PRIS - SULSO - GREMLIN Contacts

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PRIS - DNA primase small subunit PriS

UniProt:	Q97Z83	Sequences: MGTFTLHQGQTNLIKSFFRNYYLNAELELPKDMELREFALQPFGSDTYVRHLSFSSSEELRDYLVNRNLPLHLFYSSARYQLPSARNMEEKAWMGSDLLFDIDADHLCKLRSIRFCPVCGNAVVSEKCERDNVETLEYVEMTSECIKRGLEQTRNLVEILEDDFGLKPKVYFSGNRGFHVQVDCYGNCALLDSDERKEIAEYVMGIGVPGYPGGSENAPGWVGRKNRGINGVTIDEQVTIDVKRLIRIPNSLHGKSGLIVKRVPNLDDFEFNETLSPFTGYTIFLPYITIETEVLGSIIKLNRGIPIKIKSSIGIYLHLRNLGEVKAYVR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	330 (284)
Sequences:	493 (359)
Seq/√Len:	21.3

HALSA - PRIS
SULSO - PRIS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
163_D	202_Y	4.956	1.00
172_F	258_L	4.723	1.00
159_I	203_V	4.328	1.00
54_F	63_Y	4.315	1.00
192_D	195_E	3.788	1.00
153_T	263_V	3.572	1.00
18_F	24_N	3.531	1.00
283_I	308_K	3.516	1.00
252_L	259_I	3.339	1.00
102_I	149_G	3.271	1.00
310_K	314_G	3.265	1.00
191_L	199_I	3.130	1.00
116_C	145_C	2.870	0.99
41_Q	48_Y	2.812	0.99
39_A	48_Y	2.548	0.98
153_T	178_F	2.544	0.98
98_L	191_L	2.543	0.98
265_N	268_D	2.468	0.98
142_T	145_C	2.276	0.96
40_L	54_F	2.268	0.96
61_R	65_V	2.168	0.95
39_A	73_L	2.090	0.94
249_P	253_H	2.085	0.94
245_L	256_S	2.052	0.93
154_R	267_D	2.027	0.93
169_K	262_R	2.007	0.92
128_C	145_C	1.973	0.92
157_V	161_E	1.918	0.90
204_M	255_K	1.878	0.89
218_A	221_W	1.861	0.89
39_A	74_F	1.823	0.88
96_S	248_I	1.784	0.87
245_L	253_H	1.745	0.86
60_L	64_L	1.721	0.85
31_K	183_D	1.678	0.83
160_L	166_L	1.643	0.82
287_Y	306_P	1.605	0.80
171_Y	262_R	1.604	0.80
169_K	183_D	1.594	0.80
193_S	241_D	1.583	0.79
205_G	236_E	1.567	0.79
41_Q	240_I	1.563	0.78
17_F	24_N	1.552	0.78
273_E	286_P	1.510	0.76
174_G	179_H	1.509	0.76
18_F	39_A	1.502	0.76
72_H	77_S	1.500	0.75
146_I	178_F	1.499	0.75
18_F	22_Y	1.481	0.75
166_L	188_C	1.480	0.74
74_F	237_Q	1.467	0.74
21_Y	147_K	1.463	0.74
75_Y	180_V	1.461	0.74
219_P	223_G	1.454	0.73
100_F	191_L	1.453	0.73
96_S	242_V	1.452	0.73
17_F	20_N	1.450	0.73
20_N	24_N	1.441	0.72
102_I	145_C	1.433	0.72
98_L	200_A	1.432	0.72
245_L	249_P	1.429	0.72
221_W	224_R	1.426	0.72
58_E	61_R	1.426	0.72
104_A	248_I	1.407	0.71
185_Y	190_L	1.398	0.70
55_S	59_E	1.381	0.69
250_N	256_S	1.380	0.69
181_Q	246_I	1.378	0.69
201_E	236_E	1.373	0.69
104_A	138_Y	1.356	0.68
182_V	293_E	1.348	0.67
287_Y	291_E	1.334	0.66
259_I	280_G	1.317	0.65
51_H	105_D	1.315	0.65
95_G	189_A	1.313	0.65
166_L	199_I	1.305	0.65
39_A	72_H	1.290	0.64
32_D	95_G	1.289	0.64
245_L	254_G	1.286	0.63
39_A	237_Q	1.270	0.62
160_L	207_G	1.266	0.62
72_H	237_Q	1.266	0.62
192_D	242_V	1.252	0.61
56_S	59_E	1.251	0.61
240_I	257_G	1.246	0.61
51_H	83_P	1.245	0.61
96_S	138_Y	1.232	0.60
184_C	309_I	1.212	0.59
55_S	156_L	1.208	0.58
200_A	203_V	1.207	0.58
