GREMLIN Database
Q97Z28 - Lipoate protein ligase A, hypothetical (LplA-like2)
UniProt: Q97Z28 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 344 (308)
Sequences: 1392 (1024)
Seq/√Len: 58.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_D192_N4.3191.00
235_E238_L3.7351.00
278_S283_E3.6441.00
189_T194_E3.5251.00
117_D122_K3.2291.00
264_K269_L3.1101.00
232_T235_E3.0371.00
81_M87_G2.9391.00
110_E114_R2.8611.00
38_V89_E2.8411.00
200_D203_E2.6291.00
118_K211_S2.5141.00
173_S177_K2.4761.00
126_R132_E2.3761.00
176_L180_L2.3651.00
74_T144_F2.3511.00
119_L207_I2.3231.00
65_R168_V2.3211.00
62_V69_I2.3201.00
61_E65_R2.3201.00
42_P68_E2.3071.00
286_L303_E2.2961.00
47_V53_V2.2821.00
309_S317_E2.2581.00
45_V62_V2.2131.00
138_I189_T2.1161.00
118_K214_E2.0871.00
61_E168_V2.0681.00
265_L268_G2.0451.00
175_K290_D2.0241.00
302_L321_W1.9971.00
131_V138_I1.9481.00
85_Q155_T1.9371.00
136_R193_K1.9341.00
237_A241_S1.9251.00
86_L201_M1.8721.00
310_R313_D1.8561.00
136_R189_T1.8150.99
161_D164_A1.7940.99
139_S155_T1.7690.99
73_P239_K1.7680.99
60_E64_K1.7620.99
70_G246_I1.7340.99
255_G275_K1.7270.99
243_P248_N1.7070.99
123_A133_V1.6950.99
55_Q182_R1.6890.99
129_N175_K1.6870.99
284_S307_K1.6840.99
274_V285_V1.6740.99
25_L146_E1.6650.99
157_L160_F1.6470.99
11_N83_P1.6460.99
21_E25_L1.6190.99
16_I41_D1.6030.99
189_T193_K1.6000.99
41_D81_M1.5780.99
59_I63_K1.5660.98
226_N229_E1.5540.98
46_L79_I1.5360.98
305_R321_W1.5250.98
15_H230_K1.5230.98
46_L81_M1.5210.98
132_E135_G1.5190.98
236_L240_Y1.5160.98
114_R214_E1.5060.98
38_V46_L1.4980.98
313_D316_N1.4590.97
297_T325_V1.4540.97
21_E239_K1.4450.97
55_Q178_D1.4440.97
46_L85_Q1.4430.97
122_K134_N1.4220.97
265_L270_V1.4210.97
142_G153_T1.4100.97
89_E152_V1.4080.97
79_I85_Q1.4050.97
283_E308_W1.4050.97
19_G233_I1.4030.97
88_W154_G1.4030.97
317_E320_T1.3900.97
304_A307_K1.3830.97
315_E319_R1.3780.96
81_M85_Q1.3770.96
15_H237_A1.3750.96
281_L310_R1.3600.96
243_P251_R1.3600.96
158_L199_L1.3510.96
162_V166_I1.3470.96
23_L34_I1.3410.96
236_L239_K1.3380.96
79_I155_T1.3360.96
23_L27_V1.3140.95
17_L240_Y1.3040.95
44_A81_M1.3020.95
297_T302_L1.3010.95
176_L256_D1.3000.95
51_Q56_E1.2990.95
158_L204_L1.2980.95
134_N194_E1.2960.95
115_A211_S1.2950.95
124_S135_G1.2900.95
309_S313_D1.2870.95
133_V191_V1.2860.95
175_K187_R1.2810.95
39_I201_M1.2770.95
28_A31_S1.2660.94
33_P93_N1.2540.94
254_I311_V1.2530.94
86_L204_L1.2410.94
123_A131_V1.2260.93
243_P310_R1.2190.93
