GREMLIN Database
Q97Z26 - Biotin synthase (BioB)
UniProt: Q97Z26 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 351 (309)
Sequences: 114 (94)
Seq/√Len: 5.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
207_I216_A4.4230.95
217_V282_L4.2570.94
212_S215_D3.7900.89
51_N60_E3.5890.86
221_W225_S3.5790.86
18_A38_I3.1740.78
54_Y172_R3.1500.77
217_V260_A3.0370.74
314_N323_N2.9090.71
61_V234_A2.8760.70
77_L194_E2.5780.61
225_S270_D2.5420.60
214_K218_N2.5140.59
108_H114_D2.2790.51
162_A171_L2.2700.51
254_Y314_N2.1400.46
261_R303_S2.0980.45
166_K248_P2.0970.45
17_G37_T2.0500.43
24_F160_I2.0350.43
138_T158_V2.0190.42
17_G57_Q1.9760.41
41_L47_G1.9460.40
318_G324_V1.9150.39
129_L228_A1.9030.39
254_Y323_N1.9010.39
70_L313_S1.8770.38
39_N104_G1.8590.37
167_V171_L1.8510.37
40_L58_A1.8460.37
37_T57_Q1.8320.36
326_W332_M1.8280.36
39_N322_K1.8270.36
14_L19_D1.8200.36
99_Q307_G1.8190.36
58_A244_E1.8170.36
158_V215_D1.8110.36
189_I228_A1.8020.35
274_F282_L1.7860.35
139_Y153_A1.7790.35
203_I228_A1.7490.34
106_L158_V1.7280.33
213_E253_V1.7250.33
35_N172_R1.7090.33
104_G322_K1.6870.32
39_N71_I1.6840.32
166_K170_E1.6740.32
261_R265_E1.6460.31
249_V314_N1.6360.31
36_T172_R1.6220.30
71_I236_Y1.6070.30
59_R263_L1.6060.30
104_G313_S1.5950.29
54_Y103_I1.5940.29
151_A318_G1.5920.29
36_T309_N1.5750.29
50_A168_F1.5640.29
71_I313_S1.5580.28
51_N58_A1.5550.28
37_T104_G1.5400.28
17_G234_A1.5350.28
221_W270_D1.5230.27
19_D78_R1.5160.27
37_T70_L1.5130.27
57_Q104_G1.5120.27
264_I274_F1.4930.27
57_Q70_L1.4910.27
249_V323_N1.4880.27
315_E323_N1.4680.26
216_A225_S1.4670.26
71_I104_G1.4640.26
159_A280_G1.4580.26
17_G70_L1.4500.26
39_N313_S1.4410.25
186_L222_Y1.4370.25
220_M230_I1.4340.25
224_H230_I1.4280.25
156_I235_F1.4250.25
71_I322_K1.4050.24
203_I223_A1.4040.24
70_L104_G1.3830.24
158_V228_A1.3830.24
40_L321_L1.3700.24
56_G238_E1.3690.24
189_I223_A1.3560.23
168_F261_R1.3530.23
235_F241_T1.3470.23
156_I165_E1.3340.23
12_V202_G1.3230.22
136_T314_N1.3180.22
156_I251_V1.3140.22
116_I147_E1.3100.22
53_S251_V1.3010.22
41_L71_I1.3000.22
138_T228_A1.2870.22
51_N155_M1.2750.21
166_K215_D1.2710.21
17_G36_T1.2700.21
71_I238_E1.2580.21
171_L200_N1.2500.21
162_A338_K1.2480.21
162_A167_V1.2370.20
197_G201_A1.2330.20
254_Y315_E1.2310.20
136_T249_V1.2280.20
149_R197_G1.2270.20
154_D319_R1.2270.20
68_K156_I1.2240.20
313_S322_K1.2230.20
160_I172_R1.2190.20
192_A303_S1.2170.20
23_G264_I1.2150.20
142_K195_V1.2050.20
22_L103_I1.1880.19
122_I156_I1.1780.19
