GREMLIN Database
Q97Z19 - Dihydrolipoamide dehydrogenase (PdhD-1)
UniProt: Q97Z19 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 446 (419)
Sequences: 12630 (8239)
Seq/√Len: 402.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
167_V243_G4.2551.00
33_K110_E4.2091.00
275_D279_R3.9411.00
383_G397_L3.0751.00
266_S273_V3.0121.00
115_S118_T2.9811.00
165_S188_Q2.9081.00
3_Y105_E2.8491.00
188_Q219_N2.7801.00
138_K257_P2.7091.00
259_G262_I2.6721.00
3_Y29_L2.6551.00
162_V187_S2.6211.00
190_T221_E2.6211.00
114_I120_K2.5721.00
203_E344_K2.5211.00
118_T125_I2.5101.00
210_K214_E2.5071.00
128_F131_L2.5071.00
396_I415_F2.4611.00
17_A132_I2.4541.00
112_E120_K2.4231.00
138_K255_Q2.3751.00
165_S244_N2.3711.00
29_L107_E2.3571.00
69_G72_G2.3551.00
375_N378_N2.3521.00
167_V192_L2.3121.00
140_M253_R2.2761.00
109_G121_V2.2511.00
120_K125_I2.2461.00
385_V390_A2.2001.00
6_V126_V2.1851.00
152_S155_D2.1701.00
5_I21_L2.1651.00
114_I125_I2.1271.00
308_A312_I2.1211.00
379_E404_R2.0661.00
195_S223_N2.0021.00
13_A287_I2.0001.00
6_V119_V1.9991.00
6_V31_A1.9851.00
230_H235_I1.9731.00
176_V191_L1.9681.00
118_T127_E1.9491.00
113_I131_L1.9311.00
138_K253_R1.9211.00
344_K348_E1.8961.00
400_V405_I1.8701.00
343_D347_K1.8581.00
145_N228_K1.8401.00
183_S188_Q1.8391.00
6_V128_F1.8351.00
343_D371_K1.8011.00
75_E78_D1.7861.00
166_M187_S1.7711.00
346_A373_G1.7641.00
276_K321_L1.7591.00
372_L383_G1.7341.00
336_Q391_E1.7211.00
176_V333_T1.7171.00
6_V29_L1.7011.00
4_D129_D1.6911.00
166_M182_Y1.6851.00
133_I290_V1.6751.00
8_I111_V1.6471.00
196_K206_R1.6351.00
107_E126_V1.6321.00
151_L245_V1.6261.00
279_R282_N1.6151.00
130_N283_N1.6121.00
164_S188_Q1.6031.00
132_I312_I1.5791.00
194_R225_R1.5551.00
78_D82_S1.5411.00
117_S283_N1.5351.00
164_S244_N1.5291.00
96_R108_L1.5231.00
285_Y311_H1.5191.00
345_E348_E1.5141.00
406_R409_S1.5141.00
208_I386_I1.5071.00
277_Y311_H1.5011.00
5_I26_K1.5001.00
31_A126_V1.5001.00
130_N312_I1.4941.00
36_F106_T1.4931.00
151_L159_L1.4911.00
221_E224_I1.4771.00
183_S218_V1.4771.00
20_I310_L1.4701.00
184_R216_D1.4601.00
135_T290_V1.4591.00
156_A182_Y1.4501.00
372_L428_A1.4451.00
57_L60_R1.4271.00
151_L155_D1.4261.00
29_L126_V1.4231.00
190_T219_N1.4071.00
4_D27_K1.3991.00
266_S281_K1.3921.00
228_K235_I1.3901.00
5_I132_I1.3861.00
351_V381_V1.3831.00
3_Y107_E1.3741.00
268_N273_V1.3661.00
85_N89_D1.3611.00
30_V99_I1.3521.00
196_K203_E1.3381.00
278_R291_I1.3381.00
209_I386_I1.3371.00
205_A386_I1.3321.00
113_I119_V1.3301.00
202_P371_K1.3241.00
69_G75_E1.3201.00
114_I118_T1.3181.00
43_F154_D1.3121.00
201_F339_I1.3081.00
279_R283_N1.3001.00
205_A369_Y1.2991.00
113_I133_I1.2761.00
