GREMLIN Database
Q97Z75 - Ammonium transporter
UniProt: Q97Z75 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 509 (400)
Sequences: 4778 (2546)
Seq/√Len: 127.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_L278_L4.6551.00
249_A442_F4.6251.00
450_K453_G4.0741.00
395_V399_L3.5551.00
315_V360_I3.3201.00
120_A209_L3.2701.00
342_A362_S3.2621.00
250_A449_L3.1681.00
350_V358_I3.0961.00
402_V420_L2.9441.00
461_P464_E2.9231.00
224_W436_I2.8051.00
398_L431_A2.7991.00
369_A391_I2.7861.00
276_A333_T2.6731.00
171_T299_A2.6581.00
111_A313_A2.5641.00
394_I434_A2.5331.00
428_G432_L2.4811.00
450_K454_L2.4781.00
321_M327_P2.4121.00
284_D306_N2.3821.00
218_W224_W2.3111.00
147_W173_I2.2931.00
366_P392_A2.2701.00
230_A433_A2.2651.00
365_I395_V2.2561.00
446_F450_K2.2391.00
288_G302_V2.2151.00
119_I146_A2.1471.00
253_A446_F2.1421.00
75_A174_F2.1111.00
361_F395_V2.1071.00
211_V444_I2.0911.00
202_V456_I2.0861.00
313_A336_A2.0691.00
258_L462_P2.0521.00
113_V208_S2.0151.00
74_A289_G2.0071.00
114_L177_F1.9751.00
300_I304_N1.9641.00
191_V195_M1.9411.00
106_I188_A1.9131.00
399_L402_V1.8971.00
343_I350_V1.8791.00
67_S166_N1.8761.00
124_F140_F1.8661.00
431_A435_V1.8581.00
215_V242_D1.8561.00
313_A332_A1.8521.00
231_V348_G1.8381.00
237_Y397_G1.8241.00
118_I307_I1.7841.00
311_V356_A1.7831.00
93_L330_I1.7611.00
215_V437_V1.7571.00
199_A452_I1.7431.00
425_Y429_I1.7271.00
116_I205_P1.7171.00
126_F172_F1.7111.00
246_G441_D1.6691.00
108_Y201_M1.6541.00
184_P204_V1.6481.00
130_A138_G1.6471.00
173_I303_L1.6461.00
342_A358_I1.6411.00
114_L306_N1.6381.00
228_L432_L1.6341.00
273_L329_L1.6331.00
272_V333_T1.6161.00
122_Y169_T1.6111.00
125_G216_A1.6001.00
218_W436_I1.5881.00
116_I213_S1.5861.00
115_V356_A1.5821.00
398_L427_L1.5471.00
440_Y444_I1.5461.00
245_V442_F1.5301.00
319_M364_S1.5221.00
424_W428_G1.4961.00
464_E471_A1.4771.00
196_N457_P1.4691.00
202_V452_I1.4611.00
452_I456_I1.4521.00
228_L429_I1.4461.00
432_L436_I1.4381.00
70_W73_T1.4361.00
241_V245_V1.4331.00
307_I356_A1.4291.00
130_A137_Y1.4241.00
453_G457_P1.4231.00
244_G390_G1.4211.00
258_L466_A1.4021.00
206_F448_L1.3971.00
231_V349_Y1.3941.00
269_L330_I1.3911.00
246_G445_T1.3801.00
114_L310_A1.3791.00
195_M458_L1.3751.00
428_G431_A1.3631.00
79_G110_F1.3611.00
115_V314_V1.3531.00
66_G69_A1.3521.00
186_L385_V1.3391.00
462_P466_A1.3321.00
253_A450_K1.3291.00
219_L238_V1.3291.00
104_L332_A1.3231.00
116_I209_L1.3231.00
291_P298_A1.3221.00
115_V311_V1.3181.00
369_A387_S1.3171.00
112_A201_M1.3141.00
452_I455_F1.3101.00
110_F181_A1.2981.00
118_I356_A1.2951.00
