GREMLIN Database
Q97Z45 - Uncharacterized protein
UniProt: Q97Z45 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 380 (313)
Sequences: 1678 (1326)
Seq/√Len: 74.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_K97_T7.7291.00
142_E145_I5.4771.00
63_I101_L4.9561.00
66_F100_I3.8731.00
27_L206_A3.7641.00
141_D145_I3.5221.00
317_Q320_E3.5041.00
141_D144_N3.2281.00
62_A100_I2.9971.00
63_I97_T2.7831.00
92_D95_D2.7251.00
55_I59_K2.7131.00
42_V62_A2.7041.00
43_A118_A2.6411.00
135_T173_L2.6021.00
221_K246_I2.4831.00
123_K152_P2.4511.00
26_L29_P2.4501.00
110_A113_T2.3841.00
39_H74_K2.3721.00
46_T103_I2.3651.00
74_K90_F2.3571.00
44_L62_A2.3491.00
59_K100_I2.3021.00
54_K167_D2.2901.00
299_E303_Y2.2851.00
86_V121_L2.2381.00
46_T81_S2.1571.00
88_K96_L2.1381.00
39_H129_T2.1301.00
41_I78_I2.0851.00
48_G107_G2.0621.00
151_L154_Y2.0221.00
144_N147_N1.9851.00
169_N172_L1.9651.00
67_K93_P1.9351.00
146_G150_K1.9301.00
24_K27_L1.8761.00
61_G164_I1.8731.00
58_A62_A1.8271.00
109_T136_D1.8081.00
308_K324_T1.7741.00
84_V113_T1.7681.00
159_V176_V1.7671.00
76_S90_F1.7441.00
22_I27_L1.7371.00
174_Q227_T1.6851.00
123_K155_E1.6581.00
111_L133_L1.6541.00
58_A134_L1.6421.00
22_I26_L1.6331.00
108_Q140_T1.6221.00
117_T120_S1.6201.00
44_L58_A1.5600.99
138_N167_D1.5600.99
47_S137_G1.5480.99
46_T79_T1.5150.99
256_L277_I1.5050.99
78_I114_A1.4830.99
162_F196_K1.4650.99
312_Q317_Q1.4510.99
39_H130_Y1.4350.99
56_E59_K1.4080.99
84_V114_A1.3920.99
143_T147_N1.3820.98
208_K266_V1.3720.98
109_T137_G1.3670.98
24_K28_V1.3580.98
153_Y156_K1.3560.98
22_I25_V1.3530.98
328_L332_A1.3500.98
22_I289_V1.3360.98
43_A131_L1.3320.98
111_L139_P1.3200.98
45_D137_G1.3110.98
49_S136_D1.2960.98
183_V200_K1.2950.98
94_L98_N1.2910.98
51_T104_T1.2890.98
123_K128_P1.2860.98
39_H90_F1.2800.97
110_A140_T1.2730.97
26_L238_V1.2730.97
90_F121_L1.2480.97
150_K154_Y1.2440.97
69_I75_V1.2440.97
282_A285_Q1.2430.97
115_I133_L1.2410.97
161_S172_L1.2330.97
84_V117_T1.2250.97
281_K284_D1.2230.97
71_N93_P1.2220.97
36_T70_P1.2180.97
118_A131_L1.2130.96
299_E302_Y1.2120.96
292_I296_V1.2000.96
325_L328_L1.1950.96
62_A77_F1.1940.96
316_E321_A1.1920.96
300_Y303_Y1.1900.96
132_L162_F1.1900.96
308_K311_K1.1820.96
172_L176_V1.1750.96
45_D49_S1.1730.96
42_V58_A1.1650.96
81_S106_G1.1640.96
25_V28_V1.1620.95
163_G168_Y1.1600.95
130_Y160_Y1.1570.95
114_A118_A1.1550.95
161_S177_S1.1530.95
288_F291_G1.1520.95
164_I196_K1.1520.95
49_S137_G1.1490.95
224_N227_T1.1480.95
207_A210_V1.1400.95
62_A134_L1.1360.95
