GREMLIN Database
Q97Z61 - Second ORF in transposon ISC1904
UniProt: Q97Z61 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 422 (344)
Sequences: 4394 (2821)
Seq/√Len: 152.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
264_D268_K5.4081.00
288_N291_S4.3891.00
340_P367_N4.1141.00
320_A327_V3.6251.00
206_L312_I3.0561.00
284_V316_L2.9881.00
313_H329_E2.9631.00
19_F322_L2.9361.00
347_R350_G2.8641.00
271_N275_D2.7851.00
311_S315_V2.7761.00
283_A376_M2.6531.00
312_I316_L2.4431.00
173_P182_L2.4181.00
338_S345_V2.4181.00
337_R346_S2.3621.00
334_L337_R2.3621.00
330_V372_I2.3291.00
311_S314_R2.3291.00
317_K329_E2.3191.00
274_L320_A2.3081.00
226_K302_R2.2221.00
293_F305_S2.2141.00
282_F320_A2.1771.00
225_L261_R2.1291.00
171_G187_K2.1281.00
267_H315_V2.0991.00
232_K247_G2.0651.00
335_T372_I2.0511.00
284_V327_V2.0481.00
267_H318_Y2.0251.00
354_E361_K2.0151.00
51_N55_I1.9951.00
28_R31_S1.9751.00
54_K120_K1.9741.00
206_L265_F1.9681.00
298_G301_S1.9551.00
49_L97_I1.9171.00
36_K180_V1.9111.00
342_C358_C1.8961.00
263_L311_S1.8731.00
270_V315_V1.8641.00
351_K364_R1.8181.00
317_K321_P1.8181.00
266_V315_V1.8091.00
267_H319_K1.8081.00
37_E87_H1.8071.00
247_G251_L1.8061.00
341_R360_F1.7991.00
50_W100_A1.7851.00
342_C355_C1.7631.00
353_F362_L1.7501.00
355_C358_C1.7431.00
339_C358_C1.7331.00
267_H270_V1.7111.00
339_C342_C1.7111.00
242_K245_K1.6851.00
284_V329_E1.6611.00
44_K84_K1.6401.00
232_K235_K1.6221.00
266_V311_S1.6071.00
245_K248_R1.6061.00
346_S350_G1.6031.00
199_I207_D1.6021.00
339_C355_C1.5911.00
177_E256_H1.5451.00
35_I180_V1.5341.00
20_T183_P1.5301.00
68_L72_K1.5251.00
33_E37_E1.5241.00
278_P325_S1.5211.00
286_K329_E1.5101.00
196_F373_Y1.5101.00
284_V313_H1.4931.00
208_A366_L1.4911.00
270_V318_Y1.4821.00
352_T361_K1.4581.00
32_K36_K1.4511.00
353_F360_F1.4491.00
101_F105_K1.4451.00
344_F356_E1.4371.00
179_K256_H1.4311.00
236_V248_R1.4201.00
205_T208_A1.4091.00
39_R180_V1.3961.00
370_L374_L1.3801.00
106_S118_I1.3781.00
49_L100_A1.3691.00
285_E332_P1.3661.00
348_K351_K1.3651.00
317_K327_V1.3601.00
69_P72_K1.3571.00
256_H260_N1.3561.00
209_Y213_K1.3501.00
54_K58_R1.3441.00
110_R118_I1.3441.00
270_V319_K1.3361.00
295_D301_S1.3351.00
145_T151_Y1.3231.00
104_L120_K1.3181.00
91_H131_K1.3101.00
197_L209_Y1.3061.00
111_A118_I1.3021.00
233_R237_Q1.2571.00
232_K254_Y1.2501.00
24_K179_K1.2361.00
105_K109_K1.2341.00
304_I309_W1.2321.00
196_F281_F1.2221.00
29_E32_K1.2141.00
42_L96_A1.1921.00
366_L370_L1.1911.00
70_K73_E1.1901.00
288_N332_P1.1891.00
102_S106_S1.1871.00
229_M255_S1.1861.00
272_T276_L1.1831.00
95_K98_N1.1821.00
27_E31_S1.1801.00
144_I182_L1.1761.00
347_R351_K1.1681.00
197_L277_Y1.1631.00
228_S232_K1.1511.00
270_V312_I1.1511.00
330_V375_K1.1501.00
201_S309_W1.1411.00