64_D67_S1.2941.00
191_V250_A1.2921.00
251_A379_V1.2881.00
267_H478_Y1.2871.00
245_V438_F1.2861.00
112_A205_P1.2711.00
116_I120_A1.2661.00
319_M368_M1.2611.00
429_I432_L1.2571.00
79_G281_L1.2551.00
70_W74_A1.2511.00
68_N168_P1.2481.00
364_S368_M1.2451.00
75_A171_T1.2411.00
237_Y437_V1.2411.00
71_M167_I1.2391.00
68_N171_T1.2341.00
101_N105_M1.2341.00
190_G247_A1.2311.00
394_I438_F1.2240.99
67_S295_T1.2230.99
401_G427_L1.2170.99
219_L437_V1.2110.99
291_P295_T1.2070.99
225_L433_A1.2010.99
221_A226_N1.1910.99
337_I388_T1.1900.99
174_F302_V1.1900.99
109_A200_W1.1860.99
268_S271_L1.1840.99
91_A99_A1.1720.99
395_V402_V1.1710.99
351_N405_N1.1700.99
127_G130_A1.1590.99
398_L434_A1.1570.99
248_L379_V1.1550.99
464_E472_M1.1540.99
245_V249_A1.1460.99
116_I208_S1.1430.99
397_G434_A1.1370.99
242_D441_D1.1300.99
311_V360_I1.1280.99
300_I352_G1.1270.99
467_I471_A1.1190.99
201_M205_P1.1060.99
357_L361_F1.1000.99
315_V364_S1.1000.99
406_P417_T1.0940.99
427_L431_A1.0930.99
196_N199_A1.0920.99
79_G178_V1.0900.99
208_S213_S1.0870.99
451_F454_L1.0860.99
76_T281_L1.0810.99
71_M171_T1.0800.99
390_G438_F1.0780.99
280_W336_A1.0770.99
93_L272_V1.0690.99
99_A267_H1.0690.99
459_Q465_L1.0640.99
358_I399_L1.0610.99
240_H243_A1.0570.98
76_T302_V1.0520.98
241_V438_F1.0520.98
210_L444_I1.0520.98
379_V387_S1.0480.98
105_M188_A1.0460.98
369_A373_L1.0450.98
259_A264_L1.0420.98
80_L281_L1.0410.98
351_N354_E1.0330.98
449_L458_L1.0330.98
209_L213_S1.0320.98
306_N309_T1.0320.98
309_T312_S1.0280.98
146_A353_W1.0260.98
129_P138_G1.0250.98
126_F176_Q1.0220.98
444_I448_L1.0170.98
84_P274_V1.0160.98
353_W357_L1.0140.98
95_K193_E1.0100.98
358_I403_F1.0100.98
230_A397_G1.0060.98
334_S388_T1.0060.98
241_V394_I0.9960.98
463_Q467_I0.9930.98
315_V363_G0.9930.98
307_I352_G0.9920.98
447_G451_F0.9910.98
102_S192_L0.9890.98
301_A347_A0.9870.98
77_F285_G0.9860.98
252_L379_V0.9840.98
261_E374_E0.9830.98
224_W432_L0.9810.98
361_F365_I0.9810.98
99_A477_A0.9800.98
372_W376_K0.9790.98
442_F446_F0.9770.97
452_I457_P0.9770.97
229_G429_I0.9770.97
167_I292_L0.9760.97
115_V119_I0.9720.97
195_M254_I0.9720.97
361_F399_L0.9710.97
420_L423_N0.9690.97
170_A300_I0.9690.97
249_A446_F0.9670.97
438_F442_F0.9660.97
448_L452_I0.9650.97
215_V440_Y0.9640.97
108_Y317_M0.9620.97
431_A434_A0.9580.97
453_G456_I0.9570.97
249_A253_A0.9520.97
170_A299_A0.9510.97
101_N473_H0.9500.97
439_V443_A0.9490.97
418_G421_Y0.9460.97
425_Y428_G0.9440.97
321_M325_G0.9410.97
172_F292_L0.9400.97
350_V403_F0.9360.97
273_L333_T0.9360.97
312_S315_V0.9330.97
360_I364_S0.9300.97