162_F187_I1.1350.95
321_A325_L1.1340.95
312_Q320_E1.1320.95
160_Y200_K1.1290.95
45_D109_T1.1280.95
277_I280_R1.1260.95
142_E146_G1.1040.94
293_N296_V1.1010.94
41_I122_A1.0950.94
109_T135_T1.0780.93
44_L103_I1.0690.93
147_N150_K1.0670.93
47_S109_T1.0640.93
79_T87_I1.0630.93
24_K29_P1.0590.93
330_E334_Q1.0560.93
50_M136_D1.0520.92
46_T83_N1.0510.92
290_S293_N1.0500.92
25_V29_P1.0460.92
41_I76_S1.0450.92
26_L30_E1.0420.92
66_F93_P1.0370.92
48_G109_T1.0340.92
25_V30_E1.0330.92
327_Q330_E1.0310.92
323_K327_Q1.0290.92
162_F197_L1.0270.91
35_A70_P1.0230.91
304_E307_D1.0210.91
49_S109_T1.0200.91
87_I99_E1.0200.91
280_R283_Q1.0200.91
276_V281_K1.0180.91
326_N329_N1.0160.91
174_Q178_D1.0080.91
112_Y116_L0.9970.90
81_S103_I0.9840.90
164_I193_I0.9800.89
61_G182_G0.9680.89
50_M54_K0.9670.89
130_Y200_K0.9660.89
110_A187_I0.9650.89
48_G138_N0.9650.89
115_I159_V0.9620.89
237_N240_K0.9610.89
264_D267_T0.9580.88
39_H160_Y0.9550.88
37_G73_N0.9450.88
22_I293_N0.9350.87
286_N290_S0.9350.87
122_A129_T0.9340.87
278_Q281_K0.9310.87
50_M182_G0.9310.87
233_N239_I0.9310.87
111_L138_N0.9300.87
287_T291_G0.9300.87
272_S275_Q0.9280.87
209_N263_E0.9260.87
44_L77_F0.9220.86
22_I28_V0.9210.86
162_F200_K0.9200.86
312_Q316_E0.9200.86
309_Y321_A0.9190.86
107_G137_G0.9160.86
320_E328_L0.9120.86
162_F193_I0.9050.85
286_N293_N0.8990.85
279_V282_A0.8980.85
37_G173_L0.8970.85
302_Y308_K0.8960.85
145_I148_Y0.8940.85
225_Y228_T0.8920.85
309_Y313_V0.8870.84
175_S179_K0.8840.84
174_Q184_M0.8830.84
146_G149_L0.8800.84
79_T83_N0.8800.84
108_Q111_L0.8790.84
50_M61_G0.8750.83
50_M109_T0.8720.83
28_V31_K0.8690.83
75_V96_L0.8670.83
148_Y151_L0.8650.83
159_V232_V0.8650.83
81_S88_K0.8620.82
289_V292_I0.8600.82
309_Y312_Q0.8580.82
113_T116_L0.8540.82
142_E149_L0.8530.82
120_S246_I0.8510.82
324_T328_L0.8450.81
47_S50_M0.8450.81
143_T146_G0.8440.81
230_V256_L0.8420.81
69_I73_N0.8410.81
86_V89_E0.8360.80
23_F29_P0.8360.80
222_L225_Y0.8350.80
110_A135_T0.8340.80
41_I118_A0.8330.80
42_V75_V0.8320.80
132_L170_E0.8320.80
70_P73_N0.8130.79
68_R201_A0.8130.79
178_D227_T0.8100.78
73_N172_L0.8090.78
82_S107_G0.8050.78
308_K312_Q0.8040.78
305_L332_A0.7950.77
330_E333_Q0.7940.77
130_Y170_E0.7930.77
45_D50_M0.7920.77
247_L255_F0.7920.77
124_K128_P0.7890.76
257_T260_V0.7880.76
61_G200_K0.7860.76
67_K204_Q0.7830.76
76_S121_L0.7820.76
223_L246_I0.7820.76
86_V117_T0.7800.76
139_P172_L0.7800.76
125_Y128_P0.7750.75
25_V270_P0.7740.75
161_S331_I0.7700.75
25_V33_G0.7690.75
108_Q138_N0.7680.75
