Q97Z46 - SULSO - GREMLIN Contacts

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Q97Z46 - Serine/threonine phosphatase type 1

UniProt:	Q97Z46	Sequences: MMNLDEVKSVVSNAIEIYKSKYDSPFVGNFEVDGNVVFVGDTHGAIDVTSKVFSDFAENADLVVFLGDYVDRGEDQLGNLLLILRKMIEKPDKYIVLRGNHESPITNEYYGFKEEVKEKLGEENYEMFVDLFSYMPYAVVVNGYFCIHGGLPMGLEKVEEIKKLPRPDVNPDNPIAFQLLWNDPREGIDDLDFLPSIRGEGIYFFGKRVVDNFLENNSLKGIIRGHEAADGFRTDMGGKVITVFSSRYHHMRAGILVLKKDGEFDYAYV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	269 (252)
Sequences:	2403 (1436)
Seq/√Len:	90.5

SULSO - Q97Z46

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
192_D	208_R	4.690	1.00
14_A	84_L	4.621	1.00
84_L	131_L	4.473	1.00
143_G	220_K	3.192	1.00
42_T	49_T	3.039	1.00
159_E	162_K	2.886	1.00
210_V	236_M	2.874	1.00
7_V	81_L	2.865	1.00
214_L	219_L	2.477	1.00
13_N	16_E	2.451	1.00
210_V	240_V	2.449	1.00
213_F	217_N	2.423	1.00
21_K	87_M	2.361	1.00
83_I	96_V	2.340	1.00
42_T	79_N	2.320	1.00
107_N	129_V	2.308	1.00
45_A	246_S	2.258	1.00
31_E	162_K	2.212	1.00
45_A	48_V	2.181	1.00
39_V	52_V	2.164	1.00
36_V	64_V	2.163	1.00
38_F	141_V	2.150	1.00
137_Y	176_A	2.053	1.00
104_P	133_S	2.032	1.00
18_Y	135_M	2.030	1.00
11_V	131_L	2.022	1.00
32_V	36_V	1.984	1.00
80_L	128_F	1.952	1.00
69_Y	96_V	1.935	1.00
68_D	72_R	1.859	1.00
3_N	6_E	1.830	1.00
210_V	222_I	1.819	1.00
234_T	238_G	1.787	1.00
211_D	237_G	1.768	1.00
19_K	134_Y	1.766	1.00
34_G	142_N	1.741	1.00
69_Y	97_L	1.715	1.00
17_I	88_I	1.712	1.00
10_V	85_R	1.709	1.00
43_H	68_D	1.686	1.00
56_F	63_V	1.684	1.00
62_L	93_K	1.664	1.00
66_L	146_C	1.650	1.00
155_L	175_I	1.650	1.00
115_E	119_K	1.641	1.00
140_V	145_F	1.634	1.00
80_L	84_L	1.629	1.00
56_F	257_V	1.621	1.00
14_A	88_I	1.612	1.00
112_F	128_F	1.576	1.00
97_L	139_V	1.567	1.00
30_F	95_I	1.560	1.00
161_I	179_L	1.538	1.00
64_V	139_V	1.537	1.00
241_I	258_L	1.523	1.00
234_T	241_I	1.505	1.00
145_F	179_L	1.490	1.00
170_N	180_L	1.487	1.00
14_A	18_Y	1.481	1.00
211_D	239_K	1.467	1.00
235_D	240_V	1.461	1.00
15_I	130_D	1.461	1.00
68_D	71_D	1.448	0.99
66_L	225_G	1.444	0.99
66_L	97_L	1.435	0.99
144_Y	221_G	1.426	0.99
62_L	95_I	1.407	0.99
183_D	198_R	1.385	0.99
12_S	127_M	1.377	0.99
108_E	113_K	1.374	0.99
194_L	204_F	1.369	0.99
158_V	217_N	1.365	0.99
59_N	63_V	1.355	0.99
192_D	209_V	1.348	0.99
39_V	63_V	1.347	0.99
51_K	54_S	1.321	0.99
144_Y	260_K	1.313	0.99
78_G	119_K	1.305	0.99
197_I	204_F	1.304	0.99
212_N	216_N	1.297	0.99