114_R211_S1.2150.93
65_R164_A1.2120.93
12_S241_S1.2050.93
322_F325_V1.2030.93
20_E153_T1.2020.93
113_I131_V1.1890.92
213_A220_L1.1880.92
21_E240_Y1.1720.92
187_R290_D1.1630.91
13_Q70_G1.1540.91
133_V194_E1.1470.91
67_W168_V1.1410.90
228_F231_K1.1320.90
199_L207_I1.1310.90
61_E67_W1.1200.90
254_I277_V1.1130.89
297_T301_D1.1110.89
37_F89_E1.1070.89
127_P187_R1.0970.89
46_L155_T1.0930.88
35_L212_F1.0920.88
17_L46_L1.0910.88
13_Q81_M1.0850.88
41_D70_G1.0800.88
289_G292_F1.0800.88
285_V306_L1.0790.88
17_L81_M1.0780.88
108_G111_G1.0720.87
41_D87_G1.0720.87
55_Q176_L1.0700.87
257_D271_K1.0700.87
316_N319_R1.0690.87
133_V138_I1.0690.87
26_S232_T1.0650.87
165_M188_L1.0630.87
47_V78_T1.0610.87
174_E264_K1.0560.87
94_N150_I1.0530.87
317_E321_W1.0510.86
163_D166_I1.0490.86
313_D317_E1.0490.86
94_N148_N1.0480.86
106_K110_E1.0460.86
17_L20_E1.0390.86
35_L254_I1.0310.85
38_V152_V1.0310.85
81_M160_F1.0290.85
128_K184_F1.0290.85
172_S259_R1.0210.85
300_Y304_A1.0210.85
206_K210_D1.0190.85
74_T151_A1.0080.84
141_I144_F1.0000.84
53_V69_I0.9990.84
16_I81_M0.9940.83
309_S314_L0.9910.83
129_N187_R0.9880.83
143_A152_V0.9880.83
115_A207_I0.9870.83
211_S214_E0.9860.83
113_I123_A0.9830.83
287_V299_I0.9630.81
43_P164_A0.9560.81
59_I247_F0.9540.81
133_V189_T0.9520.80
15_H19_G0.9480.80
109_A125_F0.9460.80
17_L87_G0.9460.80
23_L33_P0.9450.80
228_F232_T0.9390.80
162_V165_M0.9330.79
174_E259_R0.9330.79
305_R317_E0.9310.79
257_D273_Q0.9300.79
13_Q47_V0.9290.79
13_Q87_G0.9240.78
21_E144_F0.9170.78
164_A167_S0.9170.78
302_L327_A0.9130.78
157_L162_V0.9120.78
176_L181_A0.9120.78
79_I87_G0.9110.77
39_I205_I0.9060.77
243_P280_N0.9030.77
253_L278_S0.9020.77
57_V289_G0.9010.77
7_L45_V0.8960.76
89_E151_A0.8940.76
61_E167_S0.8930.76
14_A68_E0.8900.76
316_N320_T0.8820.75
127_P175_K0.8820.75
73_P141_I0.8770.75
78_T169_L0.8760.75
42_P83_P0.8760.75
305_R320_T0.8750.75
202_E206_K0.8680.74
39_I86_L0.8660.74
116_L138_I0.8630.73
138_I191_V0.8620.73
149_Y162_V0.8580.73
60_E63_K0.8570.73
52_A245_W0.8530.73
58_N61_E0.8520.73
50_H144_F0.8450.72
127_P290_D0.8410.72
99_Y240_Y0.8350.71
86_L205_I0.8330.71
53_V251_R0.8210.70
46_L87_G0.8170.69
197_R203_E0.8150.69
43_P80_I0.8140.69
231_K234_Q0.8130.69
73_P144_F0.8120.69
285_V307_K0.8110.69
192_N198_S0.8100.69
45_V57_V0.8050.68
8_I205_I0.8040.68
41_D85_Q0.8010.68
22_A26_S0.8010.68
174_E263_R0.7970.67
199_L210_D0.7950.67
204_L208_S0.7950.67
136_R194_E0.7930.67
166_I184_F0.7930.67
122_K194_E0.7920.67