43_A138_N0.7680.75
149_L152_P0.7640.74
63_I100_I0.7620.74
305_L324_T0.7590.74
126_Q129_T0.7560.73
43_A114_A0.7540.73
135_T168_Y0.7530.73
150_K153_Y0.7530.73
277_I282_A0.7520.73
326_N330_E0.7500.73
299_E309_Y0.7500.73
310_A314_Q0.7480.73
141_D146_G0.7470.72
23_F28_V0.7470.72
318_L325_L0.7450.72
120_S124_K0.7440.72
309_Y332_A0.7420.72
58_A77_F0.7410.72
258_V261_N0.7390.72
278_Q283_Q0.7390.72
274_L278_Q0.7390.72
121_L124_K0.7380.72
258_V262_Y0.7350.71
32_L66_F0.7310.71
313_V318_L0.7270.70
131_L159_V0.7270.70
134_L197_L0.7260.70
168_Y184_M0.7250.70
98_N259_K0.7180.69
41_I121_L0.7180.69
318_L322_T0.7160.69
196_K200_K0.7160.69
257_T267_T0.7140.69
73_N165_G0.7110.69
187_I193_I0.7110.69
29_P32_L0.7090.69
43_A161_S0.7080.68
66_F97_T0.7060.68
27_L193_I0.7050.68
318_L332_A0.7040.68
137_G182_G0.7040.68
83_N154_Y0.7030.68
111_L182_G0.6990.67
77_F96_L0.6970.67
39_H76_S0.6970.67
97_T251_Y0.6940.67
197_L205_I0.6920.67
320_E323_K0.6890.66
160_Y180_T0.6890.66
307_D321_A0.6870.66
305_L312_Q0.6860.66
235_I260_V0.6840.66
150_K179_K0.6840.66
129_T157_I0.6820.66
141_D148_Y0.6810.65
285_Q291_G0.6810.65
234_G242_F0.6800.65
231_K234_G0.6790.65
317_Q323_K0.6780.65
44_L71_N0.6780.65
98_N131_L0.6760.65
134_L164_I0.6740.65
79_T85_N0.6730.64
84_V111_L0.6720.64
59_K101_L0.6710.64
120_S123_K0.6680.64
130_Y168_Y0.6680.64
110_A139_P0.6660.64
147_N214_I0.6660.64
43_A78_I0.6660.64
220_V224_N0.6650.64
323_K334_Q0.6620.63
78_I118_A0.6610.63
326_N331_I0.6610.63
108_Q115_I0.6570.63
217_E254_N0.6560.63
220_V228_T0.6530.62
304_E308_K0.6520.62
264_D271_E0.6500.62
215_T257_T0.6490.62
65_L204_Q0.6490.62
61_G201_A0.6460.61
220_V227_T0.6450.61
158_Q181_G0.6420.61
275_Q279_V0.6410.61
39_H55_I0.6390.60
285_Q288_F0.6380.60
309_Y325_L0.6370.60
124_K127_M0.6360.60
287_T294_N0.6360.60
66_F70_P0.6350.60
80_F169_N0.6350.60
158_Q208_K0.6330.60
58_A164_I0.6320.60
250_N273_L0.6320.60
85_N103_I0.6310.60
75_V205_I0.6310.60
79_T103_I0.6300.59
164_I187_I0.6290.59
81_S140_T0.6280.59
67_K71_N0.6260.59
41_I103_I0.6240.59
222_L226_V0.6240.59
307_D310_A0.6240.59
159_V180_T0.6220.58
63_I67_K0.6210.58
37_G52_G0.6200.58
74_K202_V0.6190.58
145_I171_Q0.6190.58
101_L286_N0.6180.58
23_F27_L0.6110.57
66_F96_L0.6070.57
61_G197_L0.6060.56
257_T261_N0.6040.56
25_V142_E0.6040.56
220_V225_Y0.6030.56
319_V327_Q0.6030.56
43_A139_P0.6010.56
218_G221_K0.6010.56
196_K199_Q0.6010.56
225_Y247_L0.6000.56
279_V283_Q0.5990.56
153_Y232_V0.5980.55
102_Q218_G0.5980.55
172_L175_S0.5970.55
307_D313_V0.5910.55
