GREMLIN Database
AUBA - RNA-binding protein AU-1
UniProt: Q97Z43 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 424 (404)
Sequences: 105 (74)
Seq/√Len: 3.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
322_E351_K4.1340.83
157_M320_K3.5400.71
135_A187_L3.3090.66
158_R163_S3.2430.64
273_I331_Y3.2190.63
16_T33_I3.2070.63
190_D194_L3.2060.63
284_Y368_I3.1740.62
316_G350_L3.0400.58
157_M163_S2.8930.54
247_E250_S2.8640.54
291_I328_I2.8510.53
16_T37_F2.8090.52
157_M160_L2.7090.49
158_R161_T2.6480.48
40_E292_E2.6110.47
160_L163_S2.5830.46
386_L389_E2.5800.46
135_A173_V2.4880.43
135_A194_L2.4590.42
102_N261_K2.3790.40
33_I37_F2.2890.38
142_G316_G2.2850.38
182_V375_I2.2800.38
29_Q82_W2.2340.36
184_L316_G2.1970.36
127_E144_T2.1440.34
157_M161_T2.1400.34
310_G368_I2.1350.34
386_L412_N2.1250.34
50_I61_I2.1140.33
250_S273_I2.0010.31
389_E408_K1.9780.30
344_S347_D1.9520.30
77_K183_A1.9500.29
386_L393_N1.9490.29
226_V357_I1.9220.29
158_R164_L1.9100.29
187_L343_Y1.9030.28
344_S351_K1.8800.28
17_S40_E1.8690.28
344_S349_S1.8550.27
228_K294_E1.8540.27
49_T177_S1.8480.27
38_M409_E1.8430.27
129_K140_G1.8120.26
54_E393_N1.7970.26
317_I378_A1.7910.26
226_V229_N1.7840.26
4_R414_L1.7840.26
272_K284_Y1.7610.25
59_K215_L1.7350.25
157_M164_L1.7230.25
256_K292_E1.7150.24
40_E187_L1.6790.24
256_K302_I1.6760.24
309_E321_I1.6520.23
155_E158_R1.6410.23
302_I389_E1.6310.23
19_F189_E1.6060.22
17_S21_S1.5930.22
283_I311_N1.5820.22
65_N357_I1.5790.22
103_F375_I1.5700.21
11_Y359_T1.5630.21
275_H362_E1.5520.21
341_K350_L1.5370.21
125_L302_I1.5330.21
49_T176_R1.5200.21
19_F91_V1.5130.20
62_V207_G1.4990.20
66_G194_L1.4890.20
158_R162_L1.4870.20
366_G400_P1.4800.20
160_L164_L1.4760.20
20_S50_I1.4660.20
124_I292_E1.4540.19
160_L320_K1.4520.19
28_Q48_I1.4520.19
155_E162_L1.4300.19
135_A172_N1.4260.19
7_I107_P1.4250.19
31_V50_I1.4240.19
20_S39_Q1.4080.19
44_L183_A1.4030.19
49_T54_E1.4020.19
28_Q172_N1.3990.18
4_R135_A1.3900.18
75_V147_S1.3850.18
161_T164_L1.3840.18
18_I80_F1.3840.18
135_A386_L1.3700.18
6_R175_W1.3570.18
74_N256_K1.3540.18
225_E267_I1.3500.18
4_R129_K1.3440.18
75_V357_I1.3390.17
301_R367_K1.3390.17
213_I301_R1.3190.17
117_P413_Y1.3180.17
178_N260_G1.3170.17
252_E360_P1.3140.17
316_G398_Y1.3080.17
248_V369_R1.3040.17
10_I13_T1.3020.17
5_V64_G1.2720.16
209_D302_I1.2680.16
113_I377_I1.2570.16
166_L351_K1.2510.16
386_L390_D1.2480.16
407_A411_V1.2440.16
94_I412_N1.2410.16
370_Y376_D1.2390.16
376_D388_D1.2390.16
352_G376_D1.2390.16
315_D356_N1.2390.16
370_Y388_D1.2390.16
