GREMLIN Database
Q97Z85 - Uncharacterized protein
UniProt: Q97Z85 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 259 (243)
Sequences: 1011 (597)
Seq/√Len: 38.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
171_I236_L4.4561.00
62_A76_S4.3341.00
26_Q51_T4.2961.00
8_V21_L4.0861.00
21_L236_L3.3821.00
7_Y133_A3.3481.00
135_G166_L3.1841.00
107_T120_G3.1351.00
39_I105_V2.9911.00
23_K27_D2.9611.00
9_F124_S2.9101.00
136_L236_L2.8771.00
138_L173_N2.8101.00
146_E149_S2.6301.00
58_D94_E2.6261.00
37_A98_I2.6211.00
154_L214_L2.4751.00
26_Q38_V2.4721.00
143_L153_L2.3771.00
236_L240_I2.3731.00
34_M241_Q2.0930.99
24_N27_D1.9800.99
21_L136_L1.9680.99
227_S233_F1.9490.98
11_L135_G1.9300.98
114_F120_G1.9260.98
65_V80_S1.9190.98
14_A137_F1.8800.98
77_L81_I1.8650.98
10_I104_L1.8640.98
84_I91_I1.7830.97
29_L36_T1.7620.97
61_D64_E1.7500.97
223_I236_L1.7320.97
169_I243_V1.7010.96
59_Y90_E1.6990.96
8_V25_L1.6770.96
15_G18_K1.6720.96
144_A172_L1.6670.96
10_I22_T1.6220.95
88_A126_L1.5910.95
58_D76_S1.5770.94
32_Q234_N1.5740.94
24_N227_S1.5730.94
10_I21_L1.5600.94
78_I113_L1.5510.94
19_T28_Y1.5450.94
241_Q245_A1.5400.94
107_T114_F1.5370.94
95_I100_A1.5290.93
244_I248_E1.5130.93
95_I103_V1.5120.93
23_K26_Q1.4740.92
64_E68_N1.4530.91
136_L240_I1.4350.91
245_A249_D1.4130.90
115_A216_E1.4070.90
12_G17_G1.3940.90
12_G18_K1.3940.90
26_Q30_L1.3940.90
185_Q191_D1.3930.90
66_M76_S1.3710.89
136_L171_I1.3680.89
195_N198_D1.3680.89
95_I131_N1.3540.88
7_Y101_N1.3520.88
186_I190_G1.3510.88
206_Y210_L1.3400.88
136_L169_I1.3350.88
24_N233_F1.3310.87
6_Y240_I1.3100.87
111_I137_F1.3100.87
59_Y83_L1.3080.86
215_I219_S1.2960.86
37_A53_D1.2820.85
139_L153_L1.2810.85
141_S154_L1.2780.85
140_D151_I1.2620.84
12_G15_G1.2450.84
245_A248_E1.2450.84
25_L237_Y1.2410.83
146_E177_L1.2240.83
82_D117_R1.2190.82
92_K95_I1.2060.82
24_N230_G1.1800.80
59_Y87_K1.1750.80
88_A115_A1.1620.79
48_L52_P1.1560.79
7_Y105_V1.1470.78
19_T101_N1.1470.78
87_K90_E1.1460.78
23_K52_P1.1450.78
60_V65_V1.1080.76
85_L122_L1.1080.76
53_D131_N1.0940.75
203_L207_S1.0930.75
94_E169_I1.0870.74
16_S152_S1.0820.74
19_T186_I1.0740.73
78_I124_S1.0730.73
203_L206_Y1.0710.73
14_A45_V1.0590.72
40_N43_P1.0580.72
242_R245_A1.0550.72
171_I225_M1.0530.72
104_L124_S1.0480.72
105_V124_S1.0430.71
25_L29_L1.0310.70
187_L190_G1.0200.69
77_L149_S1.0190.69
193_A196_L1.0130.69
77_L113_L1.0020.68
185_Q199_E0.9950.68
121_R125_Q0.9860.67
195_N199_E0.9840.67
45_V48_L0.9750.66
62_A75_S0.9740.66
204_D221_N0.9710.66
210_L243_V0.9700.66
14_A248_E0.9670.65
103_V224_P0.9660.65
44_A159_S0.9660.65
24_N120_G0.9610.65
169_I239_E0.9600.65