111_L122_A0.5890.54
269_K291_G0.5890.54
73_N182_G0.5880.54
66_F76_S0.5870.54
320_E333_Q0.5850.54
268_N292_I0.5840.54
48_G51_T0.5840.54
46_T55_I0.5840.54
85_N106_G0.5830.54
135_T187_I0.5830.54
279_V284_D0.5830.54
169_N202_V0.5790.53
29_P33_G0.5750.53
48_G140_T0.5750.53
64_E202_V0.5740.52
328_L331_I0.5730.52
206_A210_V0.5720.52
255_F260_V0.5710.52
112_Y172_L0.5710.52
94_L274_L0.5710.52
168_Y200_K0.5710.52
114_A140_T0.5680.52
32_L189_D0.5670.52
95_D98_N0.5670.52
306_L312_Q0.5660.51
118_A139_P0.5640.51
315_A333_Q0.5630.51
224_N228_T0.5630.51
51_T319_V0.5600.51
102_Q120_S0.5590.51
50_M80_F0.5590.51
84_V112_Y0.5580.50
187_I192_E0.5580.50
132_L201_A0.5570.50
35_A201_A0.5560.50
54_K165_G0.5560.50
34_S51_T0.5540.50
214_I217_E0.5540.50
77_F181_G0.5520.50
50_M197_L0.5500.49
205_I260_V0.5480.49
257_T276_V0.5480.49
55_I111_L0.5470.49
254_N259_K0.5460.49
257_T264_D0.5450.49
123_K127_M0.5430.49
39_H122_A0.5410.48
146_G175_S0.5410.48
212_V241_I0.5410.48
284_D289_V0.5400.48
158_Q161_S0.5370.48
160_Y168_Y0.5340.47
139_P167_D0.5330.47
321_A332_A0.5320.47
146_G152_P0.5320.47
62_A148_Y0.5310.47
139_P168_Y0.5300.47
93_P97_T0.5300.47
48_G105_A0.5300.47
85_N112_Y0.5290.47
193_I200_K0.5290.47
110_A199_Q0.5280.47
132_L161_S0.5270.47
296_V309_Y0.5250.46
33_G289_V0.5240.46
42_V132_L0.5220.46
252_E315_A0.5220.46
31_K281_K0.5200.46
38_F199_Q0.5190.46
66_F191_N0.5190.46
324_T330_E0.5190.46
303_Y308_K0.5190.46
327_Q333_Q0.5180.45
208_K234_G0.5180.45
91_V104_T0.5160.45
315_A324_T0.5150.45
290_S294_N0.5150.45
86_V90_F0.5140.45
327_Q331_I0.5130.45
310_A322_T0.5130.45
305_L309_Y0.5120.45
49_S163_G0.5120.45
142_E171_Q0.5110.45
185_Y194_P0.5100.44
32_L173_L0.5090.44
59_K104_T0.5080.44
76_S122_A0.5070.44
291_G295_D0.5060.44
37_G251_Y0.5050.44
160_Y183_V0.5050.44
63_I128_P0.5050.44
287_T293_N0.5030.44
23_F26_L0.5020.43
117_T121_L0.5020.43
73_N186_H0.5020.43
94_L102_Q0.5020.43
253_G279_V0.5010.43
319_V322_T0.5010.43
161_S169_N0.5010.43
233_N242_F0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fx5A 1 0.9684 100 0.447 Contact Map
3txaA 1 0.7395 100 0.552 Contact Map
1q0pA 1 0.4079 100 0.576 Contact Map
1pt6A 1 0.4526 100 0.579 Contact Map
1mf7A 1 0.4658 100 0.58 Contact Map
1ijbA 1 0.4921 100 0.582 Contact Map
1n3yA 1 0.4526 100 0.582 Contact Map
1v7pC 1 0.4447 100 0.586 Contact Map
2b2xA 1 0.4395 100 0.586 Contact Map
4bj3A 1 0.4184 100 0.587 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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