GREMLIN Database
Q97Z48 - Uncharacterized protein
UniProt: Q97Z48 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 436 (330)
Sequences: 1480 (1058)
Seq/√Len: 58.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
110_P284_Y5.6101.00
148_Y177_I5.5741.00
136_L140_V4.2331.00
94_V101_E3.6531.00
147_L179_F3.5601.00
144_Q180_D3.3831.00
293_P296_F3.1291.00
201_K230_D3.0581.00
367_D370_V3.0311.00
144_Q177_I2.7841.00
172_P175_G2.6961.00
293_P299_F2.6121.00
188_R191_E2.3851.00
213_T251_L2.3521.00
186_T219_D2.2841.00
365_H370_V2.2831.00
192_A196_A2.2641.00
364_S370_V2.1781.00
378_R381_R2.1321.00
167_I199_L2.1131.00
135_K245_D2.1081.00
366_L370_V2.0901.00
247_N250_I2.0791.00
364_S367_D2.0731.00
294_Q299_F2.0581.00
223_V230_D2.0571.00
65_I68_V2.0541.00
127_N164_H1.9891.00
361_V370_V1.9851.00
127_N181_V1.9641.00
242_I265_L1.9531.00
124_M196_A1.9031.00
63_V68_V1.9001.00
296_F300_N1.8851.00
361_V364_S1.8841.00
220_K223_V1.8711.00
224_K253_K1.8711.00
366_L369_D1.8581.00
383_Y390_G1.8541.00
301_Y347_T1.8260.99
317_Y320_F1.8020.99
223_V228_K1.7960.99
174_K178_T1.7720.99
139_A212_L1.7700.99
93_Y102_V1.7320.99
364_S368_R1.7110.99
339_D342_D1.7000.99
148_Y173_A1.6870.99
361_V365_H1.6800.99
160_L164_H1.6650.99
223_V226_Y1.6610.99
129_P185_Y1.6600.99
104_F292_V1.6580.99
139_A143_A1.6470.99
295_G299_F1.6110.99
363_E366_L1.6090.99
252_K262_F1.6070.99
104_F331_I1.5850.99
240_I275_F1.5710.98
293_P300_N1.5700.98
365_H368_R1.5600.98
130_S214_D1.5450.98
190_H194_N1.5330.98
374_I377_Y1.5280.98
165_P195_F1.5180.98
64_C67_G1.5120.98
370_V373_E1.4970.98
221_R225_D1.4910.98
162_S184_G1.4880.98
130_S187_T1.4830.98
286_H341_I1.4770.98
313_L317_Y1.4750.98
380_L383_Y1.4510.97
236_Q286_H1.4450.97
339_D346_K1.4420.97
252_K256_D1.4380.97
140_V179_F1.4380.97
127_N160_L1.4320.97
222_N225_D1.4300.97
91_H104_F1.4250.97
63_V67_G1.4070.97
165_P192_A1.3920.97
361_V368_R1.3770.96
129_P183_K1.3660.96
240_I274_V1.3650.96
109_V112_Q1.3640.96
296_F299_F1.3640.96
295_G298_P1.3590.96
250_I254_L1.3540.96
120_H207_N1.3510.96
302_D305_I1.3410.96
123_I143_A1.3340.96
376_Y383_Y1.3290.96
162_S183_K1.3270.96
82_A85_I1.3230.95
376_Y380_L1.3190.95
187_T215_G1.3180.95
125_I143_A1.3130.95
220_K250_I1.2940.95
361_V366_L1.2850.95
377_Y381_R1.2850.95
382_E386_A1.2750.94
315_A318_G1.2750.94
127_N162_S1.2750.94
169_Y176_I1.2720.94
142_S242_I1.2630.94
225_D228_K1.2520.94
187_T214_D1.2390.94
361_V367_D1.2350.93
167_I170_Q1.2270.93
173_A176_I1.2240.93
102_V354_L1.2220.93
366_L373_E1.2120.93
142_S278_Q1.2100.93
201_K233_P1.2040.93
312_K318_G1.2030.93
90_S93_Y1.2010.93
378_R382_E1.2000.92
376_Y390_G1.1980.92
79_L82_A1.1970.92
122_I159_I1.1950.92
