Q97Z70 - SULSO - GREMLIN Contacts

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Q97Z70 - Lipoate protein ligase A, hypothetical (LplA-like1)

UniProt:	Q97Z70	Sequences: MSWRFVSLPPQDGYHMVTSFVSVADYVNRGGKNTLLVFSVKEPFVNVGIHQEVWLEVDLEFTKKMKIPVVRRDLGGGTVVITPGEHDYFIVVRQEDAPRNPSELYKKFLTPIVNVLRSYGLKADLRDQDIVVNGKKISGNGAMTHGNSIVIAGNILLSLDIDLISKCIRVPTEKFRDKMAKDMSEWLTSLERELGYIPPKEEINKKLKEAFEKELGIKFEDSTLTPEEIELWEKLASEKAKEEWIFYKDNRHRDIHTERCVKISSAALFATLTIRLGSC	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	279 (237)
Sequences:	2459 (1700)
Seq/√Len:	110.4

ECOLI - LPLA
BACSU - LPLJ LIPM LIPL
HALSA - Q9HSK8 Q9HMH8 Q9HHS2
SULSO - Q97Z70 Q97Z28 Q97U65 Q97U62

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
158_S	191_E	4.184	1.00
234_K	238_E	4.090	1.00
188_T	193_E	3.595	1.00
117_R	122_K	2.830	1.00
21_V	25_D	2.818	1.00
62_T	69_V	2.805	1.00
61_F	65_M	2.795	1.00
110_T	114_N	2.765	1.00
199_P	202_E	2.479	1.00
65_M	167_C	2.443	1.00
60_E	64_K	2.431	1.00
118_S	213_K	2.322	1.00
118_S	210_A	2.293	1.00
236_A	240_A	2.274	1.00
122_K	133_N	2.241	1.00
235_L	239_K	2.228	1.00
225_T	228_E	2.175	1.00
233_E	237_S	2.149	1.00
114_N	213_K	2.148	1.00
231_L	234_K	2.108	1.00
88_Y	153_G	2.066	1.00
21_V	239_K	2.016	1.00
61_F	64_K	1.935	1.00
130_I	137_I	1.908	1.00
7_S	204_N	1.897	1.00
81_I	87_D	1.886	1.00
25_D	231_L	1.837	1.00
119_Y	206_K	1.812	1.00
70_V	245_I	1.810	1.00
86_H	200_K	1.799	1.00
188_T	192_R	1.791	1.00
160_D	163_L	1.748	1.00
126_R	131_V	1.736	1.00
15_H	229_I	1.732	1.00
74_L	143_M	1.708	1.00
94_Q	147_N	1.685	1.00
42_E	68_P	1.682	1.00
39_S	89_F	1.674	1.00
12_D	15_H	1.671	1.00
25_D	145_H	1.636	1.00
128_Q	174_K	1.629	1.00
47_V	53_V	1.629	1.00
242_E	247_Y	1.616	1.00
113_V	123_A	1.601	1.00
114_N	117_R	1.591	1.00
138_S	154_N	1.571	1.00
114_N	210_A	1.554	1.00
205_K	209_E	1.532	1.00
26_Y	231_L	1.531	1.00
237_S	240_A	1.516	1.00
172_T	176_R	1.510	1.00
65_M	163_L	1.494	1.00
228_E	231_L	1.494	1.00
45_V	62_T	1.493	1.00
135_K	188_T	1.483	1.00
61_F	167_C	1.467	1.00
141_G	152_A	1.465	1.00
59_L	63_K	1.442	1.00
16_M	41_K	1.439	1.00
227_E	230_E	1.435	1.00
65_M	166_K	1.406	1.00
22_S	26_Y	1.395	1.00
46_N	81_I	1.394	1.00
59_L	69_V	1.390	1.00
123_A	132_V	1.384	1.00
20_F	152_A	1.374	1.00
115_V	210_A	1.356	1.00
53_V	246_F	1.354	1.00
234_K	237_S	1.328	1.00
222_S	228_E	1.313	0.99
