GREMLIN Database
Q97Z67 - Uncharacterized protein
UniProt: Q97Z67 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 304 (290)
Sequences: 9094 (6196)
Seq/√Len: 363.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_L150_A4.4521.00
170_D173_E3.7931.00
285_K288_P3.6201.00
15_E124_D3.4581.00
124_D149_K3.2751.00
172_K291_Y3.1481.00
125_F137_V3.0721.00
22_I32_V3.0691.00
70_D149_K3.0331.00
59_N70_D2.9711.00
60_F70_D2.6281.00
19_F132_I2.6201.00
83_L157_K2.5791.00
10_V21_I2.5511.00
67_V78_I2.5341.00
102_A140_S2.5271.00
68_I151_S2.4781.00
52_I146_V2.3521.00
81_E84_Q2.3461.00
35_R38_G2.2231.00
87_L154_L2.2161.00
73_A78_I2.2071.00
68_I149_K2.1781.00
24_E28_D2.1781.00
76_K80_E2.1741.00
60_F149_K2.1641.00
15_E132_I2.1441.00
62_I81_E2.1321.00
137_V145_G2.1101.00
74_D77_K2.0831.00
67_V152_L2.0781.00
13_A56_K2.0721.00
77_K80_E2.0691.00
58_N77_K2.0621.00
63_S66_K2.0371.00
15_E148_T2.0041.00
13_A17_E2.0011.00
16_N20_Q1.9561.00
18_V148_T1.9411.00
125_F145_G1.9361.00
295_R299_F1.9021.00
22_I26_K1.8841.00
95_G100_L1.8551.00
121_E153_K1.8291.00
172_K176_L1.7981.00
15_E19_F1.7821.00
61_E68_I1.7681.00
54_T146_V1.7681.00
169_T173_E1.7661.00
127_N131_K1.7531.00
292_K295_R1.7231.00
101_L147_I1.7041.00
168_I177_E1.7001.00
32_V52_I1.6851.00
82_A154_L1.6731.00
288_P292_K1.6611.00
20_Q23_S1.6541.00
197_N201_E1.6481.00
11_N56_K1.6481.00
120_T138_I1.6261.00
10_V50_M1.6231.00
173_E176_L1.5951.00
124_D148_T1.5931.00
64_E85_K1.5731.00
124_D132_I1.5451.00
14_D17_E1.5441.00
69_A97_I1.5381.00
102_A147_I1.5311.00
24_E30_K1.5271.00
22_I146_V1.5241.00
18_V146_V1.4871.00
119_F155_Y1.4821.00
101_L120_T1.4621.00
294_K298_D1.4571.00
62_I67_V1.4551.00
34_I146_V1.4251.00
258_G262_V1.4011.00
36_G96_S1.3931.00
18_V52_I1.3741.00
19_F23_S1.3621.00
16_N19_F1.3601.00
172_K288_P1.3551.00
243_D246_S1.3461.00
122_W151_S1.3441.00
12_P17_E1.3291.00
295_R298_D1.3191.00
242_E246_S1.3031.00
46_K49_I1.3011.00
81_E85_K1.2981.00
233_Y237_I1.2841.00
21_I52_I1.2781.00
54_T57_L1.2701.00
249_E252_S1.2691.00
260_Y263_N1.2541.00
25_S50_M1.2321.00
9_E51_I1.2301.00
70_D73_A1.2291.00
97_I150_A1.2041.00
55_E96_S1.2031.00
126_I132_I1.1981.00
231_N235_V1.1951.00
140_S144_F1.1791.00
59_N73_A1.1741.00
57_L70_D1.1661.00
260_Y268_Y1.1651.00
23_S27_K1.1561.00
23_S26_K1.1531.00
75_V100_L1.1511.00
101_L116_P1.1451.00
22_I126_I1.1371.00
292_K296_V1.1251.00
257_Y260_Y1.1231.00
264_L268_Y1.1221.00
282_P285_K1.1171.00
201_E205_S1.1171.00
12_P21_I1.1111.00
261_G265_L1.1081.00
76_K92_I1.1061.00
76_K94_D1.0791.00
110_S115_T1.0711.00
198_K201_E1.0681.00
18_V54_T1.0631.00
235_V239_D1.0591.00
69_A78_I1.0521.00
15_E126_I1.0501.00
8_L50_M1.0461.00
35_R51_I1.0451.00
218_D221_I1.0401.00
75_V95_G1.0311.00
19_F126_I1.0271.00
137_V147_I1.0221.00
268_Y271_D1.0161.00
15_E70_D1.0151.00
134_W138_I1.0101.00
17_E20_Q1.0031.00
199_A203_H0.9981.00
7_V48_D0.9971.00
291_Y295_R0.9871.00
123_V134_W0.9831.00
67_V82_A0.9801.00
281_Y289_V0.9771.00
132_I148_T0.9751.00
230_K233_Y0.9751.00
66_K284_N0.9721.00
79_R88_L0.9691.00
25_S32_V0.9681.00
40_H43_R0.9671.00
34_I54_T0.9661.00
76_K93_Y0.9651.00
