GREMLIN Database
PRIS - DNA primase small subunit PriS
UniProt: Q97Z83 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 330 (284)
Sequences: 493 (359)
Seq/√Len: 21.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
163_D202_Y4.9561.00
172_F258_L4.7231.00
159_I203_V4.3281.00
54_F63_Y4.3151.00
192_D195_E3.7881.00
153_T263_V3.5721.00
18_F24_N3.5311.00
283_I308_K3.5161.00
252_L259_I3.3391.00
102_I149_G3.2711.00
310_K314_G3.2651.00
191_L199_I3.1301.00
116_C145_C2.8700.99
41_Q48_Y2.8120.99
39_A48_Y2.5480.98
153_T178_F2.5440.98
98_L191_L2.5430.98
265_N268_D2.4680.98
142_T145_C2.2760.96
40_L54_F2.2680.96
61_R65_V2.1680.95
39_A73_L2.0900.94
249_P253_H2.0850.94
245_L256_S2.0520.93
154_R267_D2.0270.93
169_K262_R2.0070.92
128_C145_C1.9730.92
157_V161_E1.9180.90
204_M255_K1.8780.89
218_A221_W1.8610.89
39_A74_F1.8230.88
96_S248_I1.7840.87
245_L253_H1.7450.86
60_L64_L1.7210.85
31_K183_D1.6780.83
160_L166_L1.6430.82
287_Y306_P1.6050.80
171_Y262_R1.6040.80
169_K183_D1.5940.80
193_S241_D1.5830.79
205_G236_E1.5670.79
41_Q240_I1.5630.78
17_F24_N1.5520.78
273_E286_P1.5100.76
174_G179_H1.5090.76
18_F39_A1.5020.76
72_H77_S1.5000.75
146_I178_F1.4990.75
18_F22_Y1.4810.75
166_L188_C1.4800.74
74_F237_Q1.4670.74
21_Y147_K1.4630.74
75_Y180_V1.4610.74
219_P223_G1.4540.73
100_F191_L1.4530.73
96_S242_V1.4520.73
17_F20_N1.4500.73
20_N24_N1.4410.72
102_I145_C1.4330.72
98_L200_A1.4320.72
245_L249_P1.4290.72
221_W224_R1.4260.72
58_E61_R1.4260.72
104_A248_I1.4070.71
185_Y190_L1.3980.70
55_S59_E1.3810.69
250_N256_S1.3800.69
181_Q246_I1.3780.69
201_E236_E1.3730.69
104_A138_Y1.3560.68
182_V293_E1.3480.67
287_Y291_E1.3340.66
259_I280_G1.3170.65
51_H105_D1.3150.65
95_G189_A1.3130.65
166_L199_I1.3050.65
39_A72_H1.2900.64
32_D95_G1.2890.64
245_L254_G1.2860.63
39_A237_Q1.2700.62
160_L207_G1.2660.62
72_H237_Q1.2660.62
192_D242_V1.2520.61
56_S59_E1.2510.61
240_I257_G1.2460.61
51_H83_P1.2450.61
96_S138_Y1.2320.60
184_C309_I1.2120.59
55_S156_L1.2080.58
200_A203_V1.2070.58
268_D289_T1.2060.58
77_S182_V1.2010.58
96_S243_K1.1880.57
253_H316_Y1.1760.56
251_S260_V1.1560.55
215_S222_V1.1520.55
218_A226_N1.1520.55
164_F253_H1.1460.54
21_Y217_N1.1440.54
54_F255_K1.1390.54
196_R235_D1.1360.54
33_M38_F1.1350.54
113_I148_R1.1340.54
116_C142_T1.1340.54
277_P281_Y1.1240.53
35_L104_A1.1230.53
178_F320_R1.1070.52
42_P47_T1.1070.52
142_T175_N1.0990.51
16_S20_N1.0980.51
271_F274_T1.0980.51
156_L178_F1.0890.51
147_K267_D1.0830.50
63_Y66_N1.0830.50
18_F21_Y1.0810.50
141_M145_C1.0760.50
277_P280_G1.0700.49
243_K253_H1.0690.49
212_P228_G1.0670.49
60_L154_R1.0650.49
161_E164_F1.0610.49
142_T246_I1.0490.48
24_N64_L1.0460.48
61_R86_R1.0450.48
21_Y172_F1.0430.48
179_H235_D1.0430.48
174_G196_R1.0430.48
174_G235_D1.0430.48
179_H196_R1.0430.48
163_D271_F1.0430.48
95_G190_L1.0380.47
76_S247_R1.0280.47
225_K229_I1.0270.46
65_V81_Q1.0260.46
244_R250_N1.0250.46
199_I266_L1.0240.46
258_L272_N1.0200.46
74_F197_K1.0160.46
159_I234_I1.0100.45
152_Q280_G1.0050.45
152_Q155_N1.0030.45
204_M236_E1.0020.45
160_L182_V1.0000.45