18_Y	96_V	1.297	0.99
178_Q	182_N	1.295	0.99
71_D	101_H	1.283	0.99
171_P	174_P	1.268	0.99
236_M	244_F	1.259	0.98
213_F	219_L	1.231	0.98
38_F	223_I	1.229	0.98
8_K	127_M	1.225	0.98
43_H	101_H	1.209	0.98
15_I	19_K	1.207	0.98
72_R	100_N	1.201	0.98
214_L	222_I	1.196	0.98
57_A	63_V	1.192	0.98
134_Y	167_P	1.185	0.98
103_S	171_P	1.150	0.97
64_V	95_I	1.150	0.97
174_P	177_F	1.150	0.97
140_V	219_L	1.148	0.97
17_I	21_K	1.145	0.97
46_I	247_R	1.138	0.97
27_V	30_F	1.126	0.97
10_V	81_L	1.122	0.97
210_V	214_L	1.119	0.97
9_S	13_N	1.117	0.97
15_I	134_Y	1.091	0.96
182_N	201_G	1.085	0.96
68_D	100_N	1.081	0.96
181_W	184_P	1.077	0.96
140_V	214_L	1.077	0.96
191_L	208_R	1.063	0.96
145_F	219_L	1.053	0.95
138_A	161_I	1.049	0.95
4_L	123_E	1.044	0.95
223_I	258_L	1.032	0.95
32_V	35_N	1.031	0.95
221_G	234_T	1.029	0.95
147_I	222_I	1.019	0.95
149_G	183_D	1.015	0.94
36_V	141_V	1.012	0.94
68_D	226_H	1.008	0.94
77_L	120_L	1.007	0.94
114_E	118_E	1.007	0.94
39_V	53_F	0.998	0.94
198_R	226_H	0.996	0.94
29_N	140_V	0.996	0.94
33_D	142_N	0.991	0.94
4_L	121_G	0.991	0.94
211_D	215_E	0.972	0.93
43_H	72_R	0.955	0.92
41_D	100_N	0.954	0.92
12_S	15_I	0.952	0.92
99_G	102_E	0.949	0.92
100_N	226_H	0.944	0.92
145_F	213_F	0.941	0.92
207_K	211_D	0.938	0.92
160_E	163_K	0.934	0.92
71_D	100_N	0.933	0.92
41_D	71_D	0.933	0.92
250_H	255_I	0.930	0.91
43_H	71_D	0.928	0.91
10_V	88_I	0.927	0.91
183_D	226_H	0.924	0.91
192_D	206_G	0.924	0.91
153_M	203_Y	0.912	0.91
215_E	239_K	0.910	0.90
77_L	116_V	0.907	0.90
205_F	240_V	0.907	0.90
68_D	198_R	0.900	0.90
86_K	90_K	0.898	0.90
244_F	249_H	0.893	0.90
68_D	101_H	0.892	0.90
37_V	259_K	0.890	0.90
178_Q	201_G	0.886	0.89
39_V	94_Y	0.886	0.89
196_S	201_G	0.885	0.89
140_V	158_V	0.879	0.89
223_I	241_I	0.874	0.89
86_K	94_Y	0.871	0.88
83_I	94_Y	0.870	0.88
151_L	209_V	0.863	0.88
85_R	88_I	0.861	0.88
66_L	69_Y	0.857	0.88
100_N	198_R	0.857	0.88
222_I	240_V	0.856	0.88
43_H	100_N	0.856	0.88
71_D	183_D	0.850	0.87
129_V	133_S	0.847	0.87
29_N	158_V	0.844	0.87
138_A	147_I	0.843	0.87
53_F	94_Y	0.840	0.87
113_K	117_K	0.838	0.86
14_A	131_L	0.837	0.86
174_P	178_Q	0.832	0.86
136_P	166_R	0.826	0.86
147_I	161_I	0.825	0.86
68_D	225_G	0.825	0.86
72_R	101_H	0.825	0.86
223_I	260_K	0.825	0.86
64_V	146_C	0.820	0.85
156_E	216_N	0.819	0.85
148_H	181_W	0.818	0.85
17_I	20_S	0.816	0.85
246_S	249_H	0.816	0.85
72_R	226_H	0.815	0.85
205_F	210_V	0.814	0.85
221_G	241_I	0.813	0.85
29_N	161_I	0.810	0.85