157_L	203_I	1.311	0.99
61_F	67_I	1.308	0.99
132_V	137_I	1.305	0.99
17_V	20_F	1.290	0.99
131_V	134_G	1.286	0.99
174_K	178_K	1.274	0.99
85_E	154_N	1.270	0.99
17_V	46_N	1.265	0.99
230_E	234_K	1.259	0.99
135_K	192_R	1.255	0.99
175_F	179_M	1.250	0.99
41_K	81_I	1.238	0.99
86_H	203_I	1.238	0.99
174_K	186_W	1.233	0.99
23_V	34_T	1.227	0.99
128_Q	186_W	1.225	0.99
78_T	168_I	1.206	0.99
16_M	81_I	1.200	0.99
166_K	169_R	1.198	0.99
57_V	62_T	1.192	0.99
201_E	205_K	1.190	0.99
138_S	153_G	1.190	0.99
132_V	193_E	1.175	0.99
175_F	180_A	1.172	0.99
60_E	63_K	1.166	0.99
58_D	169_R	1.166	0.99
46_N	85_E	1.162	0.99
108_F	111_P	1.157	0.99
36_L	39_S	1.149	0.99
137_I	190_L	1.144	0.99
81_I	85_E	1.137	0.98
53_V	57_V	1.134	0.98
15_H	19_S	1.129	0.98
140_N	153_G	1.124	0.98
124_D	134_G	1.119	0.98
13_G	70_V	1.114	0.98
224_L	232_W	1.110	0.98
17_V	81_I	1.101	0.98
191_E	197_I	1.101	0.98
34_T	93_R	1.096	0.98
42_E	83_P	1.093	0.98
51_Q	56_E	1.093	0.98
123_A	130_I	1.092	0.98
208_K	212_E	1.081	0.98
140_N	151_I	1.079	0.98
242_E	245_I	1.077	0.98
5_F	208_K	1.077	0.98
46_N	79_V	1.075	0.98
161_I	165_S	1.060	0.98
196_Y	202_E	1.054	0.98
106_K	110_T	1.054	0.98
74_L	152_A	1.047	0.97
23_V	27_V	1.045	0.97
227_E	231_L	1.039	0.97
86_H	204_N	1.025	0.97
118_S	206_K	1.009	0.97
177_D	181_K	1.006	0.97
67_I	167_C	1.001	0.97
43_P	163_L	0.995	0.96
162_D	184_S	0.993	0.96
27_V	33_N	0.992	0.96
128_Q	178_K	0.991	0.96
142_A	151_I	0.985	0.96
94_Q	149_I	0.982	0.96
81_I	152_A	0.981	0.96
222_S	225_T	0.976	0.96
27_V	93_R	0.975	0.96
47_V	78_T	0.972	0.96
61_F	166_K	0.969	0.96
92_V	149_I	0.958	0.96
82_T	163_L	0.958	0.96
118_S	209_E	0.956	0.96
58_D	61_F	0.949	0.95
11_Q	83_P	0.947	0.95
156_L	159_L	0.941	0.95
243_E	246_F	0.932	0.95
230_E	233_E	0.926	0.95
164_I	187_L	0.922	0.95
115_V	206_K	0.921	0.95
80_V	167_C	0.921	0.95
19_S	232_W	0.917	0.94
117_R	121_L	0.906	0.94
115_V	207_L	0.892	0.94
12_D	240_A	0.892	0.94
113_V	130_I	0.888	0.93
229_I	233_E	0.887	0.93
163_L	166_K	0.886	0.93
79_V	87_D	0.886	0.93
53_V	59_L	0.883	0.93
116_L	203_I	0.880	0.93
89_F	151_I	0.880	0.93
14_Y	236_A	0.869	0.93
210_A	213_K	0.865	0.93
89_F	152_A	0.863	0.92
22_S	232_W	0.856	0.92
180_A	183_M	0.849	0.92
109_L	125_L	0.847	0.92
24_A	145_H	0.846	0.92
77_G	138_S	0.842	0.92
55_L	177_D	0.841	0.91
89_F	141_G	0.838	0.91
75_G	139_G	0.830	0.91
15_H	236_A	0.830	0.91
