Q97Z28 - SULSO - GREMLIN Contacts

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Q97Z28 - Lipoate protein ligase A, hypothetical (LplA-like2)

UniProt:	Q97Z28	Sequences: MRELRFLIERNSQAHILAGEEALLLSVANGSQPILRFVIFDPPAVLVGYHQAVEQEVNIEEVKKRGWEIGRRPTGGGTIIMGPWQLGWEIYANNDLLGYTPENAIKIGAEGVIRALDKLGIKASFRPKNDVEVNGRKISGIGAFSEGNYIAVTGTILLDFDVDAMISVLRLSSEKLKDKLARDFKDRLTWVNKELKRSLDMEELIKISRDSFAEVLGIKLSDDYYNEFEKKTIQELALKYSSPEWIFNLRRPLIGDDIRYVERKLPGGLVKVQVKMVSKNLIESVLVTGDFFIEPRTAIYDLEARLKWSRVEDLENEIRTWFNSVKAIGITADDLIKIIEEVVR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	344 (308)
Sequences:	1392 (1024)
Seq/√Len:	58.3

ECOLI - LPLA
BACSU - LPLJ LIPM LIPL
HALSA - Q9HSK8 Q9HMH8
SULSO - Q97Z28 Q97Z70 Q97U65 Q97U62

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
159_D	192_N	4.319	1.00
235_E	238_L	3.735	1.00
278_S	283_E	3.644	1.00
189_T	194_E	3.525	1.00
117_D	122_K	3.229	1.00
264_K	269_L	3.110	1.00
232_T	235_E	3.037	1.00
81_M	87_G	2.939	1.00
110_E	114_R	2.861	1.00
38_V	89_E	2.841	1.00
200_D	203_E	2.629	1.00
118_K	211_S	2.514	1.00
173_S	177_K	2.476	1.00
126_R	132_E	2.376	1.00
176_L	180_L	2.365	1.00
74_T	144_F	2.351	1.00
119_L	207_I	2.323	1.00
65_R	168_V	2.321	1.00
62_V	69_I	2.320	1.00
61_E	65_R	2.320	1.00
42_P	68_E	2.307	1.00
286_L	303_E	2.296	1.00
47_V	53_V	2.282	1.00
309_S	317_E	2.258	1.00
45_V	62_V	2.213	1.00
138_I	189_T	2.116	1.00
118_K	214_E	2.087	1.00
61_E	168_V	2.068	1.00
265_L	268_G	2.045	1.00
175_K	290_D	2.024	1.00
302_L	321_W	1.997	1.00
131_V	138_I	1.948	1.00
85_Q	155_T	1.937	1.00
136_R	193_K	1.934	1.00
237_A	241_S	1.925	1.00
86_L	201_M	1.872	1.00
310_R	313_D	1.856	1.00
136_R	189_T	1.815	0.99
161_D	164_A	1.794	0.99
139_S	155_T	1.769	0.99
73_P	239_K	1.768	0.99
60_E	64_K	1.762	0.99
70_G	246_I	1.734	0.99
255_G	275_K	1.727	0.99
243_P	248_N	1.707	0.99
123_A	133_V	1.695	0.99
55_Q	182_R	1.689	0.99
129_N	175_K	1.687	0.99
284_S	307_K	1.684	0.99
274_V	285_V	1.674	0.99
25_L	146_E	1.665	0.99
157_L	160_F	1.647	0.99
11_N	83_P	1.646	0.99
21_E	25_L	1.619	0.99
16_I	41_D	1.603	0.99
189_T	193_K	1.600	0.99
41_D	81_M	1.578	0.99
59_I	63_K	1.566	0.98
226_N	229_E	1.554	0.98
46_L	79_I	1.536	0.98
305_R	321_W	1.525	0.98
15_H	230_K	1.523	0.98
46_L	81_M	1.521	0.98
132_E	135_G	1.519	0.98
236_L	240_Y	1.516	0.98
114_R	214_E	1.506	0.98
38_V	46_L	1.498	0.98
313_D	316_N	1.459	0.97
297_T	325_V	1.454	0.97