149_Y191_V0.7910.67
58_N170_R0.7910.67
8_I36_R0.7890.67
14_A240_Y0.7840.66
54_E254_I0.7800.66
16_I20_E0.7790.66
129_N268_G0.7790.66
175_K179_K0.7780.66
39_I43_P0.7770.65
89_E153_T0.7730.65
158_L192_N0.7680.65
231_K235_E0.7670.64
282_I314_L0.7670.64
88_W141_I0.7650.64
36_R108_G0.7610.64
203_E206_K0.7600.64
50_H143_A0.7600.64
61_E64_K0.7600.64
264_K290_D0.7560.63
129_N179_K0.7560.63
91_Y151_A0.7540.63
25_L203_E0.7520.63
21_E73_P0.7520.63
90_I112_V0.7520.63
324_S328_I0.7520.63
46_L186_D0.7510.63
129_N290_D0.7420.62
36_R176_L0.7390.62
55_Q273_Q0.7380.61
109_A131_V0.7320.61
92_A150_I0.7280.60
15_H234_Q0.7260.60
275_K284_S0.7220.60
74_T141_I0.7190.59
84_W190_W0.7150.59
291_F299_I0.7130.59
251_R280_N0.7090.58
38_V44_A0.7090.58
24_L50_H0.7070.58
306_L314_L0.7070.58
24_L155_T0.7030.58
141_I154_G0.7020.58
16_I52_A0.7000.57
234_Q238_L0.7000.57
50_H85_Q0.6950.57
117_D121_I0.6940.57
171_L176_L0.6930.57
256_D311_V0.6910.56
96_L270_V0.6910.56
11_N122_K0.6880.56
174_E177_K0.6850.56
138_I157_L0.6840.56
299_I303_E0.6830.56
201_M205_I0.6810.55
176_L184_F0.6770.55
243_P246_I0.6770.55
139_S154_G0.6730.54
22_A233_I0.6690.54
161_D167_S0.6670.54
13_Q41_D0.6670.54
82_G183_D0.6650.54
272_V287_V0.6630.53
305_R312_E0.6620.53
108_G143_A0.6580.53
80_I178_D0.6580.53
23_L138_I0.6550.52
123_A138_I0.6540.52
10_R15_H0.6520.52
156_I191_V0.6510.52
109_A141_I0.6510.52
81_M190_W0.6510.52
99_Y141_I0.6440.51
49_Y153_T0.6430.51
301_D304_A0.6430.51
320_T323_N0.6410.51
20_E89_E0.6410.51
43_P67_W0.6380.51
75_G140_G0.6370.50
217_G235_E0.6350.50
81_M153_T0.6340.50
49_Y142_G0.6320.50
301_D305_R0.6300.50
45_V184_F0.6290.50
41_D46_L0.6270.49
172_S269_L0.6270.49
94_N145_S0.6230.49
74_T153_T0.6220.49
24_L146_E0.6190.48
207_I210_D0.6190.48
15_H24_L0.6190.48
259_R269_L0.6170.48
58_N167_S0.6170.48
91_Y154_G0.6160.48
303_E306_L0.6120.48
86_L156_I0.6110.48
13_Q68_E0.6100.47
31_S34_I0.6090.47
16_I85_Q0.6060.47
121_I133_V0.6060.47
225_Y233_I0.6040.47
19_G225_Y0.6040.47
109_A143_A0.6040.47
89_E142_G0.6030.47
10_R19_G0.5970.46
172_S177_K0.5970.46
41_D155_T0.5950.46
229_E232_T0.5950.46
20_E46_L0.5940.46
81_M155_T0.5940.46
324_S327_A0.5930.46
203_E207_I0.5910.45
12_S70_G0.5910.45
17_L35_L0.5900.45
111_G116_L0.5890.45
224_Y235_E0.5890.45
38_V41_D0.5880.45
130_D137_K0.5870.45
187_R268_G0.5870.45
85_Q183_D0.5860.45
230_K234_Q0.5860.45
145_S150_I0.5850.45
209_R213_A0.5840.45
41_D45_V0.5830.45
85_Q186_D0.5820.44
210_D217_G0.5820.44
