KPRS - SULSO - GREMLIN Contacts

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KPRS - Ribose-phosphate pyrophosphokinase

UniProt:	Q97Z86	Sequences: MIIIGGSATNGIDESLSKILSIPLVKVENKIFPDGESYIRVPSSIRDEEVLLVQTTDYPQDKHLIELFLIAETIRDLGAKKLTAIVPYLAYSRQDRRFKDGEAISIKTILHILSEVGVNTLVVVEPHKPEELSYFKGELKIVHPYHQIARKIKEIIEDPFILAPDRGALDRARKIAEEINAPYSYIEKERDRTTGEVRIKEAPNINLKGKDVVIIDDIISTGGTIVQATRLAYSLGAKSVTAAAIHLLLVGGAKERLREVGVKTLIGTNTINVNDKDIITIDVSQSIALSL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	291 (287)
Sequences:	3981 (2058)
Seq/√Len:	121.5

ECOLI - KPRS
BACSU - KPRS
HALSA - KPRS
SULSO - KPRS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
15_S	269_N	4.552	1.00
239_S	263_K	4.489	1.00
264_T	279_I	4.303	1.00
255_E	259_E	3.419	1.00
71_A	118_V	3.272	1.00
269_N	282_D	3.260	1.00
211_D	239_S	3.105	1.00
64_L	109_I	2.962	1.00
4_I	25_V	2.819	1.00
252_G	256_R	2.781	1.00
161_I	172_A	2.720	1.00
19_I	288_A	2.648	1.00
3_I	17_S	2.593	1.00
247_L	267_G	2.477	1.00
69_L	105_S	2.469	1.00
211_D	238_K	2.454	1.00
155_I	264_T	2.387	1.00
26_K	42_P	2.379	1.00
10_N	14_E	2.314	1.00
8_A	55_T	2.267	1.00
230_R	234_S	2.261	1.00
49_E	81_K	2.259	1.00
227_Q	230_R	2.231	1.00
124_V	287_I	2.158	1.00
31_I	62_K	2.137	1.00
233_Y	263_K	2.127	1.00
57_D	272_N	2.120	1.00
124_V	270_T	2.089	1.00
124_V	283_V	2.073	1.00
225_I	242_A	2.033	1.00
160_F	210_K	2.006	1.00
14_E	18_K	2.004	1.00
219_I	244_A	1.993	1.00
16_L	53_V	1.986	1.00
56_T	90_A	1.921	1.00
13_D	24_L	1.902	1.00
220_S	250_V	1.862	1.00
113_L	118_V	1.854	1.00
111_H	136_K	1.851	1.00
2_I	48_E	1.827	1.00
163_A	168_A	1.791	1.00
159_P	181_A	1.771	1.00
125_E	245_I	1.731	1.00
162_L	212_V	1.728	1.00
230_R	261_G	1.714	1.00
52_L	74_I	1.712	1.00
219_I	265_L	1.711	1.00
28_E	42_P	1.677	1.00
12_I	287_I	1.666	1.00
11_G	15_S	1.663	1.00
108_T	116_V	1.662	1.00
150_R	154_E	1.633	1.00
222_G	226_V	1.614	1.00
242_A	262_V	1.613	1.00
241_T	263_K	1.607	1.00
249_L	265_L	1.591	1.00
270_T	283_V	1.573	1.00
209_G	238_K	1.558	1.00
241_T	264_T	1.532	1.00
27_V	70_I	1.514	1.00
151_K	279_I	1.501	1.00
86_V	121_L	1.482	1.00
12_I	16_L	1.470	1.00
168_A	171_R	1.457	1.00
192_R	196_E	1.451	1.00
3_I	53_V	1.447	1.00
7_S	29_N	1.424	1.00
211_D	241_T	1.417	1.00
233_Y	240_V	1.416	1.00
273_V	276_K	1.412	1.00
50_V	74_I	1.398	1.00
34_D	88_Y	1.380	1.00
219_I	225_I	1.374	1.00
152_I	266_I	1.359	1.00
28_E	40_R	1.355	1.00
257_L	265_L	1.348	1.00
45_I	74_I	1.342	1.00
244_A	267_G	1.338	1.00
17_S	24_L	1.329	1.00
83_T	120_T	1.328	1.00
252_G	255_E	1.317	1.00
86_V	113_L	1.299	1.00
151_K	266_I	1.292	1.00
5_G	13_D	1.285	1.00
95_D	130_E	1.277	1.00
212_V	232_A	1.272	1.00
148_I	281_I	1.253	0.99
162_L	184_S	1.235	0.99
167_G	190_R	1.234	0.99
273_V	278_I	1.228	0.99
30_K	38_Y	1.224	0.99