163_N219_D1.1880.92
373_E378_R1.1710.92
199_L202_Q1.1680.91
78_I82_A1.1650.91
370_V374_I1.1640.91
165_P191_E1.1630.91
125_I160_L1.1560.91
88_K105_I1.1390.90
375_R378_R1.1240.90
314_I320_F1.1180.90
223_V227_E1.1160.89
198_N202_Q1.1110.89
363_E367_D1.1100.89
78_I81_M1.1020.89
117_S151_N1.0930.88
375_R381_R1.0910.88
224_K228_K1.0850.88
69_I322_I1.0840.88
373_E376_Y1.0820.88
220_K249_R1.0820.88
363_E370_V1.0780.88
380_L384_S1.0770.88
364_S369_D1.0730.88
109_V315_A1.0710.87
171_G175_G1.0650.87
386_A390_G1.0640.87
135_K139_A1.0610.87
362_V365_H1.0490.86
375_R379_L1.0440.86
183_K196_A1.0380.86
189_L217_P1.0370.86
374_I378_R1.0340.86
361_V369_D1.0270.85
314_I317_Y1.0190.85
373_E380_L1.0190.85
124_M209_I1.0190.85
333_F336_D1.0150.84
127_N147_L1.0110.84
221_R224_K1.0110.84
360_E368_R1.0090.84
64_C68_V1.0010.84
331_I352_V1.0000.84
369_D375_R0.9980.83
239_T253_K0.9970.83
352_V356_R0.9940.83
383_Y387_L0.9930.83
374_I379_L0.9890.83
329_Y345_R0.9830.82
313_L320_F0.9820.82
105_I109_V0.9790.82
369_D373_E0.9730.82
379_L382_E0.9730.82
360_E367_D0.9720.82
144_Q179_F0.9670.81
381_R384_S0.9640.81
88_K91_H0.9630.81
220_K224_K0.9620.81
124_M216_K0.9580.81
118_S154_D0.9550.81
195_F198_N0.9550.81
83_I87_L0.9540.81
185_Y215_G0.9500.80
142_S147_L0.9490.80
246_Y262_F0.9490.80
160_L166_E0.9450.80
87_L90_S0.9420.80
188_R219_D0.9340.79
359_P365_H0.9310.79
73_N77_N0.9300.79
63_V66_K0.9300.79
189_L196_A0.9290.79
89_Q92_T0.9260.79
164_H179_F0.9220.78
150_L156_V0.9110.77
377_Y380_L0.9090.77
373_E383_Y0.9060.77
261_K280_T0.9040.77
128_S187_T0.9030.77
126_D215_G0.8970.76
104_F322_I0.8950.76
139_A158_L0.8900.76
147_L173_A0.8880.76
329_Y351_S0.8870.75
229_F232_P0.8850.75
172_P180_D0.8840.75
155_Y323_P0.8780.75
292_V333_F0.8750.74
67_G71_L0.8710.74
69_I75_Y0.8690.74
216_K245_D0.8690.74
143_A212_L0.8660.74
170_Q199_L0.8650.74
67_G70_V0.8610.73
152_E173_A0.8580.73
368_R371_I0.8530.73
65_I73_N0.8510.72
322_I330_T0.8480.72
125_I139_A0.8450.72
241_G246_Y0.8430.72
175_G198_N0.8420.72
293_P298_P0.8420.72
143_A158_L0.8370.71
132_R182_G0.8360.71
99_P102_V0.8340.71
166_E184_G0.8340.71
191_E194_N0.8340.71
305_I331_I0.8280.70
376_Y379_L0.8280.70
194_N230_D0.8280.70
188_R213_T0.8270.70
208_K238_I0.8250.70
196_A217_P0.8230.70
116_T151_N0.8230.70
135_K242_I0.8210.70
380_L389_A0.8200.70
297_M321_V0.8200.70
333_F337_Y0.8180.69
224_K257_K0.8170.69
78_I111_Q0.8170.69
213_T246_Y0.8150.69
350_K354_L0.8140.69
97_D104_F0.8120.69
125_I199_L0.8110.69
167_I195_F0.8110.69
369_D374_I0.8100.69
344_Q349_T0.8100.69
77_N86_S0.8070.68
189_L211_M0.8060.68
359_P362_V0.8030.68
365_H369_D0.8030.68
387_L390_G0.8010.68
382_E388_E0.8010.68
139_A242_I0.8000.68
