GREMLIN Database
Q97Z24 - Acetoin utilization protein
UniProt: Q97Z24 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 348 (293)
Sequences: 5155 (3333)
Seq/√Len: 194.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_K77_E3.0931.00
178_L183_I3.0921.00
116_Y289_I3.0331.00
159_E244_S2.9371.00
152_L155_L2.9161.00
233_E276_R2.8951.00
60_T63_D2.8611.00
110_S291_Y2.8061.00
154_L245_Y2.7521.00
152_L181_K2.7261.00
175_Q204_E2.6321.00
162_A238_L2.4961.00
110_S150_T2.4031.00
224_T227_I2.3871.00
66_V156_E2.3741.00
225_D269_S2.3591.00
114_I154_L2.3011.00
67_V177_I2.2961.00
113_A289_I2.2591.00
57_E63_D2.2431.00
186_I234_I2.2321.00
15_V112_T2.2281.00
147_V247_L2.2181.00
272_L275_L2.2121.00
113_A122_Y2.2081.00
115_K153_K2.1721.00
65_M73_I2.1231.00
73_I144_I2.1181.00
135_P176_F2.1141.00
139_V172_N2.0901.00
99_M143_P2.0721.00
76_L144_I2.0321.00
184_L215_I1.9901.00
19_R105_L1.9661.00
70_R74_G1.9031.00
164_V277_I1.8991.00
65_M70_R1.8941.00
168_A261_K1.8461.00
61_K65_M1.8131.00
114_I150_T1.7991.00
182_P209_K1.7851.00
215_I237_L1.7691.00
67_V152_L1.7511.00
61_K74_G1.7371.00
134_M176_F1.7351.00
69_T135_P1.7211.00
254_G265_L1.7171.00
210_G213_Y1.6771.00
265_L269_S1.6731.00
107_L149_I1.6571.00
76_L143_P1.6441.00
148_A177_I1.6211.00
59_A108_G1.6191.00
147_V291_Y1.6151.00
225_D266_T1.6041.00
151_A247_L1.5811.00
290_A307_F1.5791.00
13_G119_F1.5741.00
115_K157_K1.5571.00
103_I144_I1.5351.00
57_E112_T1.5341.00
170_H175_Q1.5321.00
252_V307_F1.5291.00
229_E272_L1.5131.00
39_R43_K1.5061.00
152_L156_E1.4931.00
32_D36_A1.4881.00
223_S227_I1.4781.00
135_P177_I1.4581.00
58_Y105_L1.4501.00
77_E100_F1.4421.00
20_F109_S1.4281.00
205_I211_R1.4281.00
139_V196_F1.4101.00
188_I232_L1.4051.00
238_L246_V1.3871.00
246_V281_K1.3761.00
115_K158_G1.3681.00
256_K264_D1.3611.00
185_K249_V1.3611.00
248_V277_I1.3581.00
155_L181_K1.3491.00
144_I149_I1.3481.00
219_L231_S1.3411.00
61_K104_L1.3391.00
163_I174_L1.3321.00
134_M137_R1.3311.00
147_V249_V1.3271.00
14_I39_R1.3261.00
153_K157_K1.3161.00
17_D55_R1.3111.00
202_I218_P1.3011.00
69_T136_N1.2921.00
238_L280_I1.2921.00
72_Y138_A1.2901.00
256_K266_T1.2861.00
64_L104_L1.2851.00
134_M172_N1.2801.00
123_V292_G1.2801.00
219_L263_L1.2741.00
64_L149_I1.2601.00
168_A263_L1.2581.00
148_A178_L1.2511.00
228_F273_L1.2511.00
276_R279_R1.2341.00
233_E272_L1.2301.00
190_A262_S1.2241.00
255_H267_T1.2201.00
278_R288_I1.2191.00
254_G270_Y1.2151.00
74_G78_E1.2111.00
151_A163_I1.2031.00
29_M129_G1.2001.00
38_V304_M1.1991.00
19_R101_E1.1971.00
266_T269_S1.1951.00
162_A184_L1.1851.00
174_L249_V1.1791.00
100_F144_I1.1781.00
63_D153_K1.1761.00
74_G77_E1.1601.00
166_V273_L1.1551.00
191_Y194_N1.1541.00
19_R22_E1.1491.00
21_T36_A1.1451.00
59_A111_F1.1331.00
63_D66_V1.1221.00
41_F305_V1.1041.00
267_T302_L1.0991.00
151_A161_V1.0901.00
271_N310_G1.0851.00
186_I217_I1.0831.00
63_D111_F1.0781.00
122_Y278_R1.0761.00
40_D43_K1.0571.00
57_E105_L1.0551.00
190_A195_F1.0531.00
64_L73_I1.0471.00
61_K70_R1.0451.00
235_L276_R1.0441.00
163_I183_I1.0431.00
221_L262_S1.0411.00
15_V109_S1.0371.00
15_V54_I1.0361.00
184_L241_Y1.0341.00
111_F153_K1.0321.00
134_M139_V1.0131.00
162_A246_V1.0131.00