268_D	289_T	1.206	0.58
77_S	182_V	1.201	0.58
96_S	243_K	1.188	0.57
253_H	316_Y	1.176	0.56
251_S	260_V	1.156	0.55
215_S	222_V	1.152	0.55
218_A	226_N	1.152	0.55
164_F	253_H	1.146	0.54
21_Y	217_N	1.144	0.54
54_F	255_K	1.139	0.54
196_R	235_D	1.136	0.54
33_M	38_F	1.135	0.54
113_I	148_R	1.134	0.54
116_C	142_T	1.134	0.54
277_P	281_Y	1.124	0.53
35_L	104_A	1.123	0.53
178_F	320_R	1.107	0.52
42_P	47_T	1.107	0.52
142_T	175_N	1.099	0.51
16_S	20_N	1.098	0.51
271_F	274_T	1.098	0.51
156_L	178_F	1.089	0.51
147_K	267_D	1.083	0.50
63_Y	66_N	1.083	0.50
18_F	21_Y	1.081	0.50
141_M	145_C	1.076	0.50
277_P	280_G	1.070	0.49
243_K	253_H	1.069	0.49
212_P	228_G	1.067	0.49
60_L	154_R	1.065	0.49
161_E	164_F	1.061	0.49
142_T	246_I	1.049	0.48
24_N	64_L	1.046	0.48
61_R	86_R	1.045	0.48
21_Y	172_F	1.043	0.48
179_H	235_D	1.043	0.48
174_G	196_R	1.043	0.48
174_G	235_D	1.043	0.48
179_H	196_R	1.043	0.48
163_D	271_F	1.043	0.48
95_G	190_L	1.038	0.47
76_S	247_R	1.028	0.47
225_K	229_I	1.027	0.46
65_V	81_Q	1.026	0.46
244_R	250_N	1.025	0.46
199_I	266_L	1.024	0.46
258_L	272_N	1.020	0.46
74_F	197_K	1.016	0.46
159_I	234_I	1.010	0.45
152_Q	280_G	1.005	0.45
152_Q	155_N	1.003	0.45
204_M	236_E	1.002	0.45
160_L	182_V	1.000	0.45
40_L	68_N	0.997	0.44
258_L	276_S	0.989	0.44
288_I	306_P	0.988	0.44
35_L	64_L	0.987	0.44
55_S	182_V	0.984	0.44
64_L	185_Y	0.983	0.44
197_K	237_Q	0.977	0.43
303_R	306_P	0.976	0.43
66_N	204_M	0.976	0.43
113_I	141_M	0.973	0.43
106_H	246_I	0.965	0.42
237_Q	240_I	0.960	0.42
44_G	47_T	0.959	0.42
191_L	239_T	0.952	0.42
183_D	319_L	0.944	0.41
203_V	234_I	0.942	0.41
73_L	149_G	0.938	0.41
38_F	248_I	0.938	0.41
250_N	254_G	0.935	0.40
30_P	64_L	0.935	0.40
38_F	55_S	0.928	0.40
232_V	244_R	0.925	0.40
21_Y	194_D	0.916	0.39
149_G	197_K	0.915	0.39
77_S	241_D	0.915	0.39
173_S	182_V	0.912	0.39
211_Y	313_I	0.901	0.38
160_L	163_D	0.899	0.38
39_A	149_G	0.898	0.38
42_P	49_V	0.889	0.38
78_A	96_S	0.885	0.37
253_H	256_S	0.884	0.37
151_E	251_S	0.883	0.37
18_F	237_Q	0.882	0.37
199_I	286_P	0.876	0.37
44_G	89_E	0.874	0.37
80_Y	91_K	0.873	0.37
209_P	228_G	0.869	0.36
150_L	272_N	0.865	0.36
97_D	246_I	0.865	0.36
19_R	23_L	0.864	0.36
174_G	177_G	0.864	0.36
140_E	272_N	0.862	0.36
17_F	255_K	0.862	0.36
191_L	195_E	0.858	0.36
272_N	316_Y	0.857	0.36
166_L	180_V	0.856	0.35
87_N	105_D	0.854	0.35
246_I	253_H	0.850	0.35
159_I	194_D	0.850	0.35
41_Q	45_S	0.850	0.35
188_C	191_L	0.846	0.35
102_I	142_T	0.843	0.35
51_H	91_K	0.837	0.34
244_R	252_L	0.836	0.34
38_F	145_C	0.827	0.34
246_I	254_G	0.825	0.34
22_Y	37_E	0.824	0.34
147_K	270_E	0.821	0.33
108_C	145_C	0.818	0.33
113_I	147_K	0.817	0.33
241_D	254_G	0.817	0.33
181_Q	184_C	0.812	0.33
105_D	245_L	0.808	0.33
80_Y	95_G	0.804	0.32
108_C	114_R	0.798	0.32
145_C	175_N	0.797	0.32
