GREMLIN Database
Q97Z70 - Lipoate protein ligase A, hypothetical (LplA-like1)
UniProt: Q97Z70 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 279 (237)
Sequences: 2459 (1700)
Seq/√Len: 110.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
158_S191_E4.1841.00
234_K238_E4.0901.00
188_T193_E3.5951.00
117_R122_K2.8301.00
21_V25_D2.8181.00
62_T69_V2.8051.00
61_F65_M2.7951.00
110_T114_N2.7651.00
199_P202_E2.4791.00
65_M167_C2.4431.00
60_E64_K2.4311.00
118_S213_K2.3221.00
118_S210_A2.2931.00
236_A240_A2.2741.00
122_K133_N2.2411.00
235_L239_K2.2281.00
225_T228_E2.1751.00
233_E237_S2.1491.00
114_N213_K2.1481.00
231_L234_K2.1081.00
88_Y153_G2.0661.00
21_V239_K2.0161.00
61_F64_K1.9351.00
130_I137_I1.9081.00
7_S204_N1.8971.00
81_I87_D1.8861.00
25_D231_L1.8371.00
119_Y206_K1.8121.00
70_V245_I1.8101.00
86_H200_K1.7991.00
188_T192_R1.7911.00
160_D163_L1.7481.00
126_R131_V1.7361.00
15_H229_I1.7321.00
74_L143_M1.7081.00
94_Q147_N1.6851.00
42_E68_P1.6821.00
39_S89_F1.6741.00
12_D15_H1.6711.00
25_D145_H1.6361.00
128_Q174_K1.6291.00
47_V53_V1.6291.00
242_E247_Y1.6161.00
113_V123_A1.6011.00
114_N117_R1.5911.00
138_S154_N1.5711.00
114_N210_A1.5541.00
205_K209_E1.5321.00
26_Y231_L1.5311.00
237_S240_A1.5161.00
172_T176_R1.5101.00
65_M163_L1.4941.00
228_E231_L1.4941.00
45_V62_T1.4931.00
135_K188_T1.4831.00
61_F167_C1.4671.00
141_G152_A1.4651.00
59_L63_K1.4421.00
16_M41_K1.4391.00
227_E230_E1.4351.00
65_M166_K1.4061.00
22_S26_Y1.3951.00
46_N81_I1.3941.00
59_L69_V1.3901.00
123_A132_V1.3841.00
20_F152_A1.3741.00
115_V210_A1.3561.00
53_V246_F1.3541.00
234_K237_S1.3281.00
222_S228_E1.3130.99
157_L203_I1.3110.99
61_F67_I1.3080.99
132_V137_I1.3050.99
17_V20_F1.2900.99
131_V134_G1.2860.99
174_K178_K1.2740.99
85_E154_N1.2700.99
17_V46_N1.2650.99
230_E234_K1.2590.99
135_K192_R1.2550.99
175_F179_M1.2500.99
41_K81_I1.2380.99
86_H203_I1.2380.99
174_K186_W1.2330.99
23_V34_T1.2270.99
128_Q186_W1.2250.99
78_T168_I1.2060.99
16_M81_I1.2000.99
166_K169_R1.1980.99
57_V62_T1.1920.99
201_E205_K1.1900.99
138_S153_G1.1900.99
132_V193_E1.1750.99
175_F180_A1.1720.99
60_E63_K1.1660.99
58_D169_R1.1660.99
46_N85_E1.1620.99
108_F111_P1.1570.99
36_L39_S1.1490.99
137_I190_L1.1440.99
81_I85_E1.1370.98
53_V57_V1.1340.98
15_H19_S1.1290.98
140_N153_G1.1240.98
124_D134_G1.1190.98
13_G70_V1.1140.98
224_L232_W1.1100.98
17_V81_I1.1010.98
191_E197_I1.1010.98
34_T93_R1.0960.98
42_E83_P1.0930.98
51_Q56_E1.0930.98
123_A130_I1.0920.98
208_K212_E1.0810.98
140_N151_I1.0790.98
242_E245_I1.0770.98
5_F208_K1.0770.98
46_N79_V1.0750.98
161_I165_S1.0600.98