83_L90_E0.9580.65
26_Q140_D0.9580.65
180_E224_P0.9520.64
207_S210_L0.9440.63
65_V69_Y0.9420.63
19_T23_K0.9410.63
194_E197_I0.9390.63
82_D116_Y0.9310.62
213_L219_S0.9280.62
27_D58_D0.9250.62
14_A245_A0.9190.61
139_L157_S0.9180.61
125_Q128_R0.9170.61
25_L104_L0.9140.61
60_V80_S0.9100.61
150_F189_W0.9090.60
85_L119_T0.9090.60
186_I189_W0.9080.60
142_F149_S0.8920.59
23_K49_P0.8850.58
105_V131_N0.8810.58
69_Y103_V0.8790.58
13_T115_A0.8740.57
165_D169_I0.8690.57
39_I103_V0.8620.56
172_L217_S0.8570.56
144_A178_L0.8520.55
52_P105_V0.8500.55
185_Q193_A0.8500.55
6_Y21_L0.8480.55
88_A150_F0.8420.55
22_T104_L0.8400.54
54_F169_I0.8330.54
121_R163_R0.8310.54
63_Y70_H0.8270.53
58_D154_L0.8270.53
19_T37_A0.8260.53
78_I192_N0.8220.53
133_A166_L0.8200.53
31_D50_Y0.8200.53
20_T127_I0.8150.52
20_T240_I0.8150.52
21_L227_S0.8140.52
81_I157_S0.8100.52
124_S164_L0.8080.52
235_E238_A0.8080.52
123_I133_A0.8080.52
97_Q166_L0.8070.51
137_F156_L0.8040.51
109_G112_E0.7990.51
145_K152_S0.7970.51
193_A197_I0.7900.50
20_T34_M0.7900.50
135_G160_I0.7900.50
162_F177_L0.7870.50
54_F194_E0.7850.49
200_L210_L0.7840.49
38_V54_F0.7830.49
48_L230_G0.7810.49
9_F205_E0.7780.49
244_I247_G0.7760.49
152_S166_L0.7720.48
150_F172_L0.7700.48
247_G250_Y0.7660.48
213_L224_P0.7650.48
120_G160_I0.7640.48
21_L102_Y0.7600.47
21_L225_M0.7600.47
65_V79_A0.7580.47
116_Y149_S0.7570.47
63_Y111_I0.7540.47
102_Y214_L0.7520.47
113_L127_I0.7450.46
19_T80_S0.7390.45
210_L214_L0.7360.45
159_S213_L0.7290.44
154_L166_L0.7280.44
83_L149_S0.7200.44
150_F154_L0.7180.43
241_Q246_G0.7160.43
115_A159_S0.7120.43
93_S223_I0.7110.43
117_R162_F0.7110.43
185_Q190_G0.7100.43
118_D122_L0.7100.43
88_A175_I0.7100.43
133_A249_D0.7030.42
248_E251_L0.7020.42
104_L136_L0.6990.42
189_W192_N0.6990.42
44_A77_L0.6980.42
116_Y226_S0.6980.42
93_S180_E0.6970.42
88_A178_L0.6940.41
68_N179_T0.6930.41
77_L226_S0.6910.41
25_L234_N0.6910.41
17_G20_T0.6870.41
21_L29_L0.6850.41
70_H84_I0.6840.41
49_P54_F0.6840.41
84_I236_L0.6810.40
51_T181_K0.6790.40
186_I193_A0.6770.40
123_I147_A0.6770.40
63_Y238_A0.6730.40
114_F147_A0.6720.39
8_V240_I0.6710.39
96_D210_L0.6680.39
207_S213_L0.6680.39
8_V136_L0.6670.39
89_S169_I0.6670.39
8_V22_T0.6670.39
198_D250_Y0.6660.39
145_K148_R0.6610.39
92_K126_L0.6610.39
63_Y67_Q0.6590.38
50_Y140_D0.6580.38
14_A186_I0.6500.38
203_L231_K0.6460.37
104_L227_S0.6430.37
102_Y241_Q0.6430.37
84_I218_L0.6410.37
189_W199_E0.6400.37
90_E93_S0.6390.37
192_N196_L0.6370.37
81_I123_I0.6360.36
127_I136_L0.6360.36
68_N178_L0.6350.36
62_A66_M0.6350.36
165_D170_N0.6320.36
14_A18_K0.6310.36
14_A17_G0.6310.36
59_Y84_I0.6310.36
