GREMLIN Database
Q97Z18 - Uncharacterized protein
UniProt: Q97Z18 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 133 (114)
Sequences: 876 (426)
Seq/√Len: 39.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_K113_E4.1711.00
31_T59_L3.4801.00
21_V50_V3.3191.00
120_L130_T3.2991.00
94_V114_L3.1441.00
40_I117_G2.8901.00
47_E89_K2.7421.00
83_A88_V2.6791.00
16_K47_E2.4981.00
35_L52_F2.2841.00
74_N78_H2.2691.00
42_A88_V2.2531.00
21_V34_P2.2401.00
39_S86_N2.1640.99
46_Y125_L2.1550.99
23_H30_R2.0210.99
35_L50_V1.9500.99
124_T129_R1.8910.98
35_L80_F1.8290.98
52_F60_L1.7840.98
81_D85_E1.6850.97
91_Y115_V1.6030.95
39_S83_A1.5740.95
49_S91_Y1.5600.95
84_K111_G1.4500.92
17_I46_Y1.4480.92
84_K113_E1.4140.91
120_L124_T1.3710.90
18_L120_L1.3090.88
15_K128_D1.3050.87
89_K123_L1.2730.86
15_K46_Y1.2510.85
103_M108_V1.2460.85
97_L108_V1.2460.85
120_L129_R1.2200.84
78_H82_M1.2010.83
42_A83_A1.1910.82
29_D55_K1.1810.82
73_G95_Q1.1800.82
39_S79_F1.1780.81
18_L127_A1.1430.79
96_S100_M1.0980.77
61_D107_D1.0910.76
36_F79_F1.0790.75
17_I129_R1.0770.75
94_V116_G1.0570.74
116_G119_T1.0560.74
49_S123_L1.0540.74
16_K123_L1.0430.73
50_V90_M1.0430.73
16_K126_E1.0370.72
37_M121_I1.0370.72
62_K110_E1.0290.72
63_K85_E1.0240.71
18_L130_T1.0030.70
17_I37_M0.9900.69
21_V37_M0.9800.68
49_S89_K0.9760.68
94_V99_D0.9750.68
24_G36_F0.9630.67
49_S125_L0.9610.66
42_A118_S0.9610.66
19_I37_M0.9560.66
34_P50_V0.9350.64
81_D84_K0.9330.64
63_K66_E0.9230.63
77_I81_D0.9050.62
22_T33_A0.8770.59
73_G100_M0.8690.59
35_L76_F0.8670.58
71_K100_M0.8620.58
105_E111_G0.8550.57
22_T32_Y0.8510.57
46_Y128_D0.8500.57
30_R55_K0.8330.55
90_M112_I0.8240.55
37_M117_G0.8200.54
16_K74_N0.7900.51
96_S101_C0.7880.51
19_I121_I0.7840.51
52_F96_S0.7670.49
57_P101_C0.7660.49
74_N82_M0.7640.49
42_A129_R0.7430.47
97_L115_V0.7410.47
22_T30_R0.7360.47
57_P99_D0.7270.46
104_K107_D0.7180.45
41_S74_N0.7140.45
81_D110_E0.7110.44
60_L109_V0.7110.44
63_K105_E0.7090.44
37_M46_Y0.7070.44
66_E77_I0.6940.43
39_S88_V0.6940.43
61_D103_M0.6860.42
55_K101_C0.6840.42
33_A117_G0.6840.42
57_P92_V0.6830.42
68_E117_G0.6780.41
67_E105_E0.6740.41
30_R33_A0.6740.41
59_L90_M0.6690.41
65_Q90_M0.6680.40
57_P96_S0.6650.40
66_E81_D0.6610.40
33_A36_F0.6520.39
45_E126_E0.6440.38
44_M123_L0.6420.38
35_L59_L0.6310.37
29_D54_I0.6200.36
32_Y68_E0.6160.36
19_I34_P0.6160.36
20_V53_M0.6140.36
17_I125_L0.6140.36
22_T55_K0.6110.36
80_F94_V0.6110.36
62_K70_K0.6090.35
125_L128_D0.6080.35
91_Y113_E0.6060.35
75_P78_H0.6020.35
22_T117_G0.5980.34
106_D114_L0.5950.34
69_R72_G0.5940.34
14_K43_S0.5930.34
15_K90_M0.5840.33
118_S122_D0.5790.33
37_M112_I0.5790.33
14_K126_E0.5740.32
100_M114_L0.5730.32
23_H32_Y0.5730.32
18_L123_L0.5720.32
35_L109_V0.5720.32
87_G101_C0.5720.32
49_S120_L0.5710.32
20_V37_M0.5690.32
43_S116_G0.5680.32
15_K70_K0.5670.32
17_I78_H0.5650.32
42_A47_E0.5640.32
57_P100_M0.5620.32
28_L32_Y0.5590.31
59_L64_W0.5560.31
14_K122_D0.5540.31
51_F54_I0.5510.31
105_E112_I0.5500.31
79_F111_G0.5430.30
52_F101_C0.5370.30
81_D105_E0.5330.29
67_E70_K0.5320.29
33_A96_S0.5280.29
59_L123_L0.5250.29
36_F117_G0.5240.29
115_V119_T0.5220.28
23_H33_A0.5210.28
127_A130_T0.5200.28
67_E89_K0.5180.28
67_E81_D0.5170.28
36_F96_S0.5170.28
42_A48_T0.5160.28
45_E55_K0.5120.28
17_I87_G0.5110.28
69_R113_E0.5110.28
59_L84_K0.5110.28
120_L123_L0.5100.28
94_V105_E0.5090.27
78_H118_S0.5080.27
20_V62_K0.5070.27
84_K90_M0.5020.27
119_T123_L0.5010.27
78_H124_T0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pnxA 4 0.9023 100 0.323 Contact Map
2qs7A 3 0.8722 100 0.356 Contact Map
3mc3A 3 0.812 99.9 0.456 Contact Map
1jx7A 5 0.8647 99.8 0.556 Contact Map
2hy5B 1 0.8797 99.8 0.567 Contact Map
2hy5A 2 0.8647 99.7 0.604 Contact Map
2d1pB 1 0.8797 99.7 0.604 Contact Map
2d1pA 2 0.8797 99.6 0.622 Contact Map
1l1sA 3 0.8045 99.5 0.648 Contact Map
2fb6A 3 0.8421 99.4 0.669 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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