GREMLIN Database
Q97Z21 - Glutaredoxin related protein
UniProt: Q97Z21 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 171 (165)
Sequences: 956 (654)
Seq/√Len: 50.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_E94_E3.4611.00
105_L133_L3.4061.00
107_V135_I3.3921.00
102_S132_K3.3891.00
24_C41_T2.7961.00
164_I168_S2.7251.00
19_I22_Q2.6091.00
104_K136_Y2.5341.00
31_H39_V2.4441.00
143_E147_K2.3371.00
23_Q65_I2.1931.00
155_K162_V2.1681.00
103_V158_F2.0371.00
124_V131_V2.0351.00
64_G135_I2.0261.00
53_K59_Y2.0151.00
30_F74_F1.9741.00
19_I140_E1.9380.99
27_D50_V1.9250.99
100_R130_N1.9190.99
88_L93_V1.8760.99
93_V97_K1.8540.99
9_E12_N1.8230.99
17_G20_T1.8040.99
16_K54_R1.7910.99
8_K12_N1.7820.99
143_E146_D1.7140.99
106_F144_E1.6930.99
24_C28_S1.6490.98
137_D140_E1.6450.98
94_E98_Q1.6230.98
102_S134_E1.6200.98
104_K148_Y1.6170.98
80_R122_Y1.6140.98
58_V81_I1.6040.98
60_Y125_S1.5690.98
88_L123_Q1.5650.97
104_K160_D1.5580.97
113_K167_D1.5480.97
22_Q65_I1.5450.97
94_E97_K1.5020.97
81_I126_Q1.5000.97
86_V123_Q1.4910.97
43_N47_K1.4810.96
86_V89_D1.4630.96
93_V127_I1.4540.96
116_I120_F1.4530.96
6_V11_L1.4400.96
26_G74_F1.4070.95
28_S39_V1.4010.95
65_I140_E1.3990.95
25_N29_L1.3650.94
64_G107_V1.3260.94
27_D39_V1.3240.93
15_K84_N1.2560.92
18_D21_I1.2380.91
53_K60_Y1.2350.91
7_I11_L1.2160.90
121_L133_L1.2140.90
146_D149_R1.2050.90
142_E146_D1.2020.90
46_K144_E1.1990.90
21_I24_C1.1980.89
80_R85_V1.1910.89
76_N119_E1.1780.89
110_D139_T1.1760.89
9_E13_A1.1610.88
67_I110_D1.1490.87
117_T156_I1.1140.86
31_H37_V1.0990.85
80_R86_V1.0940.85
157_I162_V1.0760.84
80_R126_Q1.0560.83
92_E170_Q1.0510.82
44_N47_K1.0420.82
145_R152_S1.0400.82
96_A124_V1.0310.81
136_Y148_Y1.0310.81
28_S41_T1.0240.81
55_G59_Y1.0220.80
63_Y134_E1.0200.80
121_L158_F1.0120.80
28_S32_E1.0060.79
32_E161_K0.9960.79
93_V123_Q0.9870.78
113_K117_T0.9860.78
23_Q50_V0.9670.77
110_D137_D0.9560.76
52_V135_I0.9550.76
106_F150_V0.9540.76
56_D59_Y0.9370.74
12_N15_K0.9270.74
88_L92_E0.9270.74
24_C39_V0.9220.73
156_I164_I0.9160.73
58_V126_Q0.9120.72
60_Y126_Q0.9080.72
106_F157_I0.9080.72
29_L32_E0.8970.71
105_L122_Y0.8910.71
16_K82_S0.8840.70
147_K161_K0.8830.70
16_K98_Q0.8810.70
60_Y77_S0.8800.70
88_L170_Q0.8790.69
152_S155_K0.8750.69
90_E93_V0.8680.68
129_E161_K0.8570.68
104_K159_N0.8540.67
101_G130_N0.8540.67
122_Y133_L0.8530.67
11_L14_I0.8510.67
80_R84_N0.8480.67
97_K127_I0.8440.66
10_Y13_A0.8390.66
51_K61_T0.8370.66
123_Q126_Q0.8290.65
121_L156_I0.8150.64
150_V157_I0.8070.63
24_C47_K0.8050.63
15_K82_S0.7970.62
100_R150_V0.7960.62
149_R165_P0.7850.61
13_A84_N0.7820.60
22_Q25_N0.7810.60
107_V137_D0.7780.60
13_A16_K0.7730.59
96_A131_V0.7730.59
24_C35_N0.7700.59
69_N151_L0.7630.58
6_V13_A0.7630.58