235_T255_A0.7990.68
222_N226_Y0.7980.67
237_I258_S0.7940.67
330_T335_A0.7910.67
236_Q259_S0.7850.66
269_S272_P0.7830.66
383_Y389_A0.7820.66
227_E230_D0.7810.66
295_G300_N0.7810.66
253_K257_K0.7780.66
147_L151_N0.7750.65
77_N88_K0.7750.65
215_G260_G0.7730.65
367_D373_E0.7710.65
160_L168_K0.7710.65
198_N201_K0.7700.65
105_I110_P0.7680.64
186_T218_T0.7640.64
301_Y334_T0.7580.63
66_K69_I0.7580.63
332_T335_A0.7570.63
377_Y382_E0.7570.63
239_T255_A0.7560.63
314_I318_G0.7510.63
116_T206_P0.7510.63
130_S215_G0.7490.63
147_L171_G0.7480.62
291_I294_Q0.7480.62
380_L387_L0.7450.62
189_L245_D0.7440.62
242_I245_D0.7440.62
373_E382_E0.7410.62
348_V356_R0.7400.62
329_Y332_T0.7380.61
120_H208_K0.7380.61
76_Y107_Y0.7360.61
66_K70_V0.7340.61
275_F278_Q0.7340.61
352_V355_Q0.7340.61
142_S212_L0.7340.61
127_N136_L0.7330.61
380_L390_G0.7320.61
312_K317_Y0.7320.61
159_I192_A0.7300.61
200_A207_N0.7300.61
365_H374_I0.7280.60
226_Y230_D0.7260.60
61_C65_I0.7240.60
372_L376_Y0.7240.60
193_V237_I0.7220.60
126_D187_T0.7220.60
71_L74_F0.7200.59
238_I278_Q0.7200.59
134_E180_D0.7180.59
119_I206_P0.7170.59
147_L177_I0.7160.59
189_L218_T0.7160.59
364_S372_L0.7150.59
141_Q144_Q0.7110.59
166_E186_T0.7100.58
94_V97_D0.7100.58
70_V76_Y0.7080.58
333_F339_D0.7070.58
237_I254_L0.7050.58
246_Y250_I0.7030.58
89_Q256_D0.7000.57
313_L316_V0.6990.57
189_L216_K0.6980.57
370_V378_R0.6980.57
143_A179_F0.6970.57
81_M88_K0.6970.57
189_L206_P0.6950.57
351_S355_Q0.6930.57
189_L212_L0.6920.56
188_R218_T0.6920.56
83_I346_K0.6900.56
359_P368_R0.6890.56
384_S389_A0.6880.56
125_I158_L0.6880.56
122_I196_A0.6860.56
208_K278_Q0.6830.55
131_M187_T0.6820.55
239_T250_I0.6790.55
80_D83_I0.6730.54
368_R372_L0.6720.54
139_A146_L0.6720.54
378_R383_Y0.6710.54
164_H190_H0.6700.54
379_L387_L0.6690.54
221_R226_Y0.6680.54
207_N235_T0.6650.54
380_L391_K0.6610.53
239_T252_K0.6610.53
225_D229_F0.6600.53
122_I199_L0.6600.53
360_E363_E0.6600.53
103_G109_V0.6560.53
81_M324_A0.6560.53
128_S214_D0.6500.52
243_G260_G0.6480.52
94_V199_L0.6480.52
373_E377_Y0.6470.52
82_A92_T0.6450.51
69_I73_N0.6440.51
125_I249_R0.6430.51
128_S215_G0.6420.51
359_P363_E0.6410.51
173_A261_K0.6400.51
294_Q300_N0.6370.50
188_R282_S0.6370.50
188_R265_L0.6360.50
105_I108_I0.6340.50
386_A391_K0.6320.50
173_A267_D0.6320.50
129_P216_K0.6310.50
131_M260_G0.6310.50
194_N226_Y0.6310.50
120_H238_I0.6280.49
84_A106_V0.6270.49
142_S275_F0.6260.49
374_I380_L0.6260.49
137_N140_V0.6250.49
162_S216_K0.6230.49
240_I265_L0.6230.49
171_G177_I0.6230.49
374_I382_E0.6230.49
61_C75_Y0.6210.49
228_K257_K0.6200.49
141_Q175_G0.6190.48
174_K325_G0.6190.48
376_Y382_E0.6180.48
274_V278_Q0.6140.48
105_I363_E0.6120.48