265_L268_Y0.9471.00
176_L180_K0.9431.00
36_G54_T0.9361.00
80_E84_Q0.9261.00
90_P119_F0.9161.00
97_I152_L0.9111.00
79_R82_A0.9111.00
77_K81_E0.9091.00
11_N55_E0.9061.00
63_S68_I0.8991.00
262_V266_K0.8991.00
82_A85_K0.8971.00
86_G157_K0.8971.00
15_E57_L0.8951.00
289_V293_L0.8921.00
225_S228_S0.8881.00
221_I225_S0.8841.00
288_P291_Y0.8841.00
58_N70_D0.8801.00
23_S131_K0.8781.00
26_K29_N0.8781.00
201_E217_K0.8781.00
7_V49_I0.8751.00
80_E83_L0.8751.00
123_V150_A0.8721.00
65_N87_L0.8691.00
147_I150_A0.8641.00
239_D242_E0.8501.00
20_Q24_E0.8481.00
12_P54_T0.8471.00
258_G261_G0.8471.00
79_R157_K0.8451.00
259_I263_N0.8431.00
31_K49_I0.8421.00
17_E21_I0.8361.00
265_L269_V0.8351.00
78_I152_L0.8341.00
18_V126_I0.8331.00
195_G198_K0.8301.00
126_I148_T0.8251.00
233_Y236_E0.8101.00
71_S150_A0.8091.00
37_F96_S0.8081.00
247_I250_R0.8081.00
201_E204_A0.8051.00
189_L227_V0.8021.00
222_P226_E0.8011.00
19_F22_I0.8001.00
180_K183_G0.8001.00
255_Y258_G0.7971.00
263_N266_K0.7971.00
11_N53_T0.7931.00
123_V147_I0.7921.00
241_V245_I0.7911.00
127_N133_R0.7891.00
260_Y271_D0.7891.00
30_K50_M0.7891.00
89_F100_L0.7861.00
62_I85_K0.7851.00
192_E195_G0.7801.00
265_L272_D0.7791.00
257_Y261_G0.7771.00
279_K293_L0.7761.00
160_K231_N0.7741.00
260_Y264_L0.7701.00
62_I87_L0.7671.00
198_K294_K0.7651.00
135_R138_I0.7621.00
33_G49_I0.7601.00
120_T123_V0.7591.00
225_S229_D0.7531.00
67_V154_L0.7531.00
296_V299_F0.7491.00
287_H291_Y0.7491.00
264_L275_L0.7481.00
101_L138_I0.7461.00
197_N200_F0.7411.00
221_I226_E0.7401.00
118_N135_R0.7401.00
264_L274_L0.7391.00
88_L157_K0.7371.00
200_F204_A0.7361.00
12_P56_K0.7341.00
88_L158_P0.7331.00
222_P225_S0.7331.00
241_V244_F0.7321.00
176_L291_Y0.7311.00
226_E229_D0.7291.00
162_F235_V0.7291.00
221_I227_V0.7271.00
100_L116_P0.7251.00
19_F26_K0.7221.00
125_F133_R0.7170.99
157_K161_V0.7170.99
241_V246_S0.7160.99
242_E245_I0.7160.99
45_I49_I0.7140.99
268_Y272_D0.7130.99
54_T71_S0.7120.99
119_F153_K0.7120.99
89_F116_P0.7110.99
272_D275_L0.7110.99
267_V272_D0.7100.99
248_A251_V0.7090.99
79_R83_L0.7090.99
127_N137_V0.7080.99
190_L193_Y0.7060.99
220_G227_V0.7040.99
260_Y266_K0.7010.99
215_Y218_D0.7010.99
293_L296_V0.7000.99
159_S229_D0.7000.99
256_M260_Y0.6990.99
254_Y258_G0.6990.99
123_V137_V0.6970.99
293_L297_L0.6960.99
120_T150_A0.6960.99
203_H206_Y0.6950.99
195_G199_A0.6930.99
78_I97_I0.6920.99
180_K184_L0.6910.99
60_F68_I0.6910.99
78_I89_F0.6880.99
268_Y274_L0.6880.99
166_R224_I0.6870.99
104_N135_R0.6870.99
197_N294_K0.6860.99
26_K129_F0.6840.99
250_R254_Y0.6820.99
221_I228_S0.6810.99
15_E18_V0.6800.99
197_N219_E0.6780.99
39_S94_D0.6770.99
239_D243_D0.6770.99
21_I50_M0.6770.99
75_V92_I0.6770.99
87_L156_E0.6750.99
268_Y273_S0.6740.99
223_M226_E0.6730.99
19_F127_N0.6720.99
262_V265_L0.6720.99
78_I82_A0.6710.99
136_A144_F0.6690.99
260_Y265_L0.6650.99
203_H207_V0.6620.99
265_L271_D0.6600.99
67_V81_E0.6500.99
246_S249_E0.6490.99
231_N234_I0.6470.99
16_N132_I0.6450.99
223_M227_V0.6450.99
172_K287_H0.6450.99
166_R245_I0.6450.99
205_S208_T0.6440.99
271_D275_L0.6430.99
219_E222_P0.6420.99
