GREMLIN Database
Q97Z59 - Uncharacterized protein
UniProt: Q97Z59 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 225 (204)
Sequences: 3700 (2846)
Seq/√Len: 199.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_E139_Q3.4991.00
29_K200_E3.2171.00
122_E127_E3.0151.00
22_R83_V2.7541.00
181_A189_L2.7281.00
138_I152_K2.7271.00
6_V37_K2.7191.00
4_K35_V2.7151.00
6_V39_K2.7011.00
119_K143_E2.6861.00
4_K37_K2.5641.00
99_I134_D2.4751.00
142_E148_V2.4401.00
116_Y144_L2.3101.00
11_V104_A2.2851.00
11_V100_A2.2631.00
110_D150_K2.1931.00
134_D156_K2.0941.00
98_L165_F2.0371.00
20_S24_R1.9881.00
141_A151_F1.9301.00
21_R118_D1.9101.00
129_E136_I1.8911.00
112_G115_D1.7831.00
169_A173_A1.7271.00
104_A117_F1.7131.00
123_K140_I1.7111.00
130_N133_D1.7051.00
103_A116_Y1.6981.00
5_I23_L1.6971.00
91_W128_G1.6971.00
162_M166_E1.6951.00
27_V34_V1.6831.00
119_K140_I1.6811.00
148_V152_K1.6731.00
98_L161_R1.6351.00
40_A167_D1.6241.00
20_S118_D1.6121.00
116_Y120_A1.6011.00
139_Q148_V1.5751.00
42_M168_E1.5691.00
109_G163_S1.5551.00
108_R113_Y1.5441.00
135_N152_K1.5321.00
39_K170_E1.5251.00
107_Q111_N1.5231.00
30_F204_E1.5141.00
103_A151_F1.5051.00
119_K127_E1.4961.00
59_E63_I1.4731.00
86_K126_L1.4191.00
147_D150_K1.4071.00
103_A137_L1.3991.00
88_K91_W1.3781.00
6_V186_D1.3371.00
117_F121_Q1.3331.00
170_E174_M1.3271.00
39_K167_D1.3041.00
104_A116_Y1.2971.00
52_A60_A1.2821.00
38_H114_W1.2811.00
138_I148_V1.2811.00
182_L199_L1.2801.00
9_H117_F1.2621.00
123_K129_E1.2611.00
40_A105_E1.2471.00
122_E126_L1.2391.00
102_K158_K1.2311.00
154_D160_A1.2181.00
178_G181_A1.2061.00
99_I102_K1.2041.00
158_K162_M1.1961.00
22_R195_E1.1751.00
184_V202_V1.1641.00
30_F200_E1.1521.00
152_K156_K1.1461.00
74_Y77_D1.1351.00
18_V75_Y1.1331.00
79_D87_G1.1301.00
194_Q198_Y1.1211.00
37_K108_R1.1031.00
42_M165_F1.1001.00
139_Q143_E1.0941.00
190_I202_V1.0881.00
30_F207_L1.0821.00
166_E170_E1.0691.00
25_K83_V1.0681.00
32_E207_L1.0671.00
73_R77_D1.0621.00
153_E159_K1.0421.00
105_E167_D1.0411.00
26_V196_E1.0371.00
123_K136_I1.0331.00
79_D85_G1.0331.00
150_K159_K1.0291.00
11_V117_F1.0271.00
68_F72_K1.0091.00
24_R118_D1.0071.00
200_E204_E1.0031.00
109_G160_A0.9981.00
104_A113_Y0.9961.00
140_I144_L0.9961.00
25_K28_N0.9861.00
16_C179_V0.9861.00
69_S73_R0.9861.00
59_E65_K0.9861.00
58_E63_I0.9841.00
23_L36_V0.9831.00
24_R114_W0.9801.00
67_E70_I0.9760.99
15_F78_Y0.9750.99
49_D99_I0.9740.99
165_F168_E0.9730.99
42_M98_L0.9730.99
8_F171_A0.9720.99
12_L97_P0.9690.99
25_K29_K0.9650.99
88_K128_G0.9580.99
120_A137_L0.9550.99
76_P81_E0.9450.99
119_K144_L0.9450.99
70_I74_Y0.9320.99
183_L189_L0.9270.99
53_A56_T0.9270.99
54_A57_E0.9240.99
120_A131_V0.9220.99
17_F126_L0.9190.99
22_R78_Y0.9190.99
11_V120_A0.9140.99
169_A172_H0.9100.99
100_A131_V0.8990.99
134_D138_I0.8940.99
150_K153_E0.8880.99
170_E186_D0.8850.99
136_I139_Q0.8840.99
58_E61_K0.8770.99
21_R24_R0.8760.99
95_L132_N0.8750.99
134_D152_K0.8700.99
174_M183_L0.8700.99
53_A57_E0.8680.99
170_E173_A0.8560.99
196_E200_E0.8560.99
44_I47_L0.8550.99
97_P101_C0.8540.99
139_Q142_E0.8530.99
17_F85_G0.8510.99
188_W206_L0.8490.99
106_Y154_D0.8480.99
59_E62_E0.8420.99
149_E153_E0.8410.98
105_E108_R0.8350.98
27_V36_V0.8320.98
42_M96_P0.8320.98
8_F183_L0.8290.98
105_E160_A0.8280.98
25_K196_E0.8270.98
74_Y78_Y0.8250.98
47_L94_S0.8190.98
73_R76_P0.8180.98
