GREMLIN Database
Q97Z42 - Aconitate hydratase
UniProt: Q97Z42 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 855 (836)
Sequences: 2110 (838)
Seq/√Len: 29.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
542_F548_P5.4341.00
276_F347_I5.2481.00
631_L712_V4.9771.00
307_I329_A4.9651.00
266_K346_D4.8081.00
453_L457_E4.6431.00
419_K455_Y4.5591.00
747_T773_V4.4381.00
703_H722_E4.4341.00
703_H706_D4.4211.00
444_A466_F4.4131.00
241_R349_E4.1471.00
310_V313_S4.0821.00
316_E322_G4.0801.00
246_I255_V3.9731.00
543_D547_K3.8741.00
419_K423_E3.7261.00
732_K758_E3.6801.00
326_K330_Q3.6721.00
457_E462_H3.6171.00
808_I822_G3.5221.00
247_Q250_V3.4911.00
422_V455_Y3.4261.00
437_A469_T3.4171.00
484_E488_E3.3991.00
420_K560_E3.3461.00
212_L302_A3.3381.00
812_K818_I3.2981.00
75_V168_I3.1441.00
676_H680_L3.1031.00
359_I374_V2.9761.00
626_N793_N2.9431.00
262_L348_V2.9301.00
806_L822_G2.9131.00
424_M543_D2.8951.00
420_K423_E2.8951.00
629_I792_V2.8921.00
124_Y479_P2.8901.00
191_A324_F2.8871.00
808_I820_T2.8361.00
238_I346_D2.8301.00
423_E455_Y2.7971.00
112_D159_R2.7811.00
810_F820_T2.7501.00
136_K139_E2.7411.00
779_P805_E2.6861.00
733_Q736_S2.6801.00
483_E510_L2.6781.00
703_H718_Q2.6621.00
455_Y458_A2.6541.00
97_Q609_L2.6471.00
696_K709_I2.5900.99
356_E372_R2.5770.99
21_E28_S2.5710.99
494_Y531_I2.5540.99
793_N811_V2.5530.99
730_A757_A2.5350.99
52_E56_E2.4810.99
262_L350_V2.4650.99
238_I345_S2.4580.99
351_D354_K2.4160.99
281_S336_Y2.4000.99
754_A794_I2.3900.99
534_D537_N2.3830.99
530_R533_I2.3800.99
146_Q601_D2.3560.99
93_E609_L2.3510.99
238_I266_K2.3510.99
123_Y132_F2.3240.99
374_V531_I2.2950.99
701_T715_V2.2860.99
625_T793_N2.2830.99
134_M164_G2.2750.99
121_V435_S2.2690.99
21_E26_K2.2650.99
805_E821_K2.2520.98
692_L782_R2.2480.98
422_V458_A2.2420.98
377_K515_F2.2380.98
708_K718_Q2.2290.98
623_D796_G2.2210.98
261_E265_K2.2080.98
370_S373_E2.1750.98
710_A715_V2.1490.98
437_A464_V2.1410.98
177_S206_I2.1390.98
713_Y717_M2.1330.98
608_R677_E2.1310.98
132_F135_K2.1290.98
298_Y303_A2.1240.98
29_D343_R2.1180.98
177_S211_I2.1070.98
810_F818_I2.1000.98
487_K510_L2.0960.98
559_K563_A2.0890.97
633_L689_M2.0870.97
281_S338_D2.0730.97
138_F584_N2.0700.97
261_E368_R2.0680.97
632_L692_L2.0600.97
398_A469_T2.0520.97
356_E370_S2.0480.97
359_I517_A2.0360.97
837_K846_E2.0110.97
413_G520_I2.0090.97
165_K580_I2.0070.97
727_V792_V1.9870.97
374_V525_Y1.9790.96