112_T115_K1.0121.00
66_V153_K1.0021.00
107_L146_D1.0021.00
281_K286_S0.9991.00
179_Y214_N0.9981.00
13_G54_I0.9911.00
275_L279_R0.9891.00
22_E98_G0.9870.99
164_V186_I0.9850.99
166_V250_A0.9830.99
57_E115_K0.9740.99
58_Y104_L0.9720.99
185_K214_N0.9650.99
274_G307_F0.9640.99
190_A221_L0.9580.99
200_G216_N0.9480.99
61_K73_I0.9480.99
247_L289_I0.9430.99
104_L108_G0.9400.99
275_L310_G0.9380.99
248_V290_A0.9360.99
66_V152_L0.9280.99
79_S95_H0.9200.99
255_H303_S0.9180.99
67_V149_I0.9170.99
127_L130_F0.9150.99
58_Y101_E0.9150.99
171_G185_K0.9120.99
236_D240_L0.9050.99
162_A186_I0.8980.99
228_F265_L0.8830.99
114_I289_I0.8800.99
180_D209_K0.8800.99
160_R241_Y0.8750.99
182_P213_Y0.8680.99
238_L286_S0.8670.99
110_S126_P0.8660.99
162_A237_L0.8650.99
249_V293_G0.8650.99
235_L280_I0.8640.99
59_A63_D0.8630.99
84_Y87_F0.8610.99
150_T247_L0.8600.99
153_K158_G0.8590.99
297_G300_S0.8510.98
77_E104_L0.8450.98
62_E65_M0.8440.98
29_M127_L0.8440.98
246_V277_I0.8440.98
188_I234_I0.8430.98
121_D278_R0.8410.98
237_L240_L0.8410.98
164_V232_L0.8390.98
235_L239_E0.8320.98
166_V277_I0.8320.98
179_Y206_G0.8300.98
41_F45_A0.8270.98
128_G146_D0.8250.98
281_K287_S0.8180.98
246_V288_I0.8150.98
64_L144_I0.8140.98
175_Q216_N0.8140.98
191_Y195_F0.8120.98
184_L237_L0.8100.98
271_N275_L0.8090.98
272_L276_R0.8090.98
166_V274_G0.8080.98
188_I219_L0.8070.98
148_A174_L0.8070.98
181_K241_Y0.8060.98
67_V135_P0.8040.98
76_L100_F0.8000.98
164_V234_I0.8000.98
190_A261_K0.7950.98
175_Q179_Y0.7930.98
114_I153_K0.7930.98
179_Y210_G0.7910.98
191_Y218_P0.7860.97
27_H141_F0.7830.97
110_S289_I0.7780.97
85_I90_Q0.7770.97
114_I247_L0.7770.97
220_P223_S0.7770.97
217_I231_S0.7760.97
69_T72_Y0.7740.97
188_I228_F0.7720.97
246_V286_S0.7700.97
176_F179_Y0.7700.97
17_D20_F0.7690.97
179_Y204_E0.7680.97
40_D44_L0.7670.97
267_T303_S0.7650.97
229_E233_E0.7640.97
163_I178_L0.7640.97
257_N297_G0.7630.97
152_L178_L0.7560.97
274_G310_G0.7550.97
65_M74_G0.7510.97
138_A143_P0.7500.97
247_L291_Y0.7480.97
257_N300_S0.7450.97
300_S303_S0.7440.97
60_T108_G0.7430.96
188_I231_S0.7430.96
67_V148_A0.7430.96
195_F262_S0.7420.96
254_G263_L0.7410.96
48_K53_E0.7410.96
227_I230_K0.7410.96
35_K125_I0.7400.96
41_F44_L0.7390.96
145_N177_I0.7350.96
223_S228_F0.7350.96
305_V309_E0.7330.96
281_K288_I0.7320.96
83_P86_G0.7310.96
67_V178_L0.7300.96
25_F96_Y0.7280.96
276_R280_I0.7270.96
90_Q93_T0.7240.96
252_V293_G0.7200.96
136_N176_F0.7200.96
43_K53_E0.7190.96
43_K48_K0.7190.96
191_Y201_K0.7180.96
59_A64_L0.7180.96
116_Y122_Y0.7180.96
66_V149_I0.7170.96
106_V127_L0.7160.96
64_L107_L0.7110.95
170_H199_T0.7090.95
39_R53_E0.7070.95
86_G90_Q0.7060.95
29_M34_S0.7060.95
41_F302_L0.7030.95
108_G112_T0.7000.95
299_M302_L0.7000.95
113_A124_Y0.7000.95
160_R244_S0.6990.95
87_F90_Q0.6990.95
290_A312_L0.6990.95
248_V288_I0.6970.95
100_F104_L0.6910.95
99_M103_I0.6880.95
56_P109_S0.6790.94
16_W39_R0.6790.94
158_G244_S0.6780.94
151_A174_L0.6770.94
21_T35_K0.6770.94
20_F35_K0.6730.94
38_V42_I0.6730.94
222_G264_D0.6690.94
237_L241_Y0.6660.94
98_G102_D0.6640.94
75_L79_S0.6640.94
128_G293_G0.6610.93
124_Y291_Y0.6570.93
81_K85_I0.6570.93
113_A123_V0.6550.93
