Q97Z45 - SULSO - GREMLIN Contacts

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Q97Z45 - Uncharacterized protein

UniProt:	Q97Z45	Sequences: MTLSLRVDTSHKYSFNADVRYIFKVLLVPEKLGSATGFHYIVALDTSGSMTGYKIELAKQGAIELFKRIPNGNKVSFITFSSNVNVIKEFVDPLDLTNEILQITAGGQTALYTAILTANSLAKKYQMPTYLLLLTDGNPTDETNIGNYLKLPYYEKIQVYSFGIGDDYNEQLLQSVSDKTGGVMYHISDANEIPQKLPQKAVTQIAAKNVTVDITAEGNVKLLNYVTTPVKVNGIENVIKIFGETILPANYEGNFLTVKVNYEDPVTNKPESLLQVIQVRKAQDQNTFVSGINNDVINEYRYYELLDKYAKQVQAEQLVEATKTLNQLNEIAQQTRRIDFMETTRRLSEGLETTKRIGTVEQTKRLSKEVTSEVTRKLRE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	380 (313)
Sequences:	1678 (1326)
Seq/√Len:	74.9

ECOLI - YFBK
SULSO - Q97Z45 Q97Z48

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
67_K	97_T	7.729	1.00
142_E	145_I	5.477	1.00
63_I	101_L	4.956	1.00
66_F	100_I	3.873	1.00
27_L	206_A	3.764	1.00
141_D	145_I	3.522	1.00
317_Q	320_E	3.504	1.00
141_D	144_N	3.228	1.00
62_A	100_I	2.997	1.00
63_I	97_T	2.783	1.00
92_D	95_D	2.725	1.00
55_I	59_K	2.713	1.00
42_V	62_A	2.704	1.00
43_A	118_A	2.641	1.00
135_T	173_L	2.602	1.00
221_K	246_I	2.483	1.00
123_K	152_P	2.451	1.00
26_L	29_P	2.450	1.00
110_A	113_T	2.384	1.00
39_H	74_K	2.372	1.00
46_T	103_I	2.365	1.00
74_K	90_F	2.357	1.00
44_L	62_A	2.349	1.00
59_K	100_I	2.302	1.00
54_K	167_D	2.290	1.00
299_E	303_Y	2.285	1.00
86_V	121_L	2.238	1.00
46_T	81_S	2.157	1.00
88_K	96_L	2.138	1.00
39_H	129_T	2.130	1.00
41_I	78_I	2.085	1.00
48_G	107_G	2.062	1.00
151_L	154_Y	2.022	1.00
144_N	147_N	1.985	1.00
169_N	172_L	1.965	1.00
67_K	93_P	1.935	1.00
146_G	150_K	1.930	1.00
24_K	27_L	1.876	1.00
61_G	164_I	1.873	1.00
58_A	62_A	1.827	1.00
109_T	136_D	1.808	1.00
308_K	324_T	1.774	1.00
84_V	113_T	1.768	1.00
159_V	176_V	1.767	1.00
76_S	90_F	1.744	1.00
22_I	27_L	1.737	1.00
174_Q	227_T	1.685	1.00
123_K	155_E	1.658	1.00
111_L	133_L	1.654	1.00
58_A	134_L	1.642	1.00
22_I	26_L	1.633	1.00
108_Q	140_T	1.622	1.00
117_T	120_S	1.620	1.00
44_L	58_A	1.560	0.99
138_N	167_D	1.560	0.99
47_S	137_G	1.548	0.99
46_T	79_T	1.515	0.99
256_L	277_I	1.505	0.99
78_I	114_A	1.483	0.99
162_F	196_K	1.465	0.99
312_Q	317_Q	1.451	0.99
39_H	130_Y	1.435	0.99
56_E	59_K	1.408	0.99
84_V	114_A	1.392	0.99
143_T	147_N	1.382	0.98
208_K	266_V	1.372	0.98
109_T	137_G	1.367	0.98
24_K	28_V	1.358	0.98
153_Y	156_K	1.356	0.98
22_I	25_V	1.353	0.98
328_L	332_A	1.350	0.98
22_I	289_V	1.336	0.98
43_A	131_L	1.332	0.98
111_L	139_P	1.320	0.98