356_N376_D1.2390.16
342_Y352_G1.2390.16
352_G356_N1.2390.16
356_N370_Y1.2390.16
352_G370_Y1.2390.16
342_Y370_Y1.2390.16
342_Y376_D1.2390.16
315_D376_D1.2390.16
315_D370_Y1.2390.16
342_Y356_N1.2390.16
315_D388_D1.2390.16
356_N388_D1.2390.16
342_Y388_D1.2390.16
315_D342_Y1.2390.16
352_G388_D1.2390.16
315_D352_G1.2390.16
262_L316_G1.2330.16
45_S258_S1.2310.16
173_V194_L1.2280.16
49_T149_H1.2250.16
126_S187_L1.2240.16
7_I146_F1.2210.16
188_K357_I1.2170.16
386_L408_K1.2140.16
174_K210_F1.2130.16
322_E344_S1.2080.15
223_L362_E1.2040.15
210_F330_E1.1980.15
377_I384_I1.1930.15
215_L236_Y1.1900.15
106_E386_L1.1900.15
286_R329_V1.1880.15
155_E328_I1.1760.15
26_I409_E1.1690.15
86_V151_V1.1690.15
97_S170_G1.1660.15
9_G237_H1.1580.15
19_F357_I1.1580.15
24_Y95_D1.1540.15
392_L407_A1.1510.15
15_L267_I1.1490.15
173_V208_E1.1460.15
94_I156_K1.1440.15
148_E159_L1.1420.15
248_V336_W1.1410.15
363_L412_N1.1360.14
93_E207_G1.1360.14
9_G14_A1.1300.14
52_D150_I1.1270.14
159_L163_S1.1240.14
34_S385_A1.1220.14
391_E394_K1.1200.14
115_I382_S1.1150.14
336_W386_L1.1080.14
78_Y242_L1.1070.14
29_Q197_R1.1060.14
272_K287_G1.1010.14
152_D159_L1.1010.14
103_F182_V1.1000.14
80_F406_K1.0970.14
152_D156_K1.0960.14
169_K257_G1.0940.14
190_D220_K1.0920.14
158_R304_L1.0890.14
8_R14_A1.0870.14
248_V314_L1.0860.14
63_M137_V1.0850.14
325_D360_P1.0830.14
313_I415_I1.0830.14
79_S288_G1.0820.14
151_V199_E1.0800.14
283_I323_E1.0760.14
28_Q46_A1.0750.14
6_R147_S1.0670.14
236_Y327_D1.0590.13
152_D328_I1.0520.13
201_R414_L1.0520.13
194_L343_Y1.0400.13
26_I357_I1.0370.13
218_P371_L1.0310.13
92_I174_K1.0260.13
23_S319_K1.0220.13
235_K305_R1.0180.13
326_Y357_I1.0170.13
50_I126_S1.0160.13
91_V375_I1.0080.13
283_I344_S1.0050.13
132_S378_A1.0030.13
85_P152_D1.0010.13
28_Q330_E0.9990.13
21_S196_L0.9980.13
70_D203_F0.9970.13
99_T386_L0.9960.13
20_S46_A0.9960.13
79_S219_D0.9960.13
44_L195_I0.9930.13
94_I106_E0.9930.13
12_A258_S0.9900.13
90_S308_F0.9850.12
185_N393_N0.9810.12
192_E363_L0.9800.12
51_K54_E0.9780.12
7_I15_L0.9770.12
126_S341_K0.9760.12
20_S139_R0.9740.12
291_I304_L0.9670.12
100_Y386_L0.9640.12
18_I55_D0.9610.12
13_T315_D0.9590.12
13_T352_G0.9590.12
13_T342_Y0.9590.12
13_T376_D0.9590.12
13_T356_N0.9590.12
13_T388_D0.9590.12
13_T370_Y0.9590.12
36_R237_H0.9580.12
114_V117_P0.9550.12
256_K308_F0.9540.12
138_W380_R0.9540.12
320_K378_A0.9460.12
82_W197_R0.9450.12
73_R160_L0.9450.12
147_S363_L0.9440.12
157_M162_L0.9430.12
73_R386_L0.9410.12
252_E325_D0.9380.12
207_G232_D0.9370.12
48_I70_D0.9360.12
304_L328_I0.9360.12