237_Y241_V0.9260.97
71_M292_L0.9260.97
162_G165_A0.9250.96
159_G163_A0.9210.96
177_F306_N0.9200.96
94_S383_L0.9180.96
241_V434_A0.9150.96
88_L274_V0.9120.96
188_A200_W0.9060.96
69_A73_T0.9040.96
312_S335_G0.9040.96
224_W228_L0.9010.96
354_E357_L0.8980.96
386_F390_G0.8970.96
280_W306_N0.8970.96
432_L435_V0.8930.96
462_P465_L0.8880.96
426_Q429_I0.8850.95
127_G142_Y0.8840.95
314_V318_L0.8830.95
419_A422_G0.8800.95
124_F213_S0.8770.95
83_V181_A0.8760.95
252_L442_F0.8740.95
236_G345_P0.8730.95
401_G430_Q0.8730.95
176_Q290_D0.8710.95
446_F453_G0.8700.95
170_A303_L0.8700.95
222_G226_N0.8680.95
245_V390_G0.8640.95
319_M363_G0.8630.95
199_A456_I0.8630.95
373_L387_S0.8600.95
253_A453_G0.8590.95
448_L451_F0.8570.95
98_Y193_E0.8560.95
317_M327_P0.8540.95
334_S363_G0.8490.94
95_K264_L0.8480.94
109_A204_V0.8480.94
304_N347_A0.8470.94
372_W377_L0.8460.94
195_M449_L0.8440.94
452_I458_L0.8370.94
65_T293_G0.8360.94
88_L271_L0.8360.94
109_A188_A0.8310.94
99_A103_A0.8280.94
215_V218_W0.8270.94
406_P421_Y0.8260.94
370_L387_S0.8250.93
120_A213_S0.8210.93
198_K202_V0.8200.93
374_E384_G0.8190.93
338_T392_A0.8150.93
66_G294_A0.8140.93
271_L274_V0.8110.93
69_A294_A0.8030.93
443_A447_G0.8030.93
311_V315_V0.8020.92
435_V439_V0.8000.92
95_K259_A0.8000.92
287_N344_T0.7970.92
69_A74_A0.7930.92
102_S106_I0.7900.92
318_L322_K0.7890.92
237_Y341_V0.7880.92
98_Y460_A0.7880.92
217_Y221_A0.7820.92
128_Y138_G0.7810.91
103_A273_L0.7810.91
402_V427_L0.7810.91
215_V441_D0.7790.91
123_S143_P0.7790.91
222_G227_Q0.7760.91
258_L262_R0.7760.91
394_I398_L0.7740.91
88_L270_P0.7730.91
68_N167_I0.7720.91
188_A191_V0.7700.91
254_I458_L0.7700.91
338_T388_T0.7700.91
104_L197_F0.7690.91
198_K321_M0.7690.91
100_V329_L0.7690.91
167_I171_T0.7670.91
464_E467_I0.7660.91
75_A178_V0.7620.90
161_S165_A0.7620.90
418_G422_G0.7580.90
399_L403_F0.7560.90
211_V445_T0.7560.90
283_W344_T0.7560.90
122_Y172_F0.7550.90
349_Y404_A0.7530.90
343_I358_I0.7520.90
242_D246_G0.7500.90
206_F210_L0.7470.90
65_T68_N0.7420.89
118_I173_I0.7420.89
105_M192_L0.7420.89
424_W431_A0.7420.89
308_A343_I0.7420.89
369_A372_W0.7380.89
368_M372_W0.7370.89
269_L329_L0.7310.89
255_G459_Q0.7300.88
211_V448_L0.7290.88
417_T421_Y0.7280.88
328_T475_E0.7240.88
114_L307_I0.7230.88
326_K474_G0.7210.88
427_L434_A0.7210.88
218_W440_Y0.7190.88
83_V110_F0.7180.88
346_A358_I0.7170.88
225_L230_A0.7160.88
390_G394_I0.7130.87
447_G450_K0.7120.87
197_F473_H0.7120.87
291_P301_A0.7120.87
117_W216_A0.7110.87
231_V404_A0.7100.87
419_A423_N0.7070.87
101_N188_A0.7060.87
248_L252_L0.7060.87
79_G181_A0.7040.87