80_L	131_L	0.809	0.85
68_D	249_H	0.800	0.84
100_N	183_D	0.797	0.84
43_H	73_G	0.783	0.83
7_V	124_N	0.782	0.82
177_F	201_G	0.776	0.82
152_P	178_Q	0.776	0.82
17_I	87_M	0.773	0.82
39_V	65_F	0.772	0.82
159_E	163_K	0.772	0.82
139_V	146_C	0.772	0.82
55_D	257_V	0.771	0.82
28_G	166_R	0.768	0.81
124_N	127_M	0.768	0.81
53_F	63_V	0.766	0.81
82_L	86_K	0.763	0.81
52_V	245_S	0.762	0.81
107_N	111_G	0.759	0.81
210_V	235_D	0.759	0.81
168_D	176_A	0.758	0.80
71_D	226_H	0.756	0.80
212_N	215_E	0.756	0.80
53_F	57_A	0.753	0.80
100_N	181_W	0.751	0.80
186_E	233_R	0.747	0.79
246_S	255_I	0.746	0.79
47_D	75_D	0.745	0.79
29_N	35_N	0.744	0.79
41_D	226_H	0.740	0.79
207_K	237_G	0.740	0.79
47_D	251_M	0.738	0.79
101_H	181_W	0.734	0.78
80_L	135_M	0.730	0.78
214_L	239_K	0.728	0.78
72_R	181_W	0.727	0.78
29_N	138_A	0.727	0.78
39_V	56_F	0.726	0.78
116_V	124_N	0.720	0.77
104_P	125_Y	0.720	0.77
15_I	131_L	0.717	0.77
30_F	139_V	0.716	0.77
111_G	115_E	0.715	0.76
221_G	240_V	0.715	0.76
130_D	134_Y	0.707	0.76
193_F	209_V	0.705	0.75
50_S	63_V	0.703	0.75
252_R	255_I	0.701	0.75
47_D	247_R	0.698	0.75
147_I	179_L	0.698	0.75
232_F	247_R	0.698	0.75
37_V	56_F	0.697	0.75
181_W	226_H	0.697	0.75
14_A	17_I	0.696	0.75
72_R	198_R	0.696	0.75
43_H	226_H	0.694	0.74
145_F	222_I	0.690	0.74
43_H	70_V	0.688	0.74
81_L	85_R	0.680	0.73
113_K	125_Y	0.680	0.73
41_D	68_D	0.679	0.73
148_H	183_D	0.679	0.73
72_R	183_D	0.678	0.73
123_E	127_M	0.675	0.72
28_G	32_V	0.674	0.72
70_V	100_N	0.673	0.72
29_N	32_V	0.672	0.72
97_L	146_C	0.668	0.71
30_F	64_V	0.665	0.71
143_G	239_K	0.664	0.71
45_A	115_E	0.663	0.71
27_V	32_V	0.661	0.71
180_L	184_P	0.656	0.70
101_H	183_D	0.655	0.70
141_V	146_C	0.650	0.69
80_L	132_F	0.648	0.69
50_S	82_L	0.648	0.69
58_E	86_K	0.648	0.69
53_F	82_L	0.646	0.69
68_D	183_D	0.646	0.69
227_E	244_F	0.642	0.68
16_E	20_S	0.641	0.68
149_G	226_H	0.638	0.68
69_Y	83_I	0.637	0.68
48_V	247_R	0.636	0.68
70_V	101_H	0.635	0.68
41_D	101_H	0.635	0.68
21_K	62_L	0.633	0.67
196_S	199_G	0.631	0.67
171_P	177_F	0.629	0.67
27_V	162_K	0.626	0.67
228_A	247_R	0.626	0.67
43_H	181_W	0.622	0.66
28_G	35_N	0.620	0.66
119_K	246_S	0.619	0.66
104_P	126_E	0.618	0.66
49_T	53_F	0.618	0.66
125_Y	132_F	0.617	0.65
39_V	83_I	0.614	0.65
104_P	108_E	0.612	0.65
59_N	86_K	0.612	0.65
133_S	169_V	0.611	0.65
120_L	124_N	0.610	0.65
53_F	86_K	0.608	0.64
45_A	247_R	0.605	0.64
131_L	147_I	0.595	0.63
158_V	219_L	0.594	0.62
49_T	83_I	0.590	0.62