21_E	239_K	1.445	0.97
55_Q	178_D	1.444	0.97
46_L	85_Q	1.443	0.97
122_K	134_N	1.422	0.97
265_L	270_V	1.421	0.97
142_G	153_T	1.410	0.97
89_E	152_V	1.408	0.97
79_I	85_Q	1.405	0.97
283_E	308_W	1.405	0.97
19_G	233_I	1.403	0.97
88_W	154_G	1.403	0.97
317_E	320_T	1.390	0.97
304_A	307_K	1.383	0.97
315_E	319_R	1.378	0.96
81_M	85_Q	1.377	0.96
15_H	237_A	1.375	0.96
281_L	310_R	1.360	0.96
243_P	251_R	1.360	0.96
158_L	199_L	1.351	0.96
162_V	166_I	1.347	0.96
23_L	34_I	1.341	0.96
236_L	239_K	1.338	0.96
79_I	155_T	1.336	0.96
23_L	27_V	1.314	0.95
17_L	240_Y	1.304	0.95
44_A	81_M	1.302	0.95
297_T	302_L	1.301	0.95
176_L	256_D	1.300	0.95
51_Q	56_E	1.299	0.95
158_L	204_L	1.298	0.95
134_N	194_E	1.296	0.95
115_A	211_S	1.295	0.95
124_S	135_G	1.290	0.95
309_S	313_D	1.287	0.95
133_V	191_V	1.286	0.95
175_K	187_R	1.281	0.95
39_I	201_M	1.277	0.95
28_A	31_S	1.266	0.94
33_P	93_N	1.254	0.94
254_I	311_V	1.253	0.94
86_L	204_L	1.241	0.94
123_A	131_V	1.226	0.93
243_P	310_R	1.219	0.93
114_R	211_S	1.215	0.93
65_R	164_A	1.212	0.93
12_S	241_S	1.205	0.93
322_F	325_V	1.203	0.93
20_E	153_T	1.202	0.93
113_I	131_V	1.189	0.92
213_A	220_L	1.188	0.92
21_E	240_Y	1.172	0.92
187_R	290_D	1.163	0.91
13_Q	70_G	1.154	0.91
133_V	194_E	1.147	0.91
67_W	168_V	1.141	0.90
228_F	231_K	1.132	0.90
199_L	207_I	1.131	0.90
61_E	67_W	1.120	0.90
254_I	277_V	1.113	0.89
297_T	301_D	1.111	0.89
37_F	89_E	1.107	0.89
127_P	187_R	1.097	0.89
46_L	155_T	1.093	0.88
35_L	212_F	1.092	0.88
17_L	46_L	1.091	0.88
13_Q	81_M	1.085	0.88
41_D	70_G	1.080	0.88
289_G	292_F	1.080	0.88
285_V	306_L	1.079	0.88
17_L	81_M	1.078	0.88
108_G	111_G	1.072	0.87
41_D	87_G	1.072	0.87
55_Q	176_L	1.070	0.87
257_D	271_K	1.070	0.87
316_N	319_R	1.069	0.87
133_V	138_I	1.069	0.87
26_S	232_T	1.065	0.87
165_M	188_L	1.063	0.87
47_V	78_T	1.061	0.87
174_E	264_K	1.056	0.87
94_N	150_I	1.053	0.87
317_E	321_W	1.051	0.86
163_D	166_I	1.049	0.86
313_D	317_E	1.049	0.86
94_N	148_N	1.048	0.86
106_K	110_E	1.046	0.86
17_L	20_E	1.039	0.86
35_L	254_I	1.031	0.85
38_V	152_V	1.031	0.85
81_M	160_F	1.029	0.85
128_K	184_F	1.029	0.85
172_S	259_R	1.021	0.85
300_Y	304_A	1.021	0.85
206_K	210_D	1.019	0.85
74_T	151_A	1.008	0.84
141_I	144_F	1.000	0.84
53_V	69_I	0.999	0.84
16_I	81_M	0.994	0.83
309_S	314_L	0.991	0.83
129_N	187_R	0.988	0.83
143_A	152_V	0.988	0.83
115_A	207_I	0.987	0.83
211_S	214_E	0.986	0.83
113_I	123_A	0.983	0.83