354_F387_G1.2671.00
203_E207_S1.2591.00
120_K123_G1.2591.00
370_V423_A1.2571.00
397_L424_I1.2571.00
171_G197_I1.2491.00
112_E259_G1.2481.00
375_N379_E1.2471.00
346_A351_V1.2461.00
144_I147_I1.2421.00
403_N409_S1.2401.00
210_K220_I1.2361.00
132_I287_I1.2331.00
225_R237_E1.2291.00
227_V235_I1.2181.00
201_F329_Q1.2141.00
204_D371_K1.2141.00
192_L241_V1.2121.00
63_E66_Y1.2121.00
305_A309_S1.2101.00
193_S222_E1.2041.00
326_K401_V1.2041.00
372_L397_L1.1901.00
342_N345_E1.1861.00
169_I246_I1.1781.00
389_K392_E1.1771.00
196_K210_K1.1711.00
191_L220_I1.1681.00
89_D93_N1.1651.00
338_G394_I1.1641.00
210_K222_E1.1631.00
337_V386_I1.1601.00
211_D214_E1.1581.00
150_T229_I1.1531.00
329_Q339_I1.1461.00
99_I104_G1.1451.00
212_S215_F1.1421.00
155_D158_N1.1401.00
272_I290_V1.1391.00
86_E90_Y1.1311.00
167_V234_V1.1281.00
330_V416_V1.1271.00
215_F367_D1.1271.00
141_V152_S1.1261.00
268_N292_D1.1261.00
31_A111_V1.1251.00
19_S102_S1.1221.00
265_L272_I1.1141.00
27_K105_E1.1081.00
151_L156_A1.1071.00
53_D57_L1.1061.00
395_N416_V1.1031.00
82_S86_E1.0981.00
145_N148_E1.0951.00
68_I71_D1.0921.00
229_I246_I1.0881.00
26_K313_L1.0861.00
197_I210_K1.0851.00
260_I265_L1.0771.00
143_S147_I1.0761.00
395_N421_S1.0751.00
107_E124_R1.0721.00
13_A301_A1.0701.00
213_L218_V1.0681.00
351_V373_G1.0661.00
176_V213_L1.0661.00
105_E124_R1.0661.00
307_I322_I1.0621.00
161_S245_V1.0611.00
166_M245_V1.0601.00
77_K160_N1.0581.00
131_L284_V1.0501.00
26_K130_N1.0491.00
68_I72_G1.0481.00
84_R88_I1.0471.00
224_I238_K1.0471.00
8_I133_I1.0431.00
112_E262_I1.0401.00
340_V401_V1.0381.00
205_A384_E1.0361.00
24_K310_L1.0321.00
273_V281_K1.0301.00
208_I211_D1.0271.00
278_R308_A1.0261.00
167_V241_V1.0261.00
274_V291_I1.0241.00
338_G390_A1.0211.00
113_I128_F1.0181.00
330_V391_E1.0181.00
31_A121_V1.0171.00
259_G263_L1.0161.00
209_I337_V1.0161.00
214_E219_N1.0161.00
149_N245_V1.0151.00
211_D215_F1.0111.00
345_E349_F1.0091.00
58_L62_K1.0071.00
20_I24_K1.0051.00
26_K129_D1.0041.00
165_S190_T1.0031.00
10_G30_V1.0021.00
169_I248_Y1.0011.00
88_I91_L0.9981.00
99_I106_T0.9981.00
34_E43_F0.9981.00
405_I409_S0.9971.00
197_I222_E0.9921.00
256_L267_I0.9921.00
166_M247_V0.9911.00
375_N381_V0.9901.00
212_S367_D0.9891.00
165_S187_S0.9891.00
116_P283_N0.9861.00
351_V375_N0.9841.00
24_K313_L0.9821.00
69_G73_E0.9801.00
323_D402_N0.9791.00
3_Y27_K0.9771.00
40_C45_C0.9771.00
208_I212_S0.9751.00
287_I308_A0.9721.00
10_G36_F0.9691.00
93_N96_R0.9651.00
54_A83_K0.9641.00
59_N216_D0.9621.00
61_F64_I0.9611.00
130_N285_Y0.9611.00
207_S211_D0.9571.00
113_I263_L0.9561.00
121_V126_V0.9541.00
221_E241_V0.9531.00
340_V398_T0.9521.00
171_G193_S0.9511.00
