GREMLIN Database
KPRS - Ribose-phosphate pyrophosphokinase
UniProt: Q97Z86 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 291 (287)
Sequences: 3981 (2058)
Seq/√Len: 121.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_S269_N4.5521.00
239_S263_K4.4891.00
264_T279_I4.3031.00
255_E259_E3.4191.00
71_A118_V3.2721.00
269_N282_D3.2601.00
211_D239_S3.1051.00
64_L109_I2.9621.00
4_I25_V2.8191.00
252_G256_R2.7811.00
161_I172_A2.7201.00
19_I288_A2.6481.00
3_I17_S2.5931.00
247_L267_G2.4771.00
69_L105_S2.4691.00
211_D238_K2.4541.00
155_I264_T2.3871.00
26_K42_P2.3791.00
10_N14_E2.3141.00
8_A55_T2.2671.00
230_R234_S2.2611.00
49_E81_K2.2591.00
227_Q230_R2.2311.00
124_V287_I2.1581.00
31_I62_K2.1371.00
233_Y263_K2.1271.00
57_D272_N2.1201.00
124_V270_T2.0891.00
124_V283_V2.0731.00
225_I242_A2.0331.00
160_F210_K2.0061.00
14_E18_K2.0041.00
219_I244_A1.9931.00
16_L53_V1.9861.00
56_T90_A1.9211.00
13_D24_L1.9021.00
220_S250_V1.8621.00
113_L118_V1.8541.00
111_H136_K1.8511.00
2_I48_E1.8271.00
163_A168_A1.7911.00
159_P181_A1.7711.00
125_E245_I1.7311.00
162_L212_V1.7281.00
230_R261_G1.7141.00
52_L74_I1.7121.00
219_I265_L1.7111.00
28_E42_P1.6771.00
12_I287_I1.6661.00
11_G15_S1.6631.00
108_T116_V1.6621.00
150_R154_E1.6331.00
222_G226_V1.6141.00
242_A262_V1.6131.00
241_T263_K1.6071.00
249_L265_L1.5911.00
270_T283_V1.5731.00
209_G238_K1.5581.00
241_T264_T1.5321.00
27_V70_I1.5141.00
151_K279_I1.5011.00
86_V121_L1.4821.00
12_I16_L1.4701.00
168_A171_R1.4571.00
192_R196_E1.4511.00
3_I53_V1.4471.00
7_S29_N1.4241.00
211_D241_T1.4171.00
233_Y240_V1.4161.00
273_V276_K1.4121.00
50_V74_I1.3981.00
34_D88_Y1.3801.00
219_I225_I1.3741.00
152_I266_I1.3591.00
28_E40_R1.3551.00
257_L265_L1.3481.00
45_I74_I1.3421.00
244_A267_G1.3381.00
17_S24_L1.3291.00
83_T120_T1.3281.00
252_G255_E1.3171.00
86_V113_L1.2991.00
151_K266_I1.2921.00
5_G13_D1.2851.00
95_D130_E1.2771.00
212_V232_A1.2721.00
148_I281_I1.2530.99
162_L184_S1.2350.99
167_G190_R1.2340.99
273_V278_I1.2280.99
30_K38_Y1.2240.99
11_G14_E1.1960.99
214_I228_A1.1940.99
107_K111_H1.1920.99
19_I285_Q1.1870.99
20_L288_A1.1850.99
152_I213_V1.1780.99
98_F102_E1.1760.99
6_G54_Q1.1740.99
72_E76_D1.1740.99
41_V74_I1.1670.99
197_V227_Q1.1670.99
229_T262_V1.1630.99
15_S284_S1.1590.99
7_S31_I1.1590.99
9_T55_T1.1510.99
167_G188_K1.1450.99
107_K136_K1.1430.99
40_R102_E1.1350.99
162_L232_A1.1210.99
15_S282_D1.1210.99
161_I179_I1.1100.99
233_Y261_G1.0950.99
219_I222_G1.0950.99
247_L273_V1.0920.99
197_V201_E1.0840.99
68_F112_I1.0830.98
159_P213_V1.0800.98
3_I22_I1.0790.98
52_L70_I1.0780.98
198_R201_E1.0670.98
17_S23_P1.0650.98
222_G256_R1.0600.98
114_S136_K1.0560.98
159_P211_D1.0400.98
19_I289_L1.0340.98
113_L121_L1.0300.98
151_K155_I1.0280.98
208_K235_L1.0260.98
52_L71_A1.0250.98
160_F212_V1.0240.98
49_E83_T1.0230.98
186_I228_A1.0210.98
166_R170_D1.0200.98
249_L267_G1.0190.98
231_L234_S1.0070.98
148_I243_A1.0070.98
273_V280_T1.0070.98
13_D17_S1.0050.98
151_K264_T1.0030.98
38_Y102_E1.0020.97
165_D188_K1.0000.97
222_G252_G0.9930.97
81_K119_N0.9920.97
