GREMLIN Database
Q97Z65 - Intracellular proteinase
UniProt: Q97Z65 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 173 (161)
Sequences: 14732 (9848)
Seq/√Len: 776.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_K32_K2.8151.00
164_T167_K2.7221.00
7_L66_Y2.6711.00
34_V66_Y2.4541.00
7_L36_A2.4281.00
119_R147_E2.4161.00
145_V168_A2.2941.00
120_K139_V2.2561.00
119_R146_D2.2431.00
5_K34_V2.2191.00
116_V121_L2.1811.00
34_V56_I2.1751.00
145_V164_T1.9951.00
43_K53_I1.9851.00
25_R166_I1.9441.00
128_K132_I1.9141.00
117_K137_I1.9141.00
29_E166_I1.7861.00
94_F148_N1.7621.00
119_R149_L1.7501.00
120_K137_I1.7111.00
23_F27_M1.6891.00
93_F98_K1.6121.00
94_F100_V1.5871.00
120_K146_D1.5731.00
142_D160_A1.5651.00
145_V150_I1.5631.00
38_K83_L1.5561.00
130_D134_A1.5531.00
102_A151_S1.5351.00
14_F46_G1.4991.00
45_I51_T1.4961.00
57_A60_D1.4851.00
16_D20_L1.4681.00
68_A99_P1.4511.00
8_F70_V1.4491.00
99_P168_A1.4451.00
88_N92_K1.4161.00
101_A165_L1.3871.00
130_D133_A1.3841.00
89_I93_F1.3831.00
43_K51_T1.3741.00
59_K85_E1.3701.00
131_V140_D1.3661.00
37_W40_A1.3631.00
119_R148_N1.3551.00
152_S157_D1.3431.00
8_F23_F1.3391.00
141_N160_A1.3371.00
150_I168_A1.3351.00
87_K91_R1.3271.00
102_A110_L1.2981.00
101_A161_F1.2971.00
92_K96_L1.2961.00
112_S134_A1.2891.00
84_E88_N1.2891.00
121_L138_Y1.2871.00
94_F149_L1.2511.00
85_E88_N1.2451.00
94_F115_L1.2321.00
56_I60_D1.2271.00
131_V136_G1.2251.00
88_N91_R1.2131.00
145_V148_N1.2001.00
97_K148_N1.2001.00
6_V68_A1.1971.00
51_T55_D1.1891.00
12_E45_I1.1701.00
14_F19_L1.1621.00
26_V162_A1.1601.00
10_V35_I1.1531.00
97_K100_V1.1321.00
87_K113_A1.1291.00
17_I21_Y1.1191.00
19_L35_I1.1171.00
21_Y159_P1.1121.00
128_K140_D1.0991.00
82_T112_S1.0961.00
111_I138_Y1.0851.00
164_T168_A1.0831.00
150_I161_F1.0691.00
24_Y28_E1.0681.00
91_R95_E1.0641.00
92_K95_E1.0581.00
40_A57_A1.0541.00
21_Y24_Y1.0541.00
120_K144_V1.0481.00
9_L86_V1.0411.00
23_F35_I1.0391.00
16_D50_Y1.0361.00
114_N117_K1.0341.00
105_H127_I1.0321.00
67_I98_K1.0321.00
94_F97_K1.0281.00
70_V161_F1.0251.00
108_Q130_D1.0161.00
10_V19_L1.0121.00
21_Y162_A0.9991.00
120_K141_N0.9871.00
36_A56_I0.9741.00
152_S161_F0.9701.00
129_D133_A0.9651.00
124_V154_V0.9621.00
143_V164_T0.9581.00
8_F33_P0.9431.00
99_P148_N0.9421.00
38_K85_E0.9411.00
71_I90_T0.9151.00
81_R112_S0.9141.00
25_R162_A0.9101.00
150_I165_L0.8941.00
102_A107_P0.8891.00
56_I61_V0.8881.00
14_F52_V0.8851.00
31_F68_A0.8741.00
6_V31_F0.8731.00
153_R157_D0.8691.00
22_P70_V0.8651.00
159_P163_S0.8651.00
93_F96_L0.8501.00
99_P150_I0.8501.00
38_K58_F0.8491.00
71_I109_I0.8441.00
127_I130_D0.8411.00
24_Y27_M0.8391.00
22_P158_L0.8361.00
12_E39_E0.8341.00