287_V	299_I	0.963	0.81
43_P	164_A	0.956	0.81
59_I	247_F	0.954	0.81
133_V	189_T	0.952	0.80
15_H	19_G	0.948	0.80
109_A	125_F	0.946	0.80
17_L	87_G	0.946	0.80
23_L	33_P	0.945	0.80
228_F	232_T	0.939	0.80
162_V	165_M	0.933	0.79
174_E	259_R	0.933	0.79
305_R	317_E	0.931	0.79
257_D	273_Q	0.930	0.79
13_Q	47_V	0.929	0.79
13_Q	87_G	0.924	0.78
21_E	144_F	0.917	0.78
164_A	167_S	0.917	0.78
302_L	327_A	0.913	0.78
157_L	162_V	0.912	0.78
176_L	181_A	0.912	0.78
79_I	87_G	0.911	0.77
39_I	205_I	0.906	0.77
243_P	280_N	0.903	0.77
253_L	278_S	0.902	0.77
57_V	289_G	0.901	0.77
7_L	45_V	0.896	0.76
89_E	151_A	0.894	0.76
61_E	167_S	0.893	0.76
14_A	68_E	0.890	0.76
316_N	320_T	0.882	0.75
127_P	175_K	0.882	0.75
73_P	141_I	0.877	0.75
78_T	169_L	0.876	0.75
42_P	83_P	0.876	0.75
305_R	320_T	0.875	0.75
202_E	206_K	0.868	0.74
39_I	86_L	0.866	0.74
116_L	138_I	0.863	0.73
138_I	191_V	0.862	0.73
149_Y	162_V	0.858	0.73
60_E	63_K	0.857	0.73
52_A	245_W	0.853	0.73
58_N	61_E	0.852	0.73
50_H	144_F	0.845	0.72
127_P	290_D	0.841	0.72
99_Y	240_Y	0.835	0.71
86_L	205_I	0.833	0.71
53_V	251_R	0.821	0.70
46_L	87_G	0.817	0.69
197_R	203_E	0.815	0.69
43_P	80_I	0.814	0.69
231_K	234_Q	0.813	0.69
73_P	144_F	0.812	0.69
285_V	307_K	0.811	0.69
192_N	198_S	0.810	0.69
45_V	57_V	0.805	0.68
8_I	205_I	0.804	0.68
41_D	85_Q	0.801	0.68
22_A	26_S	0.801	0.68
174_E	263_R	0.797	0.67
199_L	210_D	0.795	0.67
204_L	208_S	0.795	0.67
136_R	194_E	0.793	0.67
166_I	184_F	0.793	0.67
122_K	194_E	0.792	0.67
149_Y	191_V	0.791	0.67
58_N	170_R	0.791	0.67
8_I	36_R	0.789	0.67
14_A	240_Y	0.784	0.66
54_E	254_I	0.780	0.66
16_I	20_E	0.779	0.66
129_N	268_G	0.779	0.66
175_K	179_K	0.778	0.66
39_I	43_P	0.777	0.65
89_E	153_T	0.773	0.65
158_L	192_N	0.768	0.65
231_K	235_E	0.767	0.64
282_I	314_L	0.767	0.64
88_W	141_I	0.765	0.64
36_R	108_G	0.761	0.64
203_E	206_K	0.760	0.64
50_H	143_A	0.760	0.64
61_E	64_K	0.760	0.64
264_K	290_D	0.756	0.63
129_N	179_K	0.756	0.63
91_Y	151_A	0.754	0.63
25_L	203_E	0.752	0.63
21_E	73_P	0.752	0.63
90_I	112_V	0.752	0.63
324_S	328_I	0.752	0.63
46_L	186_D	0.751	0.63
129_N	290_D	0.742	0.62
36_R	176_L	0.739	0.62
55_Q	273_Q	0.738	0.61
109_A	131_V	0.732	0.61
92_A	150_I	0.728	0.60
15_H	234_Q	0.726	0.60
275_K	284_S	0.722	0.60
74_T	141_I	0.719	0.59
84_W	190_W	0.715	0.59
291_F	299_I	0.713	0.59
251_R	280_N	0.709	0.58
38_V	44_A	0.709	0.58
24_L	50_H	0.707	0.58