14_A21_L0.6290.36
163_R219_S0.6290.36
80_S234_N0.6250.36
234_N249_D0.6250.36
135_G158_S0.6220.35
45_V244_I0.6210.35
21_L25_L0.6210.35
139_L152_S0.6170.35
157_S217_S0.6160.35
128_R132_K0.6160.35
108_P112_E0.6150.35
180_E205_E0.6120.34
83_L146_E0.6110.34
14_A57_R0.6100.34
129_G175_I0.6070.34
13_T116_Y0.6050.34
155_L193_A0.6030.34
50_Y233_F0.6030.34
194_E199_E0.5980.33
117_R120_G0.5960.33
135_G168_I0.5960.33
206_Y209_E0.5960.33
151_I173_N0.5950.33
95_I134_L0.5940.33
191_D198_D0.5910.33
123_I198_D0.5910.33
13_T82_D0.5880.33
40_N44_A0.5880.33
141_S175_I0.5860.32
13_T79_A0.5860.32
106_D112_E0.5850.32
120_G163_R0.5850.32
148_R207_S0.5840.32
44_A139_L0.5840.32
24_N31_D0.5830.32
200_L213_L0.5830.32
169_I236_L0.5820.32
27_D240_I0.5820.32
30_L51_T0.5800.32
206_Y217_S0.5800.32
162_F165_D0.5790.32
188_A191_D0.5790.32
117_R156_L0.5740.31
48_L55_D0.5730.31
6_Y35_D0.5690.31
160_I163_R0.5690.31
137_F221_N0.5660.31
173_N225_M0.5640.31
58_D199_E0.5630.31
187_L191_D0.5630.31
122_L137_F0.5630.31
100_A169_I0.5620.31
31_D51_T0.5620.31
7_Y10_I0.5610.30
59_Y115_A0.5590.30
159_S223_I0.5550.30
221_N242_R0.5540.30
204_D231_K0.5470.29
175_I224_P0.5470.29
106_D110_Q0.5460.29
54_F159_S0.5450.29
30_L70_H0.5420.29
25_L236_L0.5410.29
189_W196_L0.5370.29
191_D236_L0.5370.29
217_S220_Y0.5370.29
171_I210_L0.5360.29
101_N123_I0.5360.29
150_F153_L0.5340.28
209_E212_N0.5340.28
215_I218_L0.5330.28
37_A54_F0.5320.28
59_Y91_I0.5310.28
50_Y156_L0.5290.28
6_Y244_I0.5290.28
8_V102_Y0.5280.28
13_T139_L0.5270.28
138_L242_R0.5260.28
44_A81_I0.5260.28
102_Y169_I0.5250.28
54_F58_D0.5250.28
33_E47_H0.5240.28
44_A141_S0.5240.28
148_R168_I0.5230.28
76_S107_T0.5210.28
14_A28_Y0.5200.27
105_V203_L0.5200.27
196_L200_L0.5190.27
29_L104_L0.5180.27
92_K96_D0.5150.27
151_I166_L0.5150.27
60_V145_K0.5140.27
192_N195_N0.5130.27
65_V232_G0.5110.27
119_T162_F0.5110.27
88_A103_V0.5090.27
203_L235_E0.5070.27
230_G233_F0.5050.26
107_T116_Y0.5040.26
76_S148_R0.5030.26
49_P52_P0.5030.26
171_I191_D0.5030.26
92_K129_G0.5030.26
120_G226_S0.5030.26
84_I220_Y0.5020.26
161_K206_Y0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yrbA 2 0.9421 100 0.586 Contact Map
3ohmA 1 0.9151 99.9 0.738 Contact Map
1cipA 1 0.9112 99.9 0.744 Contact Map
4qj3A 1 0.9189 99.8 0.776 Contact Map
2qm8A 2 0.8417 99.7 0.799 Contact Map
3p32A 2 0.7722 99.7 0.799 Contact Map
4fidA 1 0.8417 99.7 0.801 Contact Map
2akaB 1 0.8764 99.7 0.808 Contact Map
2wwwA 2 0.722 99.6 0.811 Contact Map
2wsmA 2 0.7181 99.6 0.811 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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