96_L313_D0.5820.44
128_K186_D0.5810.44
214_E307_K0.5810.44
128_K183_D0.5790.44
80_I247_F0.5770.44
46_L190_W0.5770.44
141_I153_T0.5760.44
275_K278_S0.5750.44
255_G278_S0.5740.44
126_R186_D0.5740.44
50_H155_T0.5730.43
85_Q153_T0.5730.43
57_V62_V0.5720.43
162_V188_L0.5710.43
69_I251_R0.5710.43
39_I158_L0.5700.43
17_L236_L0.5690.43
10_R98_G0.5690.43
167_S247_F0.5680.43
65_R167_S0.5680.43
204_L293_I0.5680.43
6_F15_H0.5670.43
298_A326_K0.5660.43
7_L205_I0.5650.43
39_I44_A0.5650.43
38_V143_A0.5640.42
143_A191_V0.5640.42
13_Q17_L0.5630.42
117_D123_A0.5630.42
143_A293_I0.5630.42
191_V204_L0.5610.42
171_L175_K0.5610.42
142_G183_D0.5580.42
16_I190_W0.5570.42
117_D279_K0.5560.42
300_Y307_K0.5550.41
306_L309_S0.5540.41
183_D188_L0.5520.41
128_K188_L0.5510.41
26_S65_R0.5510.41
223_D229_E0.5470.41
121_I194_E0.5460.41
138_I173_S0.5460.41
186_D280_N0.5460.41
301_D314_L0.5460.41
88_W155_T0.5450.40
281_L307_K0.5440.40
56_E140_G0.5440.40
12_S68_E0.5430.40
321_W325_V0.5430.40
38_V158_L0.5420.40
297_T305_R0.5410.40
106_K124_S0.5400.40
178_D311_V0.5360.39
132_E187_R0.5350.39
38_V74_T0.5350.39
19_G36_R0.5340.39
314_L318_I0.5340.39
46_L152_V0.5310.39
163_D304_A0.5300.39
113_I116_L0.5300.39
107_I110_E0.5300.39
227_E320_T0.5290.39
232_T236_L0.5280.39
279_K304_A0.5260.38
6_F19_G0.5240.38
277_V280_N0.5240.38
13_Q23_L0.5240.38
114_R215_V0.5220.38
20_E242_S0.5210.38
108_G204_L0.5210.38
275_K283_E0.5200.38
301_D313_D0.5200.38
16_I153_T0.5190.38
175_K289_G0.5190.38
6_F209_R0.5180.38
24_L107_I0.5170.37
78_T187_R0.5170.37
233_I237_A0.5160.37
315_E324_S0.5160.37
23_L132_E0.5150.37
274_V294_E0.5140.37
20_E36_R0.5140.37
324_S329_G0.5130.37
259_R271_K0.5120.37
13_Q246_I0.5120.37
180_L187_R0.5110.37
25_L149_Y0.5070.36
274_V282_I0.5060.36
22_A91_Y0.5050.36
175_K264_K0.5050.36
16_I38_V0.5040.36
81_M86_L0.5030.36
281_L284_S0.5030.36
16_I155_T0.5020.36
46_L153_T0.5020.36
75_G169_L0.5010.36
79_I190_W0.5000.36
52_A85_Q0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a7rA 1 0.9535 100 0.256 Contact Map
2e5aA 1 0.9128 100 0.295 Contact Map
1vqzA 1 0.9477 100 0.296 Contact Map
2c8mA 1 0.6744 100 0.427 Contact Map
2p0lA 1 0.689 100 0.526 Contact Map
2p5iA 1 0.689 100 0.545 Contact Map
2qhsA 1 0.5959 100 0.59 Contact Map
1w66A 1 0.5872 100 0.607 Contact Map
3r07C 1 0.2529 99.5 0.849 Contact Map
2dxuA 2 0.625 98.2 0.91 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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