241_D	281_Y	0.797	0.32
88_M	242_V	0.791	0.32
237_Q	241_D	0.785	0.31
72_H	178_F	0.784	0.31
90_E	211_Y	0.784	0.31
139_V	144_E	0.784	0.31
107_L	152_Q	0.781	0.31
218_A	222_V	0.781	0.31
255_K	263_V	0.780	0.31
214_G	221_W	0.779	0.31
41_Q	91_K	0.778	0.31
162_D	315_I	0.776	0.31
75_Y	246_I	0.775	0.31
178_F	220_G	0.775	0.31
288_I	322_L	0.771	0.30
220_G	224_R	0.771	0.30
33_M	40_L	0.771	0.30
49_V	229_I	0.771	0.30
219_P	226_N	0.769	0.30
263_V	266_L	0.766	0.30
208_V	229_I	0.765	0.30
238_V	245_L	0.765	0.30
223_G	227_R	0.765	0.30
22_Y	36_R	0.759	0.30
244_R	247_R	0.758	0.30
52_L	86_R	0.755	0.30
23_L	61_R	0.753	0.29
163_D	201_E	0.753	0.29
96_S	153_T	0.750	0.29
40_L	203_V	0.749	0.29
44_G	199_I	0.748	0.29
72_H	254_G	0.746	0.29
41_Q	276_S	0.745	0.29
239_T	243_K	0.745	0.29
109_K	113_I	0.743	0.29
148_R	280_G	0.740	0.29
51_H	254_G	0.738	0.29
55_S	194_D	0.734	0.28
160_L	270_E	0.733	0.28
48_Y	77_S	0.733	0.28
172_F	272_N	0.732	0.28
74_F	149_G	0.732	0.28
79_R	223_G	0.730	0.28
216_E	219_P	0.728	0.28
75_Y	234_I	0.727	0.28
27_L	30_P	0.726	0.28
238_V	253_H	0.723	0.28
244_R	254_G	0.720	0.28
115_F	138_Y	0.718	0.28
150_L	271_F	0.717	0.27
17_F	145_C	0.716	0.27
32_D	96_S	0.714	0.27
108_C	128_C	0.713	0.27
72_H	106_H	0.709	0.27
19_R	156_L	0.709	0.27
141_M	269_F	0.708	0.27
18_F	43_F	0.704	0.27
40_L	259_I	0.703	0.27
93_W	242_V	0.702	0.27
206_I	228_G	0.702	0.27
163_D	199_I	0.700	0.27
269_F	274_T	0.698	0.26
167_K	206_I	0.696	0.26
80_Y	239_T	0.696	0.26
55_S	298_I	0.690	0.26
273_E	305_I	0.688	0.26
74_F	178_F	0.685	0.26
166_L	175_N	0.685	0.26
233_T	256_S	0.684	0.26
315_I	318_H	0.682	0.26
64_L	199_I	0.680	0.26
19_R	56_S	0.679	0.25
220_G	223_G	0.678	0.25
106_H	116_C	0.676	0.25
128_C	141_M	0.674	0.25
170_V	180_V	0.674	0.25
116_C	128_C	0.667	0.25
176_R	245_L	0.667	0.25
214_G	223_G	0.665	0.25
152_Q	181_Q	0.665	0.25
77_S	202_Y	0.660	0.25
115_F	148_R	0.660	0.25
66_N	213_G	0.655	0.24
100_F	178_F	0.654	0.24
108_C	142_T	0.654	0.24
74_F	244_R	0.652	0.24
95_G	255_K	0.650	0.24
105_D	260_V	0.650	0.24
270_E	273_E	0.649	0.24
66_N	180_V	0.648	0.24
92_A	314_G	0.646	0.24
249_P	256_S	0.644	0.24
232_V	250_N	0.642	0.24
201_E	227_R	0.642	0.24
21_Y	189_A	0.641	0.24
217_N	223_G	0.637	0.23
56_S	305_I	0.634	0.23
116_C	141_M	0.633	0.23
150_L	258_L	0.632	0.23
166_L	191_L	0.632	0.23
19_R	143_S	0.629	0.23
59_E	312_S	0.627	0.23
293_E	298_I	0.625	0.23
72_H	255_K	0.625	0.23
36_R	196_R	0.625	0.23
36_R	235_D	0.625	0.23
150_L	275_L	0.622	0.23
94_M	285_L	0.621	0.23
99_L	129_E	0.619	0.23
313_I	317_L	0.619	0.23
214_G	219_P	0.618	0.23
250_N	253_H	0.618	0.23
202_Y	257_G	0.616	0.22
24_N	303_R	0.615	0.22
146_I	175_N	0.615	0.22
175_N	232_V	0.614	0.22
80_Y	90_E	0.613	0.22
139_V	255_K	0.613	0.22
144_E	154_R	0.613	0.22
301_L	313_I	0.612	0.22
