GREMLIN Database
PCNA2 - DNA polymerase sliding clamp 2
UniProt: Q97Z84 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 245 (239)
Sequences: 645 (446)
Seq/√Len: 28.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
130_F157_S4.4571.00
216_L224_L3.9691.00
129_P190_A3.4631.00
132_A162_L3.1601.00
11_F88_L2.8781.00
155_I164_F2.8341.00
90_L97_L2.7221.00
196_Y218_F2.5360.99
90_L99_L2.4920.99
155_I162_L2.4530.99
8_A88_L2.4070.99
230_L234_G2.4010.99
227_R237_D2.3830.99
30_T53_S2.3700.99
51_L234_G2.3680.99
49_I236_G2.2790.99
154_N193_S2.2600.98
27_F36_V2.2540.98
75_V99_L2.1650.98
150_G166_V2.1610.98
208_R228_F2.1250.98
29_V59_F2.0910.97
42_S239_Y2.0220.97
50_F235_Y2.0220.97
113_L206_K1.9840.97
43_R46_F1.9560.96
32_E143_I1.9520.96
70_F97_L1.9400.96
223_P242_P1.9340.96
15_L27_F1.8690.95
132_A157_S1.7880.94
196_Y201_V1.7780.94
225_K228_F1.7300.93
40_D200_Y1.7180.92
81_R107_R1.7100.92
51_L143_I1.7090.92
117_E139_F1.7040.92
39_I43_R1.6910.92
42_S200_Y1.6690.91
215_E227_R1.6260.90
205_T208_R1.6190.90
40_D44_V1.6150.90
70_F232_Q1.6100.90
29_V61_V1.5690.88
81_R145_E1.5690.88
74_D173_A1.5680.88
79_L155_I1.5630.88
129_P219_G1.5580.88
109_F166_V1.5280.87
216_L226_L1.5260.87
24_E71_K1.5060.86
14_I125_N1.4940.86
40_D69_G1.4840.85
132_A185_L1.4830.85
221_Q244_A1.4710.85
28_I120_Q1.4540.84
30_T59_F1.4470.84
99_L186_E1.4430.84
43_R124_V1.4430.84
230_L233_E1.4370.83
80_K86_D1.4150.82
108_S174_K1.4090.82
212_D233_E1.4020.82
14_I231_P1.3910.81
11_F36_V1.3770.81
26_N116_V1.3510.79
72_L86_D1.3500.79
134_L139_F1.3500.79
27_F68_I1.3430.79
57_E88_L1.3180.78
43_R197_G1.3080.77
166_V196_Y1.2750.75
53_S59_F1.2730.75
32_E54_S1.2710.75
30_T35_R1.2670.75
69_G168_G1.2660.75
18_V29_V1.2530.74
122_P222_I1.2470.74
150_G205_T1.2440.73
142_I177_L1.2430.73
58_G109_F1.2360.73
44_V200_Y1.2270.72
15_L25_A1.2200.72
170_L173_A1.2140.72
11_F167_I1.2050.71
46_F124_V1.2030.71
163_Y191_D1.2020.71
156_H167_I1.1980.70
204_T240_I1.1920.70
90_L172_T1.1800.69
127_E189_G1.1780.69
109_F133_Q1.1700.69
12_S240_I1.1660.68
79_L133_Q1.1640.68
136_T210_A1.1540.68
125_N169_D1.1510.67
143_I202_A1.1430.67
137_I153_L1.1380.66
34_I180_D1.1380.66
62_S94_E1.1330.66
235_Y239_Y1.1130.65
105_F134_L1.0880.63
161_K176_E1.0820.62
127_E232_Q1.0760.62
124_V204_T1.0720.62
134_L142_I1.0690.62
135_L180_D1.0600.61
39_I44_V1.0560.61
90_L193_S1.0540.60
78_I198_M1.0540.60
39_I119_T1.0440.60
207_M238_F1.0420.59
45_V240_I1.0410.59
229_K235_Y1.0330.59
169_D224_L1.0310.59
122_P125_N1.0300.59
21_F48_D1.0250.58
60_E94_E1.0110.57
45_V200_Y1.0070.57
225_K237_D0.9990.56
