GREMLIN Database
Q97Z47 - Uncharacterized protein
UniProt: Q97Z47 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 209 (170)
Sequences: 661 (624)
Seq/√Len: 47.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_Y194_S6.1571.00
89_A93_Q3.5201.00
60_S66_S2.7291.00
165_E187_K2.5161.00
41_Q46_Q2.4021.00
173_T176_Y2.3691.00
148_V198_L2.2551.00
89_A92_E2.2401.00
132_S139_N2.1241.00
139_N142_V2.0241.00
67_E70_P1.9290.99
181_F184_V1.8140.99
140_V190_V1.7890.99
125_F190_V1.7740.99
43_A47_Q1.7470.99
156_S181_F1.7440.98
44_S47_Q1.7430.98
116_F168_N1.7340.98
67_E73_E1.6960.98
137_P201_N1.6950.98
156_S187_K1.6750.98
45_G48_S1.6040.97
43_A49_V1.6000.97
154_I167_L1.5990.97
57_N83_E1.5610.97
51_Q73_E1.5250.96
48_S51_Q1.5150.96
155_I196_I1.5110.96
64_A67_E1.5030.96
150_R176_Y1.4830.96
167_L203_V1.4800.96
44_S88_T1.4620.95
120_K123_L1.4530.95
197_K200_N1.4480.95
52_Q57_N1.4390.95
146_P170_T1.4250.95
59_L62_Q1.4160.95
60_S63_S1.4100.94
54_A60_S1.3990.94
72_T80_V1.3940.94
61_Q91_T1.3930.94
147_E170_T1.3500.93
173_T196_I1.3300.93
136_S142_V1.3230.92
50_E80_V1.3100.92
158_E163_Y1.3100.92
136_S170_T1.2790.91
166_D169_S1.2620.90
40_E50_E1.2530.90
46_Q51_Q1.2510.90
130_S174_Y1.2500.90
81_V87_E1.2430.90
135_R145_D1.2420.90
63_S66_S1.2350.89
90_K93_Q1.2300.89
62_Q67_E1.2220.89
150_R167_L1.2220.89
129_P148_V1.2210.89
54_A58_Q1.2140.89
71_V83_E1.1980.88
139_N164_L1.1960.88
137_P140_V1.1950.88
70_P91_T1.1930.88
43_A51_Q1.1920.88
195_I205_R1.1680.87
71_V78_Q1.1640.86
45_G74_Q1.1490.86
125_F157_F1.1470.86
63_S69_Q1.1350.85
73_E81_V1.1110.84
61_Q64_A1.1080.84
67_E74_Q1.1070.83
154_I168_N1.1030.83
44_S74_Q1.0990.83
52_Q58_Q1.0910.83
39_V45_G1.0870.82
47_Q52_Q1.0860.82
73_E79_Q1.0860.82
85_P89_A1.0840.82
89_A94_P1.0840.82
143_I187_K1.0810.82
149_S169_S1.0800.82
48_S62_Q1.0770.82
90_K94_P1.0750.82
98_T102_S1.0720.81
190_V193_N1.0530.80
88_T94_P1.0470.80
54_A66_S1.0470.80
60_S65_T1.0440.80
38_P49_V1.0400.79
180_V184_V1.0400.79
76_A85_P1.0390.79
63_S68_Q1.0390.79
38_P43_A1.0350.79
53_P59_L1.0320.79
137_P142_V1.0320.79
164_L188_I1.0160.78
46_Q55_D1.0100.77
167_L201_N1.0080.77
145_D199_G1.0070.77
59_L63_S1.0060.77
46_Q79_Q1.0040.77
86_S89_A1.0020.77
156_S165_E0.9960.76
85_P93_Q0.9930.76
146_P200_N0.9870.76
197_K203_V0.9870.76
60_S87_E0.9850.76
129_P141_I0.9830.75
162_L195_I0.9810.75
147_E202_T0.9740.75
63_S73_E0.9730.75
98_T101_V0.9720.75
81_V88_T0.9700.74
147_E174_Y0.9680.74
58_Q66_S0.9610.74
54_A65_T0.9570.73
49_V52_Q0.9210.71
37_P46_Q0.9030.69
82_V86_S0.8970.69
142_V201_N0.8920.68
197_K202_T0.8890.68
141_I162_L0.8810.67
149_S166_D0.8800.67
54_A59_L0.8660.66
45_G80_V0.8660.66
96_S100_T0.8650.66
96_S101_V0.8580.65
59_L65_T0.8570.65
154_I165_E0.8570.65
56_Q78_Q0.8540.65
116_F123_L0.8530.65
46_Q71_V0.8450.64
58_Q75_Q0.8430.64
131_I155_I0.8430.64
141_I201_N0.8300.62