79_R93_V1.1391.00
229_M251_L1.1391.00
62_G65_K1.1331.00
340_P370_L1.1301.00
266_V312_I1.1251.00
315_V318_Y1.1150.99
198_A373_Y1.1150.99
139_G142_V1.1130.99
335_T375_K1.1110.99
274_L323_Y1.1040.99
225_L258_E1.1010.99
146_V175_I1.0960.99
263_L315_V1.0960.99
338_S375_K1.0940.99
271_N323_Y1.0840.99
91_H133_T1.0820.99
203_L307_T1.0720.99
46_I96_A1.0660.99
240_A244_T1.0640.99
266_V270_V1.0610.99
201_S313_H1.0610.99
106_S111_A1.0580.99
274_L282_F1.0570.99
270_V316_L1.0560.99
283_A372_I1.0510.99
110_R119_E1.0510.99
99_D129_R1.0480.99
275_D323_Y1.0460.99
348_K364_R1.0450.99
362_L370_L1.0430.99
244_T248_R1.0310.99
89_A92_Y1.0300.99
27_E35_I1.0290.99
259_R263_L1.0240.99
347_R364_R1.0220.99
362_L366_L1.0200.99
128_V131_K1.0180.99
230_E233_R1.0130.99
199_I209_Y1.0130.99
236_V251_L1.0130.99
214_F363_D1.0090.99
77_P81_E1.0060.99
340_P362_L1.0050.99
21_Y186_Y1.0040.99
295_D299_S1.0040.99
73_E76_K1.0040.99
233_R251_L0.9940.99
286_K332_P0.9930.99
41_L84_K0.9800.99
107_W120_K0.9800.99
274_L325_S0.9760.99
197_L210_D0.9750.99
232_K250_L0.9750.99
106_S110_R0.9730.99
314_R317_K0.9730.99
50_W104_L0.9720.99
32_K180_V0.9710.99
319_K322_L0.9660.99
136_K145_T0.9660.99
128_V132_T0.9580.98
289_K310_R0.9580.98
351_K363_D0.9570.98
232_K251_L0.9510.98
346_S353_F0.9510.98
229_M258_E0.9480.98
107_W121_P0.9470.98
71_K75_Y0.9460.98
66_I70_K0.9450.98
295_D298_G0.9430.98
213_K272_T0.9400.98
332_P335_T0.9390.98
337_R345_V0.9370.98
334_L375_K0.9330.98
344_F357_R0.9310.98
129_R172_E0.9290.98
281_F326_F0.9280.98
55_I59_K0.9270.98
138_V141_S0.9270.98
40_T43_Q0.9250.98
46_I100_A0.9220.98
352_T362_L0.9170.98
193_P278_P0.9120.98
229_M237_Q0.9050.98
91_H95_K0.9010.98
221_Q225_L0.9010.98
196_F283_A0.9000.98
44_K48_Y0.8980.98
218_S307_T0.8950.98
53_T101_F0.8950.98
266_V308_V0.8930.98
156_W159_S0.8930.98
54_K104_L0.8910.97
70_K75_Y0.8910.97
18_H187_K0.8870.97
208_A214_F0.8830.97
203_L303_K0.8820.97
106_S109_K0.8780.97
207_D269_F0.8780.97
340_P360_F0.8760.97
205_T216_T0.8750.97
142_V145_T0.8740.97
236_V247_G0.8720.97
143_R151_Y0.8700.97
134_L147_R0.8670.97
76_K79_R0.8670.97
95_K129_R0.8660.97
233_R255_S0.8650.97
366_L369_S0.8630.97
71_K74_V0.8620.97
320_A325_S0.8610.97
46_I103_I0.8520.97
66_I69_P0.8520.97
136_K139_G0.8520.97
250_L253_K0.8500.97
341_R370_L0.8490.97
281_F328_K0.8480.97
134_L137_V0.8470.97
18_H185_R0.8460.97
205_T214_F0.8450.97
368_A371_N0.8430.96
350_G364_R0.8430.96
76_K80_E0.8410.96
69_P75_Y0.8370.96
85_I93_V0.8340.96
291_S304_I0.8340.96
221_Q261_R0.8300.96
330_V376_M0.8270.96
69_P73_E0.8250.96
273_L282_F0.8250.96
94_D98_N0.8190.96
346_S364_R0.8180.96
340_P374_L0.8180.96
271_N319_K0.8180.96
99_D174_I0.8160.96
230_E234_A0.8120.96
338_S371_N0.8120.96
293_F301_S0.8090.96
