GREMLIN Database
Q97Z27 - Uncharacterized protein
UniProt: Q97Z27 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 301 (264)
Sequences: 118 (98)
Seq/√Len: 6.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_S126_K4.3720.96
253_E271_T3.9480.93
262_D279_R3.4800.88
25_W73_G2.9140.76
46_V242_A2.6160.67
81_T85_D2.4240.61
138_A181_G2.4150.61
63_I98_Y2.4000.60
238_N263_A2.3980.60
46_V205_L2.2970.57
25_W189_L2.2730.56
131_D246_G2.2540.55
172_L224_A2.2050.53
40_K144_G2.1620.52
105_I129_L2.1610.52
243_R253_E2.1140.50
86_V139_I2.0990.50
105_I242_A2.0980.50
205_L242_A2.0920.49
200_V242_A2.0490.48
129_L242_A2.0470.48
39_C42_C2.0390.48
177_K182_D2.0340.47
108_T128_A2.0340.47
38_N43_G2.0340.47
136_N149_V2.0310.47
41_H131_D1.9750.45
86_V142_I1.9740.45
217_T223_V1.9530.45
184_E187_R1.9430.44
129_L200_V1.9060.43
139_I152_Y1.8700.42
117_A145_Q1.8700.42
203_M242_A1.8450.41
43_G144_G1.8210.40
149_V279_R1.8100.40
35_C42_C1.7960.39
35_C39_C1.7960.39
31_T35_C1.7810.39
37_F201_G1.7790.39
76_L95_L1.7640.38
206_V211_N1.7300.37
171_I200_V1.7160.36
29_S35_C1.6780.35
222_I255_F1.6770.35
73_G265_A1.6600.35
215_P262_D1.6320.34
80_S171_I1.6300.34
143_L199_I1.6070.33
132_M232_F1.6000.33
46_V132_M1.5620.32
76_L137_D1.5510.31
200_V265_A1.5470.31
129_L265_A1.5450.31
145_Q186_I1.5240.30
41_H47_L1.5120.30
138_A142_I1.4840.29
59_I272_Y1.4810.29
86_V131_D1.4630.29
80_S181_G1.4500.28
170_V201_G1.4390.28
84_G135_D1.4340.28
86_V152_Y1.4250.27
143_L177_K1.4120.27
40_K176_K1.4100.27
233_P262_D1.4020.27
215_P279_R1.3980.27
225_L239_L1.3850.26
129_L171_I1.3840.26
25_W156_F1.3760.26
98_Y221_I1.3720.26
46_V203_M1.3630.26
276_K280_E1.3590.26
32_G35_C1.3590.26
31_T39_C1.3570.26
31_T42_C1.3570.26
151_D154_N1.3510.25
252_V279_R1.3370.25
197_L233_P1.3360.25
106_A120_F1.3330.25
76_L268_E1.3290.25
26_K98_Y1.3080.24
98_Y116_I1.3070.24
225_L257_V1.2990.24
27_S232_F1.2970.24
44_R48_E1.2940.24
131_D143_L1.2770.23
41_H177_K1.2760.23
134_S185_S1.2750.23
221_I239_L1.2520.23
29_S39_C1.2440.23
29_S42_C1.2440.23
177_K201_G1.2360.22
96_K180_E1.2290.22
84_G208_T1.2290.22
249_Y253_E1.2230.22
179_L224_A1.2050.22
191_E232_F1.1980.22
81_T148_T1.1840.21
42_C47_L1.1830.21
39_C47_L1.1830.21
70_G73_G1.1740.21
73_G125_V1.1700.21
189_L232_F1.1680.21
64_M197_L1.1490.20
56_Q94_L1.1470.20
87_P120_F1.1470.20
125_V265_A1.1360.20
87_P109_G1.1350.20
115_E271_T1.1320.20
58_K61_K1.1310.20
126_K249_Y1.1300.20
110_V196_A1.1290.20
76_L106_A1.1250.20
229_R262_D1.1170.20
41_H246_G1.1170.20
183_L224_A1.1150.20
219_E257_V1.1090.19
53_G110_V1.1070.19
130_L265_A1.1030.19
81_T259_Y1.0950.19
80_S200_V1.0950.19
224_A276_K1.0880.19
160_K236_P1.0790.19
51_I59_I1.0740.19
75_I126_K1.0710.19
114_E155_S1.0620.18
124_G257_V1.0600.18
105_I265_A1.0550.18
86_V151_D1.0420.18
59_I190_Q1.0410.18
131_D182_D1.0370.18
50_M244_P1.0340.18
115_E140_K1.0300.18