306_L	314_L	0.707	0.58
24_L	155_T	0.703	0.58
141_I	154_G	0.702	0.58
16_I	52_A	0.700	0.57
234_Q	238_L	0.700	0.57
50_H	85_Q	0.695	0.57
117_D	121_I	0.694	0.57
171_L	176_L	0.693	0.57
256_D	311_V	0.691	0.56
96_L	270_V	0.691	0.56
11_N	122_K	0.688	0.56
174_E	177_K	0.685	0.56
138_I	157_L	0.684	0.56
299_I	303_E	0.683	0.56
201_M	205_I	0.681	0.55
176_L	184_F	0.677	0.55
243_P	246_I	0.677	0.55
139_S	154_G	0.673	0.54
22_A	233_I	0.669	0.54
161_D	167_S	0.667	0.54
13_Q	41_D	0.667	0.54
82_G	183_D	0.665	0.54
272_V	287_V	0.663	0.53
305_R	312_E	0.662	0.53
108_G	143_A	0.658	0.53
80_I	178_D	0.658	0.53
23_L	138_I	0.655	0.52
123_A	138_I	0.654	0.52
10_R	15_H	0.652	0.52
156_I	191_V	0.651	0.52
109_A	141_I	0.651	0.52
81_M	190_W	0.651	0.52
99_Y	141_I	0.644	0.51
49_Y	153_T	0.643	0.51
301_D	304_A	0.643	0.51
320_T	323_N	0.641	0.51
20_E	89_E	0.641	0.51
43_P	67_W	0.638	0.51
75_G	140_G	0.637	0.50
217_G	235_E	0.635	0.50
81_M	153_T	0.634	0.50
49_Y	142_G	0.632	0.50
301_D	305_R	0.630	0.50
45_V	184_F	0.629	0.50
41_D	46_L	0.627	0.49
172_S	269_L	0.627	0.49
94_N	145_S	0.623	0.49
74_T	153_T	0.622	0.49
24_L	146_E	0.619	0.48
207_I	210_D	0.619	0.48
15_H	24_L	0.619	0.48
259_R	269_L	0.617	0.48
58_N	167_S	0.617	0.48
91_Y	154_G	0.616	0.48
303_E	306_L	0.612	0.48
86_L	156_I	0.611	0.48
13_Q	68_E	0.610	0.47
31_S	34_I	0.609	0.47
16_I	85_Q	0.606	0.47
121_I	133_V	0.606	0.47
225_Y	233_I	0.604	0.47
19_G	225_Y	0.604	0.47
109_A	143_A	0.604	0.47
89_E	142_G	0.603	0.47
10_R	19_G	0.597	0.46
172_S	177_K	0.597	0.46
41_D	155_T	0.595	0.46
229_E	232_T	0.595	0.46
20_E	46_L	0.594	0.46
81_M	155_T	0.594	0.46
324_S	327_A	0.593	0.46
203_E	207_I	0.591	0.45
12_S	70_G	0.591	0.45
17_L	35_L	0.590	0.45
111_G	116_L	0.589	0.45
224_Y	235_E	0.589	0.45
38_V	41_D	0.588	0.45
130_D	137_K	0.587	0.45
187_R	268_G	0.587	0.45
85_Q	183_D	0.586	0.45
230_K	234_Q	0.586	0.45
145_S	150_I	0.585	0.45
209_R	213_A	0.584	0.45
41_D	45_V	0.583	0.45
85_Q	186_D	0.582	0.44
210_D	217_G	0.582	0.44
96_L	313_D	0.582	0.44
128_K	186_D	0.581	0.44
214_E	307_K	0.581	0.44
128_K	183_D	0.579	0.44
80_I	247_F	0.577	0.44
46_L	190_W	0.577	0.44
141_I	153_T	0.576	0.44
275_K	278_S	0.575	0.44
255_G	278_S	0.574	0.44
126_R	186_D	0.574	0.44
50_H	155_T	0.573	0.43
85_Q	153_T	0.573	0.43
57_V	62_V	0.572	0.43
162_V	188_L	0.571	0.43
69_I	251_R	0.571	0.43
39_I	158_L	0.570	0.43
17_L	236_L	0.569	0.43
10_R	98_G	0.569	0.43