706_D718_Q1.9750.96
130_L463_L1.9720.96
695_E700_Y1.9590.96
795_K809_E1.9510.96
295_A298_Y1.9440.96
413_G561_I1.9410.96
624_I627_A1.9340.96
807_T819_T1.9300.96
373_E376_G1.9280.96
629_I632_L1.9230.96
295_A303_A1.9060.96
669_Y685_F1.8990.96
180_V191_A1.8980.96
579_N582_E1.8970.96
793_N809_E1.8970.96
153_G594_Q1.8920.95
240_V262_L1.8910.95
562_K565_V1.8820.95
648_I652_S1.8320.95
285_V310_V1.8200.94
411_M436_T1.8140.94
464_V469_T1.8080.94
8_K323_E1.8020.94
309_D313_S1.8010.94
19_E22_E1.7870.94
668_T671_A1.7850.94
417_L524_A1.7840.94
710_A718_Q1.7800.94
683_G746_V1.7760.94
417_L420_K1.7660.93
420_K424_M1.7630.93
649_T655_G1.7620.93
729_V792_V1.7550.93
448_K453_L1.7500.93
609_L614_S1.7420.93
14_Y331_L1.7400.93
258_Y358_A1.7390.93
241_R341_K1.7290.93
472_I645_A1.7140.92
585_E589_S1.7120.92
128_Y132_F1.7060.92
694_V702_V1.7010.92
375_K538_E1.6920.92
350_V354_K1.6920.92
53_E56_E1.6760.91
300_A303_A1.6760.91
789_D813_S1.6750.91
412_L564_Y1.6730.91
130_L134_M1.6710.91
358_A368_R1.6700.91
182_K191_A1.6650.91
241_R276_F1.6620.91
718_Q722_E1.6560.91
807_T821_K1.6540.91
149_K592_T1.6500.91
628_R724_V1.6490.91
710_A714_E1.6450.91
366_D636_K1.6450.91
809_E819_T1.6440.91
61_W345_S1.6430.91
364_N367_E1.6420.91
690_K697_E1.6390.90
787_K812_K1.6310.90
95_M100_R1.6210.90
582_E588_N1.6200.90
706_D722_E1.6120.90
424_M549_V1.6000.89
677_E680_L1.5960.89
774_I835_V1.5900.89
45_L55_L1.5900.89
106_N157_N1.5880.89
15_Y190_T1.5870.89
112_D178_T1.5850.89
454_P457_E1.5830.89
680_L717_M1.5740.89
826_I835_V1.5710.89
350_V355_I1.5710.89
584_N588_N1.5690.88
309_D326_K1.5670.88
729_V810_F1.5530.88
248_E558_L1.5520.88
424_M547_K1.5390.87
417_L424_M1.5370.87
236_E346_D1.5340.87
703_H710_A1.5330.87
56_E60_K1.5280.87
718_Q721_K1.5270.87
241_R278_P1.5200.87
304_Y307_I1.5150.87
178_T181_A1.5120.86
77_Q670_G1.5060.86
397_A461_F1.4920.86
147_F151_A1.4880.86
696_K700_Y1.4820.85
542_F546_G1.4820.85
652_S669_Y1.4810.85
486_I508_N1.4770.85
703_H724_V1.4700.85
131_E135_K1.4690.85
121_V398_A1.4550.84
777_Q823_V1.4520.84
295_A300_A1.4510.84
729_V778_I1.4390.84
563_A567_M1.4340.83
445_E448_K1.4330.83
375_K534_D1.4330.83
486_I493_T1.4320.83
445_E576_R1.4320.83
379_S532_D1.4180.83
449_E570_K1.3930.82
812_K816_E1.3900.81
41_V55_L1.3890.81
394_V496_V1.3880.81
492_E513_G1.3830.81
702_V789_D1.3830.81
837_K843_Y1.3830.81
590_L593_P1.3790.81
569_L574_Y1.3790.81
280_L336_Y1.3770.81