248_I	261_K	0.612	0.22
48_Y	73_L	0.610	0.22
143_S	182_V	0.607	0.22
247_R	250_N	0.607	0.22
23_L	266_L	0.607	0.22
138_Y	288_I	0.606	0.22
80_Y	98_L	0.606	0.22
311_S	320_R	0.603	0.22
189_A	202_Y	0.602	0.22
76_S	244_R	0.600	0.22
185_Y	213_G	0.600	0.22
107_L	181_Q	0.597	0.22
280_G	283_I	0.595	0.21
286_P	298_I	0.595	0.21
309_I	312_S	0.594	0.21
157_V	232_V	0.593	0.21
31_K	187_N	0.592	0.21
159_I	162_D	0.590	0.21
74_F	241_D	0.590	0.21
104_A	228_G	0.589	0.21
221_W	227_R	0.589	0.21
56_S	264_P	0.587	0.21
200_A	215_S	0.584	0.21
203_V	232_V	0.584	0.21
259_I	262_R	0.582	0.21
291_E	298_I	0.581	0.21
27_L	267_D	0.580	0.21
91_K	208_V	0.579	0.21
63_Y	104_A	0.578	0.21
91_K	210_G	0.577	0.21
239_T	264_P	0.577	0.21
173_S	177_G	0.576	0.21
36_R	269_F	0.575	0.21
38_F	58_E	0.574	0.21
58_E	306_P	0.572	0.20
105_D	176_R	0.570	0.20
39_A	159_I	0.569	0.20
215_S	219_P	0.568	0.20
107_L	169_K	0.568	0.20
264_P	301_L	0.566	0.20
64_L	282_T	0.564	0.20
256_S	297_S	0.564	0.20
178_F	253_H	0.564	0.20
219_P	285_L	0.563	0.20
204_M	234_I	0.562	0.20
44_G	71_L	0.560	0.20
164_F	191_L	0.559	0.20
37_E	50_R	0.556	0.20
113_I	290_I	0.555	0.20
218_A	228_G	0.553	0.20
94_M	153_T	0.552	0.20
72_H	76_S	0.551	0.20
77_S	180_V	0.547	0.19
64_L	197_K	0.547	0.19
207_G	313_I	0.545	0.19
284_F	288_I	0.543	0.19
239_T	284_F	0.540	0.19
108_C	262_R	0.538	0.19
201_E	213_G	0.536	0.19
91_K	198_E	0.535	0.19
260_V	269_F	0.535	0.19
175_N	178_F	0.532	0.19
273_E	288_I	0.531	0.19
90_E	221_W	0.529	0.19
36_R	174_G	0.527	0.19
36_R	179_H	0.527	0.19
205_G	252_L	0.527	0.19
66_N	297_S	0.526	0.19
316_Y	319_L	0.526	0.19
76_S	80_Y	0.525	0.18
74_F	247_R	0.523	0.18
78_A	95_G	0.523	0.18
78_A	193_S	0.523	0.18
255_K	286_P	0.522	0.18
218_A	223_G	0.522	0.18
185_Y	216_E	0.520	0.18
77_S	183_D	0.517	0.18
292_T	300_K	0.517	0.18
214_G	217_N	0.517	0.18
309_I	314_G	0.515	0.18
311_S	314_G	0.515	0.18
97_D	145_C	0.514	0.18
34_E	59_E	0.513	0.18
94_M	268_D	0.512	0.18
14_I	19_R	0.511	0.18
216_E	265_N	0.510	0.18
45_S	178_F	0.510	0.18
31_K	166_L	0.510	0.18
241_D	277_P	0.509	0.18
247_R	254_G	0.508	0.18
48_Y	96_S	0.508	0.18
99_L	242_V	0.506	0.18
58_E	305_I	0.504	0.18
107_L	184_C	0.502	0.18
85_A	172_F	0.501	0.18
263_V	288_I	0.500	0.17

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1zt2A	3	0.9879	100	0.238	Contact Map
4likA	1	0.8455	100	0.277	Contact Map
4mm2A	1	0.8455	100	0.297	Contact Map
1v33A	1	0.7788	100	0.369	Contact Map
2iruA	1	0.7364	95.6	0.945	Contact Map
2faoA	1	0.7879	94.4	0.949	Contact Map
3lpeB	1	0.1788	61.6	0.966	Contact Map
1ryqA	1	0.1909	43.4	0.97	Contact Map
3p8bA	1	0.1818	41.1	0.97	Contact Map
1vq8Z	1	0.2	24.2	0.973	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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