45_D	137_G	1.311	0.98
49_S	136_D	1.296	0.98
183_V	200_K	1.295	0.98
94_L	98_N	1.291	0.98
51_T	104_T	1.289	0.98
123_K	128_P	1.286	0.98
39_H	90_F	1.280	0.97
110_A	140_T	1.273	0.97
26_L	238_V	1.273	0.97
90_F	121_L	1.248	0.97
150_K	154_Y	1.244	0.97
69_I	75_V	1.244	0.97
282_A	285_Q	1.243	0.97
115_I	133_L	1.241	0.97
161_S	172_L	1.233	0.97
84_V	117_T	1.225	0.97
281_K	284_D	1.223	0.97
71_N	93_P	1.222	0.97
36_T	70_P	1.218	0.97
118_A	131_L	1.213	0.96
299_E	302_Y	1.212	0.96
292_I	296_V	1.200	0.96
325_L	328_L	1.195	0.96
62_A	77_F	1.194	0.96
316_E	321_A	1.192	0.96
300_Y	303_Y	1.190	0.96
132_L	162_F	1.190	0.96
308_K	311_K	1.182	0.96
172_L	176_V	1.175	0.96
45_D	49_S	1.173	0.96
42_V	58_A	1.165	0.96
81_S	106_G	1.164	0.96
25_V	28_V	1.162	0.95
163_G	168_Y	1.160	0.95
130_Y	160_Y	1.157	0.95
114_A	118_A	1.155	0.95
161_S	177_S	1.153	0.95
288_F	291_G	1.152	0.95
164_I	196_K	1.152	0.95
49_S	137_G	1.149	0.95
224_N	227_T	1.148	0.95
207_A	210_V	1.140	0.95
62_A	134_L	1.136	0.95
162_F	187_I	1.135	0.95
321_A	325_L	1.134	0.95
312_Q	320_E	1.132	0.95
160_Y	200_K	1.129	0.95
45_D	109_T	1.128	0.95
277_I	280_R	1.126	0.95
142_E	146_G	1.104	0.94
293_N	296_V	1.101	0.94
41_I	122_A	1.095	0.94
109_T	135_T	1.078	0.93
44_L	103_I	1.069	0.93
147_N	150_K	1.067	0.93
47_S	109_T	1.064	0.93
79_T	87_I	1.063	0.93
24_K	29_P	1.059	0.93
330_E	334_Q	1.056	0.93
50_M	136_D	1.052	0.92
46_T	83_N	1.051	0.92
290_S	293_N	1.050	0.92
25_V	29_P	1.046	0.92
41_I	76_S	1.045	0.92
26_L	30_E	1.042	0.92
66_F	93_P	1.037	0.92
48_G	109_T	1.034	0.92
25_V	30_E	1.033	0.92
327_Q	330_E	1.031	0.92
323_K	327_Q	1.029	0.92
162_F	197_L	1.027	0.91
35_A	70_P	1.023	0.91
304_E	307_D	1.021	0.91
49_S	109_T	1.020	0.91
87_I	99_E	1.020	0.91
280_R	283_Q	1.020	0.91
276_V	281_K	1.018	0.91
326_N	329_N	1.016	0.91
174_Q	178_D	1.008	0.91
112_Y	116_L	0.997	0.90
81_S	103_I	0.984	0.90
164_I	193_I	0.980	0.89
61_G	182_G	0.968	0.89
50_M	54_K	0.967	0.89
130_Y	200_K	0.966	0.89
110_A	187_I	0.965	0.89
48_G	138_N	0.965	0.89
115_I	159_V	0.962	0.89
237_N	240_K	0.961	0.89
264_D	267_T	0.958	0.88
39_H	160_Y	0.955	0.88
37_G	73_N	0.945	0.88
22_I	293_N	0.935	0.87
286_N	290_S	0.935	0.87
122_A	129_T	0.934	0.87
278_Q	281_K	0.931	0.87
50_M	182_G	0.931	0.87
233_N	239_I	0.931	0.87
111_L	138_N	0.930	0.87
287_T	291_G	0.930	0.87
272_S	275_Q	0.928	0.87
209_N	263_E	0.926	0.87
44_L	77_F	0.922	0.86
22_I	28_V	0.921	0.86
162_F	200_K	0.920	0.86