109_L	140_N	0.828	0.91
94_Q	144_T	0.827	0.91
232_W	236_A	0.824	0.91
46_N	151_I	0.818	0.90
73_D	143_M	0.812	0.90
12_D	68_P	0.807	0.90
54_W	57_V	0.806	0.90
40_V	204_N	0.802	0.89
32_K	35_L	0.802	0.89
157_L	198_P	0.796	0.89
62_T	67_I	0.788	0.89
212_E	219_F	0.787	0.89
17_V	87_D	0.785	0.88
170_V	174_K	0.782	0.88
7_S	208_K	0.774	0.88
206_K	209_E	0.773	0.88
46_N	87_D	0.770	0.87
59_L	246_F	0.770	0.87
233_E	236_A	0.768	0.87
53_V	245_I	0.766	0.87
138_S	156_L	0.760	0.87
44_F	68_P	0.759	0.87
163_L	167_C	0.757	0.87
23_V	35_L	0.752	0.86
73_D	239_K	0.749	0.86
175_F	178_K	0.748	0.86
178_K	181_K	0.745	0.86
40_V	200_K	0.742	0.85
162_D	165_S	0.740	0.85
133_N	193_E	0.739	0.85
22_S	228_E	0.734	0.85
216_G	227_E	0.733	0.85
210_A	214_E	0.731	0.85
40_V	83_P	0.727	0.84
13_G	245_I	0.726	0.84
81_I	159_L	0.724	0.84
198_P	206_K	0.717	0.83
114_N	214_E	0.710	0.83
55_L	181_K	0.710	0.83
202_E	206_K	0.710	0.83
161_I	164_I	0.707	0.83
157_L	200_K	0.707	0.83
40_V	87_D	0.699	0.82
88_Y	127_D	0.698	0.82
46_N	154_N	0.698	0.82
200_K	204_N	0.694	0.81
63_K	242_E	0.689	0.81
79_V	85_E	0.688	0.81
226_P	229_I	0.687	0.81
137_I	188_T	0.686	0.81
40_V	74_L	0.685	0.81
195_G	199_P	0.684	0.81
130_I	149_I	0.680	0.80
160_D	189_S	0.678	0.80
116_L	137_I	0.677	0.80
178_K	182_D	0.676	0.80
127_D	186_W	0.675	0.80
10_P	39_S	0.675	0.80
161_I	189_S	0.674	0.80
189_S	195_G	0.674	0.80
142_A	239_K	0.668	0.79
179_M	183_M	0.666	0.79
111_P	210_A	0.666	0.79
50_H	143_M	0.662	0.78
228_E	232_W	0.659	0.78
45_V	215_L	0.657	0.78
14_Y	245_I	0.647	0.77
39_S	87_D	0.646	0.77
124_D	131_V	0.645	0.77
89_F	142_A	0.644	0.76
53_V	87_D	0.644	0.76
17_V	40_V	0.631	0.75
116_L	123_A	0.631	0.75
90_I	108_F	0.631	0.75
15_H	233_E	0.628	0.75
112_I	207_L	0.626	0.74
89_F	150_V	0.625	0.74
117_R	123_A	0.624	0.74
140_N	143_M	0.622	0.74
174_K	182_D	0.622	0.74
39_S	46_N	0.621	0.74
44_F	81_I	0.621	0.74
205_K	230_E	0.621	0.74
19_S	224_L	0.620	0.74
175_F	182_D	0.618	0.73
36_L	211_F	0.618	0.73
45_V	57_V	0.615	0.73
188_T	191_E	0.612	0.73
110_T	213_K	0.612	0.73
214_E	217_I	0.611	0.73
128_Q	170_V	0.607	0.72
182_D	185_E	0.606	0.72
174_K	180_A	0.606	0.72
57_V	69_V	0.604	0.72
55_L	175_F	0.601	0.71
21_V	235_L	0.601	0.71
38_F	88_Y	0.600	0.71
202_E	205_K	0.597	0.71
77_G	187_L	0.595	0.71
122_K	193_E	0.594	0.70
220_E	226_P	0.593	0.70
77_G	154_N	0.590	0.70
109_L	130_I	0.589	0.70
