GREMLIN Database
Q97Z77 - Oligosaccharyl transferase STT3 subunit (B5) (Integral membrane protein 1)
UniProt: Q97Z77 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 764 (657)
Sequences: 563 (366)
Seq/√Len: 14.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_I142_A5.2151.00
143_G147_A4.2311.00
175_I214_I3.9531.00
673_V676_F3.9121.00
166_P401_Y3.8811.00
52_F56_L3.7971.00
185_G197_A3.7130.99
235_T276_L3.6640.99
49_W510_V3.6120.99
498_V512_T3.4790.99
639_T643_T3.4540.99
131_L180_F3.4490.99
145_M415_G3.2620.99
520_N523_L3.0630.98
356_M396_T3.0270.98
202_F249_L3.0190.98
130_Y134_E3.0080.98
518_D531_M2.9950.97
113_V188_K2.7730.96
133_I143_G2.6620.95
95_A99_L2.6290.94
74_G509_E2.6040.94
565_Y568_A2.5400.93
347_E502_W2.5160.93
258_G545_V2.5130.93
134_E143_G2.5050.93
535_F572_V2.4990.93
183_N187_K2.4940.93
492_S514_R2.4790.92
133_I137_T2.4680.92
584_Y588_P2.4650.92
418_V512_T2.4110.91
61_V65_W2.4080.91
96_L165_L2.3770.91
447_G453_D2.3160.90
583_W587_Y2.2970.89
204_A211_Y2.2960.89
47_D502_W2.2920.89
301_V312_G2.2360.88
151_A199_I2.1900.87
379_N418_V2.1870.87
676_F681_Y2.1700.86
29_S58_I2.1630.86
440_G444_A2.1450.86
132_S183_N2.1340.85
609_M615_I2.1180.85
116_F132_S2.1180.85
217_S391_A2.1140.85
502_W505_G2.1090.84
369_I415_G2.0550.83
302_L309_G2.0450.83
377_R420_Y2.0130.82
499_L534_M2.0000.81
25_L148_A1.9820.80
583_W588_P1.9810.80
585_V588_P1.9750.80
187_K381_V1.9720.80
130_Y146_A1.9680.80
385_L644_N1.9610.80
57_L61_V1.9590.80
153_S407_A1.9580.80
642_T645_P1.9520.79
47_D347_E1.9520.79
42_A49_W1.9480.79
101_F105_Y1.9370.79
509_E516_V1.9120.78
182_L221_A1.9000.78
347_E505_G1.8750.77
90_L95_A1.8640.76
442_I451_V1.8620.76
109_A112_T1.8420.75
538_N541_F1.8410.75
584_Y589_P1.8380.75
498_V514_R1.8290.75
42_A467_I1.8130.74
33_R47_D1.8070.74
498_V508_L1.7950.73
45_E507_W1.7880.73
137_T143_G1.7820.73
437_I441_F1.7820.73
678_E681_Y1.7620.72
223_F227_L1.7440.71
61_V170_W1.7440.71
640_Y645_P1.7430.71
401_Y502_W1.7370.71
143_G193_Y1.7310.70
461_S464_P1.7290.70
604_D608_A1.7140.70
205_E257_I1.7070.69
47_D505_G1.6950.69
568_A571_A1.6930.69
487_W491_H1.6700.68
408_Y519_E1.6650.67
619_P622_E1.6640.67
320_S329_A1.6620.67
606_G609_M1.6520.67
385_L409_M1.6470.66
308_L445_L1.6380.66
141_L423_D1.6350.66
625_N628_E1.6320.66
73_L512_T1.6280.66
16_F19_L1.6250.65
145_M418_V1.6230.65
251_S533_E1.6220.65
602_L606_G1.6200.65
131_L177_F1.6120.65
641_A645_P1.6060.64
138_N423_D1.6040.64
506_Y519_E1.6030.64
177_F180_F1.6010.64
676_F679_S1.6000.64
195_I245_V1.5890.64
240_T277_Y1.5870.63
677_I681_Y1.5810.63