168_P287_C1.0300.18
168_P288_C1.0300.18
68_S93_N1.0180.17
199_I281_I1.0170.17
96_K161_K1.0160.17
136_N150_D1.0160.17
202_L208_T1.0150.17
133_V181_G1.0110.17
117_A124_G1.0100.17
181_G278_K1.0020.17
232_F235_I0.9900.17
70_G163_N0.9860.17
143_L171_I0.9780.17
89_W165_K0.9730.17
206_V268_E0.9680.16
143_L246_G0.9600.16
166_I176_K0.9580.16
134_S149_V0.9580.16
120_F210_M0.9550.16
242_A263_A0.9550.16
104_I167_V0.9520.16
32_G42_C0.9500.16
32_G39_C0.9500.16
35_C47_L0.9460.16
41_H182_D0.9460.16
37_F253_E0.9220.16
91_Y165_K0.9210.16
108_T253_E0.9190.16
139_I181_G0.9180.16
133_V225_L0.9160.16
28_I93_N0.9120.15
108_T195_D0.9080.15
152_Y253_E0.9020.15
146_P194_P0.8980.15
46_V105_I0.8920.15
45_R249_Y0.8920.15
121_K147_F0.8870.15
110_V262_D0.8860.15
28_I121_K0.8860.15
150_D247_K0.8850.15
242_A266_F0.8830.15
245_R268_E0.8780.15
108_T132_M0.8730.15
90_R104_I0.8720.15
33_T93_N0.8710.15
35_C244_P0.8660.15
253_E266_F0.8650.15
201_G253_E0.8600.14
40_K142_I0.8590.14
144_G289_G0.8580.14
73_G156_F0.8570.14
172_L179_L0.8540.14
46_V208_T0.8510.14
48_E186_I0.8500.14
239_L256_A0.8430.14
142_I174_L0.8430.14
106_A202_L0.8400.14
41_H143_L0.8360.14
75_I182_D0.8350.14
144_G209_Q0.8350.14
143_L185_S0.8290.14
34_Y170_V0.8260.14
176_K210_M0.8170.14
177_K185_S0.8150.14
62_E90_R0.8140.14
25_W77_S0.8110.14
242_A265_A0.8090.14
243_R288_C0.8070.14
243_R287_C0.8070.14
29_S79_G0.8060.14
65_E76_L0.8060.14
106_A210_M0.8040.14
86_V138_A0.8000.13
45_R189_L0.7940.13
129_L289_G0.7940.13
154_N189_L0.7930.13
173_G182_D0.7890.13
174_L181_G0.7890.13
37_F75_I0.7790.13
72_E214_R0.7740.13
145_Q278_K0.7720.13
104_I197_L0.7710.13
77_S109_G0.7700.13
40_K289_G0.7690.13
164_I265_A0.7680.13
144_G179_L0.7650.13
144_G239_L0.7630.13
143_L182_D0.7600.13
77_S267_P0.7570.13
51_I61_K0.7560.13
202_L285_N0.7560.13
84_G109_G0.7550.13
80_S263_A0.7550.13
46_V129_L0.7520.13
156_F199_I0.7500.13
202_L205_L0.7500.13
139_I243_R0.7500.13
111_V159_L0.7460.13
84_G252_V0.7450.13
58_K172_L0.7440.13
172_L199_I0.7430.13
226_R262_D0.7420.13
45_R265_A0.7410.13
93_N237_I0.7370.12
202_L253_E0.7350.12
112_K115_E0.7350.12
152_Y243_R0.7330.12
27_S132_M0.7310.12
95_L180_E0.7300.12
75_I177_K0.7280.12
129_L249_Y0.7220.12
184_E203_M0.7220.12
76_L99_S0.7200.12
105_I203_M0.7190.12
29_S134_S0.7160.12
172_L219_E0.7150.12
111_V268_E0.7110.12
74_I280_E0.7100.12
107_H241_C0.7090.12
78_G241_C0.7090.12
107_H169_H0.7090.12
78_G107_H0.7090.12
195_D224_A0.7090.12
78_G169_H0.7090.12
169_H241_C0.7090.12
243_R260_D0.7090.12
81_T212_A0.7080.12
73_G248_S0.7070.12
93_N96_K0.7020.12
173_G208_T0.6990.12
25_W88_I0.6980.12
177_K224_A0.6940.12
230_D275_A0.6910.12
76_L128_A0.6880.12
110_V278_K0.6850.12
35_C50_M0.6840.12
80_S110_V0.6840.12
103_T131_D0.6820.12
133_V177_K0.6750.12
59_I112_K0.6710.11
139_I253_E0.6690.11
136_N184_E0.6690.11
100_D257_V0.6680.11
57_G61_K0.6640.11