461_F526_A1.3740.81
420_K557_S1.3710.80
490_G512_K1.3660.80
694_V709_I1.3640.80
756_L822_G1.3580.80
122_D140_R1.3520.80
656_L660_Q1.3450.79
179_V315_L1.3420.79
329_A335_F1.3360.79
367_E636_K1.3310.78
393_A532_D1.3180.78
103_K596_D1.3100.77
623_D795_K1.3090.77
366_D736_S1.3080.77
701_T712_V1.3070.77
14_Y191_A1.3040.77
628_R791_T1.3030.77
121_V464_V1.3020.77
811_V817_K1.3000.77
142_L146_Q1.2970.77
397_A526_A1.2830.76
450_T564_Y1.2830.76
422_V454_P1.2780.76
805_E823_V1.2750.75
633_L712_V1.2740.75
378_L515_F1.2740.75
419_K422_V1.2660.75
97_Q615_E1.2660.75
623_D798_K1.2650.75
779_P821_K1.2650.75
728_I752_V1.2640.75
292_A303_A1.2630.75
93_E597_I1.2600.74
483_E487_K1.2590.74
809_E817_K1.2520.74
381_E515_F1.2520.74
411_M495_A1.2520.74
327_K331_L1.2430.73
736_S747_T1.2420.73
632_L693_L1.2420.73
286_P317_L1.2360.73
32_Y344_Y1.2340.73
485_D489_N1.2330.73
417_L557_S1.2320.73
630_L752_V1.2290.73
453_L463_L1.2240.72
525_Y530_R1.2210.72
395_V511_L1.2180.72
700_Y711_S1.2180.72
77_Q683_G1.2130.72
134_M138_F1.2130.72
632_L729_V1.2080.71
480_K484_E1.2050.71
247_Q356_E1.1980.71
632_L782_R1.1950.70
693_L704_F1.1940.70
450_T453_L1.1890.70
10_S323_E1.1790.69
833_M836_K1.1780.69
527_L554_I1.1770.69
716_A720_K1.1720.69
79_Y82_V1.1690.69
208_G292_A1.1680.69
777_Q825_R1.1680.69
236_E345_S1.1670.69
623_D797_I1.1650.68
530_R538_E1.1610.68
717_M720_K1.1590.68
826_I832_L1.1570.68
173_L289_A1.1570.68
656_L711_S1.1550.68
533_I538_E1.1530.68
245_E282_L1.1510.67
650_P655_G1.1450.67
292_A300_A1.1450.67
16_P332_Q1.1450.67
182_K324_F1.1390.67
359_I369_I1.1340.66
49_K70_M1.1310.66
629_I729_V1.1260.66
68_A231_Y1.1220.65
248_E559_K1.1200.65
544_P547_K1.1190.65
88_L155_F1.1170.65
12_I191_A1.1150.65
729_V756_L1.1120.65
159_R581_F1.1090.65
420_K554_I1.1040.64
609_L612_W1.1010.64
657_Y677_E1.0970.64
791_T811_V1.0960.64
275_F561_I1.0880.63
533_I539_P1.0820.63
756_L808_I1.0820.63
705_P710_A1.0820.63
527_L540_I1.0810.63
423_E454_P1.0800.62
428_V434_T1.0780.62
454_P458_A1.0760.62
232_L828_N1.0680.62
266_K347_I1.0670.61
204_T303_A1.0670.61
243_T349_E1.0660.61
369_I381_E1.0650.61
46_D50_I1.0630.61
422_V459_L1.0620.61
542_F547_K1.0620.61
316_E326_K1.0600.61
80_T472_I1.0590.61
694_V700_Y1.0590.61
131_E586_L1.0570.61
38_I55_L1.0570.61
123_Y126_T1.0550.61
572_E576_R1.0530.60
98_L846_E1.0490.60
44_N70_M1.0470.60
395_V493_T1.0460.60
79_Y683_G1.0460.60
649_T652_S1.0450.60