127_D	174_K	0.589	0.70
77_G	129_D	0.588	0.70
209_E	234_K	0.588	0.70
95_E	98_P	0.587	0.70
84_G	189_S	0.586	0.69
130_I	138_S	0.585	0.69
84_G	158_S	0.584	0.69
224_L	229_I	0.583	0.69
45_V	168_I	0.582	0.69
183_M	186_W	0.582	0.69
54_W	242_E	0.580	0.69
93_R	147_N	0.579	0.69
41_K	85_E	0.579	0.69
73_D	150_V	0.578	0.68
23_V	91_V	0.575	0.68
100_N	104_L	0.575	0.68
16_M	153_G	0.575	0.68
58_D	64_K	0.574	0.68
205_K	220_E	0.571	0.67
36_L	40_V	0.570	0.67
91_V	150_V	0.568	0.67
21_V	143_M	0.567	0.67
53_V	62_T	0.567	0.67
34_T	228_E	0.565	0.67
80_V	163_L	0.564	0.67
140_N	152_A	0.562	0.66
81_I	153_G	0.562	0.66
226_P	230_E	0.561	0.66
8_L	19_S	0.559	0.66
7_S	221_D	0.559	0.66
79_V	154_N	0.558	0.66
202_E	213_K	0.557	0.66
174_K	177_D	0.554	0.65
64_K	230_E	0.550	0.65
36_L	87_D	0.549	0.64
33_N	93_R	0.549	0.64
7_S	39_S	0.548	0.64
156_L	189_S	0.546	0.64
157_L	191_E	0.544	0.64
161_I	184_S	0.540	0.63
160_D	166_K	0.540	0.63
232_W	235_L	0.539	0.63
24_A	28_N	0.539	0.63
59_L	62_T	0.536	0.63
8_L	224_L	0.535	0.62
137_I	189_S	0.533	0.62
168_I	186_W	0.532	0.62
209_E	212_E	0.531	0.62
144_T	149_I	0.531	0.62
179_M	186_W	0.531	0.62
47_V	69_V	0.531	0.62
78_T	186_W	0.530	0.62
105_Y	108_F	0.530	0.62
53_V	69_V	0.529	0.62
20_F	38_F	0.528	0.61
77_G	128_Q	0.523	0.61
12_D	236_A	0.523	0.61
156_L	164_I	0.523	0.61
166_K	213_K	0.521	0.60
231_L	235_L	0.521	0.60
113_V	125_L	0.521	0.60
203_I	207_L	0.521	0.60
9_P	221_D	0.519	0.60
97_A	149_I	0.514	0.59
10_P	230_E	0.514	0.59
61_F	163_L	0.513	0.59
104_L	144_T	0.508	0.59
118_S	202_E	0.507	0.58
235_L	238_E	0.507	0.58
11_Q	15_H	0.506	0.58
195_G	202_E	0.506	0.58
6_V	222_S	0.505	0.58
174_K	183_M	0.505	0.58
8_L	23_V	0.504	0.58
35_L	41_K	0.503	0.58
89_F	143_M	0.503	0.58
25_D	29_R	0.503	0.58
84_G	159_L	0.501	0.58
231_L	237_S	0.500	0.57
40_V	89_F	0.500	0.57

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3a7rA	1	0.957	100	0.187	Contact Map
2e5aA	1	0.9534	100	0.239	Contact Map
1vqzA	1	0.9642	100	0.268	Contact Map
2c8mA	1	0.8315	100	0.281	Contact Map
2p0lA	1	0.8495	100	0.394	Contact Map
2p5iA	1	0.853	100	0.419	Contact Map
2qhsA	1	0.7384	100	0.466	Contact Map
1w66A	1	0.7204	100	0.498	Contact Map
2dxuA	2	0.7527	98.2	0.88	Contact Map
2eayA	2	0.7276	98	0.888	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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