151_L	210_V	0.589	0.62
16_E	19_K	0.589	0.62
184_P	206_G	0.589	0.62
9_S	12_S	0.588	0.62
51_K	55_D	0.586	0.61
170_N	174_P	0.586	0.61
67_G	102_E	0.584	0.61
73_G	181_W	0.582	0.61
5_D	9_S	0.581	0.61
165_P	168_D	0.578	0.60
257_V	260_K	0.578	0.60
28_G	137_Y	0.578	0.60
8_K	12_S	0.577	0.60
76_Q	251_M	0.576	0.60
38_F	260_K	0.574	0.60
144_Y	223_I	0.572	0.60
121_G	125_Y	0.571	0.59
185_R	204_F	0.569	0.59
183_D	199_G	0.565	0.59
77_L	81_L	0.564	0.59
115_E	246_S	0.562	0.58
67_G	99_G	0.562	0.58
101_H	110_Y	0.561	0.58
140_V	147_I	0.560	0.58
52_V	56_F	0.559	0.58
37_V	63_V	0.556	0.57
206_G	209_V	0.556	0.57
44_G	102_E	0.555	0.57
157_K	217_N	0.554	0.57
236_M	240_V	0.552	0.57
107_N	110_Y	0.552	0.57
121_G	124_N	0.552	0.57
82_L	85_R	0.552	0.57
71_D	198_R	0.550	0.57
215_E	218_S	0.549	0.57
153_M	178_Q	0.548	0.56
97_L	138_A	0.546	0.56
21_K	27_V	0.546	0.56
49_T	79_N	0.546	0.56
46_I	50_S	0.545	0.56
71_D	149_G	0.543	0.56
145_F	161_I	0.541	0.55
77_L	119_K	0.541	0.55
76_Q	115_E	0.539	0.55
39_V	223_I	0.537	0.55
144_Y	220_K	0.537	0.55
138_A	155_L	0.534	0.54
3_N	9_S	0.533	0.54
60_A	93_K	0.530	0.54
152_P	182_N	0.530	0.54
101_H	226_H	0.530	0.54
103_S	170_N	0.526	0.53
42_T	247_R	0.525	0.53
225_G	244_F	0.525	0.53
145_F	158_V	0.525	0.53
138_A	168_D	0.524	0.53
11_V	127_M	0.524	0.53
138_A	151_L	0.523	0.53
152_P	155_L	0.523	0.53
248_Y	255_I	0.522	0.53
184_P	224_R	0.522	0.53
228_A	244_F	0.521	0.53
41_D	225_G	0.520	0.53
41_D	44_G	0.520	0.53
114_E	117_K	0.520	0.53
48_V	246_S	0.517	0.52
10_V	15_I	0.517	0.52
109_Y	253_A	0.516	0.52
28_G	135_M	0.512	0.51
228_A	233_R	0.511	0.51
215_E	223_I	0.508	0.51
183_D	227_E	0.508	0.51
187_G	207_K	0.506	0.51
145_F	217_N	0.506	0.51
20_S	92_D	0.505	0.50
125_Y	129_V	0.504	0.50
74_E	251_M	0.504	0.50
90_K	93_K	0.503	0.50
208_R	211_D	0.503	0.50
59_N	82_L	0.502	0.50
43_H	183_D	0.501	0.50
100_N	148_H	0.501	0.50
124_N	215_E	0.501	0.50
39_V	42_T	0.500	0.50

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4il1A	1	0.974	100	0.219	Contact Map
1auiA	1	0.974	100	0.22	Contact Map
4ja7A	1	0.9665	100	0.234	Contact Map
3icfA	2	0.9591	100	0.259	Contact Map
4f0zA	1	0.974	100	0.275	Contact Map
1fjmA	1	0.9703	100	0.282	Contact Map
4i5lC	1	0.9665	100	0.299	Contact Map
4movA	1	0.9703	100	0.303	Contact Map
3h63A	1	0.9665	100	0.307	Contact Map
2z72A	1	0.9182	100	0.522	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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