PCNA2 - SULSO - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

PCNA2 - DNA polymerase sliding clamp 2

UniProt:	Q97Z84	Sequences: MKAKVIDAVSFSYILRTVGDFLSEANFIVTKEGIRVSGIDPSRVVFLDIFLPSSYFEGFEVSQEKEIIGFKLEDVNDILKRVLKDDTLILSSNESKLTLTFDGEFTRSFELPLIQVESTQPPSVNLEFPFKAQLLTITFADIIDELSDLGEVLNIHSKENKLYFEVIGDLSTAKVELSTDNGTLLEASGADVSSSYGMEYVANTTKMRRASDSMELYFGSQIPLKLRFKLPQEGYGDFYIAPRAD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	245 (239)
Sequences:	645 (446)
Seq/√Len:	28.9

HALSA - PCNA
SULSO - PCNA2 PCNA3 PCNA1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
130_F	157_S	4.457	1.00
216_L	224_L	3.969	1.00
129_P	190_A	3.463	1.00
132_A	162_L	3.160	1.00
11_F	88_L	2.878	1.00
155_I	164_F	2.834	1.00
90_L	97_L	2.722	1.00
196_Y	218_F	2.536	0.99
90_L	99_L	2.492	0.99
155_I	162_L	2.453	0.99
8_A	88_L	2.407	0.99
230_L	234_G	2.401	0.99
227_R	237_D	2.383	0.99
30_T	53_S	2.370	0.99
51_L	234_G	2.368	0.99
49_I	236_G	2.279	0.99
154_N	193_S	2.260	0.98
27_F	36_V	2.254	0.98
75_V	99_L	2.165	0.98
150_G	166_V	2.161	0.98
208_R	228_F	2.125	0.98
29_V	59_F	2.091	0.97
42_S	239_Y	2.022	0.97
50_F	235_Y	2.022	0.97
113_L	206_K	1.984	0.97
43_R	46_F	1.956	0.96
32_E	143_I	1.952	0.96
70_F	97_L	1.940	0.96
223_P	242_P	1.934	0.96
15_L	27_F	1.869	0.95
132_A	157_S	1.788	0.94
196_Y	201_V	1.778	0.94
225_K	228_F	1.730	0.93
40_D	200_Y	1.718	0.92
81_R	107_R	1.710	0.92
51_L	143_I	1.709	0.92
117_E	139_F	1.704	0.92
39_I	43_R	1.691	0.92
42_S	200_Y	1.669	0.91
215_E	227_R	1.626	0.90
205_T	208_R	1.619	0.90
40_D	44_V	1.615	0.90
70_F	232_Q	1.610	0.90
29_V	61_V	1.569	0.88
81_R	145_E	1.569	0.88
74_D	173_A	1.568	0.88
79_L	155_I	1.563	0.88
129_P	219_G	1.558	0.88
109_F	166_V	1.528	0.87
216_L	226_L	1.526	0.87
24_E	71_K	1.506	0.86
14_I	125_N	1.494	0.86
40_D	69_G	1.484	0.85
132_A	185_L	1.483	0.85
221_Q	244_A	1.471	0.85
28_I	120_Q	1.454	0.84
30_T	59_F	1.447	0.84
99_L	186_E	1.443	0.84
43_R	124_V	1.443	0.84
230_L	233_E	1.437	0.83
80_K	86_D	1.415	0.82
108_S	174_K	1.409	0.82
212_D	233_E	1.402	0.82
14_I	231_P	1.391	0.81
11_F	36_V	1.377	0.81
26_N	116_V	1.351	0.79
72_L	86_D	1.350	0.79
134_L	139_F	1.350	0.79
27_F	68_I	1.343	0.79
57_E	88_L	1.318	0.78
43_R	197_G	1.308	0.77
166_V	196_Y	1.275	0.75
53_S	59_F	1.273	0.75
32_E	54_S	1.271	0.75
30_T	35_R	1.267	0.75
69_G	168_G	1.266	0.75