196_Y202_E1.0540.98
106_K110_T1.0540.98
74_L152_A1.0470.97
23_V27_V1.0450.97
227_E231_L1.0390.97
86_H204_N1.0250.97
118_S206_K1.0090.97
177_D181_K1.0060.97
67_I167_C1.0010.97
43_P163_L0.9950.96
162_D184_S0.9930.96
27_V33_N0.9920.96
128_Q178_K0.9910.96
142_A151_I0.9850.96
94_Q149_I0.9820.96
81_I152_A0.9810.96
222_S225_T0.9760.96
27_V93_R0.9750.96
47_V78_T0.9720.96
61_F166_K0.9690.96
92_V149_I0.9580.96
82_T163_L0.9580.96
118_S209_E0.9560.96
58_D61_F0.9490.95
11_Q83_P0.9470.95
156_L159_L0.9410.95
243_E246_F0.9320.95
230_E233_E0.9260.95
164_I187_L0.9220.95
115_V206_K0.9210.95
80_V167_C0.9210.95
19_S232_W0.9170.94
117_R121_L0.9060.94
115_V207_L0.8920.94
12_D240_A0.8920.94
113_V130_I0.8880.93
229_I233_E0.8870.93
163_L166_K0.8860.93
79_V87_D0.8860.93
53_V59_L0.8830.93
116_L203_I0.8800.93
89_F151_I0.8800.93
14_Y236_A0.8690.93
210_A213_K0.8650.93
89_F152_A0.8630.92
22_S232_W0.8560.92
180_A183_M0.8490.92
109_L125_L0.8470.92
24_A145_H0.8460.92
77_G138_S0.8420.92
55_L177_D0.8410.91
89_F141_G0.8380.91
75_G139_G0.8300.91
15_H236_A0.8300.91
109_L140_N0.8280.91
94_Q144_T0.8270.91
232_W236_A0.8240.91
46_N151_I0.8180.90
73_D143_M0.8120.90
12_D68_P0.8070.90
54_W57_V0.8060.90
40_V204_N0.8020.89
32_K35_L0.8020.89
157_L198_P0.7960.89
62_T67_I0.7880.89
212_E219_F0.7870.89
17_V87_D0.7850.88
170_V174_K0.7820.88
7_S208_K0.7740.88
206_K209_E0.7730.88
46_N87_D0.7700.87
59_L246_F0.7700.87
233_E236_A0.7680.87
53_V245_I0.7660.87
138_S156_L0.7600.87
44_F68_P0.7590.87
163_L167_C0.7570.87
23_V35_L0.7520.86
73_D239_K0.7490.86
175_F178_K0.7480.86
178_K181_K0.7450.86
40_V200_K0.7420.85
162_D165_S0.7400.85
133_N193_E0.7390.85
22_S228_E0.7340.85
216_G227_E0.7330.85
210_A214_E0.7310.85
40_V83_P0.7270.84
13_G245_I0.7260.84
81_I159_L0.7240.84
198_P206_K0.7170.83
114_N214_E0.7100.83
55_L181_K0.7100.83
202_E206_K0.7100.83
161_I164_I0.7070.83
157_L200_K0.7070.83
40_V87_D0.6990.82
88_Y127_D0.6980.82
46_N154_N0.6980.82
200_K204_N0.6940.81
63_K242_E0.6890.81
79_V85_E0.6880.81
226_P229_I0.6870.81
137_I188_T0.6860.81
40_V74_L0.6850.81
195_G199_P0.6840.81
130_I149_I0.6800.80
160_D189_S0.6780.80
116_L137_I0.6770.80
178_K182_D0.6760.80
127_D186_W0.6750.80
10_P39_S0.6750.80
161_I189_S0.6740.80
189_S195_G0.6740.80
142_A239_K0.6680.79
179_M183_M0.6660.79
111_P210_A0.6660.79
50_H143_M0.6620.78
228_E232_W0.6590.78
45_V215_L0.6570.78
14_Y245_I0.6470.77
39_S87_D0.6460.77
124_D131_V0.6450.77
89_F142_A0.6440.76
53_V87_D0.6440.76
17_V40_V0.6310.75
116_L123_A0.6310.75
90_I108_F0.6310.75
15_H233_E0.6280.75
112_I207_L0.6260.74
89_F150_V0.6250.74
