IF2A - SULSO - GREMLIN Contacts

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IF2A - Translation initiation factor 2 subunit alpha

UniProt:	Q97Z79	Sequences: MIYSRSKLPSEGEILIATVKQVFDYGSYVSLDEYGGLQAFLPWSEVSSKWVKNIRDVLKENRKVIVKVIRVDRRKGTVDVSLKKVTDDERRKKNLQWKKIQRLDKILELVSQKLKLSEKDAWEQVAWKLEAKYGDPITAIEKAVKEGEKILIDAGVPEIWVKPLLEEASKHAEERKVKMSGLITVRTNEPLGVEKIKEVISKALENIEQDYESLLNIKIYTIGAPRYRVDVVGTNPKEASEALNQIISNLIKIGKEENVDISVVKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	266 (223)
Sequences:	970 (776)
Seq/√Len:	52.0

HALSA - IF2A
SULSO - IF2A

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
46_V	58_L	4.105	1.00
22_V	58_L	3.786	1.00
39_A	80_V	3.613	1.00
118_E	121_A	2.887	1.00
130_E	133_Y	2.862	1.00
47_S	52_K	2.598	1.00
202_K	205_E	2.475	1.00
127_W	130_E	2.408	1.00
121_A	124_Q	2.340	1.00
113_K	116_L	2.262	1.00
17_A	64_V	2.247	1.00
49_K	52_K	2.223	1.00
33_E	52_K	2.187	1.00
18_T	27_S	2.148	1.00
105_K	108_E	2.147	1.00
115_K	118_E	2.139	1.00
18_T	30_S	2.129	1.00
120_D	123_E	2.066	1.00
125_V	128_K	2.018	1.00
41_L	66_V	1.969	1.00
12_G	55_R	1.966	1.00
33_E	71_V	1.910	0.99
50_W	55_R	1.906	0.99
43_W	64_V	1.901	0.99
165_L	168_A	1.896	0.99
48_S	51_V	1.894	0.99
23_F	39_A	1.890	0.99
33_E	36_G	1.689	0.99
122_W	126_A	1.682	0.99
52_K	68_V	1.677	0.99
43_W	55_R	1.646	0.98
168_A	171_H	1.642	0.98
17_A	69_I	1.639	0.98
49_K	75_K	1.632	0.98
27_S	69_I	1.618	0.98
47_S	60_E	1.610	0.98
12_G	43_W	1.573	0.98
97_W	100_I	1.573	0.98
10_S	33_E	1.565	0.98
18_T	55_R	1.555	0.98
27_S	58_L	1.546	0.97
21_Q	38_Q	1.538	0.97
52_K	59_K	1.514	0.97
30_S	36_G	1.500	0.97
42_P	65_I	1.499	0.97
72_D	75_K	1.473	0.97
81_S	86_T	1.470	0.97
129_L	132_K	1.464	0.96
18_T	49_K	1.462	0.96
19_V	44_S	1.457	0.96
163_P	166_E	1.449	0.96
30_S	33_E	1.447	0.96
21_Q	60_E	1.444	0.96
102_R	105_K	1.428	0.96
41_L	77_T	1.421	0.96
42_P	48_S	1.395	0.95
144_V	147_G	1.392	0.95
22_V	65_I	1.388	0.95
191_L	195_K	1.383	0.95
31_L	47_S	1.383	0.95
10_S	27_S	1.357	0.95
114_L	117_S	1.351	0.94
11_E	60_E	1.347	0.94
20_K	23_F	1.338	0.94
126_A	129_L	1.322	0.94
20_K	38_Q	1.302	0.93
124_Q	127_W	1.270	0.92
18_T	63_K	1.260	0.92
123_E	126_A	1.259	0.92
22_V	53_N	1.253	0.92
174_E	177_V	1.252	0.92
132_K	135_D	1.241	0.91
17_A	41_L	1.237	0.91
25_Y	40_F	1.232	0.91
189_E	195_K	1.230	0.91
41_L	82_L	1.228	0.91
167_E	180_S	1.220	0.91
42_P	63_K	1.217	0.91
48_S	65_I	1.213	0.91
44_S	60_E	1.205	0.90
48_S	61_N	1.200	0.90
14_I	65_I	1.198	0.90
41_L	72_D	1.194	0.90
17_A	61_N	1.185	0.89
25_Y	42_P	1.183	0.89
26_G	67_K	1.179	0.89
46_V	57_V	1.168	0.89
59_K	65_I	1.152	0.88
60_E	63_K	1.148	0.88
66_V	82_L	1.132	0.87
27_S	62_R	1.124	0.87
33_E	42_P	1.116	0.86
16_I	47_S	1.116	0.86
12_G	49_K	1.107	0.86
33_E	49_K	1.104	0.86
22_V	46_V	1.101	0.86
27_S	57_V	1.098	0.86
144_V	148_E	1.098	0.86
117_S	120_D	1.090	0.85
38_Q	81_S	1.089	0.85
15_L	78_V	1.083	0.85