352_P413_L1.5790.63
655_V662_A1.5700.63
115_I162_L1.5660.62
24_G308_L1.5620.62
120_L130_Y1.5600.62
318_P345_V1.5590.62
622_E661_F1.5540.62
160_N166_P1.5520.62
603_G606_G1.5520.62
314_S318_P1.5490.62
375_I378_G1.5160.60
127_I304_F1.5120.60
24_G512_T1.5080.59
386_L445_L1.4970.59
104_T387_V1.4890.58
653_S656_S1.4790.58
56_L274_A1.4790.58
133_I412_T1.4740.58
231_N235_T1.4670.57
260_M328_Y1.4590.57
57_L72_V1.4580.57
371_M488_I1.4470.56
43_V46_F1.4440.56
371_M385_L1.4430.56
73_L509_E1.4410.56
217_S387_V1.4410.56
128_A177_F1.4380.56
53_Y71_D1.4340.55
371_M474_F1.4320.55
94_V99_L1.4320.55
26_S123_G1.4310.55
74_G88_I1.4260.55
542_A615_I1.4250.55
605_I609_M1.4230.55
142_A415_G1.4180.55
532_A604_D1.4170.54
369_I417_G1.4020.54
183_N381_V1.4020.54
425_L512_T1.3930.53
477_T512_T1.3900.53
347_E401_Y1.3800.52
167_K523_L1.3760.52
186_L222_A1.3720.52
626_L630_N1.3690.52
127_I131_L1.3670.52
345_V524_N1.3660.52
131_L476_T1.3650.52
175_I581_A1.3640.52
628_E631_N1.3630.52
134_E140_R1.3610.51
75_W527_Q1.3610.51
54_N516_V1.3590.51
300_A312_G1.3520.51
523_L527_Q1.3490.51
48_P111_Y1.3450.51
53_Y160_N1.3440.50
191_I288_K1.3420.50
320_S331_I1.3410.50
184_Q187_K1.3410.50
342_D348_Y1.3390.50
23_V240_T1.3360.50
74_G82_I1.3350.50
366_L498_V1.3350.50
238_L246_T1.3320.50
75_W80_Y1.3250.49
651_L665_P1.3250.49
186_L279_D1.3240.49
415_G657_Q1.3210.49
92_F96_L1.3190.49
415_G649_Q1.3180.49
44_N48_P1.3130.49
100_P304_F1.3130.49
306_L310_L1.3100.49
439_V453_D1.3100.49
660_P664_T1.3050.48
29_S316_L1.2980.48
519_E523_L1.2970.48
48_P532_A1.2970.48
177_F200_V1.2970.48
516_V519_E1.2950.48
264_A321_A1.2930.48
132_S199_I1.2920.48
519_E522_T1.2920.48
160_N527_Q1.2890.47
174_F218_L1.2850.47
582_Q585_V1.2830.47
193_Y197_A1.2790.47
316_L669_N1.2720.47
347_E503_D1.2670.46
444_A448_I1.2660.46
652_A660_P1.2600.46
234_I380_L1.2570.46
101_F190_N1.2560.46
117_S173_V1.2520.45
49_W331_I1.2520.45
71_D166_P1.2500.45
167_K399_Q1.2480.45
252_L271_L1.2450.45
120_L270_L1.2430.45
439_V444_A1.2400.45
167_K171_G1.2310.44
534_M545_V1.2290.44
485_A507_W1.2280.44
522_T528_I1.2240.44
146_A417_G1.2220.44
501_W505_G1.2210.44
303_I310_L1.2200.44
185_G198_G1.2190.44
197_A200_V1.2150.43
305_I308_L1.2140.43
596_F602_L1.2130.43
82_I509_E1.2120.43
301_V317_R1.2120.43
452_A498_V1.2100.43
46_F507_W1.2080.43
186_L476_T1.1960.42
639_T649_Q1.1930.42
123_G407_A1.1910.42
124_L460_A1.1890.42
322_P328_Y1.1880.42
221_A225_L1.1880.42
129_S272_I1.1870.42
663_W666_K1.1860.42
627_T631_N1.1810.42
654_Q665_P1.1790.42
117_S385_L1.1790.42
642_T648_A1.1770.41