172_T176_E0.9970.56
140_A144_D0.9960.56
122_P234_G0.9890.55
149_L173_A0.9870.55
25_A36_V0.9840.55
43_R243_R0.9720.54
183_T202_A0.9690.54
7_D149_L0.9670.54
153_L164_F0.9570.53
99_L143_I0.9550.53
131_K215_E0.9450.52
23_S73_E0.9430.52
37_S243_R0.9410.52
124_V244_A0.9390.52
191_D208_R0.9370.51
224_L244_A0.9370.51
156_H216_L0.9360.51
140_A198_M0.9340.51
77_D121_P0.9320.51
111_L205_T0.9300.51
39_I42_S0.9200.50
25_A72_L0.9150.50
208_R211_S0.9120.49
42_S171_S0.9070.49
47_L148_D0.9020.49
31_K41_P0.8970.48
24_E151_E0.8940.48
18_V36_V0.8920.48
22_L25_A0.8870.48
43_R240_I0.8800.47
40_D43_R0.8800.47
146_L164_F0.8700.46
16_R230_L0.8700.46
155_I159_E0.8630.46
160_N179_T0.8600.45
12_S56_F0.8500.45
70_F111_L0.8490.45
165_E205_T0.8450.44
24_E198_M0.8430.44
55_Y234_G0.8430.44
46_F121_P0.8420.44
15_L238_F0.8400.44
14_I27_F0.8380.44
153_L162_L0.8370.44
14_I211_S0.8280.43
111_L191_D0.8260.43
24_E238_F0.8220.43
117_E168_G0.8220.43
75_V117_E0.8210.42
47_L201_V0.8200.42
9_V76_N0.8190.42
55_Y79_L0.8090.42
59_F202_A0.8090.42
128_F219_G0.8010.41
17_T108_S0.7990.41
63_Q151_E0.7990.41
29_V68_I0.7980.41
26_N67_I0.7970.41
144_D177_L0.7940.40
146_L166_V0.7900.40
11_F82_V0.7890.40
34_I97_L0.7850.40
109_F118_S0.7830.40
8_A114_I0.7820.40
77_D145_E0.7800.39
54_S188_S0.7790.39
87_T125_N0.7770.39
55_Y194_S0.7710.39
82_V101_F0.7710.39
133_Q213_S0.7700.39
123_S206_K0.7700.39
45_V63_Q0.7700.39
154_N226_L0.7690.39
55_Y231_P0.7690.39
26_N130_F0.7660.38
74_D145_E0.7610.38
147_S166_V0.7600.38
47_L196_Y0.7600.38
101_F178_S0.7570.38
90_L192_V0.7560.38
22_L198_M0.7560.38
59_F214_M0.7530.37
109_F238_F0.7530.37
163_Y174_K0.7480.37
93_N99_L0.7450.37
43_R112_P0.7440.37
20_D203_N0.7420.37
72_L90_L0.7360.36
190_A205_T0.7310.36
136_T230_L0.7250.35
132_A187_A0.7250.35
201_V224_L0.7240.35
135_L172_T0.7230.35
49_I163_Y0.7220.35
129_P210_A0.7170.35
116_V152_V0.7160.35
220_S238_F0.7120.34
46_F126_L0.7100.34
127_E213_S0.7070.34
37_S46_F0.7060.34
113_L123_S0.7050.34
44_V241_A0.7050.34
36_V47_L0.7050.34
112_P155_I0.7020.34
90_L159_E0.7020.34
19_G138_T0.7010.34
69_G115_Q0.6970.33
32_E134_L0.6950.33
217_Y227_R0.6900.33
84_K207_M0.6820.32
91_S94_E0.6800.32
17_T27_F0.6780.32
124_V151_E0.6720.32
40_D168_G0.6720.32
238_F244_A0.6710.32
85_D187_A0.6710.32
47_L70_F0.6710.32
109_F151_E0.6700.32
128_F132_A0.6700.32
184_L190_A0.6700.32
193_S212_D0.6700.32
156_H191_D0.6670.31
148_D172_T0.6670.31
78_I157_S0.6660.31
64_E209_R0.6630.31
58_G115_Q0.6610.31
61_V64_E0.6610.31
22_L44_V0.6590.31
140_A208_R0.6590.31
24_E178_S0.6590.31
34_I113_L0.6580.31
8_A179_T0.6580.31