292_A295_A1.0410.60
315_L325_V1.0400.59
298_Y304_Y1.0390.59
650_P659_K1.0390.59
123_Y129_S1.0390.59
259_I350_V1.0380.59
80_T739_S1.0380.59
690_K695_E1.0340.59
173_L206_I1.0320.59
76_M84_L1.0300.59
656_L659_K1.0300.59
571_P575_K1.0290.59
76_M168_I1.0280.59
396_L511_L1.0270.58
785_G812_K1.0270.58
801_K804_K1.0250.58
633_L637_I1.0220.58
528_A533_I1.0200.58
619_E837_K1.0190.58
32_Y339_S1.0150.58
457_E463_L1.0110.57
375_K532_D1.0100.57
595_G599_S1.0090.57
378_L513_G0.9980.56
271_K346_D0.9970.56
79_Y670_G0.9970.56
706_D724_V0.9970.56
132_F136_K0.9960.56
292_A304_Y0.9960.56
359_I531_I0.9960.56
747_T750_L0.9950.56
428_V459_L0.9950.56
777_Q827_D0.9940.56
366_D668_T0.9910.56
412_L565_V0.9900.56
85_L158_L0.9890.56
90_A610_P0.9870.55
209_L285_V0.9840.55
256_V583_G0.9830.55
36_I209_L0.9810.55
17_L27_I0.9810.55
123_Y128_Y0.9800.55
616_E846_E0.9790.55
295_A736_S0.9790.55
711_S714_E0.9790.55
313_S316_E0.9750.55
135_K586_L0.9740.54
428_V431_Y0.9740.54
785_G810_F0.9720.54
387_K482_V0.9720.54
93_E97_Q0.9710.54
803_K823_V0.9690.54
41_V45_L0.9680.54
524_A551_L0.9630.54
74_V197_I0.9620.54
705_P718_Q0.9610.53
449_E573_L0.9610.53
80_T645_A0.9590.53
695_E709_I0.9590.53
121_V469_T0.9590.53
631_L689_M0.9570.53
240_V350_V0.9570.53
62_K65_E0.9560.53
40_N431_Y0.9560.53
602_E608_R0.9550.53
748_K753_K0.9540.53
238_I292_A0.9530.53
335_F431_Y0.9490.52
593_P599_S0.9480.52
585_E588_N0.9450.52
692_L729_V0.9440.52
565_V568_A0.9440.52
727_V747_T0.9390.52
16_P331_L0.9370.52
787_K813_S0.9330.51
13_Y190_T0.9320.51
374_V515_F0.9300.51
258_Y350_V0.9270.51
283_L287_D0.9250.51
102_P777_Q0.9230.50
794_I822_G0.9210.50
247_Q353_S0.9200.50
356_E373_E0.9180.50
95_M104_M0.9150.50
377_K381_E0.9150.50
138_F515_F0.9120.50
58_I234_V0.9120.50
612_W615_E0.9100.49
651_D655_G0.9100.49
212_L505_G0.9070.49
826_I831_E0.9060.49
419_K454_P0.9050.49
657_Y676_H0.9020.49
530_R535_F0.9010.49
105_I848_F0.8990.49
417_L551_L0.8990.49
139_E664_S0.8980.49
45_L52_E0.8960.48
427_R458_A0.8930.48
37_L71_P0.8920.48
40_N195_V0.8910.48
77_Q168_I0.8860.48
415_G436_T0.8810.47
794_I808_I0.8810.47
72_T181_A0.8800.47
758_E782_R0.8790.47
240_V347_I0.8760.47
41_V50_I0.8720.46
241_R347_I0.8700.46
608_R675_N0.8700.46
453_L462_H0.8700.46
428_V526_A0.8690.46
195_V302_A0.8690.46
307_I335_F0.8670.46
417_L539_P0.8640.46
727_V754_A0.8630.46
275_F303_A0.8620.46
727_V756_L0.8610.46
82_V472_I0.8610.46
369_I515_F0.8570.45