137_T218_L1.1770.41
143_G148_A1.1770.41
387_V406_T1.1770.41
21_L24_G1.1740.41
52_F412_T1.1730.41
500_S504_Y1.1660.41
602_L609_M1.1650.41
557_S560_Y1.1620.41
124_L375_I1.1610.41
415_G533_E1.1600.41
54_N510_V1.1590.40
128_A204_A1.1590.40
346_A518_D1.1570.40
224_L309_G1.1570.40
244_V304_F1.1530.40
303_I542_A1.1510.40
652_A655_V1.1500.40
442_I448_I1.1470.40
652_A662_A1.1470.40
303_I445_L1.1450.40
40_P44_N1.1420.40
37_A43_V1.1390.39
168_T575_V1.1370.39
118_D122_A1.1350.39
168_T171_G1.1320.39
231_N603_G1.1300.39
47_D401_Y1.1300.39
243_V247_S1.1290.39
506_Y520_N1.1290.39
104_T181_L1.1270.39
346_A511_L1.1240.39
676_F680_L1.1240.39
344_T571_A1.1220.39
530_L548_N1.1220.39
199_I354_T1.1220.39
28_V31_L1.1190.38
323_I329_A1.1180.38
140_R302_L1.1120.38
485_A488_I1.1110.38
119_I302_L1.1100.38
129_S307_T1.1090.38
127_I644_N1.1090.38
672_I676_F1.1080.38
19_L146_A1.1070.38
224_L374_L1.1060.38
50_Y167_K1.1040.38
408_Y547_E1.1030.38
238_L280_L1.1020.38
493_P514_R1.1020.38
356_M563_P1.1000.37
215_D242_M1.0950.37
670_S674_Q1.0930.37
557_S571_A1.0900.37
437_I440_G1.0900.37
20_P437_I1.0890.37
333_P397_S1.0880.37
126_V405_Y1.0880.37
303_I311_S1.0870.37
445_L456_L1.0870.37
659_E664_T1.0850.37
37_A532_A1.0850.37
302_L430_K1.0840.37
669_N674_Q1.0840.37
654_Q660_P1.0810.36
298_V302_L1.0810.36
73_L215_D1.0800.36
171_G525_G1.0790.36
124_L173_V1.0760.36
148_A588_P1.0750.36
213_Y395_G1.0730.36
97_A241_I1.0730.36
186_L315_I1.0730.36
47_D503_D1.0730.36
456_L459_L1.0690.36
137_T142_A1.0690.36
168_T404_N1.0690.36
421_I449_S1.0680.36
605_I608_A1.0640.36
401_Y505_G1.0610.35
662_A667_A1.0610.35
149_I195_I1.0580.35
674_Q677_I1.0580.35
297_I374_L1.0540.35
49_W467_I1.0430.35
602_L616_A1.0430.35
315_I318_P1.0420.34
196_P365_F1.0420.34
440_G448_I1.0410.34
177_F264_A1.0390.34
48_P160_N1.0370.34
131_L134_E1.0340.34
391_A546_L1.0320.34
665_P668_Y1.0290.34
299_I304_F1.0270.34
146_A280_L1.0230.34
297_I542_A1.0230.34
348_Y402_L1.0190.33
443_L446_V1.0190.33
518_D523_L1.0180.33
386_L473_S1.0170.33
171_G506_Y1.0120.33
24_G376_R1.0100.33
48_P507_W1.0060.33
100_P312_G0.9990.32
406_T545_V0.9980.32
61_V445_L0.9960.32
386_L391_A0.9900.32
21_L38_N0.9890.32
50_Y524_N0.9880.32
413_L475_L0.9880.32
670_S676_F0.9870.32
185_G487_W0.9860.32
301_V309_G0.9840.32
270_L423_D0.9840.32
308_L383_L0.9830.32
208_W399_Q0.9810.32
42_A481_W0.9790.31
283_S286_L0.9750.31
29_S615_I0.9740.31
168_T399_Q0.9740.31
289_E442_I0.9730.31
29_S244_V0.9700.31
53_Y527_Q0.9650.31
186_L373_Y0.9590.31
279_D385_L0.9580.30
477_T481_W0.9580.30
119_I652_A0.9540.30
218_L369_I0.9530.30
