Q97Z27 - SULSO - GREMLIN Contacts

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Q97Z27 - Uncharacterized protein

UniProt:	Q97Z27	Sequences: MRPLFLYAPNLKRYESEFLDSRKGWKSISVTGTYCAFNCKHCGRRVLESMIDGSTQGKIEKEIMEAISRGDEGIILSGGSTSRGDVPIWRYSNLLKRYSDRLTIIAHTGVVKNEEIARKFKESGVKIALLDMVSDNDAIKDILGQPFTVDDYLNSFKYLKKVNIKIVPHVILGLSKKGLEGDLESIRLLQEVNPDALIIVGLMPLVGTQMNASRPPTPEEIIVALRTARDTFPNIPINLGCARPRGKSYLEVEKFAVDYDIDAIAFPEDETYEYAKSKREIFLSNACCGNIVFDIFKVITS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	301 (264)
Sequences:	118 (98)
Seq/√Len:	6.0

SULSO - Q97Z27

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
99_S	126_K	4.372	0.96
253_E	271_T	3.948	0.93
262_D	279_R	3.480	0.88
25_W	73_G	2.914	0.76
46_V	242_A	2.616	0.67
81_T	85_D	2.424	0.61
138_A	181_G	2.415	0.61
63_I	98_Y	2.400	0.60
238_N	263_A	2.398	0.60
46_V	205_L	2.297	0.57
25_W	189_L	2.273	0.56
131_D	246_G	2.254	0.55
172_L	224_A	2.205	0.53
40_K	144_G	2.162	0.52
105_I	129_L	2.161	0.52
243_R	253_E	2.114	0.50
86_V	139_I	2.099	0.50
105_I	242_A	2.098	0.50
205_L	242_A	2.092	0.49
200_V	242_A	2.049	0.48
129_L	242_A	2.047	0.48
39_C	42_C	2.039	0.48
177_K	182_D	2.034	0.47
108_T	128_A	2.034	0.47
38_N	43_G	2.034	0.47
136_N	149_V	2.031	0.47
41_H	131_D	1.975	0.45
86_V	142_I	1.974	0.45
217_T	223_V	1.953	0.45
184_E	187_R	1.943	0.44
129_L	200_V	1.906	0.43
139_I	152_Y	1.870	0.42
117_A	145_Q	1.870	0.42
203_M	242_A	1.845	0.41
43_G	144_G	1.821	0.40
149_V	279_R	1.810	0.40
35_C	42_C	1.796	0.39
35_C	39_C	1.796	0.39
31_T	35_C	1.781	0.39
37_F	201_G	1.779	0.39
76_L	95_L	1.764	0.38
206_V	211_N	1.730	0.37
171_I	200_V	1.716	0.36
29_S	35_C	1.678	0.35
222_I	255_F	1.677	0.35
73_G	265_A	1.660	0.35
215_P	262_D	1.632	0.34
80_S	171_I	1.630	0.34
143_L	199_I	1.607	0.33
132_M	232_F	1.600	0.33
46_V	132_M	1.562	0.32
76_L	137_D	1.551	0.31
200_V	265_A	1.547	0.31
129_L	265_A	1.545	0.31
145_Q	186_I	1.524	0.30
41_H	47_L	1.512	0.30
138_A	142_I	1.484	0.29
59_I	272_Y	1.481	0.29
86_V	131_D	1.463	0.29
80_S	181_G	1.450	0.28
170_V	201_G	1.439	0.28
84_G	135_D	1.434	0.28
86_V	152_Y	1.425	0.27
143_L	177_K	1.412	0.27
40_K	176_K	1.410	0.27
233_P	262_D	1.402	0.27
215_P	279_R	1.398	0.27
225_L	239_L	1.385	0.26
129_L	171_I	1.384	0.26
25_W	156_F	1.376	0.26
98_Y	221_I	1.372	0.26
46_V	203_M	1.363	0.26
276_K	280_E	1.359	0.26
32_G	35_C	1.359	0.26
31_T	39_C	1.357	0.26
31_T	42_C	1.357	0.26
151_D	154_N	1.351	0.25
252_V	279_R	1.337	0.25
197_L	233_P	1.336	0.25
106_A	120_F	1.333	0.25
76_L	268_E	1.329	0.25
26_K	98_Y	1.308	0.24
98_Y	116_I	1.307	0.24
225_L	257_V	1.299	0.24