40_L68_N0.9970.44
258_L276_S0.9890.44
288_I306_P0.9880.44
35_L64_L0.9870.44
55_S182_V0.9840.44
64_L185_Y0.9830.44
197_K237_Q0.9770.43
303_R306_P0.9760.43
66_N204_M0.9760.43
113_I141_M0.9730.43
106_H246_I0.9650.42
237_Q240_I0.9600.42
44_G47_T0.9590.42
191_L239_T0.9520.42
183_D319_L0.9440.41
203_V234_I0.9420.41
73_L149_G0.9380.41
38_F248_I0.9380.41
250_N254_G0.9350.40
30_P64_L0.9350.40
38_F55_S0.9280.40
232_V244_R0.9250.40
21_Y194_D0.9160.39
149_G197_K0.9150.39
77_S241_D0.9150.39
173_S182_V0.9120.39
211_Y313_I0.9010.38
160_L163_D0.8990.38
39_A149_G0.8980.38
42_P49_V0.8890.38
78_A96_S0.8850.37
253_H256_S0.8840.37
151_E251_S0.8830.37
18_F237_Q0.8820.37
199_I286_P0.8760.37
44_G89_E0.8740.37
80_Y91_K0.8730.37
209_P228_G0.8690.36
150_L272_N0.8650.36
97_D246_I0.8650.36
19_R23_L0.8640.36
174_G177_G0.8640.36
140_E272_N0.8620.36
17_F255_K0.8620.36
191_L195_E0.8580.36
272_N316_Y0.8570.36
166_L180_V0.8560.35
87_N105_D0.8540.35
246_I253_H0.8500.35
159_I194_D0.8500.35
41_Q45_S0.8500.35
188_C191_L0.8460.35
102_I142_T0.8430.35
51_H91_K0.8370.34
244_R252_L0.8360.34
38_F145_C0.8270.34
246_I254_G0.8250.34
22_Y37_E0.8240.34
147_K270_E0.8210.33
108_C145_C0.8180.33
113_I147_K0.8170.33
241_D254_G0.8170.33
181_Q184_C0.8120.33
105_D245_L0.8080.33
80_Y95_G0.8040.32
108_C114_R0.7980.32
145_C175_N0.7970.32
241_D281_Y0.7970.32
88_M242_V0.7910.32
237_Q241_D0.7850.31
72_H178_F0.7840.31
90_E211_Y0.7840.31
139_V144_E0.7840.31
107_L152_Q0.7810.31
218_A222_V0.7810.31
255_K263_V0.7800.31
214_G221_W0.7790.31
41_Q91_K0.7780.31
162_D315_I0.7760.31
75_Y246_I0.7750.31
178_F220_G0.7750.31
288_I322_L0.7710.30
220_G224_R0.7710.30
33_M40_L0.7710.30
49_V229_I0.7710.30
219_P226_N0.7690.30
263_V266_L0.7660.30
208_V229_I0.7650.30
238_V245_L0.7650.30
223_G227_R0.7650.30
22_Y36_R0.7590.30
244_R247_R0.7580.30
52_L86_R0.7550.30
23_L61_R0.7530.29
163_D201_E0.7530.29
96_S153_T0.7500.29
40_L203_V0.7490.29
44_G199_I0.7480.29
72_H254_G0.7460.29
41_Q276_S0.7450.29
239_T243_K0.7450.29
109_K113_I0.7430.29
148_R280_G0.7400.29
51_H254_G0.7380.29
55_S194_D0.7340.28
160_L270_E0.7330.28
48_Y77_S0.7330.28
172_F272_N0.7320.28
74_F149_G0.7320.28
79_R223_G0.7300.28
216_E219_P0.7280.28
75_Y234_I0.7270.28
27_L30_P0.7260.28
238_V253_H0.7230.28
244_R254_G0.7200.28
115_F138_Y0.7180.28
150_L271_F0.7170.27
17_F145_C0.7160.27
32_D96_S0.7140.27
108_C128_C0.7130.27
72_H106_H0.7090.27
19_R156_L0.7090.27
141_M269_F0.7080.27
18_F43_F0.7040.27
40_L259_I0.7030.27
93_W242_V0.7020.27
206_I228_G0.7020.27
163_D199_I0.7000.27
269_F274_T0.6980.26
167_K206_I0.6960.26
80_Y239_T0.6960.26
55_S298_I0.6900.26
273_E305_I0.6880.26
74_F178_F0.6850.26
166_L175_N0.6850.26
233_T256_S0.6840.26
315_I318_H0.6820.26
64_L199_I0.6800.26
19_R56_S0.6790.25
220_G223_G0.6780.25
106_H116_C0.6760.25
128_C141_M0.6740.25
170_V180_V0.6740.25
116_C128_C0.6670.25
176_R245_L0.6670.25
214_G223_G0.6650.25
152_Q181_Q0.6650.25
77_S202_Y0.6600.25
115_F148_R0.6600.25
66_N213_G0.6550.24
100_F178_F0.6540.24
108_C142_T0.6540.24
74_F244_R0.6520.24
95_G255_K0.6500.24
105_D260_V0.6500.24
