GREMLIN Database
IF2A - Translation initiation factor 2 subunit alpha
UniProt: Q97Z79 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 266 (223)
Sequences: 970 (776)
Seq/√Len: 52.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_V58_L4.1051.00
22_V58_L3.7861.00
39_A80_V3.6131.00
118_E121_A2.8871.00
130_E133_Y2.8621.00
47_S52_K2.5981.00
202_K205_E2.4751.00
127_W130_E2.4081.00
121_A124_Q2.3401.00
113_K116_L2.2621.00
17_A64_V2.2471.00
49_K52_K2.2231.00
33_E52_K2.1871.00
18_T27_S2.1481.00
105_K108_E2.1471.00
115_K118_E2.1391.00
18_T30_S2.1291.00
120_D123_E2.0661.00
125_V128_K2.0181.00
41_L66_V1.9691.00
12_G55_R1.9661.00
33_E71_V1.9100.99
50_W55_R1.9060.99
43_W64_V1.9010.99
165_L168_A1.8960.99
48_S51_V1.8940.99
23_F39_A1.8900.99
33_E36_G1.6890.99
122_W126_A1.6820.99
52_K68_V1.6770.99
43_W55_R1.6460.98
168_A171_H1.6420.98
17_A69_I1.6390.98
49_K75_K1.6320.98
27_S69_I1.6180.98
47_S60_E1.6100.98
12_G43_W1.5730.98
97_W100_I1.5730.98
10_S33_E1.5650.98
18_T55_R1.5550.98
27_S58_L1.5460.97
21_Q38_Q1.5380.97
52_K59_K1.5140.97
30_S36_G1.5000.97
42_P65_I1.4990.97
72_D75_K1.4730.97
81_S86_T1.4700.97
129_L132_K1.4640.96
18_T49_K1.4620.96
19_V44_S1.4570.96
163_P166_E1.4490.96
30_S33_E1.4470.96
21_Q60_E1.4440.96
102_R105_K1.4280.96
41_L77_T1.4210.96
42_P48_S1.3950.95
144_V147_G1.3920.95
22_V65_I1.3880.95
191_L195_K1.3830.95
31_L47_S1.3830.95
10_S27_S1.3570.95
114_L117_S1.3510.94
11_E60_E1.3470.94
20_K23_F1.3380.94
126_A129_L1.3220.94
20_K38_Q1.3020.93
124_Q127_W1.2700.92
18_T63_K1.2600.92
123_E126_A1.2590.92
22_V53_N1.2530.92
174_E177_V1.2520.92
132_K135_D1.2410.91
17_A41_L1.2370.91
25_Y40_F1.2320.91
189_E195_K1.2300.91
41_L82_L1.2280.91
167_E180_S1.2200.91
42_P63_K1.2170.91
48_S65_I1.2130.91
44_S60_E1.2050.90
48_S61_N1.2000.90
14_I65_I1.1980.90
41_L72_D1.1940.90
17_A61_N1.1850.89
25_Y42_P1.1830.89
26_G67_K1.1790.89
46_V57_V1.1680.89
59_K65_I1.1520.88
60_E63_K1.1480.88
66_V82_L1.1320.87
27_S62_R1.1240.87
33_E42_P1.1160.86
16_I47_S1.1160.86
12_G49_K1.1070.86
33_E49_K1.1040.86
22_V46_V1.1010.86
27_S57_V1.0980.86
144_V148_E1.0980.86
117_S120_D1.0900.85
38_Q81_S1.0890.85
15_L78_V1.0830.85
18_T57_V1.0740.84
206_N209_Q1.0740.84
24_D32_D1.0720.84
167_E170_K1.0620.84
146_E149_K1.0550.83
45_E70_R1.0490.83
17_A28_Y1.0450.83
31_L80_V1.0390.82
27_S43_W1.0330.82
52_K57_V1.0190.81
36_G48_S1.0170.81