107_P123_S0.8341.00
68_A165_L0.8301.00
87_K112_S0.8161.00
21_Y158_L0.8141.00
112_S135_G0.8051.00
36_A61_V0.8051.00
23_F33_P0.7991.00
19_L23_F0.7991.00
37_W54_S0.7941.00
14_F72_P0.7931.00
142_D145_V0.7911.00
70_V101_A0.7901.00
136_G140_D0.7841.00
10_V14_F0.7811.00
31_F166_I0.7791.00
135_G138_Y0.7791.00
122_T144_V0.7741.00
8_F19_L0.7711.00
71_I86_V0.7701.00
69_L93_F0.7621.00
83_L86_V0.7531.00
66_Y93_F0.7421.00
131_V135_G0.7381.00
68_A101_A0.7381.00
103_I158_L0.7361.00
89_I92_K0.7351.00
64_E92_K0.7341.00
121_L136_G0.7301.00
99_P165_L0.7221.00
26_V165_L0.7171.00
16_D46_G0.7151.00
91_R113_A0.7141.00
43_K54_S0.7141.00
108_Q127_I0.7111.00
71_I106_G0.7061.00
7_L61_V0.7041.00
125_N138_Y0.6961.00
25_R163_S0.6951.00
90_T109_I0.6921.00
94_F119_R0.6831.00
150_I164_T0.6771.00
102_A106_G0.6761.00
65_D96_L0.6731.00
34_V55_D0.6641.00
122_T138_Y0.6601.00
40_A54_S0.6591.00
110_L113_A0.6581.00
142_D157_D0.6561.00
129_D132_I0.6531.00
141_N144_V0.6501.00
16_D48_H0.6451.00
26_V31_F0.6431.00
118_G137_I0.6431.00
6_V26_V0.6431.00
13_E45_I0.6381.00
123_S138_Y0.6371.00
61_V66_Y0.6341.00
160_A163_S0.6221.00
125_N154_V0.6211.00
84_E87_K0.6151.00
87_K90_T0.6151.00
158_L162_A0.6091.00
87_K109_I0.6051.00
139_V142_D0.6021.00
25_R29_E0.6011.00
66_Y69_L0.6001.00
126_S129_D0.5991.00
80_I83_L0.5921.00
78_E82_T0.5911.00
5_K67_I0.5851.00
9_L36_A0.5841.00
64_E96_L0.5791.00
121_L131_V0.5781.00
103_I161_F0.5781.00
8_F22_P0.5781.00
45_I49_G0.5731.00
90_T113_A0.5721.00
18_E155_P0.5691.00
18_E73_G0.5671.00
79_H82_T0.5661.00
15_E24_Y0.5611.00
90_T115_L0.5611.00
27_M33_P0.5581.00
100_V149_L0.5531.00
111_I131_V0.5501.00
132_I138_Y0.5481.00
25_R28_E0.5481.00
117_K135_G0.5471.00
41_N53_I0.5471.00
82_T87_K0.5451.00
101_A150_I0.5431.00
111_I116_V0.5431.00
39_E57_A0.5331.00
61_V64_E0.5311.00
100_V148_N0.5311.00
91_R115_L0.5291.00
160_A164_T0.5291.00
123_S127_I0.5291.00
124_V155_P0.5281.00
7_L89_I0.5261.00
58_F86_V0.5261.00
107_P131_V0.5241.00
143_V150_I0.5231.00
9_L69_L0.5191.00
10_V44_V0.5171.00
37_W55_D0.5151.00
25_R159_P0.5141.00
22_P26_V0.5091.00
17_I158_L0.5091.00
21_Y25_R0.5071.00
163_S167_K0.5041.00
91_R114_N0.5031.00
36_A66_Y0.5031.00
40_A60_D0.5001.00
23_F50_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l18A 2 0.9711 100 0.162 Contact Map
2rk3A 2 0.9942 100 0.165 Contact Map
1oi4A 2 0.9827 100 0.166 Contact Map
3fseA 2 0.9884 100 0.166 Contact Map
3mgkA 2 0.9769 100 0.171 Contact Map
3er6A 2 0.9769 100 0.175 Contact Map
3ewnA 2 0.9884 100 0.175 Contact Map
2vrnA 2 0.9942 100 0.179 Contact Map
3noqA 2 0.9769 100 0.18 Contact Map
3graA 2 0.9653 100 0.181 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.007 seconds.