27_S	232_F	1.297	0.24
44_R	48_E	1.294	0.24
131_D	143_L	1.277	0.23
41_H	177_K	1.276	0.23
134_S	185_S	1.275	0.23
221_I	239_L	1.252	0.23
29_S	39_C	1.244	0.23
29_S	42_C	1.244	0.23
177_K	201_G	1.236	0.22
96_K	180_E	1.229	0.22
84_G	208_T	1.229	0.22
249_Y	253_E	1.223	0.22
179_L	224_A	1.205	0.22
191_E	232_F	1.198	0.22
81_T	148_T	1.184	0.21
42_C	47_L	1.183	0.21
39_C	47_L	1.183	0.21
70_G	73_G	1.174	0.21
73_G	125_V	1.170	0.21
189_L	232_F	1.168	0.21
64_M	197_L	1.149	0.20
56_Q	94_L	1.147	0.20
87_P	120_F	1.147	0.20
125_V	265_A	1.136	0.20
87_P	109_G	1.135	0.20
115_E	271_T	1.132	0.20
58_K	61_K	1.131	0.20
126_K	249_Y	1.130	0.20
110_V	196_A	1.129	0.20
76_L	106_A	1.125	0.20
229_R	262_D	1.117	0.20
41_H	246_G	1.117	0.20
183_L	224_A	1.115	0.20
219_E	257_V	1.109	0.19
53_G	110_V	1.107	0.19
130_L	265_A	1.103	0.19
81_T	259_Y	1.095	0.19
80_S	200_V	1.095	0.19
224_A	276_K	1.088	0.19
160_K	236_P	1.079	0.19
51_I	59_I	1.074	0.19
75_I	126_K	1.071	0.19
114_E	155_S	1.062	0.18
124_G	257_V	1.060	0.18
105_I	265_A	1.055	0.18
86_V	151_D	1.042	0.18
59_I	190_Q	1.041	0.18
131_D	182_D	1.037	0.18
50_M	244_P	1.034	0.18
115_E	140_K	1.030	0.18
168_P	287_C	1.030	0.18
168_P	288_C	1.030	0.18
68_S	93_N	1.018	0.17
199_I	281_I	1.017	0.17
96_K	161_K	1.016	0.17
136_N	150_D	1.016	0.17
202_L	208_T	1.015	0.17
133_V	181_G	1.011	0.17
117_A	124_G	1.010	0.17
181_G	278_K	1.002	0.17
232_F	235_I	0.990	0.17
70_G	163_N	0.986	0.17
143_L	171_I	0.978	0.17
89_W	165_K	0.973	0.17
206_V	268_E	0.968	0.16
143_L	246_G	0.960	0.16
166_I	176_K	0.958	0.16
134_S	149_V	0.958	0.16
120_F	210_M	0.955	0.16
242_A	263_A	0.955	0.16
104_I	167_V	0.952	0.16
32_G	42_C	0.950	0.16
32_G	39_C	0.950	0.16
35_C	47_L	0.946	0.16
41_H	182_D	0.946	0.16
37_F	253_E	0.922	0.16
91_Y	165_K	0.921	0.16
108_T	253_E	0.919	0.16
139_I	181_G	0.918	0.16
133_V	225_L	0.916	0.16
28_I	93_N	0.912	0.15
108_T	195_D	0.908	0.15
152_Y	253_E	0.902	0.15
146_P	194_P	0.898	0.15
46_V	105_I	0.892	0.15
45_R	249_Y	0.892	0.15
121_K	147_F	0.887	0.15
110_V	262_D	0.886	0.15
28_I	121_K	0.886	0.15
150_D	247_K	0.885	0.15
242_A	266_F	0.883	0.15
245_R	268_E	0.878	0.15
108_T	132_M	0.873	0.15
90_R	104_I	0.872	0.15
33_T	93_N	0.871	0.15
35_C	244_P	0.866	0.15
253_E	266_F	0.865	0.15
201_G	253_E	0.860	0.14
40_K	142_I	0.859	0.14
144_G	289_G	0.858	0.14
73_G	156_F	0.857	0.14
172_L	179_L	0.854	0.14
46_V	208_T	0.851	0.14
48_E	186_I	0.850	0.14
239_L	256_A	0.843	0.14
142_I	174_L	0.843	0.14
106_A	202_L	0.840	0.14
41_H	143_L	0.836	0.14
75_I	182_D	0.835	0.14
144_G	209_Q	0.835	0.14
143_L	185_S	0.829	0.14
34_Y	170_V	0.826	0.14