242_L329_V0.9210.12
225_E349_S0.9210.12
46_A184_L0.9150.12
4_R117_P0.9120.12
85_P368_I0.9110.12
202_E258_S0.9100.12
242_L327_D0.9090.12
70_D368_I0.9080.12
11_Y16_T0.9060.12
317_I321_I0.9020.12
35_E124_I0.9000.11
236_Y334_D0.8990.11
124_I139_R0.8990.11
88_L210_F0.8980.11
19_F159_L0.8980.11
50_I289_K0.8980.11
73_R208_E0.8960.11
24_Y414_L0.8960.11
113_I117_P0.8930.11
199_E414_L0.8890.11
173_V192_E0.8880.11
94_I100_Y0.8880.11
22_L319_K0.8840.11
24_Y368_I0.8810.11
7_I158_R0.8780.11
164_L167_N0.8750.11
47_D105_V0.8750.11
82_W318_G0.8730.11
157_M414_L0.8720.11
78_Y215_L0.8710.11
81_H412_N0.8700.11
7_I328_I0.8700.11
328_I341_K0.8670.11
50_I283_I0.8640.11
11_Y325_D0.8620.11
51_K159_L0.8600.11
92_I137_V0.8600.11
92_I302_I0.8590.11
128_T243_S0.8590.11
177_S326_Y0.8560.11
81_H201_R0.8500.11
39_Q153_E0.8500.11
9_G13_T0.8490.11
47_D61_I0.8490.11
189_E258_S0.8490.11
46_A142_G0.8480.11
24_Y302_I0.8440.11
165_P183_A0.8440.11
20_S88_L0.8410.11
333_S365_R0.8390.11
271_L368_I0.8390.11
38_M302_I0.8380.11
147_S321_I0.8360.11
94_I393_N0.8350.11
118_P362_E0.8340.11
120_D192_E0.8330.11
59_K63_M0.8330.11
179_A380_R0.8330.11
252_E285_L0.8320.11
349_S383_E0.8320.11
142_G172_N0.8260.11
312_G354_Y0.8250.11
4_R140_G0.8230.11
4_R142_G0.8220.11
111_E152_D0.8210.11
25_E60_I0.8200.11
51_K208_E0.8190.11
308_F316_G0.8190.11
197_R245_N0.8170.11
171_Y379_I0.8160.11
104_K309_E0.8160.11
63_M382_S0.8160.11
8_R13_T0.8150.11
36_R342_Y0.8140.11
36_R376_D0.8140.11
36_R388_D0.8140.11
36_R370_Y0.8140.11
36_R356_N0.8140.11
36_R352_G0.8140.11
36_R315_D0.8140.11
320_K379_I0.8120.11
31_V100_Y0.8110.11
7_I142_G0.8110.11
16_T32_E0.8090.10
74_N254_D0.8090.10
50_I368_I0.8060.10
223_L230_V0.8050.10
169_K402_S0.8020.10
132_S229_N0.8020.10
246_R296_N0.8000.10
279_D336_W0.7940.10
348_N371_L0.7940.10
135_A159_L0.7930.10
63_M215_L0.7920.10
248_V381_D0.7920.10
139_R282_V0.7910.10
24_Y284_Y0.7870.10
38_M84_S0.7870.10
213_I416_N0.7850.10
44_L328_I0.7840.10
94_I386_L0.7830.10
42_N399_M0.7810.10
34_S154_E0.7730.10
359_T392_L0.7700.10
59_K91_V0.7700.10
61_I129_K0.7670.10
165_P386_L0.7650.10
185_N386_L0.7640.10
237_H280_G0.7620.10
83_R107_P0.7620.10
78_Y327_D0.7610.10
190_D400_P0.7600.10
314_L325_D0.7590.10
132_S173_V0.7580.10
271_L304_L0.7570.10
47_D402_S0.7560.10
40_E193_R0.7550.10
82_W285_L0.7550.10
331_Y355_I0.7540.10
80_F400_P0.7540.10
120_D304_L0.7540.10
20_S23_S0.7530.10
406_K413_Y0.7510.10
124_I154_E0.7510.10
275_H388_D0.7510.10
275_H376_D0.7510.10
275_H370_Y0.7510.10
275_H352_G0.7510.10
275_H342_Y0.7510.10