36_G63_K1.0160.81
54_I59_K1.0070.80
12_G33_E1.0020.80
10_S18_T1.0010.80
12_G56_D0.9990.80
42_P60_E0.9970.80
42_P51_V0.9920.79
18_T69_I0.9910.79
50_W60_E0.9830.79
19_V64_V0.9820.78
27_S49_K0.9810.78
107_L110_V0.9800.78
92_K96_Q0.9770.78
43_W73_R0.9690.78
36_G44_S0.9690.78
111_S114_L0.9630.77
44_S48_S0.9620.77
18_T32_D0.9590.77
47_S61_N0.9550.76
43_W48_S0.9530.76
33_E55_R0.9490.76
178_K183_I0.9420.76
179_M183_I0.9360.75
33_E46_V0.9360.75
137_I140_I0.9330.75
33_E43_W0.9280.74
20_K30_S0.9230.74
53_N59_K0.9230.74
51_V60_E0.9170.74
229_V235_N0.9080.73
23_F38_Q0.9050.73
171_H174_E0.9020.72
163_P167_E0.9000.72
70_R79_D0.8910.71
42_P61_N0.8880.71
11_E63_K0.8850.71
56_D62_R0.8840.71
136_P139_A0.8770.70
158_E162_K0.8750.70
31_L43_W0.8670.69
166_E169_S0.8620.69
17_A48_S0.8610.69
40_F78_V0.8590.69
26_G37_L0.8570.68
133_Y136_P0.8530.68
128_K131_A0.8520.68
146_E162_K0.8520.68
15_L66_V0.8510.68
121_A127_W0.8490.68
18_T43_W0.8480.68
10_S43_W0.8480.68
173_E176_K0.8470.67
196_I199_V0.8420.67
75_K79_D0.8400.67
230_D233_G0.8380.67
50_W53_N0.8380.67
152_I159_I0.8370.67
138_T141_E0.8280.66
217_I224_A0.8280.66
15_L31_L0.8270.66
40_F79_D0.8250.65
178_K181_G0.8240.65
91_R97_W0.8140.64
113_K117_S0.8140.64
168_A172_A0.8130.64
27_S53_N0.8080.64
11_E21_Q0.7950.63
42_P47_S0.7950.63
13_E73_R0.7940.62
25_Y32_D0.7940.62
70_R76_G0.7910.62
56_D63_K0.7900.62
87_D90_R0.7900.62
11_E79_D0.7860.62
123_E157_P0.7780.61
108_E111_S0.7760.61
43_W47_S0.7730.60
77_T82_L0.7730.60
179_M231_V0.7690.60
27_S33_E0.7680.60
71_V82_L0.7680.60
55_R64_V0.7650.60
49_K53_N0.7630.59
44_S69_I0.7610.59
110_V113_K0.7520.58
42_P79_D0.7480.58
25_Y41_L0.7480.58
180_S199_V0.7470.58
70_R74_R0.7460.58
55_R59_K0.7420.57
43_W49_K0.7360.57
125_V129_L0.7260.56
33_E53_N0.7230.55
16_I65_I0.7190.55
135_D138_T0.7170.55
177_V182_L0.7100.54
140_I143_A0.7070.54
10_S55_R0.7060.53
114_L120_D0.7060.53
38_Q73_R0.7020.53
231_V234_T0.6980.53
55_R63_K0.6970.53
23_F72_D0.6970.53
20_K26_G0.6940.52
27_S41_L0.6920.52
139_A142_K0.6900.52
27_S46_V0.6860.51
11_E24_D0.6860.51
122_W125_V0.6850.51
70_R77_T0.6840.51
20_K32_D0.6810.51
229_V237_K0.6800.51
64_V82_L0.6770.50
126_A132_K0.6770.50
42_P64_V0.6770.50
58_L65_I0.6760.50
31_L79_D0.6750.50
25_Y66_V0.6740.50
37_L67_K0.6710.50
38_Q48_S0.6710.50
57_V69_I0.6690.50
162_K193_V0.6670.49
27_S38_Q0.6660.49
109_L112_Q0.6650.49