176_K	210_M	0.817	0.14
177_K	185_S	0.815	0.14
62_E	90_R	0.814	0.14
25_W	77_S	0.811	0.14
242_A	265_A	0.809	0.14
243_R	288_C	0.807	0.14
243_R	287_C	0.807	0.14
29_S	79_G	0.806	0.14
65_E	76_L	0.806	0.14
106_A	210_M	0.804	0.14
86_V	138_A	0.800	0.13
45_R	189_L	0.794	0.13
129_L	289_G	0.794	0.13
154_N	189_L	0.793	0.13
173_G	182_D	0.789	0.13
174_L	181_G	0.789	0.13
37_F	75_I	0.779	0.13
72_E	214_R	0.774	0.13
145_Q	278_K	0.772	0.13
104_I	197_L	0.771	0.13
77_S	109_G	0.770	0.13
40_K	289_G	0.769	0.13
164_I	265_A	0.768	0.13
144_G	179_L	0.765	0.13
144_G	239_L	0.763	0.13
143_L	182_D	0.760	0.13
77_S	267_P	0.757	0.13
51_I	61_K	0.756	0.13
202_L	285_N	0.756	0.13
84_G	109_G	0.755	0.13
80_S	263_A	0.755	0.13
46_V	129_L	0.752	0.13
156_F	199_I	0.750	0.13
202_L	205_L	0.750	0.13
139_I	243_R	0.750	0.13
111_V	159_L	0.746	0.13
84_G	252_V	0.745	0.13
58_K	172_L	0.744	0.13
172_L	199_I	0.743	0.13
226_R	262_D	0.742	0.13
45_R	265_A	0.741	0.13
93_N	237_I	0.737	0.12
202_L	253_E	0.735	0.12
112_K	115_E	0.735	0.12
152_Y	243_R	0.733	0.12
27_S	132_M	0.731	0.12
95_L	180_E	0.730	0.12
75_I	177_K	0.728	0.12
129_L	249_Y	0.722	0.12
184_E	203_M	0.722	0.12
76_L	99_S	0.720	0.12
105_I	203_M	0.719	0.12
29_S	134_S	0.716	0.12
172_L	219_E	0.715	0.12
111_V	268_E	0.711	0.12
74_I	280_E	0.710	0.12
107_H	241_C	0.709	0.12
78_G	241_C	0.709	0.12
107_H	169_H	0.709	0.12
78_G	107_H	0.709	0.12
195_D	224_A	0.709	0.12
78_G	169_H	0.709	0.12
169_H	241_C	0.709	0.12
243_R	260_D	0.709	0.12
81_T	212_A	0.708	0.12
73_G	248_S	0.707	0.12
93_N	96_K	0.702	0.12
173_G	208_T	0.699	0.12
25_W	88_I	0.698	0.12
177_K	224_A	0.694	0.12
230_D	275_A	0.691	0.12
76_L	128_A	0.688	0.12
110_V	278_K	0.685	0.12
35_C	50_M	0.684	0.12
80_S	110_V	0.684	0.12
103_T	131_D	0.682	0.12
133_V	177_K	0.675	0.12
59_I	112_K	0.671	0.11
139_I	253_E	0.669	0.11
136_N	184_E	0.669	0.11
100_D	257_V	0.668	0.11
57_G	61_K	0.664	0.11
187_R	231_T	0.663	0.11
91_Y	188_L	0.660	0.11
105_I	205_L	0.658	0.11
260_D	278_K	0.658	0.11
124_G	145_Q	0.656	0.11
170_V	282_F	0.656	0.11
28_I	276_K	0.656	0.11
30_V	153_L	0.654	0.11
125_V	163_N	0.652	0.11
170_V	238_N	0.649	0.11
105_I	200_V	0.648	0.11
25_W	105_I	0.645	0.11
81_T	101_R	0.644	0.11
164_I	199_I	0.643	0.11
133_V	175_S	0.643	0.11
116_I	184_E	0.641	0.11
28_I	54_S	0.641	0.11
167_V	212_A	0.639	0.11
73_G	202_L	0.637	0.11
74_I	137_D	0.635	0.11
28_I	282_F	0.634	0.11
142_I	177_K	0.626	0.11
57_G	166_I	0.625	0.11
110_V	253_E	0.625	0.11
219_E	228_A	0.621	0.11
86_V	133_V	0.620	0.11
63_I	112_K	0.618	0.11
202_L	210_M	0.615	0.11
41_H	80_S	0.614	0.11
117_A	133_V	0.613	0.11