275_H315_D0.7510.10
275_H356_N0.7510.10
142_G398_Y0.7490.10
337_Y365_R0.7490.10
58_G236_Y0.7490.10
131_V350_L0.7470.10
385_A415_I0.7460.10
120_D398_Y0.7440.10
7_I307_E0.7410.10
286_R327_D0.7400.10
125_L389_E0.7400.10
138_W350_L0.7390.10
136_I406_K0.7380.10
164_L304_L0.7370.10
313_I316_G0.7350.10
258_S367_K0.7340.10
326_Y367_K0.7320.10
28_Q147_S0.7320.10
78_Y236_Y0.7310.10
5_V347_D0.7300.10
6_R306_R0.7300.10
20_S399_M0.7290.10
250_S331_Y0.7280.10
48_I222_Y0.7270.10
61_I399_M0.7270.10
84_S132_S0.7210.10
164_L317_I0.7200.10
177_S207_G0.7200.10
195_I199_E0.7200.10
31_V165_P0.7190.10
98_C400_P0.7190.10
84_S260_G0.7180.10
308_F327_D0.7140.10
82_W245_N0.7130.10
188_K226_V0.7130.10
50_I406_K0.7120.10
172_N414_L0.7120.10
353_V387_L0.7120.10
163_S177_S0.7100.10
83_R207_G0.7100.10
135_A341_K0.7080.09
181_Y279_D0.7070.09
104_K154_E0.7020.09
166_L240_L0.7020.09
163_S320_K0.7010.09
92_I207_G0.6990.09
127_E401_S0.6950.09
329_V336_W0.6950.09
29_Q206_Q0.6930.09
100_Y393_N0.6910.09
84_S229_N0.6890.09
71_D156_K0.6870.09
187_L393_N0.6870.09
226_V326_Y0.6860.09
331_Y402_S0.6860.09
111_E187_L0.6850.09
171_Y371_L0.6840.09
343_Y415_I0.6820.09
386_L415_I0.6820.09
11_Y62_V0.6820.09
180_K363_L0.6810.09
267_I310_G0.6810.09
230_V414_L0.6790.09
270_F416_N0.6790.09
202_E393_N0.6770.09
9_G36_R0.6760.09
51_K177_S0.6760.09
30_S397_I0.6740.09
225_E390_D0.6740.09
101_A271_L0.6730.09
17_S42_N0.6730.09
344_S409_E0.6700.09
28_Q261_K0.6700.09
194_L414_L0.6660.09
122_K152_D0.6600.09
241_K325_D0.6560.09
4_R26_I0.6550.09
35_E189_E0.6530.09
61_I305_R0.6530.09
288_G291_I0.6520.09
156_K161_T0.6510.09
125_L152_D0.6510.09
185_N319_K0.6490.09
202_E412_N0.6450.09
126_S135_A0.6450.09
233_T238_H0.6440.09
224_D227_R0.6440.09
224_D233_T0.6440.09
227_R372_D0.6440.09
224_D238_H0.6440.09
224_D372_D0.6440.09
227_R233_T0.6440.09
238_H372_D0.6440.09
233_T372_D0.6440.09
227_R238_H0.6440.09
183_A414_L0.6430.09
102_N309_E0.6410.09
175_W241_K0.6410.09
116_K125_L0.6410.09
234_V311_N0.6400.09
120_D271_L0.6390.09
222_Y320_K0.6380.09
361_P371_L0.6370.09
58_G215_L0.6360.09
152_D412_N0.6330.09
327_D364_L0.6320.09
158_R378_A0.6310.09
190_D207_G0.6300.09
39_Q321_I0.6290.09
159_L173_V0.6260.09
94_I408_K0.6240.09
135_A142_G0.6230.09
226_V257_G0.6200.09
20_S414_L0.6200.09
194_L366_G0.6180.09
21_S115_I0.6160.09
125_L202_E0.6130.09
49_T355_I0.6130.09
69_E379_I0.6120.09
15_L151_V0.6110.09
141_K170_G0.6100.09
353_V382_S0.6060.09
44_L310_G0.6060.09
296_N367_K0.6060.09
120_D383_E0.6050.09
121_G226_V0.6040.09
44_L124_I0.6030.09
188_K254_D0.6030.09
