.82
51_R57_R0.6410.82
77_G80_F0.6410.82
82_I92_K0.6410.82
181_L208_L0.6400.82
268_G272_V0.6400.82
6_Y40_I0.6370.82
70_K73_E0.6370.82
252_Q256_E0.6360.81
262_S265_L0.6320.81
269_G272_V0.6300.81
52_S57_R0.6290.81
80_F102_I0.6270.81
131_G136_K0.6270.81
144_K182_I0.6270.81
35_F40_I0.6270.81
182_I213_Y0.6260.80
161_V166_P0.6250.80
56_K137_S0.6240.80
274_A277_S0.6230.80
88_M93_D0.6220.80
6_Y10_K0.6210.80
169_E189_Y0.6210.80
202_Q206_I0.6200.80
194_S216_S0.6200.80
47_D51_R0.6190.80
74_M124_I0.6160.79
66_D74_M0.6150.79
52_S65_S0.6140.79
166_P169_E0.6130.79
221_S256_E0.6100.79
170_V191_C0.6090.79
55_I65_S0.6070.78
59_G116_D0.6070.78
236_D243_T0.6050.78
80_F88_M0.6040.78
49_A57_R0.6010.78
220_S224_N0.6000.78
53_A60_E0.5980.77
172_D238_P0.5960.77
204_T215_C0.5950.77
175_V193_G0.5930.77
26_N44_N0.5900.76
159_L163_L0.5890.76
216_S219_F0.5890.76
149_S199_A0.5870.76
143_K158_R0.5870.76
174_F253_L0.5860.76
9_L137_S0.5850.76
139_H155_E0.5810.75
171_L227_F0.5810.75
78_G112_C0.5780.75
237_P243_T0.5770.75
157_S179_S0.5770.75
85_D118_I0.5760.75
83_K116_D0.5760.75
106_V111_E0.5730.74
56_K60_E0.5730.74
261_A264_T0.5730.74
201_L205_K0.5700.74
86_V93_D0.5700.74
144_K211_F0.5680.74
86_V92_K0.5670.74
6_Y11_G0.5660.73
77_G84_E0.5660.73
205_K216_S0.5600.73
72_N75_L0.5600.73
94_K102_I0.5590.72
253_L257_F0.5590.72
142_E154_P0.5590.72
202_Q216_S0.5590.72
52_S63_Y0.5510.71
166_P191_C0.5500.71
269_G274_A0.5500.71
117_I127_G0.5480.71
129_I138_L0.5480.71
11_G36_T0.5480.71
192_I218_L0.5470.71
7_A55_I0.5470.71
199_A202_Q0.5470.71
78_G83_K0.5460.71
37_G153_N0.5460.71
86_V90_S0.5450.71
50_N57_R0.5420.70
245_N253_L0.5400.70
220_S229_Q0.5400.70
80_F84_E0.5390.70
175_V183_E0.5370.69
218_L221_S0.5370.69
16_L52_S0.5360.69
24_L52_S0.5320.69
59_G129_I0.5320.69
78_G113_E0.5300.68
66_D122_G0.5300.68
203_K207_N0.5290.68
81_W90_S0.5290.68
46_G50_N0.5290.68
47_D65_S0.5290.68
142_E150_G0.5280.68
82_I89_G0.5240.68
85_D89_G0.5230.67
199_A203_K0.5220.67
146_F210_Y0.5200.67
53_A59_G0.5190.67
27_D216_S0.5170.67
67_D73_E0.5140.66
85_D91_Q0.5110.66
77_G81_W0.5100.66
226_P260_S0.5090.65
58_S63_Y0.5090.65
160_L275_T0.5070.65
48_I54_R0.5060.65
171_L174_F0.5060.65
79_C85_D0.5060.65
46_G60_E0.5020.64
82_I86_V0.5020.64
178_G195_D0.5010.64
250_L253_L0.5010.64
158_R183_E0.5010.64
150_G243_T0.5000.64
153_N156_T0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v97A 1 0.9459 100 0.34 Contact Map
3ldgA 1 0.9427 100 0.341 Contact Map
3lduA 1 0.949 100 0.359 Contact Map
3k0bA 1 0.9395 100 0.361 Contact Map
3tmaA 2 0.9618 100 0.408 Contact Map
3tm4A 1 0.949 100 0.414 Contact Map
3s1sA 1 0.9554 99.8 0.747 Contact Map
2ar0A 1 0.8344 99.8 0.755 Contact Map
2f8lA 1 0.7898 99.8 0.757 Contact Map
3evzA 1 0.5892 99.8 0.758 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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