187_R231_T0.6630.11
91_Y188_L0.6600.11
105_I205_L0.6580.11
260_D278_K0.6580.11
124_G145_Q0.6560.11
170_V282_F0.6560.11
28_I276_K0.6560.11
30_V153_L0.6540.11
125_V163_N0.6520.11
170_V238_N0.6490.11
105_I200_V0.6480.11
25_W105_I0.6450.11
81_T101_R0.6440.11
164_I199_I0.6430.11
133_V175_S0.6430.11
116_I184_E0.6410.11
28_I54_S0.6410.11
167_V212_A0.6390.11
73_G202_L0.6370.11
74_I137_D0.6350.11
28_I282_F0.6340.11
142_I177_K0.6260.11
57_G166_I0.6250.11
110_V253_E0.6250.11
219_E228_A0.6210.11
86_V133_V0.6200.11
63_I112_K0.6180.11
202_L210_M0.6150.11
41_H80_S0.6140.11
117_A133_V0.6130.11
47_L182_D0.6040.11
92_S109_G0.6040.11
123_S218_P0.6030.11
29_S32_G0.5970.10
167_V272_Y0.5960.10
26_K76_L0.5950.10
119_K155_S0.5930.10
32_G38_N0.5910.10
61_K148_T0.5910.10
181_G243_R0.5890.10
88_I281_I0.5890.10
61_K116_I0.5870.10
74_I194_P0.5860.10
48_E172_L0.5830.10
134_S138_A0.5830.10
177_K228_A0.5820.10
61_K235_I0.5800.10
69_R100_D0.5800.10
75_I145_Q0.5800.10
256_A260_D0.5770.10
144_G176_K0.5760.10
33_T170_V0.5750.10
129_L205_L0.5740.10
49_S83_R0.5710.10
200_V233_P0.5710.10
193_N199_I0.5680.10
176_K242_A0.5670.10
137_D282_F0.5670.10
95_L257_V0.5670.10
187_R227_T0.5640.10
61_K150_D0.5610.10
65_E93_N0.5600.10
30_V280_E0.5580.10
47_L228_A0.5580.10
41_H173_G0.5570.10
61_K167_V0.5560.10
219_E251_E0.5550.10
32_G70_G0.5540.10
95_L124_G0.5490.10
25_W265_A0.5490.10
41_H181_G0.5470.10
80_S129_L0.5460.10
24_G186_I0.5450.10
103_T146_P0.5450.10
143_L200_V0.5450.10
41_H228_A0.5430.10
35_C41_H0.5430.10
70_G102_L0.5410.10
138_A262_D0.5370.10
155_S264_I0.5370.10
47_L142_I0.5370.10
132_M242_A0.5320.10
88_I152_Y0.5320.10
197_L220_E0.5300.10
111_V136_N0.5280.10
245_R253_E0.5280.10
92_S258_D0.5270.10
30_V38_N0.5270.10
155_S170_V0.5250.10
110_V152_Y0.5240.09
239_L265_A0.5210.09
60_E193_N0.5200.09
50_M77_S0.5190.09
188_L198_I0.5180.09
138_A174_L0.5180.09
176_K192_V0.5180.09
141_D187_R0.5180.09
125_V272_Y0.5180.09
131_D173_G0.5170.09
110_V139_I0.5130.09
176_K202_L0.5110.09
265_A289_G0.5110.09
142_I256_A0.5100.09
142_I201_G0.5100.09
226_R264_I0.5080.09
108_T124_G0.5060.09
79_G241_C0.5050.09
79_G169_H0.5050.09
79_G107_H0.5050.09
177_K198_I0.5040.09
28_I96_K0.5040.09
86_V148_T0.5020.09
86_V181_G0.5020.09
107_H240_G0.5010.09
169_H240_G0.5010.09
78_G240_G0.5010.09
97_R111_V0.5000.09
182_D198_I0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r30A 2 0.9169 99.9 0.794 Contact Map
3t7vA 1 0.9269 99.9 0.801 Contact Map
3iixA 1 0.9568 99.9 0.808 Contact Map
4wcxA 1 0.9601 99.9 0.813 Contact Map
4rtbA 2 0.9203 99.9 0.822 Contact Map
4r33A 2 0.9535 99.8 0.826 Contact Map
4u0oB 1 0.7973 99.7 0.85 Contact Map
2qgqA 1 0.7907 99.6 0.862 Contact Map
4jc0A 1 0.9302 99.6 0.862 Contact Map
1oltA 1 0.9203 99.6 0.867 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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