18_V	29_V	1.253	0.74
122_P	222_I	1.247	0.74
150_G	205_T	1.244	0.73
142_I	177_L	1.243	0.73
58_G	109_F	1.236	0.73
44_V	200_Y	1.227	0.72
15_L	25_A	1.220	0.72
170_L	173_A	1.214	0.72
11_F	167_I	1.205	0.71
46_F	124_V	1.203	0.71
163_Y	191_D	1.202	0.71
156_H	167_I	1.198	0.70
204_T	240_I	1.192	0.70
90_L	172_T	1.180	0.69
127_E	189_G	1.178	0.69
109_F	133_Q	1.170	0.69
12_S	240_I	1.166	0.68
79_L	133_Q	1.164	0.68
136_T	210_A	1.154	0.68
125_N	169_D	1.151	0.67
143_I	202_A	1.143	0.67
137_I	153_L	1.138	0.66
34_I	180_D	1.138	0.66
62_S	94_E	1.133	0.66
235_Y	239_Y	1.113	0.65
105_F	134_L	1.088	0.63
161_K	176_E	1.082	0.62
127_E	232_Q	1.076	0.62
124_V	204_T	1.072	0.62
134_L	142_I	1.069	0.62
135_L	180_D	1.060	0.61
39_I	44_V	1.056	0.61
90_L	193_S	1.054	0.60
78_I	198_M	1.054	0.60
39_I	119_T	1.044	0.60
207_M	238_F	1.042	0.59
45_V	240_I	1.041	0.59
229_K	235_Y	1.033	0.59
169_D	224_L	1.031	0.59
122_P	125_N	1.030	0.59
21_F	48_D	1.025	0.58
60_E	94_E	1.011	0.57
45_V	200_Y	1.007	0.57
225_K	237_D	0.999	0.56
172_T	176_E	0.997	0.56
140_A	144_D	0.996	0.56
122_P	234_G	0.989	0.55
149_L	173_A	0.987	0.55
25_A	36_V	0.984	0.55
43_R	243_R	0.972	0.54
183_T	202_A	0.969	0.54
7_D	149_L	0.967	0.54
153_L	164_F	0.957	0.53
99_L	143_I	0.955	0.53
131_K	215_E	0.945	0.52
23_S	73_E	0.943	0.52
37_S	243_R	0.941	0.52
124_V	244_A	0.939	0.52
191_D	208_R	0.937	0.51
224_L	244_A	0.937	0.51
156_H	216_L	0.936	0.51
140_A	198_M	0.934	0.51
77_D	121_P	0.932	0.51
111_L	205_T	0.930	0.51
39_I	42_S	0.920	0.50
25_A	72_L	0.915	0.50
208_R	211_S	0.912	0.49
42_S	171_S	0.907	0.49
47_L	148_D	0.902	0.49
31_K	41_P	0.897	0.48
24_E	151_E	0.894	0.48
18_V	36_V	0.892	0.48
22_L	25_A	0.887	0.48
43_R	240_I	0.880	0.47
40_D	43_R	0.880	0.47
146_L	164_F	0.870	0.46
16_R	230_L	0.870	0.46
155_I	159_E	0.863	0.46
160_N	179_T	0.860	0.45
12_S	56_F	0.850	0.45
70_F	111_L	0.849	0.45
165_E	205_T	0.845	0.44
24_E	198_M	0.843	0.44
55_Y	234_G	0.843	0.44
46_F	121_P	0.842	0.44
15_L	238_F	0.840	0.44
14_I	27_F	0.838	0.44
153_L	162_L	0.837	0.44
14_I	211_S	0.828	0.43
111_L	191_D	0.826	0.43
24_E	238_F	0.822	0.43
117_E	168_G	0.822	0.43
75_V	117_E	0.821	0.42
47_L	201_V	0.820	0.42
9_V	76_N	0.819	0.42
55_Y	79_L	0.809	0.42
59_F	202_A	0.809	0.42
128_F	219_G	0.801	0.41
17_T	108_S	0.799	0.41
63_Q	151_E	0.799	0.41
29_V	68_I	0.798	0.41