197_I220_I0.9491.00
267_I273_V0.9481.00
343_D373_G0.9471.00
31_A109_G0.9431.00
116_P264_G0.9411.00
212_S386_I0.9391.00
59_N62_K0.9391.00
169_I250_T0.9371.00
8_I119_V0.9311.00
59_N184_R0.9301.00
55_T184_R0.9301.00
308_A311_H0.9291.00
279_R285_Y0.9271.00
274_V286_A0.9271.00
286_A290_V0.9271.00
139_P142_P0.9221.00
205_A337_V0.9221.00
109_G122_N0.9201.00
173_Y331_L0.9171.00
236_T241_V0.9151.00
196_K344_K0.9131.00
400_V410_L0.9121.00
97_K101_D0.9091.00
54_A79_L0.9081.00
16_V302_I0.9081.00
209_I333_T0.8981.00
4_D26_K0.8981.00
42_N92_S0.8971.00
52_F181_M0.8961.00
56_F60_R0.8961.00
212_S216_D0.8951.00
346_A381_V0.8941.00
113_I259_G0.8911.00
307_I311_H0.8901.00
380_I397_L0.8901.00
265_L281_K0.8881.00
86_E89_D0.8881.00
20_I309_S0.8861.00
294_E327_I0.8861.00
370_V385_V0.8841.00
175_G193_S0.8831.00
279_R311_H0.8811.00
196_K207_S0.8771.00
192_L221_E0.8761.00
227_V237_E0.8751.00
82_S160_N0.8751.00
113_I262_I0.8751.00
353_P356_A0.8731.00
90_Y361_I0.8731.00
21_L26_K0.8731.00
140_M250_T0.8711.00
165_S243_G0.8661.00
263_L284_V0.8601.00
26_K312_I0.8521.00
402_N412_L0.8511.00
168_I247_V0.8501.00
300_S327_I0.8491.00
20_I23_R0.8481.00
8_I258_K0.8471.00
192_L224_I0.8441.00
17_A309_S0.8401.00
263_L281_K0.8391.00
309_S313_L0.8381.00
277_Y321_L0.8351.00
165_S242_E0.8341.00
117_S127_E0.8341.00
184_R334_D0.8291.00
32_E35_K0.8281.00
6_V131_L0.8281.00
336_Q389_K0.8261.00
131_L283_N0.8201.00
132_I308_A0.8201.00
342_N384_E0.8161.00
183_S216_D0.8161.00
372_L427_A0.8161.00
263_L267_I0.8131.00
21_L309_S0.8091.00
272_I286_A0.8081.00
169_I226_I0.8071.00
207_S210_K0.8071.00
91_L95_G0.8061.00
135_T258_K0.8051.00
396_I399_L0.8041.00
201_F331_L0.8031.00
146_G152_S0.8031.00
140_M143_S0.8031.00
17_A305_A0.8031.00
5_I309_S0.8001.00
405_I410_L0.8001.00
304_D324_N0.7991.00
83_K87_I0.7981.00
77_K82_S0.7981.00
357_T360_A0.7961.00
192_L236_T0.7951.00
373_G376_E0.7951.00
59_N63_E0.7941.00
69_G78_D0.7921.00
34_E108_L0.7921.00
190_T243_G0.7871.00
159_L245_V0.7851.00
48_S178_I0.7841.00
84_R158_N0.7791.00
374_I407_I0.7771.00
256_L290_V0.7681.00
213_L220_I0.7671.00
144_I148_E0.7661.00
310_L315_D0.7651.00
97_K100_E0.7631.00
208_I369_Y0.7621.00
181_M185_L0.7601.00
224_I237_E0.7531.00
61_F65_V0.7491.00
278_R311_H0.7461.00
399_L405_I0.7431.00
378_N404_R0.7421.00
392_E421_S0.7411.00
198_L209_I0.7411.00
385_V393_L0.7411.00
175_G194_R0.7401.00
257_P261_E0.7401.00
92_S96_R0.7391.00
116_P263_L0.7361.00
7_I14_G0.7351.00
383_G401_V0.7341.00
179_A218_V0.7281.00
85_N88_I0.7281.00
179_A191_L0.7271.00
303_L306_V0.7261.00
82_S85_N0.7261.00
399_L410_L0.7241.00
410_L428_A0.7241.00
310_L314_K0.7231.00
96_R106_T0.7221.00