117_R123_A0.6240.74
140_N143_M0.6220.74
174_K182_D0.6220.74
39_S46_N0.6210.74
44_F81_I0.6210.74
205_K230_E0.6210.74
19_S224_L0.6200.74
175_F182_D0.6180.73
36_L211_F0.6180.73
45_V57_V0.6150.73
188_T191_E0.6120.73
110_T213_K0.6120.73
214_E217_I0.6110.73
128_Q170_V0.6070.72
182_D185_E0.6060.72
174_K180_A0.6060.72
57_V69_V0.6040.72
55_L175_F0.6010.71
21_V235_L0.6010.71
38_F88_Y0.6000.71
202_E205_K0.5970.71
77_G187_L0.5950.71
122_K193_E0.5940.70
220_E226_P0.5930.70
77_G154_N0.5900.70
109_L130_I0.5890.70
127_D174_K0.5890.70
77_G129_D0.5880.70
209_E234_K0.5880.70
95_E98_P0.5870.70
84_G189_S0.5860.69
130_I138_S0.5850.69
84_G158_S0.5840.69
224_L229_I0.5830.69
45_V168_I0.5820.69
183_M186_W0.5820.69
54_W242_E0.5800.69
93_R147_N0.5790.69
41_K85_E0.5790.69
73_D150_V0.5780.68
23_V91_V0.5750.68
100_N104_L0.5750.68
16_M153_G0.5750.68
58_D64_K0.5740.68
205_K220_E0.5710.67
36_L40_V0.5700.67
91_V150_V0.5680.67
21_V143_M0.5670.67
53_V62_T0.5670.67
34_T228_E0.5650.67
80_V163_L0.5640.67
140_N152_A0.5620.66
81_I153_G0.5620.66
226_P230_E0.5610.66
8_L19_S0.5590.66
7_S221_D0.5590.66
79_V154_N0.5580.66
202_E213_K0.5570.66
174_K177_D0.5540.65
64_K230_E0.5500.65
36_L87_D0.5490.64
33_N93_R0.5490.64
7_S39_S0.5480.64
156_L189_S0.5460.64
157_L191_E0.5440.64
161_I184_S0.5400.63
160_D166_K0.5400.63
232_W235_L0.5390.63
24_A28_N0.5390.63
59_L62_T0.5360.63
8_L224_L0.5350.62
137_I189_S0.5330.62
168_I186_W0.5320.62
209_E212_E0.5310.62
144_T149_I0.5310.62
179_M186_W0.5310.62
47_V69_V0.5310.62
78_T186_W0.5300.62
105_Y108_F0.5300.62
53_V69_V0.5290.62
20_F38_F0.5280.61
77_G128_Q0.5230.61
12_D236_A0.5230.61
156_L164_I0.5230.61
166_K213_K0.5210.60
231_L235_L0.5210.60
113_V125_L0.5210.60
203_I207_L0.5210.60
9_P221_D0.5190.60
97_A149_I0.5140.59
10_P230_E0.5140.59
61_F163_L0.5130.59
104_L144_T0.5080.59
118_S202_E0.5070.58
235_L238_E0.5070.58
11_Q15_H0.5060.58
195_G202_E0.5060.58
6_V222_S0.5050.58
174_K183_M0.5050.58
8_L23_V0.5040.58
35_L41_K0.5030.58
89_F143_M0.5030.58
25_D29_R0.5030.58
84_G159_L0.5010.58
231_L237_S0.5000.57
40_V89_F0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a7rA 1 0.957 100 0.187 Contact Map
2e5aA 1 0.9534 100 0.239 Contact Map
1vqzA 1 0.9642 100 0.268 Contact Map
2c8mA 1 0.8315 100 0.281 Contact Map
2p0lA 1 0.8495 100 0.394 Contact Map
2p5iA 1 0.853 100 0.419 Contact Map
2qhsA 1 0.7384 100 0.466 Contact Map
1w66A 1 0.7204 100 0.498 Contact Map
2dxuA 2 0.7527 98.2 0.88 Contact Map
2eayA 2 0.7276 98 0.888 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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