GREMLIN Database
Q97Z62 - Partial transposase ISC1229
UniProt: Q97Z62 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 227 (215)
Sequences: 4523 (3482)
Seq/√Len: 237.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_R97_M2.9081.00
138_F211_A2.7571.00
193_H196_K2.7161.00
79_V90_E2.6611.00
126_V138_F2.4761.00
107_V223_P2.4001.00
142_C168_L2.3891.00
26_Q88_R2.3741.00
110_T223_P2.3141.00
187_L191_E2.3081.00
133_P137_S2.1821.00
82_R90_E2.1821.00
160_I204_T2.1471.00
86_Q90_E2.1451.00
122_I214_V2.1361.00
25_A28_K2.0811.00
25_A32_R1.9311.00
83_I86_Q1.9201.00
134_R137_S1.8811.00
132_F141_Y1.8471.00
144_L207_A1.8391.00
198_K201_K1.8341.00
208_R212_R1.8181.00
111_I214_V1.7511.00
107_V217_V1.7411.00
142_C211_A1.7311.00
150_R155_E1.7271.00
121_I171_L1.7251.00
192_T196_K1.6981.00
194_K200_K1.6941.00
83_I90_E1.6931.00
114_I119_A1.6771.00
54_F58_D1.6621.00
108_L214_V1.6571.00
25_A83_I1.6401.00
222_K225_E1.6321.00
33_L84_L1.6291.00
23_K91_L1.6241.00
174_F177_E1.6121.00
97_M100_S1.5981.00
19_Y95_G1.5911.00
118_A171_L1.5871.00
186_L206_L1.5861.00
57_G61_D1.5851.00
111_I217_V1.5811.00
217_V223_P1.5671.00
81_A85_L1.5671.00
216_S220_N1.5391.00
109_L116_K1.5351.00
20_L170_S1.5341.00
50_R53_K1.5301.00
26_Q91_L1.5191.00
107_V110_T1.5091.00
27_T31_N1.4861.00
215_W219_Y1.4831.00
139_V145_D1.4821.00
176_A210_L1.4731.00
186_L213_I1.4631.00
139_V208_R1.4611.00
92_K95_G1.4551.00
180_Y190_Y1.4491.00
102_V109_L1.4241.00
189_F209_K1.3961.00
19_Y23_K1.3931.00
190_Y206_L1.3911.00
17_S125_I1.3851.00
58_D61_D1.3821.00
191_E195_D1.3701.00
176_A206_L1.3701.00
197_L201_K1.3661.00
23_K26_Q1.3661.00
99_E116_K1.3611.00
111_I210_L1.3251.00
82_R89_E1.3221.00
82_R86_Q1.3191.00
84_L88_R1.3131.00
170_S174_F1.2971.00
22_M91_L1.2881.00
173_Y207_A1.2851.00
118_A175_L1.2691.00
33_L77_I1.2611.00
125_I165_N1.2591.00
175_L210_L1.2551.00
189_F193_H1.2361.00
176_A207_A1.2301.00
26_Q84_L1.2231.00
46_L50_R1.2091.00
25_A29_Q1.1941.00
24_D28_K1.1781.00
108_L119_A1.1581.00
86_Q89_E1.1491.00
108_L218_W1.1381.00
55_S59_F1.1191.00
129_I218_W1.1101.00
29_Q33_L1.1071.00
193_H202_L1.1041.00
30_E48_E1.1031.00
95_G99_E1.1021.00
51_L58_D1.1011.00
194_K199_G1.0921.00
97_M101_N1.0891.00
21_F32_R1.0881.00
54_F57_G1.0771.00
79_V93_E1.0611.00
173_Y204_T1.0511.00
50_R57_G1.0451.00
56_K60_S1.0431.00
114_I214_V1.0351.00
26_Q30_E1.0321.00
54_F61_D1.0281.00
160_I169_R1.0241.00
172_F211_A1.0181.00
35_R39_L1.0161.00
79_V97_M1.0151.00
51_L54_F1.0111.00
193_H198_K1.0081.00
194_K202_L1.0031.00
95_G98_I1.0031.00
151_S155_E1.0021.00
54_F59_F0.9981.00
216_S219_Y0.9961.00
189_F205_A0.9921.00
200_K203_Y0.9791.00
16_V167_Y0.9701.00
114_I118_A0.9651.00
177_E200_K0.9641.00
213_I217_V0.9621.00
72_T97_M0.9611.00
88_R92_K0.9601.00
189_F192_T0.9591.00
184_P187_L0.9591.00
56_K59_F0.9581.00
186_L210_L0.9581.00
11_P70_T0.9541.00
190_Y202_L0.9491.00
20_L24_D0.9441.00
137_S140_A0.9391.00
173_Y177_E0.9261.00
47_S51_L0.9241.00
90_E93_E0.9121.00
48_E52_E0.9121.00
176_A203_Y0.9111.00
18_L22_M0.9091.00
184_P188_K0.9001.00
100_S104_Q0.8991.00
126_V129_I0.8981.00
188_K192_T0.8840.99
177_E180_Y0.8780.99
193_H197_L0.8760.99
93_E97_M0.8760.99
125_I167_Y0.8750.99
189_F206_L0.8740.99
20_L167_Y0.8700.99
71_G97_M0.8680.99
204_T207_A0.8600.99
122_I168_L0.8600.99
75_R78_Q0.8580.99
148_V155_E0.8560.99
217_V222_K0.8500.99
141_Y165_N0.8470.99
55_S58_D0.8440.99
162_K169_R0.8400.99
47_S50_R0.8370.99
88_R91_L0.8310.99
15_L94_V0.8300.99
102_V105_D0.8270.99
44_E47_S0.8270.99
30_E84_L0.8270.99