323_I327_Y0.9520.30
120_L538_N0.9510.30
555_Y620_L0.9510.30
307_T441_F0.9490.30
655_V664_T0.9480.30
247_S270_L0.9470.30
74_G512_T0.9470.30
145_M421_I0.9450.30
374_L459_L0.9440.30
247_S304_F0.9420.30
122_A320_S0.9420.30
196_P200_V0.9420.30
467_I471_A0.9410.30
311_S444_A0.9410.30
296_L443_L0.9400.30
43_V507_W0.9390.30
18_D29_S0.9380.30
661_F665_P0.9380.30
670_S679_S0.9360.29
80_Y526_T0.9360.29
412_T420_Y0.9340.29
303_I438_L0.9340.29
167_K401_Y0.9330.29
101_F104_T0.9320.29
506_Y575_V0.9310.29
132_S416_L0.9310.29
309_G590_S0.9310.29
366_L372_Y0.9300.29
171_G388_L0.9290.29
385_L413_L0.9280.29
160_N518_D0.9250.29
374_L377_R0.9200.29
252_L256_N0.9160.29
130_Y235_T0.9140.28
561_T567_V0.9130.28
379_N382_G0.9120.28
33_R159_K0.9120.28
240_T498_V0.9120.28
23_V285_T0.9100.28
604_D607_K0.9100.28
674_Q679_S0.9080.28
355_A374_L0.9070.28
659_E662_A0.9060.28
195_I445_L0.9060.28
448_I456_L0.9060.28
17_I278_L0.9050.28
237_N615_I0.9030.28
95_A203_L0.9020.28
274_A447_G0.9010.28
377_R541_F0.9000.28
28_V59_A0.8990.28
314_S537_N0.8990.28
132_S417_G0.8990.28
406_T520_N0.8940.28
630_N633_I0.8930.28
280_L415_G0.8930.28
236_A277_Y0.8920.27
220_V572_V0.8900.27
199_I592_P0.8900.27
673_V681_Y0.8880.27
366_L418_V0.8880.27
53_Y509_E0.8860.27
199_I615_I0.8860.27
179_I384_W0.8850.27
66_Y69_P0.8830.27
270_L452_A0.8830.27
249_L306_L0.8830.27
345_V386_L0.8820.27
581_A588_P0.8800.27
415_G541_F0.8790.27
137_T379_N0.8780.27
382_G621_D0.8780.27
328_Y334_F0.8770.27
479_Y482_V0.8770.27
292_D436_K0.8770.27
88_I387_V0.8760.27
292_D369_I0.8750.27
465_P468_T0.8730.27
222_A235_T0.8720.27
179_I579_S0.8710.27
421_I645_P0.8690.26
168_T506_Y0.8690.26
276_L415_G0.8690.26
306_L313_L0.8690.26
615_I624_V0.8690.26
51_L399_Q0.8690.26
673_V680_L0.8660.26
556_G616_A0.8640.26
24_G268_S0.8630.26
373_Y420_Y0.8610.26
520_N539_E0.8610.26
661_F664_T0.8600.26
596_F609_M0.8590.26
305_I310_L0.8570.26
499_L535_F0.8570.26
421_I444_A0.8560.26
445_L498_V0.8560.26
145_M324_P0.8540.26
200_V383_L0.8540.26
675_M679_S0.8470.26
306_L436_K0.8460.26
460_A585_V0.8460.26
637_I640_Y0.8450.25
204_A405_Y0.8450.25
260_M327_Y0.8440.25
244_V317_R0.8400.25
297_I498_V0.8390.25
488_I508_L0.8390.25
82_I248_F0.8390.25
124_L131_L0.8390.25
208_W211_Y0.8380.25
655_V659_E0.8380.25
334_F410_V0.8370.25
20_P446_V0.8350.25
627_T630_N0.8330.25
40_P155_A0.8300.25
87_T91_P0.8300.25
311_S423_D0.8290.25
171_G527_Q0.8280.25
578_G581_A0.8280.25
146_A367_S0.8270.25
296_L374_L0.8260.25
422_S448_I0.8260.25
673_V678_E0.8250.25
297_I444_A0.8240.25
347_E501_W0.8230.25
627_T633_I0.8230.25