18_T	57_V	1.074	0.84
206_N	209_Q	1.074	0.84
24_D	32_D	1.072	0.84
167_E	170_K	1.062	0.84
146_E	149_K	1.055	0.83
45_E	70_R	1.049	0.83
17_A	28_Y	1.045	0.83
31_L	80_V	1.039	0.82
27_S	43_W	1.033	0.82
52_K	57_V	1.019	0.81
36_G	48_S	1.017	0.81
36_G	63_K	1.016	0.81
54_I	59_K	1.007	0.80
12_G	33_E	1.002	0.80
10_S	18_T	1.001	0.80
12_G	56_D	0.999	0.80
42_P	60_E	0.997	0.80
42_P	51_V	0.992	0.79
18_T	69_I	0.991	0.79
50_W	60_E	0.983	0.79
19_V	64_V	0.982	0.78
27_S	49_K	0.981	0.78
107_L	110_V	0.980	0.78
92_K	96_Q	0.977	0.78
43_W	73_R	0.969	0.78
36_G	44_S	0.969	0.78
111_S	114_L	0.963	0.77
44_S	48_S	0.962	0.77
18_T	32_D	0.959	0.77
47_S	61_N	0.955	0.76
43_W	48_S	0.953	0.76
33_E	55_R	0.949	0.76
178_K	183_I	0.942	0.76
179_M	183_I	0.936	0.75
33_E	46_V	0.936	0.75
137_I	140_I	0.933	0.75
33_E	43_W	0.928	0.74
20_K	30_S	0.923	0.74
53_N	59_K	0.923	0.74
51_V	60_E	0.917	0.74
229_V	235_N	0.908	0.73
23_F	38_Q	0.905	0.73
171_H	174_E	0.902	0.72
163_P	167_E	0.900	0.72
70_R	79_D	0.891	0.71
42_P	61_N	0.888	0.71
11_E	63_K	0.885	0.71
56_D	62_R	0.884	0.71
136_P	139_A	0.877	0.70
158_E	162_K	0.875	0.70
31_L	43_W	0.867	0.69
166_E	169_S	0.862	0.69
17_A	48_S	0.861	0.69
40_F	78_V	0.859	0.69
26_G	37_L	0.857	0.68
133_Y	136_P	0.853	0.68
128_K	131_A	0.852	0.68
146_E	162_K	0.852	0.68
15_L	66_V	0.851	0.68
121_A	127_W	0.849	0.68
18_T	43_W	0.848	0.68
10_S	43_W	0.848	0.68
173_E	176_K	0.847	0.67
196_I	199_V	0.842	0.67
75_K	79_D	0.840	0.67
230_D	233_G	0.838	0.67
50_W	53_N	0.838	0.67
152_I	159_I	0.837	0.67
138_T	141_E	0.828	0.66
217_I	224_A	0.828	0.66
15_L	31_L	0.827	0.66
40_F	79_D	0.825	0.65
178_K	181_G	0.824	0.65
91_R	97_W	0.814	0.64
113_K	117_S	0.814	0.64
168_A	172_A	0.813	0.64
27_S	53_N	0.808	0.64
11_E	21_Q	0.795	0.63
42_P	47_S	0.795	0.63
13_E	73_R	0.794	0.62
25_Y	32_D	0.794	0.62
70_R	76_G	0.791	0.62
56_D	63_K	0.790	0.62
87_D	90_R	0.790	0.62
11_E	79_D	0.786	0.62
123_E	157_P	0.778	0.61
108_E	111_S	0.776	0.61
43_W	47_S	0.773	0.60
77_T	82_L	0.773	0.60
179_M	231_V	0.769	0.60
27_S	33_E	0.768	0.60
71_V	82_L	0.768	0.60
55_R	64_V	0.765	0.60
49_K	53_N	0.763	0.59
44_S	69_I	0.761	0.59
110_V	113_K	0.752	0.58
42_P	79_D	0.748	0.58
25_Y	41_L	0.748	0.58
180_S	199_V	0.747	0.58
70_R	74_R	0.746	0.58
55_R	59_K	0.742	0.57
43_W	49_K	0.736	0.57
125_V	129_L	0.726	0.56
33_E	53_N	0.723	0.55
16_I	65_I	0.719	0.55
135_D	138_T	0.717	0.55
177_V	182_L	0.710	0.54
140_I	143_A	0.707	0.54
10_S	55_R	0.706	0.53
114_L	120_D	0.706	0.53
38_Q	73_R	0.702	0.53
231_V	234_T	0.698	0.53
55_R	63_K	0.697	0.53
23_F	72_D	0.697	0.53
20_K	26_G	0.694	0.52
27_S	41_L	0.692	0.52
139_A	142_K	0.690	0.52
27_S	46_V	0.686	0.51
11_E	24_D	0.686	0.51
122_W	125_V	0.685	0.51
70_R	77_T	0.684	0.51
20_K	32_D	0.681	0.51
229_V	237_K	0.680	0.51
64_V	82_L	0.677	0.50
126_A	132_K	0.677	0.50
42_P	64_V	0.677	0.50
58_L	65_I	0.676	0.50
31_L	79_D	0.675	0.50