47_L	182_D	0.604	0.11
92_S	109_G	0.604	0.11
123_S	218_P	0.603	0.11
29_S	32_G	0.597	0.10
167_V	272_Y	0.596	0.10
26_K	76_L	0.595	0.10
119_K	155_S	0.593	0.10
32_G	38_N	0.591	0.10
61_K	148_T	0.591	0.10
181_G	243_R	0.589	0.10
88_I	281_I	0.589	0.10
61_K	116_I	0.587	0.10
74_I	194_P	0.586	0.10
48_E	172_L	0.583	0.10
134_S	138_A	0.583	0.10
177_K	228_A	0.582	0.10
61_K	235_I	0.580	0.10
69_R	100_D	0.580	0.10
75_I	145_Q	0.580	0.10
256_A	260_D	0.577	0.10
144_G	176_K	0.576	0.10
33_T	170_V	0.575	0.10
129_L	205_L	0.574	0.10
49_S	83_R	0.571	0.10
200_V	233_P	0.571	0.10
193_N	199_I	0.568	0.10
176_K	242_A	0.567	0.10
137_D	282_F	0.567	0.10
95_L	257_V	0.567	0.10
187_R	227_T	0.564	0.10
61_K	150_D	0.561	0.10
65_E	93_N	0.560	0.10
30_V	280_E	0.558	0.10
47_L	228_A	0.558	0.10
41_H	173_G	0.557	0.10
61_K	167_V	0.556	0.10
219_E	251_E	0.555	0.10
32_G	70_G	0.554	0.10
95_L	124_G	0.549	0.10
25_W	265_A	0.549	0.10
41_H	181_G	0.547	0.10
80_S	129_L	0.546	0.10
24_G	186_I	0.545	0.10
103_T	146_P	0.545	0.10
143_L	200_V	0.545	0.10
41_H	228_A	0.543	0.10
35_C	41_H	0.543	0.10
70_G	102_L	0.541	0.10
138_A	262_D	0.537	0.10
155_S	264_I	0.537	0.10
47_L	142_I	0.537	0.10
132_M	242_A	0.532	0.10
88_I	152_Y	0.532	0.10
197_L	220_E	0.530	0.10
111_V	136_N	0.528	0.10
245_R	253_E	0.528	0.10
92_S	258_D	0.527	0.10
30_V	38_N	0.527	0.10
155_S	170_V	0.525	0.10
110_V	152_Y	0.524	0.09
239_L	265_A	0.521	0.09
60_E	193_N	0.520	0.09
50_M	77_S	0.519	0.09
188_L	198_I	0.518	0.09
138_A	174_L	0.518	0.09
176_K	192_V	0.518	0.09
141_D	187_R	0.518	0.09
125_V	272_Y	0.518	0.09
131_D	173_G	0.517	0.09
110_V	139_I	0.513	0.09
176_K	202_L	0.511	0.09
265_A	289_G	0.511	0.09
142_I	256_A	0.510	0.09
142_I	201_G	0.510	0.09
226_R	264_I	0.508	0.09
108_T	124_G	0.506	0.09
79_G	241_C	0.505	0.09
79_G	169_H	0.505	0.09
79_G	107_H	0.505	0.09
177_K	198_I	0.504	0.09
28_I	96_K	0.504	0.09
86_V	148_T	0.502	0.09
86_V	181_G	0.502	0.09
107_H	240_G	0.501	0.09
169_H	240_G	0.501	0.09
78_G	240_G	0.501	0.09
97_R	111_V	0.500	0.09
182_D	198_I	0.500	0.09

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1r30A	2	0.9169	99.9	0.794	Contact Map
3t7vA	1	0.9269	99.9	0.801	Contact Map
3iixA	1	0.9568	99.9	0.808	Contact Map
4wcxA	1	0.9601	99.9	0.813	Contact Map
4rtbA	2	0.9203	99.9	0.822	Contact Map
4r33A	2	0.9535	99.8	0.826	Contact Map
4u0oB	1	0.7973	99.7	0.85	Contact Map
2qgqA	1	0.7907	99.6	0.862	Contact Map
4jc0A	1	0.9302	99.6	0.862	Contact Map
1oltA	1	0.9203	99.6	0.867	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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