370_L384_G0.7020.86
207_W246_G0.7000.86
124_F214_P0.7000.86
129_P137_Y0.6970.86
354_E421_Y0.6950.86
197_F327_P0.6940.86
230_A237_Y0.6940.86
187_L246_G0.6930.86
71_M75_A0.6930.86
101_N191_V0.6920.86
191_V449_L0.6900.86
205_P209_L0.6880.85
363_G395_V0.6870.85
86_V277_G0.6870.85
130_A140_F0.6850.85
445_T449_L0.6840.85
460_A465_L0.6840.85
250_A445_T0.6820.85
354_E405_N0.6810.85
312_S337_I0.6790.85
161_S164_H0.6780.85
195_M250_A0.6770.84
315_V319_M0.6750.84
245_V394_I0.6750.84
160_P163_A0.6740.84
72_L302_V0.6740.84
111_A314_V0.6720.84
81_Q279_I0.6720.84
249_A252_L0.6700.84
168_P171_T0.6690.84
145_P148_G0.6690.84
108_Y197_F0.6670.84
303_L352_G0.6660.83
435_V438_F0.6660.83
346_A350_V0.6620.83
122_Y126_F0.6620.83
405_N421_Y0.6600.83
256_P378_R0.6600.83
294_A298_A0.6590.83
287_N290_D0.6590.83
357_L403_F0.6580.83
233_F301_A0.6580.83
423_N426_Q0.6580.83
160_P164_H0.6570.83
419_A424_W0.6570.83
329_L333_T0.6560.83
203_F445_T0.6550.82
117_W125_G0.6510.82
373_L386_F0.6500.82
323_F367_W0.6490.82
123_S127_G0.6470.82
423_N427_L0.6440.81
300_I408_V0.6430.81
272_V330_I0.6420.81
203_F207_W0.6420.81
261_E264_L0.6410.81
64_D68_N0.6400.81
114_L181_A0.6390.81
70_W291_P0.6380.81
178_V239_I0.6370.81
241_V390_G0.6370.81
124_F143_P0.6360.81
354_E403_F0.6340.80
107_F336_A0.6320.80
173_I177_F0.6310.80
342_A395_V0.6310.80
219_L226_N0.6310.80
84_P278_L0.6290.80
86_V182_I0.6280.80
363_G366_P0.6280.80
174_F177_F0.6270.80
182_I185_I0.6270.80
317_M332_A0.6240.79
219_L230_A0.6230.79
112_A314_V0.6230.79
102_S105_M0.6220.79
83_V109_A0.6220.79
439_V442_F0.6190.79
203_F246_G0.6190.79
196_N464_E0.6180.79
319_M367_W0.6180.79
409_T416_L0.6150.78
283_W340_L0.6140.78
105_M191_V0.6140.78
129_P217_Y0.6130.78
163_A169_T0.6130.78
193_E264_L0.6100.78
400_T427_L0.6090.78
191_V200_W0.6070.77
114_L336_A0.6070.77
297_D409_T0.6050.77
361_F403_F0.6050.77
358_I362_S0.6050.77
372_W379_V0.6040.77
63_L68_N0.6040.77
203_F449_L0.6030.77
445_T448_L0.6010.77
170_A352_G0.5990.77
240_H397_G0.5990.77
159_G162_G0.5990.77
400_T426_Q0.5980.76
97_K264_L0.5970.76
331_G366_P0.5970.76
109_A185_I0.5950.76
63_L163_A0.5920.76
206_F452_I0.5920.76
308_A362_S0.5910.76
405_N408_V0.5890.75
320_D331_G0.5880.75
72_L299_A0.5880.75
245_V441_D0.5880.75
406_P416_L0.5870.75
237_Y434_A0.5870.75
100_V475_E0.5870.75
286_F344_T0.5870.75
110_F306_N0.5870.75
183_T239_I0.5810.74
265_E476_V0.5810.74
205_P314_V0.5800.74
130_A143_P0.5790.74
397_G400_T0.5790.74
338_T366_P0.5780.74
429_I433_A0.5770.74
67_S293_G0.5770.74
298_A301_A0.5760.74
72_L76_T0.5750.74
373_L377_L0.5740.73