240_V355_I0.8550.45
69_F195_V0.8550.45
337_D340_R0.8540.45
146_Q591_K0.8530.45
684_F747_T0.8530.45
810_F822_G0.8530.45
800_L832_L0.8520.45
426_L541_G0.8520.45
689_M697_E0.8510.45
785_G820_T0.8500.45
159_R178_T0.8500.45
449_E568_A0.8480.45
258_Y261_E0.8460.44
40_N583_G0.8460.44
240_V275_F0.8460.44
628_R726_L0.8460.44
627_A725_P0.8420.44
138_F510_L0.8400.44
792_V808_I0.8400.44
797_I806_L0.8390.44
75_V130_L0.8380.44
57_N234_V0.8350.44
802_P832_L0.8350.44
206_I213_G0.8350.44
702_V709_I0.8340.44
689_M711_S0.8330.43
444_A453_L0.8320.43
375_K379_S0.8310.43
789_D812_K0.8310.43
266_K348_V0.8300.43
47_G51_T0.8300.43
536_Y552_R0.8290.43
450_T568_A0.8270.43
65_E236_E0.8270.43
204_T213_G0.8270.43
626_N791_T0.8260.43
147_F224_V0.8260.43
151_A256_V0.8260.43
240_V259_I0.8230.43
95_M848_F0.8220.43
50_I430_P0.8210.43
280_L305_F0.8190.42
423_E544_P0.8190.42
565_V569_L0.8180.42
126_T129_S0.8170.42
122_D136_K0.8160.42
458_A462_H0.8160.42
583_G588_N0.8150.42
382_K391_D0.8150.42
396_L475_A0.8140.42
246_I355_I0.8120.42
419_K458_A0.8120.42
417_L422_V0.8100.42
785_G818_I0.8100.42
79_Y645_A0.8100.42
35_R333_E0.8100.42
121_V465_G0.8090.42
417_L540_I0.8090.42
276_F451_G0.8070.41
80_T86_V0.8050.41
645_A739_S0.8040.41
608_R676_H0.8040.41
130_L165_K0.8030.41
46_D51_T0.8030.41
543_D549_V0.8030.41
538_E769_V0.8030.41
48_S833_M0.8020.41
689_M693_L0.8010.41
754_A822_G0.8010.41
197_I230_Y0.8000.41
181_A192_F0.8000.41
453_L531_I0.8000.41
85_L413_G0.7990.41
792_V810_F0.7980.41
832_L845_L0.7960.41
777_Q780_D0.7960.41
177_S292_A0.7930.40
701_T710_A0.7920.40
621_L797_I0.7920.40
632_L786_I0.7890.40
69_F75_V0.7850.40
212_L280_L0.7850.40
792_V820_T0.7830.40
20_L830_V0.7830.40
312_V335_F0.7830.40
14_Y18_K0.7830.40
562_K566_N0.7810.40
265_K647_P0.7810.40
238_I303_A0.7800.39
18_K21_E0.7780.39
394_V429_P0.7780.39
16_P20_L0.7780.39
750_L773_V0.7770.39
424_M544_P0.7770.39
395_V482_V0.7730.39
14_Y190_T0.7720.39
443_V446_Y0.7720.39
417_L454_P0.7710.39
492_E512_K0.7710.39
624_I725_P0.7700.39
212_L329_A0.7700.39
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507_I616_E0.5240.23
378_L732_K0.5240.23
147_F413_G0.5230.23
45_L431_Y0.5230.23
419_K549_V0.5220.23
98_L615_E0.5210.23
160_I311_T0.5210.23
379_S547_K0.5210.23
706_D710_A0.5210.23
760_F819_T0.5210.23
572_E579_N0.5210.23
255_V291_I0.5200.22
680_L689_M0.5200.22
505_G508_N0.5200.22
474_N645_A0.5200.22
729_V782_R0.5200.22
