GREMLIN Database
Q97Z52 - Glutaconate CoA-transferase, subunit A (GctA)
UniProt: Q97Z52 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 268 (220)
Sequences: 3540 (1804)
Seq/√Len: 121.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_E219_P3.4151.00
138_R165_E3.3531.00
182_V191_A3.3241.00
31_K34_D3.0431.00
161_P166_K2.9891.00
193_I230_I2.6631.00
32_K60_R2.6571.00
184_K216_E2.6551.00
191_A212_I2.6531.00
61_D83_R2.5881.00
101_H104_K2.3861.00
163_S171_K2.3691.00
223_F228_P2.3651.00
37_T175_P2.2541.00
24_E56_K2.2531.00
83_R112_E2.2501.00
104_K108_E2.2111.00
159_E166_K2.1471.00
22_S25_E2.1061.00
30_V54_L2.0911.00
21_L237_A2.0451.00
178_A207_A2.0261.00
84_K112_E2.0171.00
53_A56_K2.0121.00
185_A214_A1.9871.00
80_G105_M1.9361.00
128_G174_N1.9281.00
63_Y86_R1.9051.00
37_T125_I1.8901.00
50_F179_I1.8411.00
174_N208_K1.8351.00
183_N194_L1.8341.00
188_E220_R1.8081.00
52_Y75_V1.7931.00
105_M110_E1.7711.00
185_A212_I1.7401.00
29_V237_A1.7141.00
134_F169_L1.6881.00
187_E220_R1.6411.00
32_K58_G1.6341.00
65_I173_I1.6191.00
37_T203_K1.5751.00
80_G110_E1.5641.00
141_I166_K1.5601.00
33_G61_D1.5501.00
34_D177_V1.5421.00
55_V81_L1.5241.00
54_L179_I1.5021.00
186_D190_N1.4861.00
184_K192_E1.4771.00
224_Y227_R1.4541.00
136_P160_D1.4471.00
63_Y84_K1.4471.00
185_A217_I1.4251.00
25_E28_E1.3981.00
204_A210_V1.3851.00
65_I175_P1.3791.00
144_D147_K1.3681.00
127_A135_M1.3671.00
114_L124_G1.3451.00
38_I179_I1.3431.00
133_P162_F1.3401.00
18_S187_E1.3301.00
76_L81_L1.3291.00
30_V34_D1.2981.00
55_V78_K1.2931.00
27_V53_A1.2861.00
184_K218_V1.2801.00
146_V159_E1.2771.00
150_E160_D1.2691.00
35_S65_I1.2601.00
32_K59_V1.2410.99
219_P222_Y1.2350.99
161_P164_G1.2330.99
46_N51_I1.2140.99
79_Y110_E1.2140.99
209_K237_A1.2120.99
24_E53_A1.2110.99
63_Y83_R1.1950.99
120_A137_V1.1770.99
116_D124_G1.1750.99
84_K114_L1.1730.99
125_I203_K1.1540.99
27_V30_V1.1520.99
20_L217_I1.1450.99
180_I212_I1.1410.99
123_A126_R1.1410.99
38_I51_I1.1320.99
23_L53_A1.1320.99
124_G172_A1.1290.99
77_L105_M1.1260.99
55_V79_Y1.1240.99
182_V214_A1.1220.99
132_I135_M1.1190.99
195_G226_R1.1120.99
53_A57_K1.1120.99
55_V75_V1.1110.99
58_G81_L1.1100.99
49_A241_A1.1060.99
49_A213_T1.1010.99
177_V209_K1.0940.99
211_I239_V1.0850.99
64_F82_I1.0680.98
26_A211_I1.0650.98
26_A239_V1.0640.98
133_P172_A1.0620.98
30_V177_V1.0560.98
31_K177_V1.0510.98
180_I203_K1.0410.98
21_L27_V1.0410.98