312_G386_L0.8210.24
509_E530_L0.8200.24
345_V402_L0.8200.24
59_A88_I0.8200.24
23_V146_A0.8190.24
100_P538_N0.8160.24
100_P413_L0.8150.24
383_L500_S0.8140.24
438_L442_I0.8140.24
582_Q588_P0.8140.24
209_G575_V0.8130.24
516_V563_P0.8120.24
603_G608_A0.8120.24
446_V490_T0.8100.24
157_T492_S0.8080.24
99_L104_T0.8080.24
156_L518_D0.8080.24
50_Y575_V0.8080.24
394_F398_E0.8030.24
506_Y516_V0.8020.24
120_L195_I0.8020.24
15_S20_P0.8010.24
44_N507_W0.8000.24
675_M681_Y0.7990.24
103_G106_G0.7960.23
303_I309_G0.7950.23
36_S74_G0.7950.23
74_G81_F0.7940.23
669_N672_I0.7900.23
190_N200_V0.7900.23
278_L293_S0.7900.23
290_I369_I0.7870.23
625_N629_I0.7860.23
145_M149_I0.7850.23
291_V375_I0.7840.23
168_T527_Q0.7830.23
354_T362_I0.7810.23
168_T388_L0.7800.23
215_D249_L0.7790.23
294_R300_A0.7790.23
655_V665_P0.7790.23
168_T341_I0.7780.23
310_L442_I0.7770.23
648_A669_N0.7760.23
180_F493_P0.7760.23
43_V482_V0.7740.23
390_V418_V0.7730.23
319_T322_P0.7730.23
165_L168_T0.7730.23
613_T616_A0.7730.23
160_N488_I0.7720.23
656_S662_A0.7710.23
349_I609_M0.7680.22
100_P444_A0.7680.22
634_T637_I0.7680.22
117_S374_L0.7680.22
357_I412_T0.7670.22
244_V314_S0.7670.22
123_G199_I0.7660.22
209_G402_L0.7640.22
94_V105_Y0.7630.22
520_N528_I0.7620.22
385_L424_N0.7590.22
629_I632_T0.7580.22
482_V528_I0.7570.22
601_S604_D0.7560.22
576_Y583_W0.7540.22
520_N531_M0.7530.22
14_M445_L0.7520.22
237_N323_I0.7510.22
75_W506_Y0.7510.22
75_W526_T0.7500.22
299_I308_L0.7490.22
540_T544_N0.7460.22
131_L151_A0.7460.22
197_A365_F0.7450.22
53_Y388_L0.7450.22
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301_V304_F0.6000.17
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132_S176_L0.5850.16
140_R197_A0.5840.16
206_I217_S0.5840.16
348_Y527_Q0.5840.16
50_Y344_T0.5840.16
309_G416_L0.5830.16
72_V512_T0.5830.16
154_P208_W0.5830.16
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499_L546_L0.5730.16
337_V579_S0.5730.16
494_Q513_N0.5710.16
68_V481_W0.5690.16
43_V51_L0.5690.16
155_A516_V0.5690.16
670_S673_V0.5680.16
171_G210_G0.5670.16
669_N678_E0.5660.16
27_L315_I0.5660.16
360_F410_V0.5660.16
192_W374_L0.5650.16
303_I308_L0.5630.16
404_N499_L0.5620.16
141_L148_A0.5620.16
305_I475_L0.5620.16
48_P246_T0.5610.16
127_I292_D0.5610.16
503_D519_E0.5610.16
36_S40_P0.5600.15
185_G387_V0.5600.15
369_I421_I0.5600.15
39_W403_F0.5590.15
55_A93_L0.5580.15
270_L352_P0.5580.15
234_I444_A0.5580.15
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327_Y467_I0.5560.15
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637_I642_T0.5520.15
