GREMLIN Database
Q97Z46 - Serine/threonine phosphatase type 1
UniProt: Q97Z46 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 269 (252)
Sequences: 2403 (1436)
Seq/√Len: 90.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
192_D208_R4.6901.00
14_A84_L4.6211.00
84_L131_L4.4731.00
143_G220_K3.1921.00
42_T49_T3.0391.00
159_E162_K2.8861.00
210_V236_M2.8741.00
7_V81_L2.8651.00
214_L219_L2.4771.00
13_N16_E2.4511.00
210_V240_V2.4491.00
213_F217_N2.4231.00
21_K87_M2.3611.00
83_I96_V2.3401.00
42_T79_N2.3201.00
107_N129_V2.3081.00
45_A246_S2.2581.00
31_E162_K2.2121.00
45_A48_V2.1811.00
39_V52_V2.1641.00
36_V64_V2.1631.00
38_F141_V2.1501.00
137_Y176_A2.0531.00
104_P133_S2.0321.00
18_Y135_M2.0301.00
11_V131_L2.0221.00
32_V36_V1.9841.00
80_L128_F1.9521.00
69_Y96_V1.9351.00
68_D72_R1.8591.00
3_N6_E1.8301.00
210_V222_I1.8191.00
234_T238_G1.7871.00
211_D237_G1.7681.00
19_K134_Y1.7661.00
34_G142_N1.7411.00
69_Y97_L1.7151.00
17_I88_I1.7121.00
10_V85_R1.7091.00
43_H68_D1.6861.00
56_F63_V1.6841.00
62_L93_K1.6641.00
66_L146_C1.6501.00
155_L175_I1.6501.00
115_E119_K1.6411.00
140_V145_F1.6341.00
80_L84_L1.6291.00
56_F257_V1.6211.00
14_A88_I1.6121.00
112_F128_F1.5761.00
97_L139_V1.5671.00
30_F95_I1.5601.00
161_I179_L1.5381.00
64_V139_V1.5371.00
241_I258_L1.5231.00
234_T241_I1.5051.00
145_F179_L1.4901.00
170_N180_L1.4871.00
14_A18_Y1.4811.00
211_D239_K1.4671.00
235_D240_V1.4611.00
15_I130_D1.4611.00
68_D71_D1.4480.99
66_L225_G1.4440.99
66_L97_L1.4350.99
144_Y221_G1.4260.99
62_L95_I1.4070.99
183_D198_R1.3850.99
12_S127_M1.3770.99
108_E113_K1.3740.99
194_L204_F1.3690.99
158_V217_N1.3650.99
59_N63_V1.3550.99
192_D209_V1.3480.99
39_V63_V1.3470.99
51_K54_S1.3210.99
144_Y260_K1.3130.99
78_G119_K1.3050.99
197_I204_F1.3040.99
212_N216_N1.2970.99
18_Y96_V1.2970.99
178_Q182_N1.2950.99
71_D101_H1.2830.99
171_P174_P1.2680.99
236_M244_F1.2590.98
213_F219_L1.2310.98
38_F223_I1.2290.98
8_K127_M1.2250.98
43_H101_H1.2090.98
15_I19_K1.2070.98
72_R100_N1.2010.98
214_L222_I1.1960.98
57_A63_V1.1920.98
134_Y167_P1.1850.98
103_S171_P1.1500.97
64_V95_I1.1500.97
174_P177_F1.1500.97
140_V219_L1.1480.97
17_I21_K1.1450.97
46_I247_R1.1380.97
27_V30_F1.1260.97
10_V81_L1.1220.97
210_V214_L1.1190.97
9_S13_N1.1170.97
15_I134_Y1.0910.96
182_N201_G1.0850.96
68_D100_N1.0810.96
181_W184_P1.0770.96
140_V214_L1.0770.96
191_L208_R1.0630.96
145_F219_L1.0530.95
138_A161_I1.0490.95
4_L123_E1.0440.95
223_I258_L1.0320.95
32_V35_N1.0310.95
221_G234_T1.0290.95
147_I222_I1.0190.95
149_G183_D1.0150.94
36_V141_V1.0120.94
68_D226_H1.0080.94
77_L120_L1.0070.94
114_E118_E1.0070.94
39_V53_F0.9980.94
198_R226_H0.9960.94
29_N140_V0.9960.94
33_D142_N0.9910.94
4_L121_G0.9910.94