312_Q	316_E	0.920	0.86
309_Y	321_A	0.919	0.86
107_G	137_G	0.916	0.86
320_E	328_L	0.912	0.86
162_F	193_I	0.905	0.85
286_N	293_N	0.899	0.85
279_V	282_A	0.898	0.85
37_G	173_L	0.897	0.85
302_Y	308_K	0.896	0.85
145_I	148_Y	0.894	0.85
225_Y	228_T	0.892	0.85
309_Y	313_V	0.887	0.84
175_S	179_K	0.884	0.84
174_Q	184_M	0.883	0.84
146_G	149_L	0.880	0.84
79_T	83_N	0.880	0.84
108_Q	111_L	0.879	0.84
50_M	61_G	0.875	0.83
50_M	109_T	0.872	0.83
28_V	31_K	0.869	0.83
75_V	96_L	0.867	0.83
148_Y	151_L	0.865	0.83
159_V	232_V	0.865	0.83
81_S	88_K	0.862	0.82
289_V	292_I	0.860	0.82
309_Y	312_Q	0.858	0.82
113_T	116_L	0.854	0.82
142_E	149_L	0.853	0.82
120_S	246_I	0.851	0.82
324_T	328_L	0.845	0.81
47_S	50_M	0.845	0.81
143_T	146_G	0.844	0.81
230_V	256_L	0.842	0.81
69_I	73_N	0.841	0.81
86_V	89_E	0.836	0.80
23_F	29_P	0.836	0.80
222_L	225_Y	0.835	0.80
110_A	135_T	0.834	0.80
41_I	118_A	0.833	0.80
42_V	75_V	0.832	0.80
132_L	170_E	0.832	0.80
70_P	73_N	0.813	0.79
68_R	201_A	0.813	0.79
178_D	227_T	0.810	0.78
73_N	172_L	0.809	0.78
82_S	107_G	0.805	0.78
308_K	312_Q	0.804	0.78
305_L	332_A	0.795	0.77
330_E	333_Q	0.794	0.77
130_Y	170_E	0.793	0.77
45_D	50_M	0.792	0.77
247_L	255_F	0.792	0.77
124_K	128_P	0.789	0.76
257_T	260_V	0.788	0.76
61_G	200_K	0.786	0.76
67_K	204_Q	0.783	0.76
76_S	121_L	0.782	0.76
223_L	246_I	0.782	0.76
86_V	117_T	0.780	0.76
139_P	172_L	0.780	0.76
125_Y	128_P	0.775	0.75
25_V	270_P	0.774	0.75
161_S	331_I	0.770	0.75
25_V	33_G	0.769	0.75
108_Q	138_N	0.768	0.75
43_A	138_N	0.768	0.75
149_L	152_P	0.764	0.74
63_I	100_I	0.762	0.74
305_L	324_T	0.759	0.74
126_Q	129_T	0.756	0.73
43_A	114_A	0.754	0.73
135_T	168_Y	0.753	0.73
150_K	153_Y	0.753	0.73
277_I	282_A	0.752	0.73
326_N	330_E	0.750	0.73
299_E	309_Y	0.750	0.73
310_A	314_Q	0.748	0.73
141_D	146_G	0.747	0.72
23_F	28_V	0.747	0.72
318_L	325_L	0.745	0.72
120_S	124_K	0.744	0.72
309_Y	332_A	0.742	0.72
58_A	77_F	0.741	0.72
258_V	261_N	0.739	0.72
278_Q	283_Q	0.739	0.72
274_L	278_Q	0.739	0.72
121_L	124_K	0.738	0.72
258_V	262_Y	0.735	0.71
32_L	66_F	0.731	0.71
313_V	318_L	0.727	0.70
131_L	159_V	0.727	0.70
134_L	197_L	0.726	0.70
168_Y	184_M	0.725	0.70
98_N	259_K	0.718	0.69
41_I	121_L	0.718	0.69
318_L	322_T	0.716	0.69
196_K	200_K	0.716	0.69
257_T	267_T	0.714	0.69
73_N	165_G	0.711	0.69
187_I	193_I	0.711	0.69
29_P	32_L	0.709	0.69
43_A	161_S	0.708	0.68
66_F	97_T	0.706	0.68
27_L	193_I	0.705	0.68
318_L	332_A	0.704	0.68