102_V120_G0.8200.99
121_I125_I0.8120.99
134_R215_W0.8070.99
114_I210_L0.8060.99
145_D161_S0.8020.99
89_E93_E0.8010.99
50_R58_D0.7990.99
111_I114_I0.7980.99
29_Q80_L0.7940.99
23_K27_T0.7930.99
145_D148_V0.7930.99
192_T195_D0.7910.99
53_K56_K0.7910.99
99_E103_P0.7890.99
50_R54_F0.7890.99
28_K31_N0.7850.99
75_R79_V0.7750.99
193_H205_A0.7680.98
177_E203_Y0.7620.98
16_V98_I0.7600.98
129_I215_W0.7580.98
55_S61_D0.7550.98
198_K202_L0.7480.98
44_E54_F0.7410.98
19_Y117_L0.7370.98
51_L57_G0.7340.98
29_Q32_R0.7330.98
140_A145_D0.7320.98
79_V83_I0.7320.98
29_Q83_I0.7270.98
147_V161_S0.7260.98
180_Y194_K0.7240.98
185_T224_Y0.7220.98
74_L78_Q0.7190.98
72_T75_R0.7140.98
160_I205_A0.7140.98
144_L208_R0.7140.98
29_Q84_L0.7110.98
13_R125_I0.7060.97
19_Y91_L0.7020.97
16_V120_G0.7000.97
73_V76_E0.7000.97
21_F25_A0.6990.97
136_E208_R0.6980.97
51_L55_S0.6970.97
10_N14_E0.6940.97
114_I122_I0.6940.97
145_D162_K0.6860.97
49_E53_K0.6790.97
83_I87_T0.6790.97
178_T182_R0.6730.97
22_M90_E0.6720.97
180_Y203_Y0.6680.96
212_R215_W0.6630.96
143_G169_R0.6610.96
14_E36_A0.6600.96
48_E51_L0.6590.96
177_E207_A0.6580.96
109_L119_A0.6580.96
164_G169_R0.6570.96
172_F207_A0.6520.96
52_E56_K0.6500.96
21_F24_D0.6490.96
91_L95_G0.6490.96
188_K191_E0.6480.96
80_L83_I0.6460.96
190_Y194_K0.6450.96
85_L89_E0.6450.96
53_K57_G0.6430.96
105_D109_L0.6420.95
128_D131_R0.6370.95
169_R204_T0.6290.95
158_K161_S0.6280.95
214_V217_V0.6260.95
121_I167_Y0.6260.95
18_L21_F0.6140.94
139_V212_R0.6130.94
135_P212_R0.6120.94
107_V221_N0.6120.94
51_L59_F0.6090.94
46_L54_F0.6090.94
31_N35_R0.6080.94
22_M94_V0.6080.94
8_T104_Q0.6050.94
183_N224_Y0.6010.94
38_F43_E0.5960.93
148_V157_R0.5960.93
46_L58_D0.5950.93
9_Y12_L0.5950.93
30_E33_L0.5950.93
14_E76_E0.5920.93
145_D163_R0.5890.93
18_L76_E0.5890.93
35_R41_N0.5890.93
89_E92_K0.5880.93
21_F28_K0.5840.93
61_D67_L0.5820.93
76_E79_V0.5810.92
15_L97_M0.5810.92
108_L114_I0.5750.92
179_Q186_L0.5720.92
7_D11_P0.5700.92
194_K197_L0.5700.92
95_G117_L0.5650.91
16_V121_I0.5640.91
98_I120_G0.5640.91
135_P215_W0.5630.91
126_V142_C0.5590.91
47_S58_D0.5580.91
49_E60_S0.5570.91
99_E109_L0.5550.91
70_T73_V0.5530.91
13_R16_V0.5530.91
204_T217_V0.5520.90
45_K50_R0.5520.90
120_G167_Y0.5500.90
72_T76_E0.5480.90
34_R38_F0.5430.90
209_K212_R0.5430.90
46_L51_L0.5410.90
185_T213_I0.5400.89
174_F178_T0.5390.89
54_F60_S0.5390.89
175_L207_A0.5380.89
10_N13_R0.5380.89
150_R154_I0.5360.89
177_E181_S0.5320.89
107_V111_I0.5320.89
139_V148_V0.5310.89
78_Q82_R0.5300.89
44_E56_K0.5290.89
180_Y206_L0.5290.89
213_I216_S0.5280.88
130_R219_Y0.5270.88
144_L169_R0.5250.88
81_A131_R0.5230.88
93_E96_K0.5220.88
170_S173_Y0.5190.88
18_L32_R0.5180.87
138_F214_V0.5180.87
117_L121_I0.5160.87
53_K59_F0.5140.87
95_G116_K0.5140.87
52_E59_F0.5130.87
87_T90_E0.5130.87
201_K205_A0.5120.87
18_L80_L0.5090.87
32_R80_L0.5090.87
183_N186_L0.5090.87
126_V141_Y0.5070.86
105_D123_I0.5050.86
127_G131_R0.5040.86
29_Q37_L0.5020.86
110_T123_I0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nrtA 1 0.6476 87.7 0.913 Contact Map
1keaA 2 0.7974 87.3 0.914 Contact Map
2a1jB 2 0.3392 84.6 0.917 Contact Map
3c65A 1 0.3568 84.1 0.917 Contact Map
3icxA 2 0.7665 84 0.918 Contact Map
4glxA 1 0.6035 83.3 0.918 Contact Map
3c1yA 5 0.7225 81.1 0.92 Contact Map
3plaA 2 0.8899 80.1 0.921 Contact Map
2duyA 1 0.2863 79.2 0.922 Contact Map
2a1jA 1 0.2599 79.2 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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