240_I278_Q0.6110.48
372_L375_R0.6100.47
102_V105_I0.6090.47
367_D371_I0.6090.47
118_S278_Q0.6070.47
66_K72_K0.6070.47
186_T216_K0.6060.47
73_N76_Y0.6040.47
239_T246_Y0.6030.47
105_I275_F0.6010.46
348_V352_V0.5990.46
174_K202_Q0.5980.46
217_P245_D0.5980.46
65_I147_L0.5970.46
362_V370_V0.5950.46
361_V373_E0.5920.45
69_I89_Q0.5920.45
218_T245_D0.5920.45
289_N306_R0.5920.45
179_F190_H0.5910.45
379_L391_K0.5910.45
165_P186_T0.5900.45
85_I96_S0.5890.45
161_F238_I0.5890.45
332_T336_D0.5890.45
220_K225_D0.5860.45
195_F202_Q0.5850.45
83_I90_S0.5810.44
93_Y199_L0.5780.44
63_V72_K0.5770.44
359_P367_D0.5770.44
329_Y334_T0.5770.44
378_R384_S0.5770.44
82_A86_S0.5770.44
84_A95_Y0.5770.44
139_A276_E0.5760.44
142_S265_L0.5750.44
231_I307_I0.5720.43
379_L386_A0.5710.43
213_T217_P0.5690.43
358_N367_D0.5680.43
129_P260_G0.5650.43
388_E391_K0.5640.42
62_H73_N0.5620.42
90_S361_V0.5590.42
316_V320_F0.5590.42
380_L386_A0.5550.41
69_I72_K0.5530.41
224_K230_D0.5520.41
364_S374_I0.5500.41
373_E381_R0.5500.41
61_C68_V0.5500.41
188_R277_S0.5500.41
230_D233_P0.5500.41
384_S388_E0.5490.41
80_D357_G0.5480.41
359_P364_S0.5480.41
221_R331_I0.5470.41
298_P330_T0.5470.41
253_K256_D0.5460.40
61_C73_N0.5460.40
69_I364_S0.5450.40
90_S105_I0.5440.40
124_M217_P0.5430.40
228_K236_Q0.5420.40
371_I374_I0.5420.40
120_H246_Y0.5410.40
355_Q359_P0.5410.40
236_Q342_D0.5400.40
165_P262_F0.5390.40
62_H68_V0.5380.40
349_T353_I0.5380.40
295_G329_Y0.5370.40
191_E343_N0.5350.39
382_E385_E0.5350.39
147_L176_I0.5350.39
242_I271_L0.5320.39
170_Q175_G0.5320.39
197_L237_I0.5310.39
110_P123_I0.5310.39
384_S390_G0.5310.39
84_A91_H0.5300.39
209_I227_E0.5300.39
139_A142_S0.5300.39
160_L221_R0.5260.38
117_S317_Y0.5260.38
115_I182_G0.5250.38
363_E368_R0.5240.38
91_H97_D0.5200.38
129_P240_I0.5200.38
222_N228_K0.5200.38
64_C69_I0.5180.38
149_S180_D0.5180.38
251_L262_F0.5160.37
164_H198_N0.5150.37
82_A100_T0.5140.37
330_T334_T0.5120.37
372_L378_R0.5120.37
289_N302_D0.5110.37
342_D346_K0.5100.37
375_R383_Y0.5090.37
66_K71_L0.5060.36
281_T314_I0.5060.36
210_I240_I0.5050.36
70_V75_Y0.5040.36
222_N341_I0.5030.36
297_M327_D0.5000.36
67_G76_Y0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fx5A 1 0.8165 100 0.534 Contact Map
1q0pA 1 0.3486 100 0.682 Contact Map
2b2xA 1 0.3739 100 0.683 Contact Map
3txaA 1 0.7225 100 0.684 Contact Map
1ijbA 1 0.4174 100 0.684 Contact Map
4wfqA 1 0.3876 100 0.685 Contact Map
4f1jA 1 0.3991 100 0.685 Contact Map
2x31A 2 0.3784 100 0.688 Contact Map
1v7pC 1 0.3807 100 0.689 Contact Map
1mf7A 1 0.3991 100 0.689 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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