185_A191_A1.0410.98
125_I206_A1.0210.98
195_G215_E1.0200.98
217_I240_H1.0120.98
124_G171_K1.0110.98
216_E240_H1.0100.98
205_K234_Y1.0080.98
52_Y56_K0.9960.97
21_L25_E0.9880.97
183_N215_E0.9810.97
49_A245_A0.9800.97
127_A132_I0.9800.97
192_E227_R0.9740.97
69_P102_F0.9730.97
191_A214_A0.9710.97
181_H241_A0.9670.97
179_I211_I0.9580.97
136_P162_F0.9440.96
212_I230_I0.9430.96
180_I204_A0.9410.96
101_H105_M0.9360.96
27_V57_K0.9360.96
187_E222_Y0.9350.96
87_I90_S0.9330.96
34_D176_D0.9330.96
214_A217_I0.9260.96
21_L29_V0.9240.96
211_I237_A0.9210.96
184_K194_L0.9090.96
39_S200_D0.9090.96
146_V168_V0.9060.95
160_D163_S0.8960.95
185_A238_V0.8940.95
30_V211_I0.8920.95
37_T173_I0.8900.95
89_M92_L0.8870.95
203_K207_A0.8850.95
29_V177_V0.8810.95
197_L226_R0.8730.94
106_T113_I0.8680.94
78_K101_H0.8670.94
59_V81_L0.8670.94
29_V34_D0.8620.94
191_A230_I0.8610.94
246_E249_S0.8590.94
197_L229_T0.8480.94
77_L82_I0.8410.93
126_R130_F0.8360.93
134_F171_K0.8330.93
136_P169_L0.8280.93
36_V179_I0.8200.92
49_A242_P0.8150.92
32_K61_D0.8130.92
35_S175_P0.8110.92
125_I175_P0.8030.92
147_K150_E0.8020.92
133_P167_V0.8000.91
159_E168_V0.8000.91
128_G173_I0.7990.91
69_P85_L0.7970.91
141_I168_V0.7940.91
37_T65_I0.7940.91
140_I168_V0.7840.91
134_F160_D0.7820.91
123_A132_I0.7820.91
30_V179_I0.7710.90
193_I201_E0.7710.90
180_I230_I0.7680.90
123_A135_M0.7650.90
210_V236_T0.7560.89
60_R81_L0.7550.89
178_A203_K0.7540.89
76_L82_I0.7480.89
49_A52_Y0.7470.88
162_F169_L0.7470.88
245_A248_T0.7440.88
213_T241_A0.7440.88
54_L81_L0.7410.88
218_V222_Y0.7390.88
162_F171_K0.7380.88
134_F172_A0.7340.88
29_V209_K0.7300.87
195_G224_Y0.7290.87
218_V221_S0.7250.87
118_C122_I0.7250.87
181_H213_T0.7220.87
28_E57_K0.7130.86
54_L59_V0.7110.86
27_V50_F0.7000.85
192_E223_F0.7000.85
204_A230_I0.6960.85
18_S21_L0.6890.84
22_S26_A0.6870.84
125_I202_Y0.6850.84
129_S205_K0.6820.83
65_I125_I0.6790.83
109_R150_E0.6780.83
192_E228_P0.6760.83
226_R229_T0.6760.83
26_A57_K0.6750.83
26_A30_V0.6740.83
27_V237_A0.6730.83
30_V59_V0.6710.82
50_F239_V0.6640.82
50_F54_L0.6620.82
26_A237_A0.6610.82
29_V211_I0.6600.81
160_D169_L0.6590.81
175_P207_A0.6580.81
42_S92_L0.6560.81
88_A118_C0.6550.81
163_S174_N0.6540.81
35_S63_Y0.6540.81
193_I229_T0.6490.80
42_S68_E0.6470.80
68_E91_T0.6450.80
88_A121_F0.6430.80
176_D208_K0.6420.80
85_L102_F0.6380.79
66_D73_L0.6380.79
216_E222_Y0.6370.79
124_G170_V0.6370.79
