GREMLIN Database
Q97Z51 - Glutaconate CoA-transferase, subunit B (GctB)
UniProt: Q97Z51 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 245 (201)
Sequences: 3431 (1584)
Seq/√Len: 111.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_D108_N3.8781.00
150_K154_V3.7341.00
201_E205_E3.4001.00
180_L211_V3.2471.00
80_I83_D3.1741.00
158_D208_D3.0091.00
172_F181_A2.8781.00
181_A192_E2.7771.00
194_I203_V2.7181.00
105_E158_D2.5821.00
183_N190_Y2.5751.00
214_K217_E2.5461.00
194_I200_Y2.5431.00
183_N188_K2.5131.00
177_L206_N2.4651.00
182_Y189_W2.3801.00
12_A193_A2.3351.00
200_Y213_R2.2961.00
191_L213_R2.2771.00
202_K206_N2.2761.00
160_I164_A2.0441.00
18_E21_E1.9921.00
200_Y204_V1.9871.00
13_I144_W1.9601.00
184_R188_K1.9511.00
202_K205_E1.9431.00
199_S202_K1.9001.00
183_N187_R1.8731.00
191_L200_Y1.8481.00
106_E159_F1.8171.00
177_L198_S1.8141.00
184_R187_R1.8041.00
105_E210_E1.8021.00
61_V70_P1.7591.00
148_H207_T1.7301.00
204_V211_V1.7231.00
21_E95_V1.7141.00
173_V182_Y1.6851.00
188_K212_K1.6591.00
50_I88_A1.6531.00
7_D38_M1.6481.00
204_V210_E1.6461.00
13_I97_F1.6331.00
190_Y212_K1.6151.00
155_R208_D1.5991.00
35_A97_F1.5801.00
172_F192_E1.5701.00
102_Q158_D1.5631.00
190_Y214_K1.5431.00
195_Y198_S1.5401.00
173_V189_W1.5301.00
13_I174_V1.5221.00
9_V144_W1.5051.00
158_D210_E1.4861.00
89_Q133_F1.4791.00
213_R217_E1.4381.00
181_A190_Y1.4361.00
100_P146_L1.4091.00
153_L156_R1.3781.00
66_S70_P1.3671.00
102_Q161_T1.3571.00
192_E214_K1.3441.00
152_S155_R1.3030.99
178_G203_V1.2730.99
187_R212_K1.2680.99
207_T211_V1.2640.99
16_L174_V1.2470.99
105_E155_R1.2250.99
17_L35_A1.2110.99
94_D139_R1.2110.99
102_Q162_G1.2020.99
16_L172_F1.1850.99
149_S206_N1.1850.99
100_P109_V1.1730.99
95_V142_I1.1720.99
55_A58_P1.1620.99
201_E204_V1.1540.99
194_I198_S1.1520.99
51_G55_A1.1310.98
31_P144_W1.1040.98
19_D45_K1.1010.98
194_I217_E1.0980.98
148_H177_L1.0930.98
6_V147_K1.0880.98
142_I174_V1.0800.98
17_L23_V1.0620.98
5_N8_Y1.0580.98
189_W209_F1.0450.97
152_S156_R1.0310.97
106_E168_N1.0280.97
32_S99_G1.0240.97
95_V140_K1.0210.97
214_K218_R1.0150.97
19_D46_K1.0140.97
101_A114_I1.0110.97
149_S176_N1.0020.97
140_K170_K1.0000.97
198_S202_K0.9650.96
36_S39_A0.9650.96
62_V73_V0.9620.96
12_A179_V0.9620.96
180_L204_V0.9590.96
191_L203_V0.9580.96
97_F144_W0.9440.95
10_I35_A0.9400.95
6_V34_I0.9370.95
102_Q157_V0.9350.95
179_V193_A0.9330.95
198_S203_V0.9210.95
191_L211_V0.9180.95
158_D209_F0.9160.95
177_L202_K0.8990.94
140_K172_F0.8950.94
39_A49_I0.8910.94
8_Y196_P0.8810.93
56_S79_M0.8780.93
102_Q155_R0.8750.93
102_Q150_K0.8660.93
17_L47_I0.8560.92
173_V180_L0.8530.92
59_S62_V0.8500.92
103_I153_L0.8460.92
135_L166_F0.8440.92
180_L189_W0.8400.92
6_V31_P0.8390.92
113_M125_L0.8370.92
40_R45_K0.8320.91
66_S72_F0.8290.91
59_S73_V0.8190.91
97_F174_V0.8170.91
55_A78_V0.8140.90
200_Y217_E0.8110.90
177_L203_V0.8100.90
11_K15_T0.8090.90
42_L46_K0.8070.90
187_R190_Y0.8050.90
27_L68_G0.7980.89
157_V161_T0.7970.89
17_L97_F0.7970.89
22_L87_L0.7940.89
102_Q154_V0.7930.89
215_D218_R0.7930.89
87_L93_L0.7920.89
183_N212_K0.7910.89
144_W174_V0.7880.89
55_A72_F0.7850.89
204_V213_R0.7770.88
194_I199_S0.7740.88
200_Y211_V0.7650.87
110_N164_A0.7650.87
70_P136_P0.7640.87
8_Y11_K0.7640.87
27_L53_A0.7620.87
52_V85_F0.7590.87
150_K155_R0.7590.87
66_S69_N0.7550.87
13_I35_A0.7540.87