104_G241_T1.1760.19
145_M197_G1.1750.19
84_L128_E1.1570.19
237_P312_Y1.1540.19
148_M165_E1.1530.19
221_W264_I1.1520.19
106_L194_E1.1490.19
197_G203_I1.1480.19
132_S259_I1.1470.19
236_Y322_K1.1460.19
168_F185_Y1.1440.19
72_R237_P1.1370.18
35_N309_N1.1360.18
214_K277_D1.1270.18
136_T323_N1.1270.18
59_R306_P1.1200.18
167_V257_M1.1200.18
85_K147_E1.1150.18
155_M159_A1.1100.18
136_T320_V1.1100.18
159_A202_G1.1060.18
136_T163_A1.1060.18
82_E226_R1.1000.18
13_R253_V1.0970.18
107_A137_A1.0910.17
57_Q172_R1.0840.17
18_A322_K1.0830.17
60_E73_V1.0780.17
35_N54_Y1.0720.17
113_P163_A1.0700.17
234_A312_Y1.0690.17
195_V228_A1.0690.17
106_L157_D1.0650.17
197_G228_A1.0620.17
39_N238_E1.0600.17
17_G61_V1.0600.17
13_R38_I1.0590.17
56_G207_I1.0570.17
80_L121_R1.0570.17
98_L306_P1.0560.17
104_G236_Y1.0530.17
138_T197_G1.0500.17
56_G171_L1.0480.17
182_W186_L1.0470.17
41_L56_G1.0420.17
228_A266_N1.0330.16
84_L247_K1.0250.16
51_N59_R1.0200.16
39_N70_L1.0180.16
213_E328_L1.0150.16
105_Q137_A1.0140.16
129_L195_V1.0130.16
99_Q337_I1.0040.16
172_R185_Y1.0030.16
16_F119_T1.0030.16
40_L248_P1.0020.16
54_Y57_Q0.9980.16
36_T57_Q0.9950.16
38_I322_K0.9950.16
41_L241_T0.9940.16
22_L173_G0.9940.16
82_E198_K0.9860.16
116_I120_R0.9810.15
29_F73_V0.9680.15
24_F76_P0.9680.15
235_F312_Y0.9680.15
301_M328_L0.9660.15
182_W227_G0.9630.15
111_A321_L0.9620.15
105_Q153_A0.9610.15
101_I119_T0.9580.15
39_N236_Y0.9520.15
219_L223_A0.9510.15
18_A37_T0.9470.15
168_F320_V0.9370.15
14_L243_M0.9330.15
203_I332_M0.9310.15
105_Q313_S0.9290.15
162_A243_M0.9280.15
18_A39_N0.9220.14
47_G71_I0.9210.14
53_S242_P0.9190.14
104_G130_Q0.9180.14
164_N201_A0.9180.14
153_A157_D0.9140.14
45_P180_H0.9140.14
231_S303_S0.9130.14
302_T325_P0.9120.14
82_E250_P0.9060.14
193_V197_G0.9030.14
286_E292_T0.8990.14
168_F181_S0.8980.14
172_R309_N0.8960.14
276_F312_Y0.8830.14
108_H139_Y0.8830.14
191_E282_L0.8800.14
189_I298_P0.8790.14
20_M27_G0.8780.14
80_L336_S0.8770.14
193_V203_I0.8760.14
118_I226_R0.8730.14
56_G71_I0.8720.14
234_A328_L0.8690.14
145_M203_I0.8640.14
35_N57_Q0.8620.13
131_I207_I0.8570.13
74_E338_K0.8550.13
238_E273_A0.8450.13
56_G256_R0.8440.13
70_L322_K0.8430.13
39_N105_Q0.8410.13
145_M157_D0.8350.13
78_R318_G0.8320.13
218_N257_M0.8310.13
57_Q241_T0.8230.13
59_R83_V0.8220.13
138_T182_W0.8180.13
35_N130_Q0.8170.13
58_A83_V0.8140.13
249_V254_Y0.8120.13
50_A165_E0.8110.13
103_I276_F0.8100.13
58_A66_E0.8090.13
61_V70_L0.8060.13
297_A300_F0.8020.13
39_N56_G0.8020.13