38_I66_D0.6350.79
20_L187_E0.6350.79
79_Y108_E0.6350.79
183_N216_E0.6350.79
201_E205_K0.6340.79
70_G234_Y0.6330.79
18_S238_V0.6330.79
183_N192_E0.6270.78
90_S102_F0.6260.78
69_P92_L0.6250.78
23_L241_A0.6240.78
45_R193_I0.6240.78
195_G214_A0.6240.78
38_I47_P0.6210.77
181_H214_A0.6180.77
192_E224_Y0.6170.77
124_G173_I0.6160.77
240_H243_K0.6160.77
134_F162_F0.6130.76
67_R199_E0.6120.76
48_M241_A0.6110.76
242_P245_A0.6100.76
188_E232_G0.6060.76
141_I159_E0.6040.75
37_T207_A0.6040.75
138_R167_V0.6040.75
130_F205_K0.6010.75
201_E230_I0.6010.75
47_P50_F0.6010.75
192_E229_T0.5990.75
169_L172_A0.5970.75
67_R88_A0.5940.74
202_Y205_K0.5930.74
184_K227_R0.5930.74
54_L76_L0.5920.74
67_R118_C0.5900.74
31_K59_V0.5890.74
20_L238_V0.5800.72
69_P72_G0.5780.72
128_G175_P0.5760.72
57_K81_L0.5750.72
39_S198_Y0.5690.71
38_I64_F0.5680.71
141_I146_V0.5670.71
128_G172_A0.5660.71
103_R107_E0.5660.71
59_V62_L0.5640.70
105_M108_E0.5610.70
41_I68_E0.5580.70
132_I136_P0.5580.70
247_P251_F0.5570.69
46_N92_L0.5570.69
197_L201_E0.5560.69
43_I71_F0.5550.69
209_K212_I0.5530.69
18_S188_E0.5520.69
74_E92_L0.5490.68
70_G118_C0.5440.68
104_K107_E0.5440.68
103_R106_T0.5430.67
37_T206_A0.5430.67
23_L49_A0.5420.67
43_I48_M0.5360.67
85_L111_V0.5340.66
75_V78_K0.5320.66
86_R114_L0.5280.65
119_G143_S0.5270.65
136_P141_I0.5270.65
243_K246_E0.5270.65
245_A249_S0.5270.65
46_N215_E0.5260.65
45_R198_Y0.5260.65
181_H215_E0.5240.65
146_V166_K0.5230.65
21_L26_A0.5220.64
39_S199_E0.5210.64
64_F69_P0.5190.64
123_A130_F0.5190.64
246_E251_F0.5190.64
235_V238_V0.5160.64
67_R87_I0.5160.64
24_E28_E0.5150.63
90_S106_T0.5130.63
38_I70_G0.5130.63
51_I70_G0.5120.63
77_L101_H0.5100.63
39_S47_P0.5090.63
86_R173_I0.5080.62
178_A210_V0.5080.62
82_I102_F0.5070.62
41_I67_R0.5060.62
212_I236_T0.5050.62
210_V230_I0.5050.62
65_I86_R0.5020.62
213_T239_V0.5020.62
72_G92_L0.5020.62
182_V210_V0.5000.61
177_V211_I0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1poiA 3 0.9366 100 0.28 Contact Map
4kgbA 2 0.9104 100 0.378 Contact Map
3k6mA 2 0.9142 100 0.388 Contact Map
3cdkA 2 0.8358 100 0.393 Contact Map
3rrlA 2 0.8396 100 0.397 Contact Map
1k6dA 2 0.8022 100 0.401 Contact Map
2ahuA 3 0.944 100 0.403 Contact Map
3qliA 2 0.7873 100 0.602 Contact Map
2hj0A 2 0.7985 100 0.602 Contact Map
1xr4A 2 0.7948 100 0.604 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0084 seconds.