69_N115_P0.7620.58
53_K58_V0.7550.58
11_L15_K0.7520.57
20_T48_P0.7510.57
119_E138_A0.7410.56
33_F84_N0.7390.56
18_D22_Q0.7380.56
123_Q170_Q0.7370.56
29_L33_F0.7350.56
106_F145_R0.7310.55
86_V127_I0.7260.55
89_D92_E0.7140.53
7_I15_K0.7120.53
37_V52_V0.7100.53
54_R58_V0.7090.53
70_E111_C0.7080.53
112_T165_P0.7080.53
73_P118_A0.7040.52
79_V87_N0.6980.52
148_Y157_I0.6940.51
116_I167_D0.6920.51
10_Y15_K0.6910.51
110_D150_V0.6910.51
53_K56_D0.6850.50
7_I13_A0.6840.50
65_I137_D0.6800.50
38_N130_N0.6790.50
85_V99_V0.6720.49
12_N16_K0.6690.49
65_I75_L0.6650.48
92_E96_A0.6640.48
30_F78_L0.6580.48
112_T139_T0.6510.47
11_L16_K0.6480.47
74_F106_F0.6460.46
78_L82_S0.6400.46
23_Q140_E0.6330.45
109_P118_A0.6330.45
57_R132_K0.6300.45
9_E15_K0.6290.45
6_V124_V0.6280.45
95_L124_V0.6240.44
13_A60_Y0.6220.44
90_E161_K0.6220.44
18_D47_K0.6220.44
122_Y135_I0.6200.44
9_E146_D0.6190.44
51_K58_V0.6160.43
152_S168_S0.6150.43
18_D38_N0.6120.43
103_V163_E0.6110.43
50_V54_R0.6110.43
35_N56_D0.6100.43
136_Y139_T0.6080.43
107_V133_L0.6060.42
11_L30_F0.5990.42
109_P135_I0.5970.41
62_Y73_P0.5930.41
53_K57_R0.5930.41
104_K163_E0.5910.41
45_C147_K0.5910.41
15_K36_Y0.5870.40
48_P78_L0.5860.40
7_I10_Y0.5850.40
18_D31_H0.5830.40
29_L125_S0.5820.40
48_P151_L0.5810.40
8_K11_L0.5810.40
9_E14_I0.5810.40
59_Y112_T0.5790.40
35_N38_N0.5740.39
89_D99_V0.5710.39
81_I125_S0.5700.39
138_A145_R0.5700.39
106_F155_K0.5680.39
19_I65_I0.5670.38
79_V122_Y0.5670.38
21_I28_S0.5640.38
113_K138_A0.5640.38
81_I135_I0.5610.38
48_P141_Y0.5600.38
20_T23_Q0.5600.38
105_L135_I0.5560.37
113_K152_S0.5560.37
52_V60_Y0.5550.37
7_I75_L0.5540.37
139_T145_R0.5530.37
90_E124_V0.5520.37
66_P115_P0.5520.37
42_L47_K0.5500.37
80_R112_T0.5450.36
86_V168_S0.5440.36
83_N120_F0.5400.36
94_E170_Q0.5370.36
17_G82_S0.5330.35
58_V107_V0.5330.35
8_K14_I0.5320.35
156_I169_L0.5310.35
64_G130_N0.5250.34
114_C154_P0.5240.34
10_Y14_I0.5240.34
74_F148_Y0.5230.34
65_I109_P0.5210.34
28_S38_N0.5190.34
60_Y135_I0.5190.34
18_D146_D0.5190.34
44_N134_E0.5170.34
120_F167_D0.5160.34
99_V131_V0.5100.33
101_G121_L0.5100.33
117_T122_Y0.5090.33
48_P63_Y0.5070.33
69_N109_P0.5070.33
52_V58_V0.5040.33
162_V165_P0.5010.32
33_F92_E0.5010.32
22_Q74_F0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mnnA 1 0.9298 100 0.506 Contact Map
1hyuA 2 1 100 0.522 Contact Map
1a8lA 2 1 99.9 0.668 Contact Map
2hlsA 5 0.9825 99.8 0.687 Contact Map
2ywmA 3 1 99.8 0.7 Contact Map
3ctgA 1 0.4854 98.5 0.843 Contact Map
2x8gA 2 0.4678 98.3 0.85 Contact Map
3ipzA 3 0.4678 98.3 0.852 Contact Map
3apoA 1 0.9766 98.2 0.853 Contact Map
4rqrA 1 0.4854 98.2 0.855 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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