201_S207_D0.8070.95
72_K76_K0.8060.95
25_N182_L0.8050.95
257_R261_R0.8030.95
340_P368_A0.8030.95
215_V265_F0.8020.95
174_I183_P0.8000.95
175_I182_L0.8000.95
248_R252_R0.7940.95
289_K309_W0.7940.95
291_S332_P0.7930.95
67_T71_K0.7880.95
48_Y52_L0.7870.95
370_L373_Y0.7840.95
229_M233_R0.7840.95
269_F272_T0.7800.95
367_N371_N0.7780.94
149_H152_I0.7780.94
97_I101_F0.7770.94
45_A96_A0.7750.94
91_H132_T0.7740.94
154_F157_S0.7690.94
286_K313_H0.7690.94
254_Y258_E0.7670.94
57_V61_N0.7660.94
231_V235_K0.7650.94
75_Y79_R0.7620.94
265_F269_F0.7620.94
195_N211_G0.7610.94
95_K99_D0.7590.94
353_F364_R0.7570.94
197_L282_F0.7550.94
200_D365_Q0.7540.94
146_V149_H0.7440.93
75_Y94_D0.7400.93
66_I71_K0.7390.93
144_I173_P0.7390.93
214_F366_L0.7370.93
192_T195_N0.7360.93
24_K181_Y0.7350.93
53_T104_L0.7350.93
230_E237_Q0.7340.93
95_K131_K0.7330.93
52_L74_V0.7320.93
75_Y78_L0.7310.92
300_L304_I0.7310.92
241_S244_T0.7270.92
23_I182_L0.7260.92
65_K70_K0.7250.92
26_S155_P0.7240.92
48_Y78_L0.7240.92
344_F353_F0.7220.92
346_S351_K0.7210.92
350_G353_F0.7200.92
38_Y42_L0.7190.92
258_E306_R0.7180.92
283_A373_Y0.7180.92
169_E187_K0.7170.92
218_S221_Q0.7160.92
34_L38_Y0.7150.92
204_Y208_A0.7130.92
67_T70_K0.7120.91
41_L88_L0.7120.91
334_L338_S0.7090.91
225_L257_R0.7090.91
61_N64_Y0.7090.91
91_H94_D0.7080.91
133_T136_K0.7080.91
100_A104_L0.7030.91
206_L270_V0.7000.91
52_L78_L0.6990.91
40_T44_K0.6990.91
91_H134_L0.6980.91
29_E33_E0.6980.91
172_E185_R0.6950.90
68_L71_K0.6930.90
37_E41_L0.6920.90
104_L108_R0.6920.90
287_L332_P0.6920.90
74_V97_I0.6860.90
88_L91_H0.6850.90
273_L277_Y0.6840.90
129_R174_I0.6840.90
30_K33_E0.6810.90
57_V104_L0.6780.89
237_Q251_L0.6770.89
202_N208_A0.6750.89
313_H317_K0.6730.89
310_R314_R0.6730.89
190_W193_P0.6720.89
236_V244_T0.6720.89
190_W325_S0.6710.89
262_V306_R0.6710.89
298_G305_S0.6690.89
145_T148_P0.6680.89
283_A375_K0.6670.89
206_L307_T0.6640.88
41_L44_K0.6640.88
334_L345_V0.6640.88
58_R61_N0.6630.88
235_K247_G0.6630.88
275_D281_F0.6620.88
209_Y215_V0.6620.88
356_E364_R0.6610.88
295_D304_I0.6590.88
18_H171_G0.6590.88
135_R170_L0.6590.88
225_L229_M0.6580.88
263_L267_H0.6500.87
20_T185_R0.6480.87
52_L56_Q0.6450.87
107_W110_R0.6450.87
316_L327_V0.6440.87
35_I39_R0.6390.86
207_D312_I0.6380.86
282_F316_L0.6370.86
320_A323_Y0.6350.86
22_S183_P0.6300.86
222_L225_L0.6300.86
142_V146_V0.6290.86
225_L254_Y0.6290.86
72_K75_Y0.6280.85
341_R362_L0.6270.85
283_A328_K0.6250.85
338_S343_G0.6240.85
52_L55_I0.6230.85
38_Y89_A0.6230.85
154_F158_K0.6220.85
23_I165_V0.6180.85
92_Y130_I0.6170.84
372_I375_K0.6170.84
76_K81_E0.6170.84
289_K292_M0.6170.84
234_A238_S0.6160.84
233_R238_S0.6160.84
103_I121_P0.6150.84
243_H246_R0.6130.84
130_I133_T0.6120.84
375_K378_G0.6110.84
72_K97_I0.6110.84
