GREMLIN Database
Q97Z53 - Transcriptional regulator, marR family, putative
UniProt: Q97Z53 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 154 (131)
Sequences: 22089 (16033)
Seq/√Len: 1400.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_V110_E3.1271.00
141_E151_K2.9431.00
65_K110_E2.8841.00
96_R110_E2.6761.00
67_P106_V2.5621.00
138_S141_E2.5081.00
100_S108_Y2.4841.00
144_E147_R2.2781.00
144_E148_L2.1021.00
99_R107_I2.0691.00
61_E119_L2.0121.00
53_E92_K1.9851.00
67_P70_R1.9701.00
137_L148_L1.9091.00
61_E111_L1.8451.00
100_S106_V1.8061.00
141_E144_E1.7821.00
53_E88_R1.6591.00
68_M86_I1.6211.00
114_K118_R1.6131.00
93_E114_K1.6081.00
28_L150_S1.5921.00
145_L148_L1.5901.00
141_E147_R1.5861.00
50_S53_E1.5721.00
90_E97_R1.5681.00
63_E74_K1.5631.00
86_I109_V1.5101.00
114_K117_E1.4741.00
118_R121_E1.4451.00
56_V85_I1.4421.00
87_D91_E1.4311.00
61_E116_R1.4001.00
47_I125_I1.3761.00
28_L146_E1.3541.00
59_A74_K1.3411.00
43_A125_I1.3301.00
117_E121_E1.2811.00
68_M107_I1.2581.00
70_R73_E1.2551.00
78_T81_G1.2421.00
69_S79_K1.2401.00
47_I121_E1.2321.00
56_V82_L1.2051.00
87_D104_R1.2041.00
148_L151_K1.2011.00
69_S73_E1.1501.00
77_L81_G1.1361.00
68_M109_V1.1191.00
46_Q125_I1.1011.00
65_K108_Y1.0941.00
140_D144_E1.0671.00
41_D45_E1.0661.00
68_M82_L1.0611.00
142_I146_E1.0531.00
147_R151_K1.0391.00
80_A83_T1.0251.00
94_L118_R1.0091.00
97_R107_I1.0041.00
141_E148_L0.9971.00
92_K114_K0.9841.00
113_E116_R0.9831.00
111_L115_G0.9811.00
64_G116_R0.9811.00
83_T87_D0.9791.00
43_A132_S0.9771.00
146_E150_S0.9711.00
87_D90_E0.9701.00
66_V70_R0.9671.00
30_T33_T0.9671.00
66_V74_K0.9641.00
92_K118_R0.9601.00
68_M79_K0.9561.00
43_A128_N0.9521.00
125_I128_N0.9451.00
70_R74_K0.9451.00
52_F85_I0.9411.00
32_L149_F0.9371.00
99_R104_R0.9301.00
61_E120_M0.9251.00
86_I95_V0.9251.00
96_R112_T0.9181.00
25_V146_E0.9131.00
77_L82_L0.9051.00
48_G92_K0.9021.00
47_I122_S0.8901.00
98_V108_Y0.8901.00
65_K98_V0.8871.00
113_E117_E0.8861.00
116_R120_M0.8841.00
81_G84_S0.8831.00
33_T37_N0.8761.00
94_L114_K0.8721.00
60_L95_V0.8711.00
63_E66_V0.8671.00
55_K75_Y0.8591.00
41_D51_Y0.8591.00
130_L133_F0.8481.00
137_L152_L0.8461.00
78_T84_S0.8381.00
124_K128_N0.8371.00
54_F122_S0.8351.00
129_V132_S0.8301.00
139_E143_R0.8271.00
43_A129_V0.8271.00
57_M119_L0.8251.00
90_E96_R0.8171.00
126_F130_L0.8131.00
63_E70_R0.8111.00
121_E125_I0.8101.00
128_N132_S0.8081.00
100_S103_D0.7931.00
101_E108_Y0.7921.00
61_E123_R0.7911.00
128_N131_S0.7891.00
103_D106_V0.7891.00
29_I33_T0.7871.00
87_D97_R0.7831.00
84_S87_D0.7791.00
86_I90_E0.7781.00
84_S88_R0.7741.00
56_V75_Y0.7641.00
111_L116_R0.7631.00
39_D129_V0.7581.00
43_A46_Q0.7541.00
140_D143_R0.7521.00
30_T34_R0.7441.00
34_R38_K0.7381.00
117_E120_M0.7321.00
132_S135_S0.7251.00
90_E95_V0.7251.00
124_K127_L0.7231.00
59_A66_V0.7221.00
143_R147_R0.7141.00
54_F126_F0.7141.00
134_L142_I0.7101.00
59_A63_E0.7091.00
72_A82_L0.7071.00
143_R146_E0.7061.00
138_S142_I0.7041.00
59_A75_Y0.7041.00
127_L131_S0.7011.00
64_G110_E0.6961.00
56_V71_I0.6901.00
32_L152_L0.6881.00
68_M83_T0.6871.00
52_F81_G0.6841.00
60_L66_V0.6781.00
88_R91_E0.6601.00
28_L31_G0.6591.00
58_C62_E0.6541.00
29_I32_L0.6521.00
144_E151_K0.6501.00
39_D132_S0.6461.00
72_A79_K0.6441.00
121_E124_K0.6351.00
112_T115_G0.6341.00
59_A71_I0.6311.00
60_L111_L0.6301.00
138_S151_K0.6261.00
37_N40_T0.6201.00
88_R92_K0.6191.00
137_L142_I0.6161.00
54_F119_L0.6141.00
31_G35_K0.6131.00
39_D42_K0.6111.00
82_L86_I0.6101.00
89_L94_L0.6091.00
37_N41_D0.6031.00
57_M61_E0.5981.00
40_T43_A0.5911.00
40_T126_F0.5891.00
29_I149_F0.5831.00
55_K59_A0.5801.00
93_E96_R0.5791.00
53_E85_I0.5781.00
120_M124_K0.5621.00
134_L138_S0.5501.00
68_M106_V0.5491.00
120_M123_R0.5471.00
123_R127_L0.5391.00
42_K45_E0.5331.00
71_I109_V0.5301.00
58_C123_R0.5261.00
67_P100_S0.5201.00
24_E146_E0.5191.00
38_K42_K0.5191.00
49_L118_R0.5181.00
119_L123_R0.5181.00
49_L122_S0.5171.00
136_K151_K0.5131.00
69_S72_A0.5101.00
137_L151_K0.5071.00
148_L152_L0.5041.00
30_T51_Y0.5041.00
69_S106_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fbkA 2 0.9286 99.9 0.279 Contact Map
3e6mA 2 0.9481 99.9 0.296 Contact Map
3u2rA 4 0.8636 99.9 0.298 Contact Map
3deuA 2 0.8182 99.9 0.3 Contact Map
3cjnA 2 0.9026 99.9 0.302 Contact Map
4rguA 4 0.8831 99.9 0.304 Contact Map
3bj6A 2 0.9286 99.9 0.308 Contact Map
3zplA 2 0.9286 99.9 0.31 Contact Map
3boqA 2 0.8636 99.9 0.31 Contact Map
2ethA 4 0.8831 99.9 0.313 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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