26_N	67_I	0.797	0.41
144_D	177_L	0.794	0.40
146_L	166_V	0.790	0.40
11_F	82_V	0.789	0.40
34_I	97_L	0.785	0.40
109_F	118_S	0.783	0.40
8_A	114_I	0.782	0.40
77_D	145_E	0.780	0.39
54_S	188_S	0.779	0.39
87_T	125_N	0.777	0.39
55_Y	194_S	0.771	0.39
82_V	101_F	0.771	0.39
133_Q	213_S	0.770	0.39
123_S	206_K	0.770	0.39
45_V	63_Q	0.770	0.39
154_N	226_L	0.769	0.39
55_Y	231_P	0.769	0.39
26_N	130_F	0.766	0.38
74_D	145_E	0.761	0.38
147_S	166_V	0.760	0.38
47_L	196_Y	0.760	0.38
101_F	178_S	0.757	0.38
90_L	192_V	0.756	0.38
22_L	198_M	0.756	0.38
59_F	214_M	0.753	0.37
109_F	238_F	0.753	0.37
163_Y	174_K	0.748	0.37
93_N	99_L	0.745	0.37
43_R	112_P	0.744	0.37
20_D	203_N	0.742	0.37
72_L	90_L	0.736	0.36
190_A	205_T	0.731	0.36
136_T	230_L	0.725	0.35
132_A	187_A	0.725	0.35
201_V	224_L	0.724	0.35
135_L	172_T	0.723	0.35
49_I	163_Y	0.722	0.35
129_P	210_A	0.717	0.35
116_V	152_V	0.716	0.35
220_S	238_F	0.712	0.34
46_F	126_L	0.710	0.34
127_E	213_S	0.707	0.34
37_S	46_F	0.706	0.34
113_L	123_S	0.705	0.34
44_V	241_A	0.705	0.34
36_V	47_L	0.705	0.34
112_P	155_I	0.702	0.34
90_L	159_E	0.702	0.34
19_G	138_T	0.701	0.34
69_G	115_Q	0.697	0.33
32_E	134_L	0.695	0.33
217_Y	227_R	0.690	0.33
84_K	207_M	0.682	0.32
91_S	94_E	0.680	0.32
17_T	27_F	0.678	0.32
124_V	151_E	0.672	0.32
40_D	168_G	0.672	0.32
238_F	244_A	0.671	0.32
85_D	187_A	0.671	0.32
47_L	70_F	0.671	0.32
109_F	151_E	0.670	0.32
128_F	132_A	0.670	0.32
184_L	190_A	0.670	0.32
193_S	212_D	0.670	0.32
156_H	191_D	0.667	0.31
148_D	172_T	0.667	0.31
78_I	157_S	0.666	0.31
64_E	209_R	0.663	0.31
58_G	115_Q	0.661	0.31
61_V	64_E	0.661	0.31
22_L	44_V	0.659	0.31
140_A	208_R	0.659	0.31
24_E	178_S	0.659	0.31
34_I	113_L	0.658	0.31
8_A	179_T	0.658	0.31
27_F	152_V	0.657	0.31
108_S	228_F	0.655	0.31
166_V	199_E	0.654	0.30
130_F	151_E	0.653	0.30
79_L	107_R	0.653	0.30
14_I	166_V	0.650	0.30
135_L	218_F	0.649	0.30
108_S	197_G	0.649	0.30
91_S	180_D	0.646	0.30
86_D	198_M	0.646	0.30
151_E	238_F	0.641	0.30
100_T	108_S	0.639	0.29
49_I	83_L	0.637	0.29
200_Y	239_Y	0.634	0.29
60_E	139_F	0.631	0.29
10_S	149_L	0.629	0.29
11_F	62_S	0.629	0.29
38_G	115_Q	0.627	0.29
141_D	150_G	0.626	0.29
67_I	141_D	0.625	0.29
15_L	36_V	0.624	0.29
22_L	26_N	0.620	0.28
143_I	218_F	0.619	0.28
82_V	227_R	0.619	0.28
89_I	102_D	0.619	0.28
194_S	198_M	0.618	0.28