44_K82_L0.6110.84
200_D336_S0.6090.84
362_L367_N0.6070.83
255_S259_R0.6040.83
104_L107_W0.6040.83
315_V319_K0.6030.83
41_L85_I0.6010.83
96_A100_A0.6010.83
255_S262_V0.5990.83
129_R132_T0.5970.82
76_K97_I0.5970.82
318_Y322_L0.5940.82
232_K236_V0.5930.82
350_G356_E0.5910.82
71_K98_N0.5900.82
17_V187_K0.5890.82
70_K74_V0.5890.82
97_I100_A0.5890.82
328_K376_M0.5870.81
39_R128_V0.5870.81
195_N277_Y0.5870.81
338_S353_F0.5870.81
93_V96_A0.5860.81
109_K118_I0.5850.81
215_V272_T0.5840.81
66_I75_Y0.5840.81
222_L226_K0.5820.81
260_N263_L0.5810.81
23_I158_K0.5790.81
51_N123_V0.5790.81
204_Y351_K0.5780.80
206_L266_V0.5780.80
331_N334_L0.5770.80
245_K249_E0.5760.80
74_V78_L0.5760.80
127_Y131_K0.5750.80
244_T251_L0.5740.80
38_Y88_L0.5710.80
88_L93_V0.5700.79
22_S263_L0.5700.79
223_Y302_R0.5670.79
179_K260_N0.5650.79
269_F312_I0.5640.79
34_L37_E0.5640.79
96_A99_D0.5630.79
333_H337_R0.5630.79
235_K238_S0.5630.79
27_E32_K0.5620.79
90_S133_T0.5610.78
203_L294_K0.5600.78
268_K271_N0.5590.78
293_F298_G0.5590.78
208_A216_T0.5580.78
244_T247_G0.5570.78
223_Y227_Y0.5570.78
203_L293_F0.5560.78
37_E40_T0.5530.77
38_Y130_I0.5500.77
348_K352_T0.5470.77
131_K135_R0.5460.77
123_V126_A0.5460.77
181_Y256_H0.5460.77
291_S294_K0.5450.76
51_N54_K0.5430.76
310_R313_H0.5420.76
289_K304_I0.5410.76
165_V186_Y0.5400.76
48_Y84_K0.5390.76
210_D366_L0.5390.76
130_I134_L0.5390.76
127_Y130_I0.5380.75
363_D368_A0.5380.75
266_V269_F0.5380.75
223_Y303_K0.5370.75
354_E360_F0.5360.75
201_S284_V0.5360.75
277_Y282_F0.5350.75
92_Y128_V0.5340.75
291_S295_D0.5340.75
77_P80_E0.5330.75
301_S305_S0.5300.74
176_K179_K0.5300.74
198_A283_A0.5290.74
135_R139_G0.5290.74
237_Q247_G0.5280.74
334_L353_F0.5260.74
300_L303_K0.5260.74
143_R146_V0.5260.74
135_R173_P0.5240.74
348_K363_D0.5220.73
130_I146_V0.5220.73
234_A237_Q0.5220.73
131_K134_L0.5220.73
21_Y158_K0.5200.73
204_Y347_R0.5190.73
68_L98_N0.5190.73
90_S134_L0.5180.73
39_R42_L0.5170.73
230_E298_G0.5170.73
230_E238_S0.5150.72
223_Y226_K0.5100.72
22_S181_Y0.5100.72
295_D305_S0.5080.71
91_H97_I0.5080.71
181_Y260_N0.5080.71
90_S131_K0.5050.71
46_I218_S0.5050.71
235_K250_L0.5040.71
367_N370_L0.5030.71
67_T98_N0.5030.71
42_L128_V0.5030.71
46_I50_W0.5000.70
45_A93_V0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.3081 95.2 0.935 Contact Map
1vhxA 2 0.3246 94.9 0.936 Contact Map
1iv0A 1 0.2299 93.8 0.939 Contact Map
1qypA 1 0.1019 83 0.951 Contact Map
4aybP 1 0.0948 81.4 0.952 Contact Map
2k4xA 1 0.1256 79.1 0.953 Contact Map
3j20Y 1 0.1137 78.7 0.953 Contact Map
1ffkW 1 0.1564 75 0.955 Contact Map
3j3w0 1 0.1303 73.3 0.955 Contact Map
1vd4A 1 0.1256 69.4 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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