71_D75_E0.7221.00
379_E406_R0.7181.00
202_P384_E0.7171.00
96_R100_E0.7171.00
95_G99_I0.7161.00
17_A308_A0.7161.00
269_E273_V0.7151.00
194_R199_P0.7131.00
380_I401_V0.7131.00
141_V248_Y0.7091.00
168_I175_G0.7061.00
397_L401_V0.7051.00
278_R307_I0.7011.00
176_V197_I0.6991.00
65_V78_D0.6931.00
265_L284_V0.6931.00
53_D56_F0.6921.00
21_L28_V0.6921.00
35_K43_F0.6911.00
48_S52_F0.6881.00
358_T361_I0.6851.00
159_L182_Y0.6851.00
274_V278_R0.6851.00
87_I91_L0.6800.99
3_Y6_V0.6800.99
85_N158_N0.6800.99
236_T239_G0.6760.99
150_T248_Y0.6760.99
339_I384_E0.6760.99
79_L185_L0.6750.99
87_I90_Y0.6750.99
306_V310_L0.6730.99
346_A349_F0.6720.99
147_I150_T0.6720.99
137_S252_R0.6720.99
409_S412_L0.6710.99
407_I411_A0.6690.99
180_Q213_L0.6690.99
107_E121_V0.6680.99
139_P143_S0.6670.99
399_L413_M0.6670.99
354_F423_A0.6650.99
180_Q184_R0.6650.99
193_S199_P0.6640.99
387_G390_A0.6620.99
365_F388_D0.6610.99
221_E240_E0.6590.99
7_I18_G0.6590.99
91_L94_A0.6590.99
326_K402_N0.6540.99
399_L403_N0.6530.99
74_I79_L0.6510.99
165_S183_S0.6510.99
292_D296_K0.6510.99
204_D369_Y0.6510.99
91_L361_I0.6490.99
190_T241_V0.6490.99
260_I267_I0.6480.99
93_N97_K0.6470.99
30_V104_G0.6440.99
83_K86_E0.6430.99
53_D363_N0.6430.99
285_Y312_I0.6410.99
195_S203_E0.6400.99
182_Y187_S0.6390.99
22_A104_G0.6390.99
19_S23_R0.6370.99
180_Q216_D0.6360.99
303_L307_I0.6360.99
173_Y329_Q0.6360.99
92_S95_G0.6350.99
272_I280_V0.6350.99
344_K347_K0.6340.99
192_L243_G0.6340.99
280_V286_A0.6300.99
359_R362_I0.6300.99
360_A420_F0.6290.99
53_D60_R0.6270.99
87_I94_A0.6260.99
323_D326_K0.6260.99
260_I263_L0.6230.99
88_I95_G0.6220.99
372_L380_I0.6200.99
205_A208_I0.6190.99
63_E364_G0.6160.99
58_L61_F0.6150.99
233_K242_E0.6130.99
396_I421_S0.6100.99
24_K315_D0.6080.99
167_V236_T0.6080.99
398_T413_M0.6070.99
142_P248_Y0.6070.99
398_T402_N0.6060.99
141_V147_I0.6050.99
326_K398_T0.6030.99
300_S304_D0.6020.99
36_F99_I0.6010.99
35_K92_S0.6010.99
417_H422_E0.6010.99
277_Y316_A0.6010.99
113_I283_N0.6010.99
254_P267_I0.6000.99
242_E245_V0.6000.99
358_T362_I0.6000.99
144_I226_I0.5990.99
84_R87_I0.5980.99
354_F420_F0.5980.99
147_I248_Y0.5970.99
408_E412_L0.5960.99
359_R363_N0.5960.99
237_E240_E0.5950.99
393_L420_F0.5930.99
52_F56_F0.5930.99
23_R102_S0.5910.99
334_D365_F0.5900.99
55_T185_L0.5900.99
4_D29_L0.5890.99
402_N413_M0.5890.99
370_V427_A0.5880.99
187_S244_N0.5860.98
175_G249_A0.5860.98
60_R63_E0.5850.98
143_S148_E0.5850.98
147_I229_I0.5850.98
175_G199_P0.5840.98
324_N327_I0.5830.98
326_K340_V0.5820.98
383_G424_I0.5820.98
5_I17_A0.5820.98
117_S131_L0.5810.98
223_N237_E0.5810.98
352_F356_A0.5810.98
32_E106_T0.5800.98
55_T58_L0.5790.98