194_R380_D0.5740.73
342_A399_L0.5740.73
187_L191_V0.5730.73
179_F286_F0.5720.73
360_I363_G0.5720.73
189_G381_D0.5700.73
365_I399_L0.5700.73
191_V204_V0.5690.73
351_N421_Y0.5680.73
196_N455_F0.5670.73
69_A76_T0.5670.73
467_I470_Y0.5660.72
342_A392_A0.5660.72
105_M200_W0.5640.72
123_S145_P0.5640.72
417_T422_G0.5630.72
180_A208_S0.5630.72
74_A178_V0.5630.72
470_Y476_V0.5630.72
109_A184_P0.5620.72
312_S342_A0.5620.72
257_R380_D0.5610.72
124_F141_G0.5610.72
78_V285_G0.5610.72
365_I392_A0.5610.72
424_W429_I0.5600.72
387_S391_I0.5570.71
127_G217_Y0.5570.71
103_A329_L0.5560.71
123_S144_I0.5550.71
220_F238_V0.5550.71
138_G227_Q0.5540.71
125_G213_S0.5540.71
167_I172_F0.5530.71
106_I182_I0.5530.71
304_N308_A0.5520.71
113_V184_P0.5520.71
102_S188_A0.5520.71
178_V302_V0.5520.71
306_N336_A0.5500.70
350_V355_A0.5500.70
245_V434_A0.5500.70
103_A270_P0.5500.70
439_V446_F0.5500.70
163_A166_N0.5490.70
238_V437_V0.5460.70
104_L329_L0.5460.70
291_P297_D0.5450.70
111_A310_A0.5450.70
249_A438_F0.5450.70
319_M365_I0.5440.69
81_Q287_N0.5430.69
65_T294_A0.5430.69
62_W66_G0.5420.69
324_F371_Y0.5410.69
387_S390_G0.5360.68
202_V448_L0.5330.68
237_Y433_A0.5320.68
201_M321_M0.5320.68
97_K193_E0.5280.67
418_G423_N0.5280.67
205_P213_S0.5270.67
253_A449_L0.5270.67
252_L446_F0.5260.67
139_I439_V0.5260.67
345_P400_T0.5250.67
306_N310_A0.5240.67
426_Q430_Q0.5240.67
242_D437_V0.5230.66
75_A302_V0.5230.66
172_F176_Q0.5230.66
184_P187_L0.5230.66
234_S290_D0.5220.66
240_H309_T0.5220.66
297_D300_I0.5220.66
362_S395_V0.5210.66
110_F177_F0.5210.66
174_F303_L0.5210.66
440_Y443_A0.5200.66
86_V105_M0.5190.66
160_P165_A0.5190.66
62_W65_T0.5170.66
438_F441_D0.5160.65
245_V386_F0.5160.65
409_T417_T0.5160.65
186_L240_H0.5150.65
101_N193_E0.5140.65
276_A337_I0.5120.65
443_A446_F0.5120.65
282_G285_G0.5120.65
341_V397_G0.5120.65
211_V441_D0.5110.65
225_L437_V0.5110.65
206_F444_I0.5100.65
284_D288_G0.5090.64
110_F114_L0.5050.64
276_A336_A0.5050.64
80_L85_G0.5030.63
118_I353_W0.5030.63
365_I391_I0.5030.63
437_V441_D0.5000.63
202_V455_F0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2b2hA 3 0.7623 100 0.196 Contact Map
1u7gA 3 0.7466 100 0.249 Contact Map
3b9wA 3 0.6896 100 0.39 Contact Map
3hd6A 3 0.7426 100 0.395 Contact Map
3wdoA 1 0.778 91.9 0.964 Contact Map
4j05A 3 0.3418 81.1 0.97 Contact Map
4m64A 1 0.7407 75.5 0.972 Contact Map
4pypA 1 0.6798 73.6 0.972 Contact Map
4zw9A 1 0.725 59.7 0.974 Contact Map
2jlnA 1 0.7564 54.8 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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