658_A665_P0.5520.15
183_N412_T0.5520.15
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31_L199_I0.5510.15
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368_V463_E0.5390.15
521_N525_G0.5390.15
293_S304_F0.5380.15
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60_Q195_I0.5370.15
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339_V342_D0.5330.15
315_I490_T0.5330.15
71_D539_E0.5330.15
16_F488_I0.5320.15
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276_L436_K0.5320.15
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675_M678_E0.5310.15
103_G181_L0.5310.15
315_I322_P0.5310.15
136_I174_F0.5300.15
110_V520_N0.5290.15
186_L379_N0.5290.15
382_G517_I0.5290.15
303_I678_E0.5280.15
446_V587_Y0.5280.15
363_A440_G0.5260.15
417_G424_N0.5260.15
624_V627_T0.5260.15
196_P306_L0.5250.15
316_L418_V0.5250.15
49_W449_S0.5240.14
119_I122_A0.5240.14
163_G166_P0.5240.14
251_S328_Y0.5230.14
171_G205_E0.5220.14
135_S184_Q0.5220.14
117_S124_L0.5210.14
159_K165_L0.5210.14
226_I276_L0.5210.14
155_A320_S0.5210.14
639_T642_T0.5200.14
649_Q671_L0.5180.14
235_T245_V0.5180.14
195_I375_I0.5170.14
565_Y571_A0.5170.14
146_A153_S0.5170.14
377_R446_V0.5160.14
445_L452_A0.5160.14
71_D401_Y0.5160.14
76_F79_G0.5160.14
615_I647_I0.5160.14
478_N563_P0.5150.14
448_I477_T0.5150.14
184_Q193_Y0.5140.14
327_Y363_A0.5140.14
367_S535_F0.5130.14
406_T552_L0.5130.14
49_W507_W0.5100.14
224_L310_L0.5100.14
167_K527_Q0.5090.14
101_F156_L0.5070.14
130_Y377_R0.5070.14
487_W514_R0.5060.14
181_L276_L0.5060.14
454_A457_A0.5060.14
320_S327_Y0.5050.14
185_G192_W0.5050.14
521_N524_N0.5040.14
309_G649_Q0.5040.14
322_P327_Y0.5040.14
349_I617_G0.5040.14
277_Y483_S0.5030.14
437_I445_L0.5030.14
627_T632_T0.5030.14
399_Q521_N0.5030.14
515_S575_V0.5030.14
596_F599_T0.5030.14
623_Y626_L0.5030.14
37_A116_F0.5020.14
61_V307_T0.5020.14
677_I680_L0.5020.14
310_L390_V0.5010.14
97_A122_A0.5000.14
181_L305_I0.5000.14
385_L595_F0.5000.14
482_V507_W0.5000.14
204_A208_W0.5000.14
212_T314_S0.5000.14
220_V445_L0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wajA 1 0.873 100 0.43 Contact Map
3rceA 1 0.8455 100 0.435 Contact Map
2lgzA 1 0.3482 100 0.762 Contact Map
3aagA 1 0.3037 100 0.765 Contact Map
3vu1A 2 0.3063 100 0.792 Contact Map
2zaiA 2 0.2984 100 0.815 Contact Map
3vgpA 1 0.199 100 0.818 Contact Map
3vu0A 1 0.195 100 0.829 Contact Map
3waiA 1 0.7644 99.9 0.865 Contact Map
4oujA 2 0.0877 14.3 0.985 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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