111_H114_S0.9850.97
5_G8_A0.9820.97
158_D210_K0.9750.97
237_A240_V0.9740.97
49_E80_K0.9700.97
126_P141_I0.9670.97
165_D190_R0.9620.97
6_G70_I0.9560.97
9_T272_N0.9540.97
147_Q281_I0.9520.97
198_R202_A0.9510.97
31_I37_S0.9430.96
59_P63_H0.9420.96
188_K223_G0.9410.96
173_R187_E0.9380.96
33_P220_S0.9310.96
265_L278_I0.9290.96
149_A175_I0.9290.96
68_F116_V0.9280.96
190_R223_G0.9250.96
152_I241_T0.9220.96
197_V202_A0.9080.96
106_I131_E0.9060.95
59_P62_K0.9030.95
226_V256_R0.9000.95
57_D271_I0.8960.95
144_P245_I0.8870.95
230_R233_Y0.8870.95
34_D90_A0.8820.95
124_V286_S0.8810.95
4_I70_I0.8800.95
257_L260_V0.8780.95
84_A118_V0.8780.95
231_L235_L0.8770.95
41_V70_I0.8760.95
190_R224_T0.8750.95
197_V200_K0.8730.94
151_K243_A0.8710.94
125_E171_R0.8670.94
7_S66_E0.8630.94
191_D197_V0.8630.94
151_K281_I0.8570.94
11_G272_N0.8570.94
5_G9_T0.8530.94
99_K102_E0.8530.94
258_R261_G0.8490.94
161_I175_I0.8480.94
97_R104_I0.8460.93
40_R99_K0.8460.93
225_I244_A0.8420.93
196_E201_E0.8410.93
33_P251_G0.8400.93
167_G223_G0.8390.93
242_A260_V0.8370.93
285_Q288_A0.8320.93
267_G278_I0.8310.93
196_E200_K0.8290.93
226_V230_R0.8280.93
244_A247_L0.8250.93
260_V277_D0.8240.93
174_K177_E0.8230.93
248_L271_I0.8170.92
207_L232_A0.8160.92
157_E211_D0.8150.92
36_E218_I0.8130.92
158_D211_D0.8100.92
152_I243_A0.8090.92
26_K43_S0.8030.92
164_P224_T0.8020.92
159_P210_K0.8000.91
175_I215_I0.7990.91
108_T112_I0.7970.91
229_T261_G0.7950.91
120_T140_K0.7950.91
255_E258_R0.7930.91
144_P148_I0.7910.91
67_L113_L0.7890.91
71_A84_A0.7880.91
36_E94_Q0.7880.91
34_D96_R0.7870.91
169_L185_Y0.7830.91
230_R259_E0.7800.90
158_D238_K0.7800.90
82_L119_N0.7790.90
56_T59_P0.7760.90
254_K278_I0.7730.90
165_D217_D0.7720.90
148_I268_T0.7690.90
212_V240_V0.7690.90
15_S18_K0.7670.90
6_G166_R0.7650.90
254_K258_R0.7630.89
46_R78_G0.7610.89
73_T77_L0.7610.89
118_V137_G0.7580.89
7_S27_V0.7530.89
126_P131_E0.7500.89
15_S19_I0.7490.89
74_I79_A0.7450.88
29_N39_I0.7390.88
5_G10_N0.7380.88
191_D194_T0.7370.88
199_I202_A0.7350.88
37_S61_D0.7350.88
46_R51_L0.7350.88
226_V229_T0.7310.87
208_K236_G0.7280.87
72_E111_H0.7270.87
127_H217_D0.7260.87
219_I267_G0.7250.87
114_S137_G0.7240.87
229_T242_A0.7240.87
196_E202_A0.7220.87
150_R153_K0.7160.86
194_T197_V0.7130.86
126_P139_L0.7120.86
10_N26_K0.7090.86
46_R101_G0.7090.86
40_R219_I0.7080.86
57_D63_H0.7060.85
14_E24_L0.7060.85
110_L135_F0.7060.85
94_Q218_I0.7050.85
283_V287_I0.7030.85
143_H174_K0.7030.85
207_L237_A0.7020.85
261_G277_D0.7000.85
97_R101_G0.6990.85
182_P210_K0.6960.85
72_E108_T0.6900.84
103_A108_T0.6900.84
185_Y204_N0.6790.83
269_N283_V0.6780.83
243_A266_I0.6770.83
7_S10_N0.6750.83
56_T67_L0.6740.83
68_F108_T0.6730.83
229_T260_V0.6680.82
25_V43_S0.6660.82
72_E107_K0.6650.82
265_L277_D0.6630.82
129_P170_D0.6620.82
214_I262_V0.6620.82
201_E204_N0.6610.82
121_L135_F0.6610.82
229_T233_Y0.6600.81
79_A82_L0.6590.81
163_A167_G0.6580.81
64_L68_F0.6570.81
95_D190_R0.6540.81
212_V237_A0.6520.81
5_G27_V0.6510.81
12_I53_V0.6510.81
99_K192_R0.6500.80
152_I175_I0.6480.80
3_I20_L0.6470.80