245_N411_V0.6020.09
51_K176_R0.6020.09
6_R400_P0.6000.08
61_I396_S0.6000.08
278_A334_D0.5990.08
39_Q85_P0.5980.08
28_Q42_N0.5970.08
185_N341_K0.5960.08
129_K147_S0.5940.08
96_E403_L0.5930.08
140_G152_D0.5930.08
218_P384_I0.5910.08
63_M171_Y0.5910.08
50_I60_I0.5910.08
166_L180_K0.5900.08
159_L417_R0.5880.08
15_L378_A0.5870.08
257_G261_K0.5860.08
56_D168_R0.5850.08
132_S357_I0.5830.08
111_E232_D0.5820.08
29_Q34_S0.5800.08
28_Q47_D0.5800.08
167_N198_Y0.5800.08
26_I226_V0.5780.08
207_G251_L0.5760.08
88_L247_E0.5760.08
84_S366_G0.5760.08
118_P285_L0.5740.08
5_V378_A0.5730.08
5_V302_I0.5720.08
159_L316_G0.5710.08
305_R399_M0.5710.08
17_S102_N0.5710.08
213_I355_I0.5700.08
75_V129_K0.5690.08
68_I124_I0.5690.08
7_I185_N0.5680.08
138_W165_P0.5670.08
215_L242_L0.5650.08
144_T413_Y0.5640.08
69_E211_Y0.5620.08
30_S325_D0.5620.08
5_V128_T0.5620.08
78_Y258_S0.5610.08
80_F397_I0.5610.08
142_G266_L0.5610.08
130_A247_E0.5590.08
204_R390_D0.5590.08
160_L378_A0.5590.08
151_V399_M0.5580.08
171_Y216_S0.5560.08
225_E331_Y0.5560.08
393_N412_N0.5560.08
191_L216_S0.5550.08
18_I147_S0.5520.08
23_S344_S0.5510.08
162_L243_S0.5500.08
147_S414_L0.5470.08
161_T378_A0.5460.08
29_Q339_I0.5430.08
381_D401_S0.5420.08
11_Y290_V0.5420.08
186_E319_K0.5420.08
26_I47_D0.5410.08
106_E413_Y0.5390.08
99_T321_I0.5390.08
124_I203_F0.5380.08
7_I201_R0.5380.08
46_A95_D0.5380.08
49_T140_G0.5370.08
73_R125_L0.5360.08
292_E402_S0.5350.08
192_E225_E0.5310.08
47_D156_K0.5300.08
166_L197_R0.5280.08
125_L401_S0.5250.08
13_T36_R0.5240.08
19_F234_V0.5240.08
182_V391_E0.5220.08
183_A328_I0.5220.08
4_R261_K0.5210.08
127_E368_I0.5200.08
104_K307_E0.5170.08
43_N368_I0.5170.08
132_S182_V0.5150.08
203_F226_V0.5150.08
80_F390_D0.5140.08
65_N188_K0.5140.08
51_K304_L0.5140.08
97_S386_L0.5100.08
130_A144_T0.5080.08
39_Q152_D0.5060.08
15_L307_E0.5060.08
177_S204_R0.5050.08
45_S341_K0.5040.08
139_R197_R0.5030.08
19_F130_A0.5030.08
341_K353_V0.5030.08
100_Y132_S0.5030.08
116_K401_S0.5010.08
122_K416_N0.5000.08
249_D406_K0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3exmA 1 0.375 100 0.824 Contact Map
2p12A 2 0.3467 99.7 0.896 Contact Map
4oxpA 1 0.316 99.3 0.921 Contact Map
2bx2L 3 0.7453 98.9 0.932 Contact Map
3cw2C 1 0.5283 58.2 0.977 Contact Map
2r5xA 1 0.25 24.3 0.982 Contact Map
4wesA 1 0.2783 21.1 0.982 Contact Map
1v6fA 1 0.1203 17.2 0.983 Contact Map
3u7qA 1 0.25 13.7 0.984 Contact Map
3gqsA 1 0.2217 11.2 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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