44_V	223_P	0.616	0.28
29_V	34_I	0.615	0.28
34_I	78_I	0.611	0.28
23_S	126_L	0.611	0.28
164_F	175_V	0.609	0.28
161_K	193_S	0.604	0.27
167_I	217_Y	0.599	0.27
16_R	32_E	0.598	0.27
68_I	173_A	0.597	0.27
103_G	204_T	0.593	0.27
132_A	188_S	0.592	0.27
75_V	201_V	0.591	0.26
215_E	229_K	0.591	0.26
117_E	122_P	0.590	0.26
23_S	239_Y	0.589	0.26
149_L	198_M	0.588	0.26
99_L	103_G	0.586	0.26
26_N	109_F	0.583	0.26
171_S	239_Y	0.583	0.26
18_V	73_E	0.582	0.26
127_E	188_S	0.581	0.26
17_T	125_N	0.579	0.26
22_L	131_K	0.578	0.26
158_K	191_D	0.577	0.26
79_L	117_E	0.576	0.26
30_T	65_K	0.576	0.26
21_F	195_S	0.576	0.26
88_L	151_E	0.575	0.26
201_V	208_R	0.574	0.25
70_F	166_V	0.572	0.25
165_E	188_S	0.572	0.25
117_E	193_S	0.572	0.25
61_V	164_F	0.572	0.25
8_A	233_E	0.569	0.25
82_V	185_L	0.562	0.25
23_S	204_T	0.561	0.25
86_D	190_A	0.556	0.24
17_T	236_G	0.555	0.24
151_E	200_Y	0.554	0.24
99_L	193_S	0.554	0.24
167_I	215_E	0.553	0.24
6_I	57_E	0.549	0.24
154_N	165_E	0.549	0.24
139_F	217_Y	0.548	0.24
73_E	148_D	0.547	0.24
224_L	231_P	0.545	0.24
126_L	129_P	0.544	0.24
57_E	85_D	0.544	0.24
45_V	156_H	0.543	0.24
83_L	98_T	0.540	0.24
5_V	101_F	0.539	0.23
215_E	234_G	0.539	0.23
212_D	236_G	0.536	0.23
82_V	86_D	0.536	0.23
128_F	136_T	0.534	0.23
10_S	151_E	0.533	0.23
85_D	155_I	0.530	0.23
18_V	186_E	0.530	0.23
131_K	143_I	0.526	0.23
41_P	219_G	0.526	0.23
28_I	39_I	0.525	0.23
8_A	149_L	0.524	0.23
12_S	112_P	0.523	0.23
67_I	80_K	0.521	0.22
11_F	77_D	0.519	0.22
75_V	111_L	0.519	0.22
217_Y	225_K	0.518	0.22
42_S	132_A	0.518	0.22
144_D	157_S	0.516	0.22
102_D	134_L	0.515	0.22
206_K	232_Q	0.513	0.22
22_L	116_V	0.513	0.22
43_R	239_Y	0.509	0.22
6_I	9_V	0.509	0.22
65_K	68_I	0.506	0.22
131_K	224_L	0.503	0.21
95_S	164_F	0.502	0.21
21_F	198_M	0.502	0.21
91_S	100_T	0.502	0.21
43_R	200_Y	0.500	0.21

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3a1jC	1	0.9796	100	0.277	Contact Map
3g65A	1	0.9592	100	0.3	Contact Map
3k4xA	1	0.9837	100	0.307	Contact Map
3a1jB	1	0.9592	100	0.319	Contact Map
3a1jA	1	0.9837	100	0.335	Contact Map
3fdsC	1	0.9878	100	0.373	Contact Map
1ud9A	2	0.9796	100	0.396	Contact Map
3aizC	1	0.9959	100	0.399	Contact Map
3aizA	1	0.9878	100	0.401	Contact Map
2zvvA	3	0.9959	100	0.401	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0087 seconds.