211_D215_E0.9720.93
43_H72_R0.9550.92
41_D100_N0.9540.92
12_S15_I0.9520.92
99_G102_E0.9490.92
100_N226_H0.9440.92
145_F213_F0.9410.92
207_K211_D0.9380.92
160_E163_K0.9340.92
71_D100_N0.9330.92
41_D71_D0.9330.92
250_H255_I0.9300.91
43_H71_D0.9280.91
10_V88_I0.9270.91
183_D226_H0.9240.91
192_D206_G0.9240.91
153_M203_Y0.9120.91
215_E239_K0.9100.90
77_L116_V0.9070.90
205_F240_V0.9070.90
68_D198_R0.9000.90
86_K90_K0.8980.90
244_F249_H0.8930.90
68_D101_H0.8920.90
37_V259_K0.8900.90
178_Q201_G0.8860.89
39_V94_Y0.8860.89
196_S201_G0.8850.89
140_V158_V0.8790.89
223_I241_I0.8740.89
86_K94_Y0.8710.88
83_I94_Y0.8700.88
151_L209_V0.8630.88
85_R88_I0.8610.88
66_L69_Y0.8570.88
100_N198_R0.8570.88
222_I240_V0.8560.88
43_H100_N0.8560.88
71_D183_D0.8500.87
129_V133_S0.8470.87
29_N158_V0.8440.87
138_A147_I0.8430.87
53_F94_Y0.8400.87
113_K117_K0.8380.86
14_A131_L0.8370.86
174_P178_Q0.8320.86
136_P166_R0.8260.86
147_I161_I0.8250.86
68_D225_G0.8250.86
72_R101_H0.8250.86
223_I260_K0.8250.86
64_V146_C0.8200.85
156_E216_N0.8190.85
148_H181_W0.8180.85
17_I20_S0.8160.85
246_S249_H0.8160.85
72_R226_H0.8150.85
205_F210_V0.8140.85
221_G241_I0.8130.85
29_N161_I0.8100.85
80_L131_L0.8090.85
68_D249_H0.8000.84
100_N183_D0.7970.84
43_H73_G0.7830.83
7_V124_N0.7820.82
177_F201_G0.7760.82
152_P178_Q0.7760.82
17_I87_M0.7730.82
39_V65_F0.7720.82
159_E163_K0.7720.82
139_V146_C0.7720.82
55_D257_V0.7710.82
28_G166_R0.7680.81
124_N127_M0.7680.81
53_F63_V0.7660.81
82_L86_K0.7630.81
52_V245_S0.7620.81
107_N111_G0.7590.81
210_V235_D0.7590.81
168_D176_A0.7580.80
71_D226_H0.7560.80
212_N215_E0.7560.80
53_F57_A0.7530.80
100_N181_W0.7510.80
186_E233_R0.7470.79
246_S255_I0.7460.79
47_D75_D0.7450.79
29_N35_N0.7440.79
41_D226_H0.7400.79
207_K237_G0.7400.79
47_D251_M0.7380.79
101_H181_W0.7340.78
80_L135_M0.7300.78
214_L239_K0.7280.78
72_R181_W0.7270.78
29_N138_A0.7270.78
39_V56_F0.7260.78
116_V124_N0.7200.77
104_P125_Y0.7200.77
15_I131_L0.7170.77
30_F139_V0.7160.77
111_G115_E0.7150.76
221_G240_V0.7150.76
130_D134_Y0.7070.76
193_F209_V0.7050.75
50_S63_V0.7030.75
252_R255_I0.7010.75
47_D247_R0.6980.75
147_I179_L0.6980.75
232_F247_R0.6980.75
37_V56_F0.6970.75
181_W226_H0.6970.75
14_A17_I0.6960.75
72_R198_R0.6960.75
43_H226_H0.6940.74
145_F222_I0.6900.74
43_H70_V0.6880.74
81_L85_R0.6800.73
113_K125_Y0.6800.73
41_D68_D0.6790.73
148_H183_D0.6790.73
72_R183_D0.6780.73
123_E127_M0.6750.72
28_G32_V0.6740.72
70_V100_N0.6730.72
29_N32_V0.6720.72
97_L146_C0.6680.71
30_F64_V0.6650.71
143_G239_K0.6640.71
45_A115_E0.6630.71
27_V32_V0.6610.71
180_L184_P0.6560.70
101_H183_D0.6550.70
141_V146_C0.6500.69
80_L132_F0.6480.69
50_S82_L0.6480.69
58_E86_K0.6480.69
53_F82_L0.6460.69
68_D183_D0.6460.69