193_V228_A0.8000.13
26_S81_N0.7990.13
136_T157_D0.7990.13
17_G172_R0.7990.13
167_V293_L0.7990.13
277_D281_E0.7960.13
47_G185_Y0.7950.12
115_A243_M0.7940.12
106_L138_T0.7930.12
131_I191_E0.7920.12
24_F130_Q0.7890.12
274_F316_R0.7860.12
327_Y331_E0.7820.12
164_N297_A0.7780.12
72_R255_R0.7780.12
101_I118_I0.7750.12
37_T236_Y0.7740.12
37_T313_S0.7720.12
230_I234_A0.7650.12
198_K336_S0.7640.12
38_I105_Q0.7640.12
119_T319_R0.7620.12
88_Y244_E0.7620.12
272_N338_K0.7590.12
219_L267_D0.7570.12
272_N331_E0.7550.12
104_G203_I0.7530.12
168_F172_R0.7530.12
183_K276_F0.7500.12
143_H287_I0.7500.12
33_A218_N0.7490.12
82_E273_A0.7450.12
113_P271_I0.7450.12
17_G104_G0.7430.12
205_L220_M0.7420.12
256_R280_G0.7410.12
181_S282_L0.7390.12
229_K266_N0.7380.12
215_D279_K0.7370.12
27_G56_G0.7320.12
263_L318_G0.7280.12
63_N201_A0.7270.12
235_F256_R0.7250.11
225_S247_K0.7250.11
13_R118_I0.7240.11
132_S197_G0.7200.11
118_I132_S0.7200.11
50_A174_K0.7190.11
223_A228_A0.7150.11
228_A243_M0.7140.11
46_D219_L0.7120.11
206_I240_G0.7100.11
195_V203_I0.7100.11
122_I128_E0.7060.11
106_L228_A0.7050.11
201_A328_L0.7030.11
58_A135_V0.7020.11
183_K242_P0.7000.11
167_V298_P0.6970.11
32_G98_L0.6930.11
57_Q313_S0.6910.11
18_A104_G0.6900.11
37_T322_K0.6900.11
11_W77_L0.6890.11
247_K334_L0.6870.11
245_K279_K0.6870.11
41_L50_A0.6860.11
172_R326_W0.6860.11
44_Y243_M0.6860.11
17_G313_S0.6840.11
113_P227_G0.6830.11
18_A136_T0.6820.11
13_R157_D0.6790.11
163_A301_M0.6760.11
212_S226_R0.6740.11
236_Y313_S0.6740.11
297_A332_M0.6740.11
202_G213_E0.6730.11
235_F300_F0.6710.11
68_K114_D0.6680.11
217_V271_I0.6660.11
21_V135_V0.6660.11
63_N74_E0.6640.11
50_A185_Y0.6630.11
225_S271_I0.6620.11
167_V334_L0.6620.11
256_R300_F0.6600.11
70_L231_S0.6530.11
262_W300_F0.6520.11
153_A213_E0.6510.11
183_K222_Y0.6490.11
96_Y160_I0.6470.10
183_K186_L0.6440.10
145_M149_R0.6360.10
116_I121_R0.6350.10
98_L140_T0.6350.10
85_K88_Y0.6310.10
153_A180_H0.6280.10
33_A315_E0.6240.10
117_E287_I0.6210.10
41_L108_H0.6180.10
165_E169_E0.6170.10
260_A324_V0.6170.10
285_V301_M0.6160.10
116_I151_A0.6160.10
274_F283_I0.6160.10
97_G318_G0.6130.10
18_A236_Y0.6120.10
56_G243_M0.6120.10
192_A261_R0.6110.10
119_T156_I0.6030.10
156_I209_L0.5970.10
103_I280_G0.5970.10
166_K294_N0.5960.10
50_A158_V0.5960.10
264_I288_P0.5950.10
57_Q325_P0.5940.10
217_V270_D0.5930.10
57_Q107_A0.5910.10
297_A326_W0.5910.10
168_F191_E0.5890.10
264_I290_D0.5890.10
158_V201_A0.5870.10
73_V225_S0.5860.10