46_R140_K0.6470.80
173_R189_E0.6440.80
175_I281_I0.6440.80
89_L92_S0.6440.80
145_Y175_I0.6420.80
33_P194_T0.6420.80
6_G9_T0.6420.80
71_A116_V0.6410.79
143_H149_A0.6390.79
267_G280_T0.6370.79
258_R277_D0.6360.79
160_F207_L0.6340.79
35_G221_T0.6290.78
118_V121_L0.6290.78
44_S48_E0.6240.78
219_I249_L0.6190.77
233_Y237_A0.6160.77
77_L97_R0.6160.77
123_V126_P0.6130.76
147_Q286_S0.6110.76
41_V45_I0.6110.76
8_A54_Q0.6080.76
93_R220_S0.6060.76
172_A183_Y0.6010.75
4_I27_V0.6000.75
98_F129_P0.5980.75
123_V141_I0.5970.75
127_H165_D0.5970.75
152_I155_I0.5970.75
17_S20_L0.5960.74
167_G224_T0.5960.74
71_A79_A0.5930.74
80_K119_N0.5910.74
223_G252_G0.5910.74
199_I231_L0.5900.74
93_R165_D0.5900.74
233_Y239_S0.5900.74
38_Y99_K0.5870.73
21_S153_K0.5860.73
222_G254_K0.5850.73
86_V90_A0.5840.73
69_L108_T0.5840.73
173_R177_E0.5830.73
226_V260_V0.5810.73
257_L277_D0.5790.72
75_R119_N0.5770.72
78_G140_K0.5760.72
169_L173_R0.5760.72
130_E133_S0.5750.72
156_I159_P0.5730.72
176_A181_A0.5720.71
124_V142_V0.5720.71
144_P268_T0.5710.71
128_K131_E0.5710.71
142_V286_S0.5710.71
244_A265_L0.5700.71
186_I231_L0.5690.71
191_D196_E0.5680.71
37_S66_E0.5650.70
174_K178_E0.5650.70
2_I43_S0.5640.70
156_I241_T0.5640.70
17_S22_I0.5630.70
193_T197_V0.5630.70
2_I25_V0.5620.70
83_T122_V0.5620.70
56_T64_L0.5620.70
192_R197_V0.5580.70
76_D97_R0.5580.70
166_R183_Y0.5570.69
89_L110_L0.5560.69
81_K122_V0.5560.69
191_D199_I0.5550.69
38_Y193_T0.5550.69
95_D128_K0.5540.69
33_P100_D0.5510.69
30_K119_N0.5480.68
50_V79_A0.5480.68
151_K154_E0.5470.68
168_A172_A0.5470.68
28_E38_Y0.5460.68
202_A231_L0.5460.68
95_D188_K0.5450.68
267_G273_V0.5450.68
19_I284_S0.5450.68
58_Y63_H0.5440.68
35_G218_I0.5440.68
172_A215_I0.5420.67
150_R285_Q0.5410.67
222_G242_A0.5400.67
5_G11_G0.5400.67
39_I70_I0.5370.67
266_I281_I0.5360.66
164_P188_K0.5350.66
97_R103_A0.5330.66
94_Q105_S0.5330.66
75_R82_L0.5310.66
55_T90_A0.5310.66
34_D248_L0.5280.65
108_T111_H0.5270.65
161_I166_R0.5270.65
160_F184_S0.5270.65
142_V287_I0.5260.65
89_L135_F0.5260.65
35_G283_V0.5260.65
149_A178_E0.5250.65
95_D165_D0.5230.65
187_E201_E0.5220.64
165_D223_G0.5200.64
95_D127_H0.5200.64
132_L140_K0.5190.64
256_R259_E0.5170.64
3_I24_L0.5160.64
214_I225_I0.5150.63
18_K24_L0.5140.63
115_E268_T0.5140.63
214_I229_T0.5140.63
284_S288_A0.5120.63
165_D216_D0.5100.63
188_K216_D0.5100.63
20_L289_L0.5100.63
229_T240_V0.5090.63
165_D222_G0.5090.63
194_T220_S0.5080.62
84_A121_L0.5070.62
212_V243_A0.5070.62
57_D60_Q0.5040.62
253_A257_L0.5040.62
8_A63_H0.5000.61
188_K224_T0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4twbA 2 0.9553 100 0.126 Contact Map
3s5jB 2 0.9691 100 0.145 Contact Map
2ji4A 5 0.9313 100 0.145 Contact Map
1dkuA 5 0.9519 100 0.151 Contact Map
1u9yA 3 0.9416 100 0.173 Contact Map
3dahA 5 0.9691 100 0.176 Contact Map
3lrtA 2 0.9656 100 0.191 Contact Map
3dezA 2 0.6151 100 0.686 Contact Map
1o57A 2 0.8419 100 0.709 Contact Map
3m3hA 2 0.5876 99.9 0.739 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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