165_K581_F0.5190.22
610_P614_S0.5190.22
111_A225_L0.5190.22
77_Q82_V0.5190.22
9_G458_A0.5190.22
483_E513_G0.5180.22
619_E773_V0.5180.22
304_Y802_P0.5180.22
104_M817_K0.5180.22
256_V584_N0.5180.22
720_K753_K0.5180.22
130_L552_R0.5170.22
36_I309_D0.5170.22
103_K671_A0.5170.22
435_S470_T0.5170.22
36_I283_L0.5160.22
652_S703_H0.5160.22
23_K370_S0.5160.22
77_Q645_A0.5160.22
74_V148_L0.5160.22
309_D337_D0.5160.22
168_I260_T0.5160.22
733_Q770_A0.5150.22
67_L702_V0.5150.22
676_H720_K0.5150.22
91_M378_L0.5150.22
363_R694_V0.5150.22
540_I630_L0.5150.22
159_R212_L0.5140.22
655_G726_L0.5140.22
332_Q368_R0.5140.22
629_I791_T0.5130.22
482_V487_K0.5130.22
330_Q769_V0.5120.22
304_Y329_A0.5120.22
36_I545_N0.5120.22
89_A260_T0.5120.22
115_I550_Y0.5120.22
321_D823_V0.5120.22
96_I419_K0.5110.22
97_Q533_I0.5110.22
464_V475_A0.5110.22
570_K573_L0.5110.22
111_A508_N0.5110.22
705_P722_E0.5100.22
242_L275_F0.5100.22
165_K469_T0.5100.22
256_V429_P0.5100.22
684_F728_I0.5090.22
524_A554_I0.5090.22
647_P728_I0.5090.22
285_V313_S0.5090.22
530_R557_S0.5090.22
523_V554_I0.5080.22
465_G505_G0.5080.22
231_Y286_P0.5080.22
651_D700_Y0.5080.22
91_M181_A0.5070.22
309_D312_V0.5070.22
195_V469_T0.5070.22
824_A832_L0.5070.22
18_K22_E0.5070.22
13_Y849_L0.5070.22
282_L386_G0.5070.22
197_I409_T0.5070.22
411_M601_D0.5060.22
79_Y472_I0.5060.22
111_A513_G0.5060.22
225_L275_F0.5060.22
398_A508_N0.5050.22
826_I830_V0.5050.22
411_M415_G0.5050.22
661_F756_L0.5050.22
67_L284_S0.5040.22
370_S690_K0.5040.22
342_I505_G0.5040.22
347_I450_T0.5040.22
84_L100_R0.5040.22
91_M732_K0.5030.22
211_I312_V0.5030.22
584_N676_H0.5030.22
538_E748_K0.5030.22
525_Y824_A0.5030.22
789_D792_V0.5020.21
243_T353_S0.5020.21
284_S561_I0.5020.21
396_L437_A0.5020.21
50_I69_F0.5020.21
303_A411_M0.5020.21
100_R381_E0.5010.21
54_D232_L0.5010.21
60_K547_K0.5010.21
118_S472_I0.5000.21
312_V321_D0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2b3yA 1 0.9825 100 0.272 Contact Map
1c96A 1 0.8596 100 0.475 Contact Map
4kp2A 2 0.4877 100 0.686 Contact Map
4kp1A 1 0.4865 100 0.696 Contact Map
1l5jA 1 0.5778 100 0.721 Contact Map
3vbaA 2 0.1977 100 0.906 Contact Map
2pkpA 2 0.1953 100 0.906 Contact Map
1v7lA 6 0.1906 100 0.91 Contact Map
2hcuA 1 0.2012 100 0.916 Contact Map
3q3wA 1 0.2035 100 0.918 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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