188_A191_V0.6410.99
247_I251_V0.6410.99
271_D274_L0.6400.99
188_A192_E0.6400.99
261_G264_L0.6380.99
256_M267_V0.6380.99
75_V91_S0.6360.99
232_S236_E0.6350.99
171_K290_F0.6290.99
263_N268_Y0.6280.99
115_T118_N0.6250.99
234_I238_S0.6240.99
245_I249_E0.6230.99
254_Y257_Y0.6230.99
199_A202_I0.6220.99
257_Y263_N0.6210.99
24_E50_M0.6210.99
22_I128_T0.6170.98
230_K236_E0.6170.98
215_Y226_E0.6160.98
66_K151_S0.6160.98
79_R92_I0.6150.98
104_N115_T0.6140.98
171_K193_Y0.6130.98
236_E239_D0.6130.98
213_Q219_E0.6130.98
74_D94_D0.6110.98
104_N116_P0.6080.98
18_V57_L0.6070.98
258_G267_V0.6050.98
258_G268_Y0.6030.98
256_M263_N0.6020.98
123_V138_I0.6010.98
216_S219_E0.5960.98
195_G294_K0.5910.98
69_A152_L0.5890.98
101_L152_L0.5870.98
21_I24_E0.5860.98
160_K234_I0.5860.98
255_Y260_Y0.5840.98
40_H44_E0.5840.98
17_E56_K0.5840.98
257_Y268_Y0.5840.98
91_S94_D0.5830.98
40_H103_L0.5830.98
32_V146_V0.5820.98
220_G224_I0.5800.98
190_L194_E0.5790.98
74_D96_S0.5770.98
21_I146_V0.5770.98
176_L179_R0.5760.98
89_F152_L0.5760.98
25_S30_K0.5750.98
175_K290_F0.5750.98
267_V271_D0.5750.98
118_N153_K0.5720.98
291_Y294_K0.5720.98
263_N272_D0.5700.97
220_G225_S0.5700.97
197_N204_A0.5700.97
162_F238_S0.5670.97
248_A252_S0.5660.97
101_L123_V0.5650.97
6_F38_G0.5640.97
269_V273_S0.5640.97
213_Q218_D0.5620.97
228_S234_I0.5600.97
22_I131_K0.5580.97
261_G272_D0.5570.97
242_E248_A0.5560.97
214_S217_K0.5560.97
214_S220_G0.5560.97
194_E200_F0.5550.97
215_Y221_I0.5540.97
97_I100_L0.5520.97
258_G263_N0.5520.97
111_T182_I0.5510.97
257_Y275_L0.5480.97
89_F119_F0.5480.97
67_V73_A0.5480.97
179_R182_I0.5470.97
267_V275_L0.5450.97
219_E226_E0.5450.97
171_K175_K0.5450.97
86_G159_S0.5430.97
73_A77_K0.5420.97
24_E27_K0.5410.97
69_A150_A0.5410.97
122_W134_W0.5410.97
88_L155_Y0.5390.96
266_K269_V0.5380.96
181_L191_V0.5380.96
214_S218_D0.5360.96
58_N73_A0.5350.96
261_G268_Y0.5340.96
229_D233_Y0.5330.96
37_F74_D0.5320.96
178_L191_V0.5310.96
232_S235_V0.5290.96
204_A207_V0.5290.96
15_E149_K0.5280.96
194_E203_H0.5270.96
264_L270_T0.5250.96
226_E230_K0.5240.96
179_R183_G0.5230.96
266_K271_D0.5220.96
182_I283_R0.5220.96
267_V274_L0.5220.96
35_R44_E0.5210.96
170_D176_L0.5180.96
238_S241_V0.5170.96
6_F51_I0.5170.96
33_G48_D0.5160.96
243_D247_I0.5160.96
264_L267_V0.5150.95
123_V133_R0.5130.95
256_M259_I0.5120.95
175_K179_R0.5110.95
214_S219_E0.5100.95
224_I227_V0.5090.95
258_G275_L0.5080.95
200_F203_H0.5080.95
294_K297_L0.5070.95
228_S233_Y0.5070.95
136_A139_G0.5060.95
255_Y272_D0.5060.95
258_G264_L0.5040.95
68_I71_S0.5030.95
61_E151_S0.5010.95
264_L272_D0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pm9A 5 0.9868 100 0.292 Contact Map
1f0xA 1 0.9638 100 0.296 Contact Map
2uuuA 2 0.9934 100 0.3 Contact Map
4bbyA 2 0.9737 100 0.314 Contact Map
2exrA 1 0.977 100 0.333 Contact Map
1w1oA 1 0.9704 100 0.335 Contact Map
4mlaA 1 0.9474 100 0.341 Contact Map
4o95A 1 0.9309 100 0.349 Contact Map
1wvfA 2 0.9868 100 0.363 Contact Map
4p8nA 1 0.9638 100 0.395 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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