25_Y	66_V	0.674	0.50
37_L	67_K	0.671	0.50
38_Q	48_S	0.671	0.50
57_V	69_I	0.669	0.50
162_K	193_V	0.667	0.49
27_S	38_Q	0.666	0.49
109_L	112_Q	0.665	0.49
15_L	29_V	0.665	0.49
139_A	144_V	0.663	0.49
27_S	30_S	0.658	0.48
195_K	198_E	0.657	0.48
73_R	79_D	0.655	0.48
214_L	219_I	0.655	0.48
40_F	51_V	0.654	0.48
24_D	37_L	0.653	0.48
185_V	196_I	0.653	0.48
40_F	46_V	0.652	0.48
18_T	33_E	0.651	0.48
37_L	78_V	0.650	0.48
60_E	65_I	0.649	0.48
22_V	57_V	0.648	0.47
12_G	57_V	0.648	0.47
13_E	26_G	0.646	0.47
175_R	178_K	0.646	0.47
188_N	201_S	0.644	0.47
152_I	157_P	0.641	0.47
116_L	119_K	0.640	0.47
42_P	69_I	0.640	0.47
14_I	54_I	0.639	0.46
15_L	76_G	0.638	0.46
26_G	77_T	0.638	0.46
53_N	61_N	0.630	0.46
72_D	79_D	0.630	0.46
67_K	74_R	0.629	0.45
40_F	72_D	0.628	0.45
30_S	38_Q	0.628	0.45
15_L	26_G	0.628	0.45
33_E	69_I	0.626	0.45
44_S	81_S	0.623	0.45
228_R	232_V	0.621	0.45
36_G	75_K	0.621	0.45
49_K	64_V	0.619	0.44
118_E	124_Q	0.618	0.44
51_V	54_I	0.617	0.44
22_V	47_S	0.616	0.44
9_P	33_E	0.613	0.44
38_Q	44_S	0.613	0.44
11_E	23_F	0.612	0.44
21_Q	73_R	0.606	0.43
165_L	169_S	0.605	0.43
104_D	107_L	0.602	0.43
103_L	106_I	0.601	0.43
44_S	51_V	0.601	0.43
198_E	208_E	0.598	0.42
56_D	75_K	0.598	0.42
16_I	50_W	0.594	0.42
191_L	201_S	0.593	0.42
16_I	31_L	0.586	0.41
50_W	63_K	0.586	0.41
51_V	63_K	0.584	0.41
44_S	58_L	0.583	0.41
67_K	70_R	0.581	0.41
177_V	180_S	0.580	0.40
42_P	58_L	0.578	0.40
49_K	55_R	0.578	0.40
24_D	27_S	0.566	0.39
98_K	104_D	0.564	0.39
20_K	46_V	0.562	0.39
11_E	14_I	0.562	0.39
18_T	64_V	0.560	0.38
55_R	68_V	0.558	0.38
48_S	75_K	0.556	0.38
40_F	71_V	0.552	0.38
27_S	81_S	0.550	0.37
25_Y	77_T	0.550	0.37
24_D	40_F	0.550	0.37
164_L	177_V	0.549	0.37
218_K	224_A	0.549	0.37
223_G	226_R	0.549	0.37
182_L	187_T	0.548	0.37
92_K	98_K	0.547	0.37
20_K	25_Y	0.544	0.37
100_I	103_L	0.540	0.36
83_K	86_T	0.535	0.36
25_Y	79_D	0.535	0.36
111_S	134_G	0.534	0.36
63_K	69_I	0.525	0.35
40_F	60_E	0.525	0.35
152_I	161_V	0.524	0.35
22_V	33_E	0.523	0.35
169_S	172_A	0.521	0.35
26_G	42_P	0.520	0.35
231_V	236_P	0.520	0.35
24_D	78_V	0.513	0.34
200_I	203_A	0.512	0.34
30_S	44_S	0.512	0.34
38_Q	42_P	0.511	0.34
118_E	126_A	0.511	0.34
101_Q	104_D	0.511	0.34
71_V	79_D	0.505	0.33
16_I	60_E	0.505	0.33
198_E	202_K	0.504	0.33
15_L	38_Q	0.503	0.33
106_I	151_L	0.502	0.33
209_Q	215_L	0.500	0.33

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3j81j	1	0.9323	100	0.294	Contact Map
3aevA	1	0.6316	100	0.3	Contact Map
3cw2C	1	1	100	0.307	Contact Map
1q8kA	1	0.9812	100	0.307	Contact Map
1kl9A	2	0.594	99.9	0.538	Contact Map
2a19A	1	0.6053	99.9	0.541	Contact Map
1yz7A	1	0.6504	99.9	0.556	Contact Map
4aidA	3	0.0038	99.7	0.642	Contact Map
3cdiA	3	0	99.7	0.646	Contact Map
4nbqA	3	0.2632	99.7	0.648	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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