165_E183_P0.8260.62
48_S82_V0.8200.62
55_D58_Q0.8090.60
139_N183_P0.8070.60
132_S140_V0.7990.60
85_P90_K0.7930.59
46_Q66_S0.7910.59
82_V90_K0.7830.58
58_Q61_Q0.7830.58
146_P203_V0.7810.58
117_N201_N0.7800.58
34_P37_P0.7760.57
175_V189_K0.7710.57
142_V147_E0.7700.57
135_R199_G0.7700.57
137_P184_V0.7670.56
38_P41_Q0.7630.56
145_D201_N0.7610.56
140_V153_A0.7580.55
71_V80_V0.7570.55
44_S60_S0.7540.55
63_S71_V0.7540.55
61_Q71_V0.7530.55
143_I163_Y0.7520.55
134_G152_H0.7500.55
40_E59_L0.7440.54
50_E77_P0.7370.53
40_E81_V0.7320.53
147_E195_I0.7260.52
130_S158_E0.7250.52
170_T197_K0.7250.52
57_N75_Q0.7250.52
56_Q70_P0.7240.52
137_P200_N0.7230.52
74_Q80_V0.7180.52
115_A118_K0.7170.51
114_P167_L0.7170.51
135_R151_K0.7140.51
49_V57_N0.7110.51
133_I180_V0.7090.51
147_E183_P0.7060.50
170_T203_V0.6950.49
43_A52_Q0.6890.49
132_S154_I0.6840.48
51_Q99_T0.6840.48
150_R166_D0.6780.48
91_T94_P0.6770.47
71_V89_A0.6760.47
47_Q84_Q0.6730.47
51_Q62_Q0.6730.47
151_K167_L0.6710.47
70_P84_Q0.6690.47
140_V176_Y0.6660.46
44_S82_V0.6580.46
56_Q81_V0.6540.45
77_P80_V0.6490.45
197_K201_N0.6430.44
133_I201_N0.6380.44
81_V85_P0.6360.43
55_D93_Q0.6350.43
143_I200_N0.6340.43
115_A120_K0.6300.43
153_A202_T0.6280.43
72_T81_V0.6270.42
162_L200_N0.6250.42
77_P85_P0.6240.42
44_S54_A0.6210.42
60_S68_Q0.6210.42
195_I200_N0.6200.42
117_N120_K0.6200.42
146_P198_L0.6110.41
58_Q64_A0.6050.40
172_G199_G0.6050.40
133_I136_S0.6030.40
122_P197_K0.6020.40
173_T202_T0.5980.40
176_Y197_K0.5940.39
38_P44_S0.5870.39
108_F113_N0.5850.38
148_V151_K0.5840.38
56_Q59_L0.5820.38
89_A95_Q0.5820.38
68_Q73_E0.5800.38
136_S165_E0.5800.38
142_V195_I0.5790.38
65_T87_E0.5750.37
51_Q69_Q0.5750.37
62_Q71_V0.5720.37
56_Q77_P0.5670.37
50_E53_P0.5660.37
137_P145_D0.5650.37
194_S200_N0.5640.36
195_I202_T0.5630.36
67_E72_T0.5620.36
61_Q75_Q0.5620.36
103_K110_N0.5610.36
57_N79_Q0.5610.36
131_I157_F0.5570.36
73_E83_E0.5550.36
117_N200_N0.5550.36
73_E95_Q0.5500.35
53_P88_T0.5460.35
139_N151_K0.5400.34
147_E201_N0.5360.34
143_I203_V0.5330.34
155_I201_N0.5320.33
88_T182_Q0.5250.33
37_P62_Q0.5190.32
64_A82_V0.5190.32
76_A79_Q0.5180.32
43_A46_Q0.5160.32
147_E200_N0.5160.32
69_Q86_S0.5160.32
62_Q68_Q0.5080.31
146_P159_N0.5070.31
188_I196_I0.5060.31
60_S93_Q0.5030.31
146_P201_N0.5030.31
49_V75_Q0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jpeA 1 0.5885 99.9 0.545 Contact Map
2kb3A 1 0.6651 99.9 0.551 Contact Map
2kfuA 1 0.7033 99.9 0.555 Contact Map
1mzkA 1 0.4833 99.9 0.563 Contact Map
3ounA 1 0.4306 99.9 0.564 Contact Map
2xt9B 1 0.4593 99.9 0.564 Contact Map
4h87A 2 0.555 99.9 0.566 Contact Map
1r21A 1 0.4689 99.9 0.566 Contact Map
1uhtA 1 0.5167 99.9 0.567 Contact Map
2ff4A 2 0.8134 99.9 0.572 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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