15_L29_V0.6650.49
139_A144_V0.6630.49
27_S30_S0.6580.48
195_K198_E0.6570.48
73_R79_D0.6550.48
214_L219_I0.6550.48
40_F51_V0.6540.48
24_D37_L0.6530.48
185_V196_I0.6530.48
40_F46_V0.6520.48
18_T33_E0.6510.48
37_L78_V0.6500.48
60_E65_I0.6490.48
22_V57_V0.6480.47
12_G57_V0.6480.47
13_E26_G0.6460.47
175_R178_K0.6460.47
188_N201_S0.6440.47
152_I157_P0.6410.47
116_L119_K0.6400.47
42_P69_I0.6400.47
14_I54_I0.6390.46
15_L76_G0.6380.46
26_G77_T0.6380.46
53_N61_N0.6300.46
72_D79_D0.6300.46
67_K74_R0.6290.45
40_F72_D0.6280.45
30_S38_Q0.6280.45
15_L26_G0.6280.45
33_E69_I0.6260.45
44_S81_S0.6230.45
228_R232_V0.6210.45
36_G75_K0.6210.45
49_K64_V0.6190.44
118_E124_Q0.6180.44
51_V54_I0.6170.44
22_V47_S0.6160.44
9_P33_E0.6130.44
38_Q44_S0.6130.44
11_E23_F0.6120.44
21_Q73_R0.6060.43
165_L169_S0.6050.43
104_D107_L0.6020.43
103_L106_I0.6010.43
44_S51_V0.6010.43
198_E208_E0.5980.42
56_D75_K0.5980.42
16_I50_W0.5940.42
191_L201_S0.5930.42
16_I31_L0.5860.41
50_W63_K0.5860.41
51_V63_K0.5840.41
44_S58_L0.5830.41
67_K70_R0.5810.41
177_V180_S0.5800.40
42_P58_L0.5780.40
49_K55_R0.5780.40
24_D27_S0.5660.39
98_K104_D0.5640.39
20_K46_V0.5620.39
11_E14_I0.5620.39
18_T64_V0.5600.38
55_R68_V0.5580.38
48_S75_K0.5560.38
40_F71_V0.5520.38
27_S81_S0.5500.37
25_Y77_T0.5500.37
24_D40_F0.5500.37
164_L177_V0.5490.37
218_K224_A0.5490.37
223_G226_R0.5490.37
182_L187_T0.5480.37
92_K98_K0.5470.37
20_K25_Y0.5440.37
100_I103_L0.5400.36
83_K86_T0.5350.36
25_Y79_D0.5350.36
111_S134_G0.5340.36
63_K69_I0.5250.35
40_F60_E0.5250.35
152_I161_V0.5240.35
22_V33_E0.5230.35
169_S172_A0.5210.35
26_G42_P0.5200.35
231_V236_P0.5200.35
24_D78_V0.5130.34
200_I203_A0.5120.34
30_S44_S0.5120.34
38_Q42_P0.5110.34
118_E126_A0.5110.34
101_Q104_D0.5110.34
71_V79_D0.5050.33
16_I60_E0.5050.33
198_E202_K0.5040.33
15_L38_Q0.5030.33
106_I151_L0.5020.33
209_Q215_L0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j81j 1 0.9323 100 0.294 Contact Map
3aevA 1 0.6316 100 0.3 Contact Map
3cw2C 1 1 100 0.307 Contact Map
1q8kA 1 0.9812 100 0.307 Contact Map
1kl9A 2 0.594 99.9 0.538 Contact Map
2a19A 1 0.6053 99.9 0.541 Contact Map
1yz7A 1 0.6504 99.9 0.556 Contact Map
4aidA 3 0.0038 99.7 0.642 Contact Map
3cdiA 3 0 99.7 0.646 Contact Map
4nbqA 3 0.2632 99.7 0.648 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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