137_G	182_G	0.704	0.68
83_N	154_Y	0.703	0.68
111_L	182_G	0.699	0.67
77_F	96_L	0.697	0.67
39_H	76_S	0.697	0.67
97_T	251_Y	0.694	0.67
197_L	205_I	0.692	0.67
320_E	323_K	0.689	0.66
160_Y	180_T	0.689	0.66
307_D	321_A	0.687	0.66
305_L	312_Q	0.686	0.66
235_I	260_V	0.684	0.66
150_K	179_K	0.684	0.66
129_T	157_I	0.682	0.66
141_D	148_Y	0.681	0.65
285_Q	291_G	0.681	0.65
234_G	242_F	0.680	0.65
231_K	234_G	0.679	0.65
317_Q	323_K	0.678	0.65
44_L	71_N	0.678	0.65
98_N	131_L	0.676	0.65
134_L	164_I	0.674	0.65
79_T	85_N	0.673	0.64
84_V	111_L	0.672	0.64
59_K	101_L	0.671	0.64
120_S	123_K	0.668	0.64
130_Y	168_Y	0.668	0.64
110_A	139_P	0.666	0.64
147_N	214_I	0.666	0.64
43_A	78_I	0.666	0.64
220_V	224_N	0.665	0.64
323_K	334_Q	0.662	0.63
78_I	118_A	0.661	0.63
326_N	331_I	0.661	0.63
108_Q	115_I	0.657	0.63
217_E	254_N	0.656	0.63
220_V	228_T	0.653	0.62
304_E	308_K	0.652	0.62
264_D	271_E	0.650	0.62
215_T	257_T	0.649	0.62
65_L	204_Q	0.649	0.62
61_G	201_A	0.646	0.61
220_V	227_T	0.645	0.61
158_Q	181_G	0.642	0.61
275_Q	279_V	0.641	0.61
39_H	55_I	0.639	0.60
285_Q	288_F	0.638	0.60
309_Y	325_L	0.637	0.60
124_K	127_M	0.636	0.60
287_T	294_N	0.636	0.60
66_F	70_P	0.635	0.60
80_F	169_N	0.635	0.60
158_Q	208_K	0.633	0.60
58_A	164_I	0.632	0.60
250_N	273_L	0.632	0.60
85_N	103_I	0.631	0.60
75_V	205_I	0.631	0.60
79_T	103_I	0.630	0.59
164_I	187_I	0.629	0.59
81_S	140_T	0.628	0.59
67_K	71_N	0.626	0.59
41_I	103_I	0.624	0.59
222_L	226_V	0.624	0.59
307_D	310_A	0.624	0.59
159_V	180_T	0.622	0.58
63_I	67_K	0.621	0.58
37_G	52_G	0.620	0.58
74_K	202_V	0.619	0.58
145_I	171_Q	0.619	0.58
101_L	286_N	0.618	0.58
23_F	27_L	0.611	0.57
66_F	96_L	0.607	0.57
61_G	197_L	0.606	0.56
257_T	261_N	0.604	0.56
25_V	142_E	0.604	0.56
220_V	225_Y	0.603	0.56
319_V	327_Q	0.603	0.56
43_A	139_P	0.601	0.56
218_G	221_K	0.601	0.56
196_K	199_Q	0.601	0.56
225_Y	247_L	0.600	0.56
279_V	283_Q	0.599	0.56
153_Y	232_V	0.598	0.55
102_Q	218_G	0.598	0.55
172_L	175_S	0.597	0.55
307_D	313_V	0.591	0.55
111_L	122_A	0.589	0.54
269_K	291_G	0.589	0.54
73_N	182_G	0.588	0.54
66_F	76_S	0.587	0.54
320_E	333_Q	0.585	0.54
268_N	292_I	0.584	0.54
48_G	51_T	0.584	0.54
46_T	55_I	0.584	0.54
85_N	106_G	0.583	0.54
135_T	187_I	0.583	0.54
279_V	284_D	0.583	0.54
169_N	202_V	0.579	0.53
29_P	33_G	0.575	0.53
48_G	140_T	0.575	0.53
64_E	202_V	0.574	0.52
328_L	331_I	0.573	0.52
206_A	210_V	0.572	0.52
255_F	260_V	0.571	0.52