27_F152_V0.6570.31
108_S228_F0.6550.31
166_V199_E0.6540.30
130_F151_E0.6530.30
79_L107_R0.6530.30
14_I166_V0.6500.30
135_L218_F0.6490.30
108_S197_G0.6490.30
91_S180_D0.6460.30
86_D198_M0.6460.30
151_E238_F0.6410.30
100_T108_S0.6390.29
49_I83_L0.6370.29
200_Y239_Y0.6340.29
60_E139_F0.6310.29
10_S149_L0.6290.29
11_F62_S0.6290.29
38_G115_Q0.6270.29
141_D150_G0.6260.29
67_I141_D0.6250.29
15_L36_V0.6240.29
22_L26_N0.6200.28
143_I218_F0.6190.28
82_V227_R0.6190.28
89_I102_D0.6190.28
194_S198_M0.6180.28
44_V223_P0.6160.28
29_V34_I0.6150.28
34_I78_I0.6110.28
23_S126_L0.6110.28
164_F175_V0.6090.28
161_K193_S0.6040.27
167_I217_Y0.5990.27
16_R32_E0.5980.27
68_I173_A0.5970.27
103_G204_T0.5930.27
132_A188_S0.5920.27
75_V201_V0.5910.26
215_E229_K0.5910.26
117_E122_P0.5900.26
23_S239_Y0.5890.26
149_L198_M0.5880.26
99_L103_G0.5860.26
26_N109_F0.5830.26
171_S239_Y0.5830.26
18_V73_E0.5820.26
127_E188_S0.5810.26
17_T125_N0.5790.26
22_L131_K0.5780.26
158_K191_D0.5770.26
79_L117_E0.5760.26
30_T65_K0.5760.26
21_F195_S0.5760.26
88_L151_E0.5750.26
201_V208_R0.5740.25
70_F166_V0.5720.25
165_E188_S0.5720.25
117_E193_S0.5720.25
61_V164_F0.5720.25
8_A233_E0.5690.25
82_V185_L0.5620.25
23_S204_T0.5610.25
86_D190_A0.5560.24
17_T236_G0.5550.24
151_E200_Y0.5540.24
99_L193_S0.5540.24
167_I215_E0.5530.24
6_I57_E0.5490.24
154_N165_E0.5490.24
139_F217_Y0.5480.24
73_E148_D0.5470.24
224_L231_P0.5450.24
126_L129_P0.5440.24
57_E85_D0.5440.24
45_V156_H0.5430.24
83_L98_T0.5400.24
5_V101_F0.5390.23
215_E234_G0.5390.23
212_D236_G0.5360.23
82_V86_D0.5360.23
128_F136_T0.5340.23
10_S151_E0.5330.23
85_D155_I0.5300.23
18_V186_E0.5300.23
131_K143_I0.5260.23
41_P219_G0.5260.23
28_I39_I0.5250.23
8_A149_L0.5240.23
12_S112_P0.5230.23
67_I80_K0.5210.22
11_F77_D0.5190.22
75_V111_L0.5190.22
217_Y225_K0.5180.22
42_S132_A0.5180.22
144_D157_S0.5160.22
102_D134_L0.5150.22
206_K232_Q0.5130.22
22_L116_V0.5130.22
43_R239_Y0.5090.22
6_I9_V0.5090.22
65_K68_I0.5060.22
131_K224_L0.5030.21
95_S164_F0.5020.21
21_F198_M0.5020.21
91_S100_T0.5020.21
43_R200_Y0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a1jC 1 0.9796 100 0.277 Contact Map
3g65A 1 0.9592 100 0.3 Contact Map
3k4xA 1 0.9837 100 0.307 Contact Map
3a1jB 1 0.9592 100 0.319 Contact Map
3a1jA 1 0.9837 100 0.335 Contact Map
3fdsC 1 0.9878 100 0.373 Contact Map
1ud9A 2 0.9796 100 0.396 Contact Map
3aizC 1 0.9959 100 0.399 Contact Map
3aizA 1 0.9878 100 0.401 Contact Map
2zvvA 3 0.9959 100 0.401 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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