219_N222_E0.5770.98
235_I242_E0.5760.98
383_G394_I0.5750.98
111_V119_V0.5730.98
84_R91_L0.5730.98
229_I248_Y0.5730.98
303_L322_I0.5720.98
114_I262_I0.5720.98
153_E174_A0.5710.98
163_P187_S0.5700.98
401_V405_I0.5700.98
35_K42_N0.5690.98
129_D283_N0.5680.98
169_I192_L0.5680.98
56_F334_D0.5680.98
361_I366_K0.5680.98
7_I28_V0.5680.98
98_L102_S0.5670.98
56_F336_Q0.5650.98
180_Q334_D0.5640.98
33_K255_Q0.5630.98
39_V153_E0.5620.98
354_F357_T0.5620.98
300_S324_N0.5620.98
137_S296_K0.5610.98
46_V358_T0.5600.98
302_I425_V0.5600.98
22_A27_K0.5590.98
193_S226_I0.5580.98
111_V121_V0.5570.98
224_I236_T0.5570.98
384_E397_L0.5530.98
203_E206_R0.5530.98
133_I272_I0.5520.98
310_L316_A0.5520.98
37_G40_C0.5520.98
395_N398_T0.5510.98
346_A350_S0.5490.98
303_L425_V0.5480.98
36_F96_R0.5480.98
267_I272_I0.5470.98
142_P146_G0.5470.98
153_E252_R0.5460.98
117_S129_D0.5460.98
57_L61_F0.5450.98
178_I181_M0.5450.98
104_G109_G0.5450.98
115_S262_I0.5450.98
258_K261_E0.5440.98
166_M189_V0.5430.98
287_I305_A0.5420.97
366_K388_D0.5370.97
167_V246_I0.5370.97
119_V131_L0.5370.97
154_D252_R0.5360.97
154_D157_V0.5350.97
146_G229_I0.5340.97
143_S146_G0.5330.97
209_I213_L0.5320.97
132_I309_S0.5320.97
363_N420_F0.5310.97
388_D420_F0.5300.97
40_C49_I0.5290.97
3_Y126_V0.5290.97
374_I380_I0.5280.97
394_I416_V0.5280.97
351_V379_E0.5280.97
385_V394_I0.5270.97
116_P121_V0.5270.97
89_D92_S0.5260.97
197_I206_R0.5260.97
176_V220_I0.5250.97
334_D388_D0.5250.97
77_K161_S0.5250.97
201_F337_V0.5240.97
342_N373_G0.5230.97
35_K108_L0.5230.97
183_S217_G0.5220.97
22_A28_V0.5220.97
354_F360_A0.5200.97
88_I92_S0.5190.97
116_P282_N0.5190.97
118_T121_V0.5190.97
178_I247_V0.5180.97
83_K364_G0.5180.97
287_I312_I0.5170.97
144_I229_I0.5170.97
90_Y94_A0.5160.97
119_V126_V0.5130.97
76_Y162_V0.5120.96
88_I94_A0.5120.96
399_L415_F0.5120.96
58_L74_I0.5120.96
57_L64_I0.5110.96
46_V417_H0.5110.96
168_I179_A0.5070.96
149_N229_I0.5070.96
165_S245_V0.5070.96
347_K350_S0.5070.96
113_I258_K0.5070.96
84_R157_V0.5060.96
94_A98_L0.5050.96
76_Y160_N0.5030.96
76_Y182_Y0.5020.96
40_C47_P0.5010.96
196_K199_P0.5010.96
352_F423_A0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ojtA 2 0.9798 100 0.265 Contact Map
3ladA 2 0.9731 100 0.265 Contact Map
1lvlA 2 0.9709 100 0.271 Contact Map
2wpfA 2 0.9753 100 0.277 Contact Map
2hqmA 2 0.9529 100 0.277 Contact Map
3ic9A 2 0.9776 100 0.278 Contact Map
3o0hA 2 0.9753 100 0.279 Contact Map
3dk9A 2 0.9507 100 0.28 Contact Map
2eq6A 2 0.9709 100 0.28 Contact Map
2r9zA 2 0.9641 100 0.28 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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