42_I308_L0.6550.93
163_I249_V0.6520.93
61_K100_F0.6510.93
15_V113_A0.6510.93
185_K189_Y0.6490.93
129_G146_D0.6470.93
153_K156_E0.6460.93
195_F221_L0.6450.93
83_P87_F0.6430.92
164_V238_L0.6430.92
63_D108_G0.6430.92
29_M130_F0.6410.92
271_N309_E0.6410.92
234_I277_I0.6370.92
200_G204_E0.6350.92
170_H200_G0.6340.92
146_D293_G0.6340.92
174_L185_K0.6340.92
191_Y220_P0.6320.92
103_I106_V0.6280.92
36_A40_D0.6260.91
109_S124_Y0.6260.91
84_Y88_L0.6250.91
24_S31_R0.6240.91
111_F114_I0.6240.91
155_L183_I0.6230.91
66_V107_L0.6200.91
224_T264_D0.6160.91
13_G120_L0.6130.91
248_V307_F0.6130.91
166_V188_I0.6110.90
217_I234_I0.6110.90
37_R40_D0.6110.90
57_E60_T0.6050.90
151_A183_I0.6050.90
61_K64_L0.6040.90
166_V232_L0.6020.90
123_V128_G0.5990.90
255_H300_S0.5980.89
225_D229_E0.5980.89
245_Y289_I0.5920.89
278_R310_G0.5890.89
54_I112_T0.5890.89
220_P227_I0.5890.89
62_E66_V0.5880.89
161_V245_Y0.5870.89
25_F94_V0.5870.89
206_G211_R0.5860.88
118_K121_D0.5850.88
129_G293_G0.5840.88
248_V274_G0.5840.88
134_M177_I0.5830.88
72_Y134_M0.5830.88
219_L224_T0.5820.88
226_D272_L0.5800.88
229_E269_S0.5800.88
223_S231_S0.5790.88
206_G213_Y0.5790.88
114_I245_Y0.5790.88
105_L109_S0.5790.88
45_A305_V0.5760.88
58_Y108_G0.5760.88
274_G290_A0.5740.87
168_A254_G0.5740.87
98_G101_E0.5740.87
91_G138_A0.5730.87
125_I128_G0.5730.87
109_S112_T0.5720.87
168_A190_A0.5720.87
268_N271_N0.5720.87
127_L293_G0.5710.87
103_I146_D0.5710.87
226_D230_K0.5710.87
166_V248_V0.5700.87
206_G209_K0.5690.87
52_V120_L0.5690.87
72_Y76_L0.5680.87
177_I183_I0.5680.87
175_Q200_G0.5680.87
184_L213_Y0.5680.87
130_F293_G0.5660.87
85_I89_D0.5630.86
79_S87_F0.5630.86
188_I217_I0.5630.86
206_G210_G0.5560.86
277_I288_I0.5490.85
38_V308_L0.5490.85
103_I143_P0.5480.85
165_D169_H0.5420.84
160_R243_P0.5410.84
71_D74_G0.5400.84
150_T291_Y0.5400.84
164_V246_V0.5380.84
18_Q21_T0.5380.84
208_G213_Y0.5380.84
13_G52_V0.5380.84
28_P141_F0.5370.84
150_T289_I0.5350.84
179_Y205_I0.5350.84
111_F115_K0.5340.83
29_M128_G0.5320.83
168_A260_L0.5320.83
210_G214_N0.5320.83
194_N199_T0.5300.83
109_S127_L0.5270.83
71_D75_L0.5260.83
170_H216_N0.5230.82
20_F105_L0.5220.82
199_T204_E0.5220.82
124_Y290_A0.5220.82
232_L273_L0.5200.82
76_L95_H0.5190.82
43_K50_S0.5190.82
117_S121_D0.5180.82
14_I51_F0.5170.81
128_G252_V0.5150.81
274_G278_R0.5150.81
110_S247_L0.5130.81
20_F56_P0.5120.81
41_F301_S0.5100.81
39_R48_K0.5100.81
73_I100_F0.5090.80
190_A194_N0.5080.80
75_L87_F0.5080.80
110_S124_Y0.5070.80
59_A107_L0.5060.80
123_V304_M0.5060.80
129_G249_V0.5040.80
301_S304_M0.5040.80
42_I45_A0.5040.80
128_G249_V0.5040.80
304_M307_F0.5010.79
236_D239_E0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vqmA 1 0.9569 100 0.179 Contact Map
4qa5A 1 0.9626 100 0.182 Contact Map
4bkxB 1 0.9483 100 0.184 Contact Map
4ly1A 2 0.9626 100 0.186 Contact Map
1zz1A 4 0.9511 100 0.186 Contact Map
4a69A 1 0.9626 100 0.198 Contact Map
4bz7A 3 0.9397 100 0.203 Contact Map
3menA 3 0.8534 100 0.206 Contact Map
1c3pA 1 0.9253 100 0.207 Contact Map
4zurA 2 0.8448 100 0.216 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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