11_G	14_E	1.196	0.99
214_I	228_A	1.194	0.99
107_K	111_H	1.192	0.99
19_I	285_Q	1.187	0.99
20_L	288_A	1.185	0.99
152_I	213_V	1.178	0.99
98_F	102_E	1.176	0.99
6_G	54_Q	1.174	0.99
72_E	76_D	1.174	0.99
41_V	74_I	1.167	0.99
197_V	227_Q	1.167	0.99
229_T	262_V	1.163	0.99
15_S	284_S	1.159	0.99
7_S	31_I	1.159	0.99
9_T	55_T	1.151	0.99
167_G	188_K	1.145	0.99
107_K	136_K	1.143	0.99
40_R	102_E	1.135	0.99
162_L	232_A	1.121	0.99
15_S	282_D	1.121	0.99
161_I	179_I	1.110	0.99
233_Y	261_G	1.095	0.99
219_I	222_G	1.095	0.99
247_L	273_V	1.092	0.99
197_V	201_E	1.084	0.99
68_F	112_I	1.083	0.98
159_P	213_V	1.080	0.98
3_I	22_I	1.079	0.98
52_L	70_I	1.078	0.98
198_R	201_E	1.067	0.98
17_S	23_P	1.065	0.98
222_G	256_R	1.060	0.98
114_S	136_K	1.056	0.98
159_P	211_D	1.040	0.98
19_I	289_L	1.034	0.98
113_L	121_L	1.030	0.98
151_K	155_I	1.028	0.98
208_K	235_L	1.026	0.98
52_L	71_A	1.025	0.98
160_F	212_V	1.024	0.98
49_E	83_T	1.023	0.98
186_I	228_A	1.021	0.98
166_R	170_D	1.020	0.98
249_L	267_G	1.019	0.98
231_L	234_S	1.007	0.98
148_I	243_A	1.007	0.98
273_V	280_T	1.007	0.98
13_D	17_S	1.005	0.98
151_K	264_T	1.003	0.98
38_Y	102_E	1.002	0.97
165_D	188_K	1.000	0.97
222_G	252_G	0.993	0.97
81_K	119_N	0.992	0.97
111_H	114_S	0.985	0.97
5_G	8_A	0.982	0.97
158_D	210_K	0.975	0.97
237_A	240_V	0.974	0.97
49_E	80_K	0.970	0.97
126_P	141_I	0.967	0.97
165_D	190_R	0.962	0.97
6_G	70_I	0.956	0.97
9_T	272_N	0.954	0.97
147_Q	281_I	0.952	0.97
198_R	202_A	0.951	0.97
31_I	37_S	0.943	0.96
59_P	63_H	0.942	0.96
188_K	223_G	0.941	0.96
173_R	187_E	0.938	0.96
33_P	220_S	0.931	0.96
265_L	278_I	0.929	0.96
149_A	175_I	0.929	0.96
68_F	116_V	0.928	0.96
190_R	223_G	0.925	0.96
152_I	241_T	0.922	0.96
197_V	202_A	0.908	0.96
106_I	131_E	0.906	0.95
59_P	62_K	0.903	0.95
226_V	256_R	0.900	0.95
57_D	271_I	0.896	0.95
144_P	245_I	0.887	0.95
230_R	233_Y	0.887	0.95
34_D	90_A	0.882	0.95
124_V	286_S	0.881	0.95
4_I	70_I	0.880	0.95
257_L	260_V	0.878	0.95
84_A	118_V	0.878	0.95
231_L	235_L	0.877	0.95
41_V	70_I	0.876	0.95
190_R	224_T	0.875	0.95
197_V	200_K	0.873	0.94
151_K	243_A	0.871	0.94
125_E	171_R	0.867	0.94
7_S	66_E	0.863	0.94
191_D	197_V	0.863	0.94
151_K	281_I	0.857	0.94
11_G	272_N	0.857	0.94
5_G	9_T	0.853	0.94
99_K	102_E	0.853	0.94
258_R	261_G	0.849	0.94
161_I	175_I	0.848	0.94
97_R	104_I	0.846	0.93
40_R	99_K	0.846	0.93
225_I	244_A	0.842	0.93
196_E	201_E	0.841	0.93
33_P	251_G	0.840	0.93
167_G	223_G	0.839	0.93
242_A	260_V	0.837	0.93
285_Q	288_A	0.832	0.93
267_G	278_I	0.831	0.93
196_E	200_K	0.829	0.93
226_V	230_R	0.828	0.93
244_A	247_L	0.825	0.93
260_V	277_D	0.824	0.93
174_K	177_E	0.823	0.93
248_L	271_I	0.817	0.92
207_L	232_A	0.816	0.92
157_E	211_D	0.815	0.92
36_E	218_I	0.813	0.92
158_D	211_D	0.810	0.92
152_I	243_A	0.809	0.92
26_K	43_S	0.803	0.92