112_Y	172_L	0.571	0.52
94_L	274_L	0.571	0.52
168_Y	200_K	0.571	0.52
114_A	140_T	0.568	0.52
32_L	189_D	0.567	0.52
95_D	98_N	0.567	0.52
306_L	312_Q	0.566	0.51
118_A	139_P	0.564	0.51
315_A	333_Q	0.563	0.51
224_N	228_T	0.563	0.51
51_T	319_V	0.560	0.51
102_Q	120_S	0.559	0.51
50_M	80_F	0.559	0.51
84_V	112_Y	0.558	0.50
187_I	192_E	0.558	0.50
132_L	201_A	0.557	0.50
35_A	201_A	0.556	0.50
54_K	165_G	0.556	0.50
34_S	51_T	0.554	0.50
214_I	217_E	0.554	0.50
77_F	181_G	0.552	0.50
50_M	197_L	0.550	0.49
205_I	260_V	0.548	0.49
257_T	276_V	0.548	0.49
55_I	111_L	0.547	0.49
254_N	259_K	0.546	0.49
257_T	264_D	0.545	0.49
123_K	127_M	0.543	0.49
39_H	122_A	0.541	0.48
146_G	175_S	0.541	0.48
212_V	241_I	0.541	0.48
284_D	289_V	0.540	0.48
158_Q	161_S	0.537	0.48
160_Y	168_Y	0.534	0.47
139_P	167_D	0.533	0.47
321_A	332_A	0.532	0.47
146_G	152_P	0.532	0.47
62_A	148_Y	0.531	0.47
139_P	168_Y	0.530	0.47
93_P	97_T	0.530	0.47
48_G	105_A	0.530	0.47
85_N	112_Y	0.529	0.47
193_I	200_K	0.529	0.47
110_A	199_Q	0.528	0.47
132_L	161_S	0.527	0.47
296_V	309_Y	0.525	0.46
33_G	289_V	0.524	0.46
42_V	132_L	0.522	0.46
252_E	315_A	0.522	0.46
31_K	281_K	0.520	0.46
38_F	199_Q	0.519	0.46
66_F	191_N	0.519	0.46
324_T	330_E	0.519	0.46
303_Y	308_K	0.519	0.46
327_Q	333_Q	0.518	0.45
208_K	234_G	0.518	0.45
91_V	104_T	0.516	0.45
315_A	324_T	0.515	0.45
290_S	294_N	0.515	0.45
86_V	90_F	0.514	0.45
327_Q	331_I	0.513	0.45
310_A	322_T	0.513	0.45
305_L	309_Y	0.512	0.45
49_S	163_G	0.512	0.45
142_E	171_Q	0.511	0.45
185_Y	194_P	0.510	0.44
32_L	173_L	0.509	0.44
59_K	104_T	0.508	0.44
76_S	122_A	0.507	0.44
291_G	295_D	0.506	0.44
37_G	251_Y	0.505	0.44
160_Y	183_V	0.505	0.44
63_I	128_P	0.505	0.44
287_T	293_N	0.503	0.44
23_F	26_L	0.502	0.43
117_T	121_L	0.502	0.43
73_N	186_H	0.502	0.43
94_L	102_Q	0.502	0.43
253_G	279_V	0.501	0.43
319_V	322_T	0.501	0.43
161_S	169_N	0.501	0.43
233_N	242_F	0.500	0.43

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4fx5A	1	0.9684	100	0.447	Contact Map
3txaA	1	0.7395	100	0.552	Contact Map
1q0pA	1	0.4079	100	0.576	Contact Map
1pt6A	1	0.4526	100	0.579	Contact Map
1mf7A	1	0.4658	100	0.58	Contact Map
1ijbA	1	0.4921	100	0.582	Contact Map
1n3yA	1	0.4526	100	0.582	Contact Map
1v7pC	1	0.4447	100	0.586	Contact Map
2b2xA	1	0.4395	100	0.586	Contact Map
4bj3A	1	0.4184	100	0.587	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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