227_E244_F0.6420.68
16_E20_S0.6410.68
149_G226_H0.6380.68
69_Y83_I0.6370.68
48_V247_R0.6360.68
70_V101_H0.6350.68
41_D101_H0.6350.68
21_K62_L0.6330.67
196_S199_G0.6310.67
171_P177_F0.6290.67
27_V162_K0.6260.67
228_A247_R0.6260.67
43_H181_W0.6220.66
28_G35_N0.6200.66
119_K246_S0.6190.66
104_P126_E0.6180.66
49_T53_F0.6180.66
125_Y132_F0.6170.65
39_V83_I0.6140.65
104_P108_E0.6120.65
59_N86_K0.6120.65
133_S169_V0.6110.65
120_L124_N0.6100.65
53_F86_K0.6080.64
45_A247_R0.6050.64
131_L147_I0.5950.63
158_V219_L0.5940.62
49_T83_I0.5900.62
151_L210_V0.5890.62
16_E19_K0.5890.62
184_P206_G0.5890.62
9_S12_S0.5880.62
51_K55_D0.5860.61
170_N174_P0.5860.61
67_G102_E0.5840.61
73_G181_W0.5820.61
5_D9_S0.5810.61
165_P168_D0.5780.60
257_V260_K0.5780.60
28_G137_Y0.5780.60
8_K12_S0.5770.60
76_Q251_M0.5760.60
38_F260_K0.5740.60
144_Y223_I0.5720.60
121_G125_Y0.5710.59
185_R204_F0.5690.59
183_D199_G0.5650.59
77_L81_L0.5640.59
115_E246_S0.5620.58
67_G99_G0.5620.58
101_H110_Y0.5610.58
140_V147_I0.5600.58
52_V56_F0.5590.58
37_V63_V0.5560.57
206_G209_V0.5560.57
44_G102_E0.5550.57
157_K217_N0.5540.57
236_M240_V0.5520.57
107_N110_Y0.5520.57
121_G124_N0.5520.57
82_L85_R0.5520.57
71_D198_R0.5500.57
215_E218_S0.5490.57
153_M178_Q0.5480.56
97_L138_A0.5460.56
21_K27_V0.5460.56
49_T79_N0.5460.56
46_I50_S0.5450.56
71_D149_G0.5430.56
145_F161_I0.5410.55
77_L119_K0.5410.55
76_Q115_E0.5390.55
39_V223_I0.5370.55
144_Y220_K0.5370.55
138_A155_L0.5340.54
3_N9_S0.5330.54
60_A93_K0.5300.54
152_P182_N0.5300.54
101_H226_H0.5300.54
103_S170_N0.5260.53
42_T247_R0.5250.53
225_G244_F0.5250.53
145_F158_V0.5250.53
138_A168_D0.5240.53
11_V127_M0.5240.53
138_A151_L0.5230.53
152_P155_L0.5230.53
248_Y255_I0.5220.53
184_P224_R0.5220.53
228_A244_F0.5210.53
41_D225_G0.5200.53
41_D44_G0.5200.53
114_E117_K0.5200.53
48_V246_S0.5170.52
10_V15_I0.5170.52
109_Y253_A0.5160.52
28_G135_M0.5120.51
228_A233_R0.5110.51
215_E223_I0.5080.51
183_D227_E0.5080.51
187_G207_K0.5060.51
145_F217_N0.5060.51
20_S92_D0.5050.50
125_Y129_V0.5040.50
74_E251_M0.5040.50
90_K93_K0.5030.50
208_R211_D0.5030.50
59_N82_L0.5020.50
43_H183_D0.5010.50
100_N148_H0.5010.50
124_N215_E0.5010.50
39_V42_T0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4il1A 1 0.974 100 0.219 Contact Map
1auiA 1 0.974 100 0.22 Contact Map
4ja7A 1 0.9665 100 0.234 Contact Map
3icfA 2 0.9591 100 0.259 Contact Map
4f0zA 1 0.974 100 0.275 Contact Map
1fjmA 1 0.9703 100 0.282 Contact Map
4i5lC 1 0.9665 100 0.299 Contact Map
4movA 1 0.9703 100 0.303 Contact Map
3h63A 1 0.9665 100 0.307 Contact Map
2z72A 1 0.9182 100 0.522 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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