GREMLIN Database
GCSH3 - Probable glycine cleavage system H protein 3
UniProt: Q97Z34 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 140 (122)
Sequences: 3741 (2336)
Seq/√Len: 211.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
123_P126_E4.1621.00
82_E110_R3.5001.00
63_L107_V3.0881.00
31_S108_K2.9051.00
85_D108_K2.7371.00
100_R103_D2.6321.00
36_D39_Q2.1971.00
24_I30_V2.0211.00
30_V111_V2.0121.00
29_V108_K1.9861.00
56_K112_E1.9501.00
56_K82_E1.9001.00
122_K130_Q1.8951.00
57_V77_L1.8431.00
113_D116_I1.8241.00
115_D118_K1.8051.00
80_E116_I1.7951.00
23_R31_S1.7451.00
124_I128_Y1.7201.00
12_L23_R1.7071.00
93_N96_I1.6971.00
15_E18_K1.6211.00
59_G120_T1.5921.00
12_L102_Y1.5851.00
11_D23_R1.5841.00
97_I106_I1.5831.00
27_N110_R1.5431.00
79_I111_V1.5081.00
58_N61_S1.4931.00
64_F75_F1.4741.00
52_Q55_E1.4301.00
96_I104_S1.4291.00
36_D40_Y1.4271.00
65_S72_I1.4091.00
89_E93_N1.3701.00
62_V74_K1.3451.00
17_E130_Q1.3371.00
54_G82_E1.3251.00
58_N80_E1.3151.00
29_V110_R1.3091.00
63_L75_F1.2841.00
90_V106_I1.2821.00
22_V30_V1.2761.00
50_A86_V1.2491.00
39_Q98_N1.2461.00
89_E96_I1.1831.00
37_L41_M1.1691.00
24_I111_V1.1641.00
25_E31_S1.1541.00
57_V63_L1.1401.00
65_S69_A1.1371.00
88_E91_V1.1241.00
81_G109_I1.1171.00
29_V84_F1.1021.00
10_D125_Q1.0821.00
20_V69_A1.0661.00
49_T65_S1.0621.00
93_N99_E1.0611.00
32_I107_V1.0561.00
126_E129_K1.0461.00
53_K86_V1.0361.00
48_V90_V1.0311.00
84_F110_R1.0301.00
46_F69_A1.0111.00
79_I109_I0.9420.99
125_Q128_Y0.9370.99
85_D88_E0.9280.99
50_A106_I0.9270.99
25_E108_K0.9230.99
22_V79_I0.9200.99
96_I99_E0.9190.99
55_E61_S0.9180.99
111_V114_M0.8960.99
15_E22_V0.8930.99
13_L118_K0.8860.99
15_E35_T0.8800.99
59_G116_I0.8760.99
8_F124_I0.8680.99
114_M117_I0.8650.99
25_E29_V0.8630.99
89_E92_K0.8570.99
15_E20_V0.8540.99
30_V79_I0.8460.99
24_I117_I0.8440.99
75_F107_V0.8410.99
34_V66_I0.8410.99
48_V66_I0.8360.99
10_D128_Y0.8260.99
80_E112_E0.8250.99
21_W33_G0.8170.99
8_F128_Y0.8080.98
46_F72_I0.8070.98
77_L109_I0.8060.98
18_K76_R0.7870.98
113_D117_I0.7850.98
14_Y102_Y0.7780.98
13_L117_I0.7740.98
13_L123_P0.7640.98
90_V96_I0.7630.98
44_K95_S0.7620.98
36_D102_Y0.7570.98
31_S104_S0.7560.98
102_Y124_I0.7500.97
65_S74_K0.7500.97
89_E103_D0.7490.97
95_S99_E0.7410.97
18_K71_W0.7340.97
88_E92_K0.7340.97
53_K85_D0.7310.97
32_I109_I0.7260.97
19_H43_G0.7170.97
8_F131_F0.7130.97
8_F102_Y0.7120.96
45_I66_I0.6940.96
39_Q102_Y0.6910.96
112_E116_I0.6890.96
57_V80_E0.6800.95
42_A73_G0.6780.95
57_V83_V0.6740.95
68_S71_W0.6710.95
51_K86_V0.6700.95
51_K68_S0.6700.95
24_I114_M0.6680.95
122_K126_E0.6670.95
29_V85_D0.6650.95
9_P124_I0.6560.94
67_E70_K0.6550.94
125_Q129_K0.6540.94
75_F106_I0.6470.94
14_Y35_T0.6470.94
100_R104_S0.6460.94
45_I64_F0.6340.93
70_K73_G0.6330.93
18_K60_R0.6240.93
26_D29_V0.6240.93
36_D98_N0.6220.93
9_P35_T0.6190.93
20_V46_F0.6150.92
17_E126_E0.6120.92
114_M118_K0.6120.92
29_V111_V0.6120.92
52_Q92_K0.6030.92
46_F67_E0.6010.91
53_K88_E0.5910.91
51_K83_V0.5880.91
41_M73_G0.5750.90
20_V76_R0.5720.89
54_G84_F0.5720.89
13_L24_I0.5700.89
23_R26_D0.5630.89
37_L131_F0.5630.89
35_T101_P0.5620.89
38_G73_G0.5580.88
48_V94_P0.5570.88
42_A71_W0.5520.88
20_V71_W0.5500.87
64_F107_V0.5490.87
30_V117_I0.5450.87
42_A127_V0.5450.87
45_I65_S0.5420.87
11_D124_I0.5340.86
41_M68_S0.5310.86
55_E58_N0.5290.85
8_F36_D0.5290.85
83_V107_V0.5260.85
32_I78_P0.5240.85
17_E120_T0.5230.85
62_V65_S0.5210.85
47_Q73_G0.5190.84
48_V96_I0.5170.84
45_I63_L0.5160.84
20_V38_G0.5150.84
14_Y124_I0.5150.84
62_V71_W0.5150.84
9_P14_Y0.5120.84
45_I98_N0.5090.83
66_I106_I0.5090.83
44_K47_Q0.5080.83
7_T100_R0.5080.83
20_V32_I0.5060.83
34_V38_G0.5060.83
62_V91_V0.5040.83
55_E92_K0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hgbA 1 0.9 100 0.205 Contact Map
3mxuA 3 0.9143 100 0.233 Contact Map
3tzuA 2 0.8643 100 0.274 Contact Map
3a7lA 1 0.9071 100 0.278 Contact Map
1hpcA 2 0.9286 100 0.282 Contact Map
3wdnA 1 0.8857 100 0.304 Contact Map
1onlA 1 0.9 100 0.324 Contact Map
1zkoA 2 0.8929 100 0.355 Contact Map
5a35A 1 0.7929 100 0.393 Contact Map
3u9tA 3 0.2143 97 0.847 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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