164_P	224_T	0.802	0.92
159_P	210_K	0.800	0.91
175_I	215_I	0.799	0.91
108_T	112_I	0.797	0.91
229_T	261_G	0.795	0.91
120_T	140_K	0.795	0.91
255_E	258_R	0.793	0.91
144_P	148_I	0.791	0.91
67_L	113_L	0.789	0.91
71_A	84_A	0.788	0.91
36_E	94_Q	0.788	0.91
34_D	96_R	0.787	0.91
169_L	185_Y	0.783	0.91
230_R	259_E	0.780	0.90
158_D	238_K	0.780	0.90
82_L	119_N	0.779	0.90
56_T	59_P	0.776	0.90
254_K	278_I	0.773	0.90
165_D	217_D	0.772	0.90
148_I	268_T	0.769	0.90
212_V	240_V	0.769	0.90
15_S	18_K	0.767	0.90
6_G	166_R	0.765	0.90
254_K	258_R	0.763	0.89
46_R	78_G	0.761	0.89
73_T	77_L	0.761	0.89
118_V	137_G	0.758	0.89
7_S	27_V	0.753	0.89
126_P	131_E	0.750	0.89
15_S	19_I	0.749	0.89
74_I	79_A	0.745	0.88
29_N	39_I	0.739	0.88
5_G	10_N	0.738	0.88
191_D	194_T	0.737	0.88
199_I	202_A	0.735	0.88
37_S	61_D	0.735	0.88
46_R	51_L	0.735	0.88
226_V	229_T	0.731	0.87
208_K	236_G	0.728	0.87
72_E	111_H	0.727	0.87
127_H	217_D	0.726	0.87
219_I	267_G	0.725	0.87
114_S	137_G	0.724	0.87
229_T	242_A	0.724	0.87
196_E	202_A	0.722	0.87
150_R	153_K	0.716	0.86
194_T	197_V	0.713	0.86
126_P	139_L	0.712	0.86
10_N	26_K	0.709	0.86
46_R	101_G	0.709	0.86
40_R	219_I	0.708	0.86
57_D	63_H	0.706	0.85
14_E	24_L	0.706	0.85
110_L	135_F	0.706	0.85
94_Q	218_I	0.705	0.85
283_V	287_I	0.703	0.85
143_H	174_K	0.703	0.85
207_L	237_A	0.702	0.85
261_G	277_D	0.700	0.85
97_R	101_G	0.699	0.85
182_P	210_K	0.696	0.85
72_E	108_T	0.690	0.84
103_A	108_T	0.690	0.84
185_Y	204_N	0.679	0.83
269_N	283_V	0.678	0.83
243_A	266_I	0.677	0.83
7_S	10_N	0.675	0.83
56_T	67_L	0.674	0.83
68_F	108_T	0.673	0.83
229_T	260_V	0.668	0.82
25_V	43_S	0.666	0.82
72_E	107_K	0.665	0.82
265_L	277_D	0.663	0.82
129_P	170_D	0.662	0.82
214_I	262_V	0.662	0.82
201_E	204_N	0.661	0.82
121_L	135_F	0.661	0.82
229_T	233_Y	0.660	0.81
79_A	82_L	0.659	0.81
163_A	167_G	0.658	0.81
64_L	68_F	0.657	0.81
95_D	190_R	0.654	0.81
212_V	237_A	0.652	0.81
5_G	27_V	0.651	0.81
12_I	53_V	0.651	0.81
99_K	192_R	0.650	0.80
152_I	175_I	0.648	0.80
3_I	20_L	0.647	0.80
46_R	140_K	0.647	0.80
173_R	189_E	0.644	0.80
175_I	281_I	0.644	0.80
89_L	92_S	0.644	0.80
145_Y	175_I	0.642	0.80
33_P	194_T	0.642	0.80
6_G	9_T	0.642	0.80
71_A	116_V	0.641	0.79
143_H	149_A	0.639	0.79
267_G	280_T	0.637	0.79
258_R	277_D	0.636	0.79
160_F	207_L	0.634	0.79
35_G	221_T	0.629	0.78
118_V	121_L	0.629	0.78
44_S	48_E	0.624	0.78
219_I	249_L	0.619	0.77
233_Y	237_A	0.616	0.77
77_L	97_R	0.616	0.77
123_V	126_P	0.613	0.76
147_Q	286_S	0.611	0.76
41_V	45_I	0.611	0.76
8_A	54_Q	0.608	0.76
93_R	220_S	0.606	0.76
172_A	183_Y	0.601	0.75
4_I	27_V	0.600	0.75
98_F	129_P	0.598	0.75
123_V	141_I	0.597	0.75
127_H	165_D	0.597	0.75
152_I	155_I	0.597	0.75
17_S	20_L	0.596	0.74
167_G	224_T	0.596	0.74
71_A	79_A	0.593	0.74
80_K	119_N	0.591	0.74