167_S	247_F	0.568	0.43
65_R	167_S	0.568	0.43
204_L	293_I	0.568	0.43
6_F	15_H	0.567	0.43
298_A	326_K	0.566	0.43
7_L	205_I	0.565	0.43
39_I	44_A	0.565	0.43
38_V	143_A	0.564	0.42
143_A	191_V	0.564	0.42
13_Q	17_L	0.563	0.42
117_D	123_A	0.563	0.42
143_A	293_I	0.563	0.42
191_V	204_L	0.561	0.42
171_L	175_K	0.561	0.42
142_G	183_D	0.558	0.42
16_I	190_W	0.557	0.42
117_D	279_K	0.556	0.42
300_Y	307_K	0.555	0.41
306_L	309_S	0.554	0.41
183_D	188_L	0.552	0.41
128_K	188_L	0.551	0.41
26_S	65_R	0.551	0.41
223_D	229_E	0.547	0.41
121_I	194_E	0.546	0.41
138_I	173_S	0.546	0.41
186_D	280_N	0.546	0.41
301_D	314_L	0.546	0.41
88_W	155_T	0.545	0.40
281_L	307_K	0.544	0.40
56_E	140_G	0.544	0.40
12_S	68_E	0.543	0.40
321_W	325_V	0.543	0.40
38_V	158_L	0.542	0.40
297_T	305_R	0.541	0.40
106_K	124_S	0.540	0.40
178_D	311_V	0.536	0.39
132_E	187_R	0.535	0.39
38_V	74_T	0.535	0.39
19_G	36_R	0.534	0.39
314_L	318_I	0.534	0.39
46_L	152_V	0.531	0.39
163_D	304_A	0.530	0.39
113_I	116_L	0.530	0.39
107_I	110_E	0.530	0.39
227_E	320_T	0.529	0.39
232_T	236_L	0.528	0.39
279_K	304_A	0.526	0.38
6_F	19_G	0.524	0.38
277_V	280_N	0.524	0.38
13_Q	23_L	0.524	0.38
114_R	215_V	0.522	0.38
20_E	242_S	0.521	0.38
108_G	204_L	0.521	0.38
275_K	283_E	0.520	0.38
301_D	313_D	0.520	0.38
16_I	153_T	0.519	0.38
175_K	289_G	0.519	0.38
6_F	209_R	0.518	0.38
24_L	107_I	0.517	0.37
78_T	187_R	0.517	0.37
233_I	237_A	0.516	0.37
315_E	324_S	0.516	0.37
23_L	132_E	0.515	0.37
274_V	294_E	0.514	0.37
20_E	36_R	0.514	0.37
324_S	329_G	0.513	0.37
259_R	271_K	0.512	0.37
13_Q	246_I	0.512	0.37
180_L	187_R	0.511	0.37
25_L	149_Y	0.507	0.36
274_V	282_I	0.506	0.36
22_A	91_Y	0.505	0.36
175_K	264_K	0.505	0.36
16_I	38_V	0.504	0.36
81_M	86_L	0.503	0.36
281_L	284_S	0.503	0.36
16_I	155_T	0.502	0.36
46_L	153_T	0.502	0.36
75_G	169_L	0.501	0.36
79_I	190_W	0.500	0.36
52_A	85_Q	0.500	0.36

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3a7rA	1	0.9535	100	0.256	Contact Map
2e5aA	1	0.9128	100	0.295	Contact Map
1vqzA	1	0.9477	100	0.296	Contact Map
2c8mA	1	0.6744	100	0.427	Contact Map
2p0lA	1	0.689	100	0.526	Contact Map
2p5iA	1	0.689	100	0.545	Contact Map
2qhsA	1	0.5959	100	0.59	Contact Map
1w66A	1	0.5872	100	0.607	Contact Map
3r07C	1	0.2529	99.5	0.849	Contact Map
2dxuA	2	0.625	98.2	0.91	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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