270_E273_E0.6490.24
66_N180_V0.6480.24
92_A314_G0.6460.24
249_P256_S0.6440.24
232_V250_N0.6420.24
201_E227_R0.6420.24
21_Y189_A0.6410.24
217_N223_G0.6370.23
56_S305_I0.6340.23
116_C141_M0.6330.23
150_L258_L0.6320.23
166_L191_L0.6320.23
19_R143_S0.6290.23
59_E312_S0.6270.23
293_E298_I0.6250.23
72_H255_K0.6250.23
36_R196_R0.6250.23
36_R235_D0.6250.23
150_L275_L0.6220.23
94_M285_L0.6210.23
99_L129_E0.6190.23
313_I317_L0.6190.23
214_G219_P0.6180.23
250_N253_H0.6180.23
202_Y257_G0.6160.22
24_N303_R0.6150.22
146_I175_N0.6150.22
175_N232_V0.6140.22
80_Y90_E0.6130.22
139_V255_K0.6130.22
144_E154_R0.6130.22
301_L313_I0.6120.22
248_I261_K0.6120.22
48_Y73_L0.6100.22
143_S182_V0.6070.22
247_R250_N0.6070.22
23_L266_L0.6070.22
138_Y288_I0.6060.22
80_Y98_L0.6060.22
311_S320_R0.6030.22
189_A202_Y0.6020.22
76_S244_R0.6000.22
185_Y213_G0.6000.22
107_L181_Q0.5970.22
280_G283_I0.5950.21
286_P298_I0.5950.21
309_I312_S0.5940.21
157_V232_V0.5930.21
31_K187_N0.5920.21
159_I162_D0.5900.21
74_F241_D0.5900.21
104_A228_G0.5890.21
221_W227_R0.5890.21
56_S264_P0.5870.21
200_A215_S0.5840.21
203_V232_V0.5840.21
259_I262_R0.5820.21
291_E298_I0.5810.21
27_L267_D0.5800.21
91_K208_V0.5790.21
63_Y104_A0.5780.21
91_K210_G0.5770.21
239_T264_P0.5770.21
173_S177_G0.5760.21
36_R269_F0.5750.21
38_F58_E0.5740.21
58_E306_P0.5720.20
105_D176_R0.5700.20
39_A159_I0.5690.20
215_S219_P0.5680.20
107_L169_K0.5680.20
264_P301_L0.5660.20
64_L282_T0.5640.20
256_S297_S0.5640.20
178_F253_H0.5640.20
219_P285_L0.5630.20
204_M234_I0.5620.20
44_G71_L0.5600.20
164_F191_L0.5590.20
37_E50_R0.5560.20
113_I290_I0.5550.20
218_A228_G0.5530.20
94_M153_T0.5520.20
72_H76_S0.5510.20
77_S180_V0.5470.19
64_L197_K0.5470.19
207_G313_I0.5450.19
284_F288_I0.5430.19
239_T284_F0.5400.19
108_C262_R0.5380.19
201_E213_G0.5360.19
91_K198_E0.5350.19
260_V269_F0.5350.19
175_N178_F0.5320.19
273_E288_I0.5310.19
90_E221_W0.5290.19
36_R174_G0.5270.19
36_R179_H0.5270.19
205_G252_L0.5270.19
66_N297_S0.5260.19
316_Y319_L0.5260.19
76_S80_Y0.5250.18
74_F247_R0.5230.18
78_A95_G0.5230.18
78_A193_S0.5230.18
255_K286_P0.5220.18
218_A223_G0.5220.18
185_Y216_E0.5200.18
77_S183_D0.5170.18
292_T300_K0.5170.18
214_G217_N0.5170.18
309_I314_G0.5150.18
311_S314_G0.5150.18
97_D145_C0.5140.18
34_E59_E0.5130.18
94_M268_D0.5120.18
14_I19_R0.5110.18
216_E265_N0.5100.18
45_S178_F0.5100.18
31_K166_L0.5100.18
241_D277_P0.5090.18
247_R254_G0.5080.18
48_Y96_S0.5080.18
99_L242_V0.5060.18
58_E305_I0.5040.18
107_L184_C0.5020.18
85_A172_F0.5010.18
263_V288_I0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zt2A 3 0.9879 100 0.238 Contact Map
4likA 1 0.8455 100 0.277 Contact Map
4mm2A 1 0.8455 100 0.297 Contact Map
1v33A 1 0.7788 100 0.369 Contact Map
2iruA 1 0.7364 95.6 0.945 Contact Map
2faoA 1 0.7879 94.4 0.949 Contact Map
3lpeB 1 0.1788 61.6 0.966 Contact Map
1ryqA 1 0.1909 43.4 0.97 Contact Map
3p8bA 1 0.1818 41.1 0.97 Contact Map
1vq8Z 1 0.2 24.2 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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