223_G	252_G	0.591	0.74
199_I	231_L	0.590	0.74
93_R	165_D	0.590	0.74
233_Y	239_S	0.590	0.74
38_Y	99_K	0.587	0.73
21_S	153_K	0.586	0.73
222_G	254_K	0.585	0.73
86_V	90_A	0.584	0.73
69_L	108_T	0.584	0.73
173_R	177_E	0.583	0.73
226_V	260_V	0.581	0.73
257_L	277_D	0.579	0.72
75_R	119_N	0.577	0.72
78_G	140_K	0.576	0.72
169_L	173_R	0.576	0.72
130_E	133_S	0.575	0.72
156_I	159_P	0.573	0.72
176_A	181_A	0.572	0.71
124_V	142_V	0.572	0.71
144_P	268_T	0.571	0.71
128_K	131_E	0.571	0.71
142_V	286_S	0.571	0.71
244_A	265_L	0.570	0.71
186_I	231_L	0.569	0.71
191_D	196_E	0.568	0.71
37_S	66_E	0.565	0.70
174_K	178_E	0.565	0.70
2_I	43_S	0.564	0.70
156_I	241_T	0.564	0.70
17_S	22_I	0.563	0.70
193_T	197_V	0.563	0.70
2_I	25_V	0.562	0.70
83_T	122_V	0.562	0.70
56_T	64_L	0.562	0.70
192_R	197_V	0.558	0.70
76_D	97_R	0.558	0.70
166_R	183_Y	0.557	0.69
89_L	110_L	0.556	0.69
81_K	122_V	0.556	0.69
191_D	199_I	0.555	0.69
38_Y	193_T	0.555	0.69
95_D	128_K	0.554	0.69
33_P	100_D	0.551	0.69
30_K	119_N	0.548	0.68
50_V	79_A	0.548	0.68
151_K	154_E	0.547	0.68
168_A	172_A	0.547	0.68
28_E	38_Y	0.546	0.68
202_A	231_L	0.546	0.68
95_D	188_K	0.545	0.68
267_G	273_V	0.545	0.68
19_I	284_S	0.545	0.68
58_Y	63_H	0.544	0.68
35_G	218_I	0.544	0.68
172_A	215_I	0.542	0.67
150_R	285_Q	0.541	0.67
222_G	242_A	0.540	0.67
5_G	11_G	0.540	0.67
39_I	70_I	0.537	0.67
266_I	281_I	0.536	0.66
164_P	188_K	0.535	0.66
97_R	103_A	0.533	0.66
94_Q	105_S	0.533	0.66
75_R	82_L	0.531	0.66
55_T	90_A	0.531	0.66
34_D	248_L	0.528	0.65
108_T	111_H	0.527	0.65
161_I	166_R	0.527	0.65
160_F	184_S	0.527	0.65
142_V	287_I	0.526	0.65
89_L	135_F	0.526	0.65
35_G	283_V	0.526	0.65
149_A	178_E	0.525	0.65
95_D	165_D	0.523	0.65
187_E	201_E	0.522	0.64
165_D	223_G	0.520	0.64
95_D	127_H	0.520	0.64
132_L	140_K	0.519	0.64
256_R	259_E	0.517	0.64
3_I	24_L	0.516	0.64
214_I	225_I	0.515	0.63
18_K	24_L	0.514	0.63
115_E	268_T	0.514	0.63
214_I	229_T	0.514	0.63
284_S	288_A	0.512	0.63
165_D	216_D	0.510	0.63
188_K	216_D	0.510	0.63
20_L	289_L	0.510	0.63
229_T	240_V	0.509	0.63
165_D	222_G	0.509	0.63
194_T	220_S	0.508	0.62
84_A	121_L	0.507	0.62
212_V	243_A	0.507	0.62
57_D	60_Q	0.504	0.62
253_A	257_L	0.504	0.62
8_A	63_H	0.500	0.61
188_K	224_T	0.500	0.61

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4twbA	2	0.9553	100	0.126	Contact Map
3s5jB	2	0.9691	100	0.145	Contact Map
2ji4A	5	0.9313	100	0.145	Contact Map
1dkuA	5	0.9519	100	0.151	Contact Map
1u9yA	3	0.9416	100	0.173	Contact Map
3dahA	5	0.9691	100	0.176	Contact Map
3lrtA	2	0.9656	100	0.191	Contact Map
3dezA	2	0.6151	100	0.686	Contact Map
1o57A	2	0.8419	100	0.709	Contact Map
3m3hA	2	0.5876	99.9	0.739	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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