181_A191_R0.8160.98
202_V205_D0.8150.98
119_K123_K0.8150.98
138_I142_E0.8140.98
7_F23_L0.8060.98
198_Y201_S0.8030.98
178_G191_R0.8020.98
107_Q146_L0.8020.98
20_S38_H0.8010.98
161_R165_F0.7990.98
57_E63_I0.7980.98
12_L94_S0.7930.98
7_F38_H0.7920.98
59_E64_F0.7880.98
79_D89_I0.7870.98
163_S166_E0.7800.98
103_A120_A0.7720.97
11_V131_V0.7720.97
106_Y151_F0.7720.97
20_S114_W0.7710.97
184_V199_L0.7700.97
100_A137_L0.7690.97
8_F40_A0.7630.97
184_V190_I0.7560.97
116_Y141_A0.7530.97
106_Y160_A0.7480.97
71_I75_Y0.7470.97
106_Y110_D0.7450.97
9_H121_Q0.7450.97
201_S205_D0.7440.97
81_E86_K0.7350.96
90_I128_G0.7350.96
92_V128_G0.7340.96
120_A140_I0.7310.96
103_A155_F0.7190.96
22_R196_E0.7120.96
67_E71_I0.7090.96
138_I141_A0.7090.96
19_T182_L0.7060.96
191_R194_Q0.7060.96
71_I74_Y0.7040.96
153_E157_S0.7030.95
38_H117_F0.7010.95
77_D81_E0.7000.95
106_Y150_K0.6980.95
30_F34_V0.6910.95
64_F68_F0.6900.95
150_K154_D0.6890.95
140_I143_E0.6870.95
112_G144_L0.6830.95
5_I34_V0.6800.95
11_V15_F0.6790.95
57_E62_E0.6770.94
119_K122_E0.6700.94
17_F122_E0.6630.94
136_I140_I0.6610.94
195_E198_Y0.6600.94
3_I34_V0.6540.93
4_K186_D0.6540.93
201_S204_E0.6510.93
166_E173_A0.6480.93
88_K126_L0.6450.93
75_Y87_G0.6440.93
116_Y140_I0.6430.93
7_F182_L0.6420.93
23_L27_V0.6410.93
149_E152_K0.6390.93
58_E62_E0.6390.93
66_Q69_S0.6310.92
8_F39_K0.6280.92
9_H16_C0.6260.92
102_K159_K0.6210.92
10_D97_P0.6100.91
203_I207_L0.6100.91
29_K196_E0.6090.91
57_E60_A0.6070.91
62_E65_K0.6020.90
58_E65_K0.5990.90
56_T59_E0.5990.90
115_D144_L0.5980.90
105_E163_S0.5960.90
22_R193_V0.5860.89
92_V95_L0.5840.89
100_A132_N0.5830.89
8_F41_F0.5760.88
64_F71_I0.5750.88
67_E74_Y0.5730.88
107_Q113_Y0.5720.88
39_K108_R0.5670.87
13_C16_C0.5660.87
5_I27_V0.5660.87
7_F36_V0.5660.87
138_I151_F0.5640.87
52_A56_T0.5640.87
110_D146_L0.5640.87
48_E51_K0.5630.87
109_G159_K0.5620.87
65_K68_F0.5600.87
102_K161_R0.5590.87
60_A63_I0.5580.87
102_K160_A0.5540.86
64_F67_E0.5540.86
92_V132_N0.5530.86
185_N206_L0.5490.86
110_D147_D0.5480.86
41_F176_I0.5470.86
199_L203_I0.5440.85
154_D157_S0.5380.85
95_L130_N0.5360.84
21_R85_G0.5360.84
58_E64_F0.5360.84
97_P124_F0.5350.84
47_L51_K0.5340.84
184_V203_I0.5320.84
65_K69_S0.5320.84
77_D82_K0.5320.84
12_L124_F0.5310.84
95_L124_F0.5310.84
68_F71_I0.5300.84
122_E143_E0.5280.83
168_E172_H0.5270.83
89_I92_V0.5270.83
3_I185_N0.5270.83
12_L95_L0.5220.83
19_T193_V0.5210.83
172_H177_R0.5200.83
107_Q116_Y0.5190.82
151_F154_D0.5180.82
114_W118_D0.5170.82
174_M186_D0.5130.82
3_I27_V0.5130.82
78_Y83_V0.5110.81
176_I189_L0.5070.81
78_Y82_K0.5070.81
184_V206_L0.5070.81
45_S101_C0.5060.81
53_A61_K0.5060.81
166_E169_A0.5050.81
31_K207_L0.5050.81
146_L151_F0.5050.81
129_E143_E0.5050.81
15_F22_R0.5040.81
11_V92_V0.5020.80
34_V203_I0.5020.80
55_P69_S0.5010.80
22_R25_K0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r4wA 2 0.9156 100 0.328 Contact Map
2imfA 2 0.9022 100 0.331 Contact Map
3gl5A 2 0.9689 100 0.333 Contact Map
3rppA 2 0.8978 100 0.337 Contact Map
3fz5A 2 0.8311 100 0.338 Contact Map
3kzqA 3 0.88 100 0.359 Contact Map
2in3A 1 0.8533 100 0.399 Contact Map
4nxiA 2 0.8044 100 0.523 Contact Map
3c7mA 1 0.7644 100 0.527 Contact Map
3gmfA 1 0.7689 100 0.528 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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