GREMLIN Database
GCSH2 - Probable glycine cleavage system H protein 2
UniProt: Q97Z69 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 148 (124)
Sequences: 3743 (2367)
Seq/√Len: 212.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_S129_A3.9501.00
103_D106_G3.4181.00
85_E114_K3.3861.00
66_V111_V2.9491.00
34_V112_K2.7481.00
88_E112_K2.5881.00
39_D42_Q2.0711.00
83_T120_E2.0371.00
103_D107_K1.9861.00
33_I115_M1.9671.00
31_D114_K1.9421.00
32_T112_K1.9211.00
27_L33_I1.9141.00
59_K116_S1.8831.00
117_N120_E1.8221.00
59_K85_E1.8031.00
125_F133_K1.7471.00
60_V80_A1.7461.00
119_E122_K1.7241.00
96_S99_I1.7031.00
26_K34_V1.6641.00
127_G131_I1.6551.00
13_L26_K1.5991.00
16_F21_N1.5401.00
100_I110_L1.4991.00
13_L105_Y1.4851.00
131_I135_K1.4841.00
67_A78_V1.4741.00
82_V115_M1.4741.00
62_K123_Q1.4721.00
12_N26_K1.4601.00
61_E64_R1.4531.00
92_E107_K1.4131.00
92_E96_S1.3681.00
132_Q135_K1.3441.00
17_I133_K1.3231.00
68_T75_A1.3211.00
39_D43_T1.3191.00
61_E83_T1.3001.00
65_P77_P1.2981.00
32_T114_K1.2951.00
55_K58_T1.2841.00
99_I108_G1.2831.00
57_G85_E1.2501.00
25_A33_I1.2331.00
66_V78_V1.2311.00
93_A110_L1.2211.00
53_I89_V1.1791.00
42_Q101_N1.1681.00
92_E99_I1.1491.00
60_V66_V1.1301.00
40_L44_M1.1201.00
68_T72_G1.1011.00
87_V114_K1.0941.00
27_L115_M1.0931.00
28_E34_V1.0861.00
32_T87_V1.0681.00
62_K120_E1.0651.00
52_R68_T1.0631.00
91_A94_E1.0621.00
96_S102_Q1.0591.00
23_V72_G1.0471.00
11_E128_Q1.0321.00
35_V111_V1.0191.00
56_K89_V1.0031.00
84_G113_M1.0031.00
14_Y121_L1.0021.00
129_A132_Q0.9771.00
14_Y122_K0.9581.00
49_V72_G0.9461.00
51_V93_A0.9420.99
28_E31_D0.9220.99
82_V113_M0.9140.99
58_T64_R0.9100.99
99_I102_Q0.9020.99
28_E32_T0.9000.99
115_M118_P0.9000.99
88_E91_A0.8990.99
128_Q131_I0.8990.99
16_F38_T0.8960.99
28_E112_K0.8900.99
16_F25_A0.8860.99
37_I69_M0.8800.99
9_I127_G0.8760.99
53_I110_L0.8650.99
25_A82_V0.8650.99
92_E95_K0.8530.99
27_L31_D0.8530.99
27_L121_L0.8480.99
16_F23_V0.8360.99
49_V75_A0.8270.99
9_I131_I0.8240.99
99_I107_K0.8220.99
83_T116_S0.8030.98
51_V69_M0.8010.98
80_A113_M0.7880.98
78_V111_V0.7860.98
116_S120_E0.7830.98
70_E73_K0.7820.98
21_N79_P0.7780.98
33_I82_V0.7750.98
24_W36_G0.7740.98
17_I21_N0.7700.98
98_I102_Q0.7620.98
105_Y127_G0.7580.98
11_E131_I0.7540.98
117_N121_L0.7460.97
14_Y126_S0.7380.97
56_K88_E0.7380.97
47_K98_I0.7360.97
68_T77_P0.7350.97
22_T46_G0.7280.97
93_A99_I0.7270.97
48_I69_M0.7220.97
35_V113_M0.7130.97
9_I105_Y0.7090.96
39_D105_Y0.7030.96
15_Y105_Y0.7030.96
9_I134_L0.7000.96
21_N74_W0.6840.96
78_V110_L0.6800.95
118_P121_L0.6760.95
60_V86_V0.6740.95
60_V83_T0.6660.95
91_A95_K0.6640.95
45_A76_G0.6630.95
27_L118_P0.6610.95
29_S32_T0.6510.94
31_D115_M0.6500.94
42_Q105_Y0.6350.94
71_S74_W0.6350.94
125_F129_A0.6340.93
21_N63_G0.6320.93
10_P127_G0.6320.93
54_K86_V0.6240.93
33_I121_L0.6230.93
15_Y38_T0.6160.93
31_D118_P0.6140.92
23_V79_P0.6120.92
10_P38_T0.6080.92
73_K76_G0.6050.92
118_P122_K0.6020.92
54_K89_V0.5970.91
17_I129_A0.5970.91
14_Y27_L0.5940.91
102_Q107_K0.5870.91
26_K29_S0.5870.91
23_V49_V0.5840.90
35_V81_P0.5830.90
49_V70_E0.5810.90
12_N127_G0.5800.90
48_I67_A0.5790.90
32_T115_M0.5770.90
17_I123_Q0.5750.90
32_T88_E0.5750.90
54_K71_S0.5730.90
39_D101_N0.5720.89
128_Q132_Q0.5710.89
40_L134_L0.5660.89
67_A111_V0.5540.88
56_K91_A0.5510.88
48_I68_T0.5470.87
55_K95_K0.5470.87
50_K70_E0.5430.87
44_M76_G0.5410.87
65_P68_T0.5400.87
65_P74_W0.5340.86
41_A76_G0.5330.86
51_V97_P0.5320.86
103_D108_G0.5300.86
33_I120_E0.5260.85
38_T104_P0.5240.85
45_A74_W0.5210.85
31_D34_V0.5210.85
89_V94_E0.5200.85
45_A130_A0.5200.85
47_K50_K0.5190.84
23_V74_W0.5190.84
69_M110_L0.5150.84
15_Y127_G0.5140.84
17_I43_T0.5120.84
50_K76_G0.5100.83
57_G87_V0.5090.83
86_V111_V0.5050.83
23_V35_V0.5010.82
40_L74_W0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hgbA 1 0.8581 100 0.221 Contact Map
3mxuA 3 0.8784 100 0.244 Contact Map
3tzuA 2 0.8243 100 0.287 Contact Map
3a7lA 1 0.8649 100 0.292 Contact Map
1hpcA 2 0.8851 100 0.294 Contact Map
3wdnA 1 0.8446 100 0.316 Contact Map
1onlA 1 0.8581 100 0.338 Contact Map
1zkoA 2 0.8581 100 0.354 Contact Map
5a35A 1 0.7568 100 0.382 Contact Map
3u9tA 3 0.2095 97 0.852 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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