105_E209_F0.7530.87
11_K38_M0.7500.86
175_T178_G0.7460.86
13_I142_I0.7440.86
166_F169_N0.7410.86
36_S61_V0.7240.84
79_M84_A0.7170.84
178_G194_I0.7100.83
54_E129_A0.7100.83
55_A76_S0.7090.83
32_S53_A0.7090.83
157_V208_D0.7070.83
17_L95_V0.7040.83
108_N164_A0.7020.83
27_L33_L0.6990.82
108_N168_N0.6980.82
61_V71_F0.6930.82
16_L140_K0.6890.81
177_L207_T0.6860.81
100_P103_I0.6850.81
136_P166_F0.6850.81
31_P147_K0.6840.81
194_I197_F0.6840.81
154_V208_D0.6840.81
182_Y188_K0.6810.81
180_L213_R0.6790.80
9_V13_I0.6790.80
42_L45_K0.6780.80
114_I162_G0.6770.80
149_S155_R0.6740.80
103_I109_V0.6700.80
107_T143_L0.6640.79
8_Y195_Y0.6610.79
191_L194_I0.6590.78
114_I123_V0.6580.78
7_D34_I0.6570.78
66_S71_F0.6550.78
12_A15_T0.6540.78
116_N123_V0.6540.78
142_I172_F0.6510.78
54_E130_A0.6470.77
178_G192_E0.6450.77
17_L96_M0.6420.77
39_A45_K0.6410.76
116_N124_K0.6360.76
15_T204_V0.6320.75
12_A16_L0.6310.75
95_V136_P0.6290.75
7_D41_D0.6250.75
30_I57_N0.6220.74
140_K171_V0.6220.74
104_D159_F0.6220.74
148_H180_L0.6210.74
212_K216_S0.6200.74
67_T70_P0.6180.74
102_Q152_S0.6150.74
106_E165_K0.6140.73
164_A167_S0.6140.73
52_V131_T0.6090.73
187_R214_K0.6070.73
14_S38_M0.6030.72
18_E45_K0.6010.72
39_A125_L0.6010.72
96_M134_I0.5990.72
8_Y197_F0.5990.72
91_G98_L0.5980.71
189_W211_V0.5970.71
106_E156_R0.5970.71
90_K137_L0.5950.71
177_L195_Y0.5930.71
10_I31_P0.5920.71
67_T73_V0.5910.71
22_L56_S0.5890.70
102_Q134_I0.5880.70
30_I52_V0.5840.70
124_K162_G0.5810.69
212_K215_D0.5800.69
7_D11_K0.5790.69
213_R216_S0.5770.69
22_L48_R0.5750.68
195_Y203_V0.5750.68
149_S154_V0.5740.68
49_I60_R0.5740.68
16_L142_I0.5670.67
12_A192_E0.5650.67
128_G161_T0.5650.67
30_I129_A0.5650.67
81_T115_G0.5640.67
19_D40_R0.5630.67
96_M138_S0.5610.67
10_I38_M0.5610.67
165_K170_K0.5580.66
14_S91_G0.5560.66
39_A95_V0.5560.66
212_K217_E0.5550.66
158_D161_T0.5530.65
65_P72_F0.5530.65
15_T18_E0.5520.65
71_F126_P0.5510.65
31_P34_I0.5490.65
21_E140_K0.5480.65
183_N214_K0.5460.65
109_V135_L0.5440.64
107_T173_V0.5420.64
27_L99_G0.5390.64
16_L179_V0.5380.63
113_M124_K0.5360.63
55_A75_A0.5360.63
127_G174_V0.5360.63
204_V212_K0.5320.63
135_L169_N0.5300.62
105_E188_K0.5290.62
13_I136_P0.5270.62
67_T72_F0.5250.62
114_I124_K0.5220.61
173_V178_G0.5210.61
178_G191_L0.5210.61
127_G142_I0.5190.61
128_G132_A0.5170.60
114_I127_G0.5170.60
41_D139_R0.5160.60
131_T143_L0.5150.60
19_D42_L0.5140.60
148_H209_F0.5140.60
170_K181_A0.5120.60
198_S206_N0.5120.60
205_E216_S0.5120.60
35_A39_A0.5100.59
52_V129_A0.5100.59
65_P68_G0.5090.59
150_K153_L0.5090.59
16_L96_M0.5090.59
31_P191_L0.5080.59
201_E210_E0.5080.59
115_G142_I0.5070.59
37_F61_V0.5070.59
69_N73_V0.5050.59
41_D159_F0.5040.58
184_R190_Y0.5040.58
162_G171_V0.5020.58
15_T46_K0.5020.58
85_F89_Q0.5010.58
128_G162_G0.5000.58
55_A65_P0.5000.58
64_S68_G0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1poiB 1 0.9714 100 0.244 Contact Map
2ahuA 3 0.8857 100 0.446 Contact Map
3k6mA 2 0.8531 100 0.484 Contact Map
4kgbA 2 0.8449 100 0.484 Contact Map
1xr4A 2 0.902 100 0.536 Contact Map
2hj0A 2 0.8816 100 0.574 Contact Map
3gk7A 2 0.8571 100 0.607 Contact Map
3rrlB 1 0.7918 100 0.612 Contact Map
3eh7A 2 0.8286 100 0.625 Contact Map
3d3uA 1 0.7429 100 0.627 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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