70_L234_A0.5860.10
122_I200_N0.5860.10
206_I315_E0.5850.10
269_V282_L0.5830.10
137_A241_T0.5820.10
58_A273_A0.5790.10
71_I105_Q0.5770.10
185_Y203_I0.5760.10
73_V235_F0.5730.10
201_A205_L0.5730.10
83_V163_A0.5720.10
12_V78_R0.5690.10
107_A241_T0.5680.10
157_D323_N0.5680.10
77_L222_Y0.5670.10
180_H238_E0.5670.10
104_G238_E0.5640.09
37_T241_T0.5610.09
105_Q145_M0.5600.09
39_N54_Y0.5590.09
263_L302_T0.5590.09
39_N57_Q0.5590.09
149_R227_G0.5580.09
19_D189_I0.5570.09
271_I283_I0.5550.09
60_E234_A0.5540.09
205_L227_G0.5540.09
141_F288_P0.5530.09
159_A197_G0.5530.09
185_Y265_E0.5530.09
309_N325_P0.5530.09
185_Y197_G0.5530.09
104_G107_A0.5520.09
129_L250_P0.5520.09
141_F189_I0.5510.09
297_A324_V0.5480.09
45_P197_G0.5470.09
298_P301_M0.5460.09
223_A251_V0.5460.09
49_K256_R0.5450.09
170_E284_D0.5440.09
103_I122_I0.5420.09
172_R234_A0.5400.09
277_D331_E0.5400.09
70_L105_Q0.5400.09
118_I141_F0.5390.09
218_N222_Y0.5380.09
145_M159_A0.5370.09
201_A290_D0.5370.09
215_D226_R0.5360.09
182_W263_L0.5350.09
107_A186_L0.5350.09
71_I237_P0.5350.09
117_E273_A0.5350.09
89_E278_D0.5340.09
47_G238_E0.5330.09
57_Q231_S0.5330.09
151_A271_I0.5320.09
68_K262_W0.5320.09
220_M257_M0.5320.09
159_A203_I0.5300.09
163_A248_P0.5290.09
20_M200_N0.5290.09
58_A267_D0.5290.09
194_E284_D0.5280.09
219_L251_V0.5270.09
169_E216_A0.5230.09
137_A185_Y0.5230.09
87_I288_P0.5230.09
17_G54_Y0.5230.09
97_G252_H0.5210.09
86_R238_E0.5200.09
154_D277_D0.5200.09
28_V82_E0.5190.09
141_F200_N0.5180.09
18_A71_I0.5180.09
158_V197_G0.5160.09
28_V57_Q0.5140.09
51_N316_R0.5140.09
128_E289_S0.5130.09
148_M151_A0.5130.09
17_G35_N0.5130.09
35_N230_I0.5120.09
80_L191_E0.5120.09
113_P281_E0.5120.09
39_N172_R0.5120.09
38_I313_S0.5090.09
57_Q139_Y0.5090.09
147_E290_D0.5090.09
222_Y312_Y0.5070.09
256_R316_R0.5060.09
51_N263_L0.5050.09
45_P157_D0.5050.09
101_I217_V0.5050.09
187_E331_E0.5040.09
273_A318_G0.5030.09
12_V168_F0.5020.09
246_R299_A0.5010.09
82_E109_P0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r30A 2 0.8348 99.9 0.833 Contact Map
3t7vA 1 0.8746 99.9 0.837 Contact Map
4rtbA 2 0.8917 99.9 0.84 Contact Map
3iixA 1 0.9031 99.9 0.846 Contact Map
4wcxA 1 0.9316 99.9 0.848 Contact Map
4r33A 2 0.8632 99.9 0.85 Contact Map
1tv8A 2 0.8433 99.8 0.863 Contact Map
2qgqA 1 0.7322 99.8 0.867 Contact Map
4u0oB 1 0.6895 99.8 0.868 Contact Map
1oltA 1 0.886 99.8 0.868 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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